Articles tagged with Cancer Cells
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Researchers developed a new framework combining three methods to find large DNA mutations in cancer cells. The approach reveals how these mutations contribute to cancer development and can help predict effective treatment plans.
Researchers at NUST MISIS and University of Calgary create method to monitor virus spread and immune system response in real-time using intravital microscopy. This breakthrough enables visualization of virus behavior in tissues and organs of living animals.
A $2 million phase 2 grant will be used to further develop a compound that has shown efficacy in preclinical studies against treatment-resistant multiple myeloma. The goal is to create a one-two punch when administered with proteasome inhibitors, making it an effective treatment option for patients.
Researchers found liver cells do not need ORC1 to replicate DNA, a key component of cell division. This process, called an endocycle, allows cells to copy their DNA multiple times without dividing, resulting in larger cells with more DNA. Understanding this mechanism could help explain how cancer arises and how it spreads.
Researchers at UT Austin have developed a new approach to treating cancer using enzyme therapy, which boosts the immune system by degrading kynurenine, a metabolite that suppresses the immune system. The treatment could prove effective in treating various types of cancers and is expected to initiate clinical trials soon.
Scientists develop FliptR, a fluorescent molecule that measures cell membrane tension, revealing how cells adapt their surface to volume changes. The discovery paves the way for applications in cancer cell detection and membrane tension regulation.
Researchers at Hebrew University of Jerusalem have developed a new biological drug that has shown a 50% cure rate in lab mice with acute leukemia. The single-molecule drug targets multiple leukemic proteins, making it difficult for cancer cells to evade therapy and reducing the need for multiple treatments.
Researchers at NUST MISIS have developed a system that improves cancer diagnosis accuracy and provides opportunities for targeted therapy. The magnetoferritin compound, introduced into the body before diagnosis, enhances contrast signals in imaging and targets tumor cells for destruction.
University of Bristol researchers have discovered a way to exploit hypoxia to kill cancer cells without harming healthy tissue. The study found that a specific receptor, GPRC5A, can be targeted using genetic techniques to trigger cancer cell death.
Researchers developed an immunotherapy that induces antitumor immunity by provoking necroptosis in cancer cells, destroying tumors while protecting against secondary tumor formation. The treatment provides protection against disseminated tumors and stimulates the immune system to attack persistent surviving cancer cells.
Researchers found that nanoparticles and contaminants can be deadly to human cells, especially when combined. Exposure to silver nanoparticles alone was less toxic, but combining them with cadmium ions increased cell death by 60%. The study highlights the need for regulations on nanoparticle releases into the environment.
Research suggests an inverse relationship between fever and cancer incidence, potentially linked to enhanced gamma/delta T cell activity. This mechanistic hypothesis proposes that repeated exposure to fever boosts the ability of these T cells to detect cellular abnormalities and destroy malignant cells.
Scientists have introduced a microfluidic chip for manipulation and nucleic-acid analysis of individual cells. The technique uses dielectrophoresis to trap and analyze cells efficiently, overcoming conventional methods' limitations. This innovation paves the way for personalized medicine and improved diagnostics.
Researchers at H. Lee Moffitt Cancer Center suggest that lowering pH inside cancer cells can slow down the growth and spread of the disease. By analyzing how variations in pH affect metabolic enzymes, they identified potential therapeutic targets for breast cancer treatment.
A study by researchers at the Instituto Gulbenkian de Ciencia found that the Spindle Assembly Checkpoint, a mechanism that regulates cell division, can sometimes be counterproductive. This checkpoint can increase genetic errors when cells have irreparable problems with chromosome cohesion.
Researchers at Utah State University have developed a new flavonoid molecule that can release carbon monoxide in a controlled manner, triggering cancer cell death and reducing inflammation. The unique molecules are trackable, targetable, and triggerable using visible light.
A new chemical compound has been developed and tested by scientists at the University of Huddersfield, which attracts vulnerable cancer cells while leaving healthy cells untouched. The compound contains ruthenium and is showing promising results in laboratory tests.
Researchers have gained new understanding of how autophagosomes seal off waste material, with a key role identified for ESCRT complexes. This breakthrough could lead to new cancer treatments by inhibiting autophagy closure.
Researchers discovered an anti-cancer gene called LIF6 in elephants that helps destroy cells with damaged DNA, potentially preventing cancer. This gene emerged around 25-30 million years ago and may have played a key role in enabling the growth of modern elephants.
Scientists have created specialized delivery methods using nucleic acid-based nanostructures to target cancer cells while leaving normal cells intact. The new approach utilizes aptamers to bind to specific receptors on cancer cells, allowing for the targeted delivery of chemotherapeutic drugs.
Researchers at University of Illinois Chicago discovered that a mutation in the NPM1 gene helps improve sensitivity to chemotherapy in patients. The study found that patients with this mutation tend to respond better to chemotherapy and have higher rates of remission.
Researchers identify MUC5AC gene as a key player in KRAS-mutant non-small cell lung cancers, which are resistant to current treatments. Inhibiting this gene may lead to new therapeutic strategies against KRAS-driven lung cancer.
Researchers identified specific gene activity in each cell, revealing that Wilms' tumour cells have the same characteristics as normal developing kidney cells. Adult renal carcinoma cells were found to be a version of rare healthy adult kidney cells called PT1.
Researchers developed a new sensor that detects hydrogen peroxide levels in human cells to identify effective chemotherapy drugs. The sensor can be used to screen existing drugs and predict success in individual patients' tumors. This breakthrough could lead to more targeted and effective cancer treatments.
Researchers identify a new mechanism used by Henipaviruses to hijack the DNA-damage response machinery, allowing them to prosper in cells. This discovery may lead to the development of new anti-viral therapies.
Researchers investigate how a group of cells breaks off from a colony, leading to large-scale metastasis. Mechanical engineer Amit Pathak aims to understand the mechanisms behind disease pathways and fundamental cell behavior.
Rice University's Luay Nakhleh has received $1.5 million in grants from the NSF to develop algorithms that can infer evolutionary histories of tumor cells, helping researchers understand why some cancer cells spread and mutate differently.
A computational study has shown that cancer cells proliferate less and are more vulnerable to acidic conditions than initially thought. The researchers have identified potential therapeutic targets by analyzing how variations in pH affect metabolic enzyme activity, providing opportunities for new treatments.
Senescent cells, also known as 'zombie cells,' interfere with tissue function and contribute to aging diseases. Researchers have designed a nano-carrier that selectively targets these cells, releasing drugs to kill them and improving therapeutic outcomes in pulmonary fibrosis and cancer models.
Researchers used proteomics to study the basic biology of Alzheimer's disease, cancer, and listeriosis. They found that BACE1 inhibition increases amyloid precursor protein and other substrates in Alzheimer's, while butyrate activates mitochondrial oxidation and suppresses tumor growth in colorectal cancer cells.
Leukemia cells infiltrate the central nervous system by grabbing onto laminin proteins and zipping down into the meninges region where cerebral spinal fluid circulates. This discovery arms researchers with new ways to target this pathway and potentially shut it down.
A team of international researchers has mapped the family trees of cancer cells in AML to understand its response to enasidenib and how it can be combined with other anti-cancer drugs. The study provides clues about how AML cells become resistant to therapy and may help design future therapy trials.
Researchers at the University of Adelaide have designed a new molecule that successfully targets PCNA, a protein essential for DNA replication in rapidly dividing cancer cells. The molecule shows increased potency over existing PCNA inhibitors and is likely to cause fewer side effects.
Scientists have identified a protein called SIRT7 that protects cells against senescence by keeping certain genes turned off. This function is crucial for preventing age-related deterioration and could lead to therapies targeting cellular senescence.
Researchers at Kumamoto University identified optimal PEF conditions for increasing cell membrane permeability to calcium. The study found that larger electric fields produced high calcium intake rates, while smaller fields showed undetectable intake rates initially followed by increased rates.
Researchers at Cincinnati Children's Hospital Medical Center have found a potential therapeutic target for acute myeloid leukemia (AML), a deadly blood cancer with a dismal survival rate. By targeting the F-box protein Skp2, they were able to kill AML cells and induce healthy white blood cell regeneration in preclinical tests.
Carbon nanotubes enable the creation of 'smart' materials for powering electronics, with potential applications in military technology and medical research. The unique properties of carbon nanotubes make them suitable for replacing traditional materials such as copper wire and polyester fibers.
Researchers discovered that pancreatic cancer cells' ability to alter their characteristics and shape affects where metastases form. The presence of E-cadherin protein controls this process, with its absence leading to lung metastases but not liver metastases.
Researchers at Mayo Clinic have discovered how the DNA repair protein 53BP1 relocates to chromosomes to fix damage, using RNA molecules as an off/on switch. This finding could lead to new therapies for ovarian cancer by targeting a specific protein called TIRR.
Researchers at Karolinska Institutet discovered a built-in molecular brake on human cell division that ensures two complete copies of DNA before cell division, preventing DNA damage and cancer. This process restricts growth to prevent lethal diseases like cancer.
Researchers at UCLA have developed synthetic T cells with near-perfect facsimiles of human T cells, which could lead to more effective treatments for cancer and autoimmune diseases. The artificial cells can boost the immune system and interact with immune cells, making them a promising tool in the fight against infections.
Researchers have developed a new method to diagnose oral squamous cell carcinomas (OSCCs) earlier, using the mechanical properties of cancer cells. By testing the relaxation behavior after stress release, they found that OSCC cells are 'softer' and exhibit faster contraction than benign cells.
Hollings Cancer Center researchers discovered that cancer cells protect their telomeres from damage to prevent cell death, contributing to their long lifespan. By inhibiting this mechanism, the researchers hope to develop a new treatment for cancer and potentially delay aging.
Researchers found that cancer cells produce excessive BCL-2 protein due to a ribosome defect, helping them survive chemotherapy. A drug suppressing this protein has shown promise in treating T-cell leukaemia with similar defects.
A research team at the Walter and Eliza Hall Institute identified the molecular trigger for necroptosis, a type of controlled cell death that can lead to diseases like stroke, organ transplant injury, and kidney disease. The discovery could lead to new therapeutic targets for treating cancer and immune disorders.
Researchers at NYU School of Medicine discovered that mTORC1 regulates cell crowding, which can cause proteins to solidify and interfere with cellular functions. The study suggests that malfunctioning mTORC1 may contribute to the development of aging diseases.
A new vehicle peptide has been identified for delivering therapeutically effective peptides to cancer cells. The peptide, termed peptide 1, mimics the dimerization arm of the EGF receptor, which is involved in cellular signal transductions and cancer progression.
Recent advances in cancer research focus on inhibiting key enzymes in glycolysis and glutaminolysis pathways to slow cancer cell proliferation. Several inhibitors are being tested in clinical trials, offering a promising new approach to combat cancer.
Scientists have discovered a new gene expression mechanism involving the Spt6 protein, which helps regulate messenger RNA levels in cells. The discovery suggests a potential target for treating cancers and other diseases, as abnormal RNA levels can lead to diseases such as cancer.
Researchers at USC Dornsife have discovered how the cell's emergency response team, known as paramedics, uses walking molecules to transport damaged DNA to the nucleus for repair. This process is crucial for preventing cancer formation and has implications for human health and genome editing.
University of Alberta researchers discovered 11 genes that play essential roles in cancer cell metastasis, enabling the blockage of over 99.5% of cancer metastasis in living cells. The study suggests potential therapeutic targets for preventing cancer spread.
Researchers at Karolinska Institute found that including dying cells in protein analysis improves target identification for cancer drugs. They also identified proteins upregulated in all detached and dying cells, which may be promising chemotherapeutic targets.
Researchers have obtained key information about proteins in single human cells, revealing molecular happenings inside a cell. The nanoPOTS technology allows for the analysis of samples that are 500 times smaller than previously possible, providing vital insights into cellular behavior.
Ghost Cytometry uses novel imaging technique and AI to identify and sort cells with unprecedented high-throughput speed. The system enables fast and accurate isolation and diagnosis of cancer cells, improving medical therapies.
The 2018 class of Pew-Stewart scholars is revolutionizing cancer research with promising opportunities to advance treatment, including immunotherapies and responses to these therapies. Their work will open doors to new lines of attack against cancer, addressing unexplored leads in the scientific quest to beat the disease.
The Pew scholars in the biomedical sciences will receive four-year grants to advance their explorations of biological mechanisms underpinning human health and disease. The research aims to solve biomedical puzzles including cancer, infectious diseases, and psychiatric disorders.
A new study found that CRISPR-Cas9 gene editing can activate the p53 protein, which reduces the efficiency of gene editing but also contributes to cancer cell growth. Researchers recommend further studies to improve safety for CRISPR-based therapies.
Researchers have developed a new epigenetic drug that slows down cell growth in Mantle Cell Lymphoma by inhibiting the HDAC6 gene. The substance shows high efficacy in cultured cells, murine studies and patient-derived cells with minimal toxicity to healthy cells.
Researchers at Penn State have developed a new nanoparticle-based drug delivery system that targets cancer cells using mechanical properties of diseased cells. The 'mechanotargeting' approach outperforms existing 'chemotargeting' strategy in delivering drugs to targeted cells.
Researchers discovered a key molecular machinery driving DNA segregation in yeast cells, which may hold insights into human chromosome maintenance and cancer development. Cells lacking this machinery, RSC, exhibit abnormal DNA segregation and spontaneous chromosome duplication.