Articles tagged with Cancer Cells
Researchers at the Francis Crick Institute identified a key mechanism controlling tissue structure, which could help identify drugs that make it harder for cancer cells to spread. The study found that collisions between cells help create different tissue structures, some of which aid cancer progression and can be targeted by drugs.
Researchers at TU Dresden are working on understanding the metabolism of cancer cells, tracing the development of childhood leukemia, and developing novel electronic components using 2D materials. The institution has received a total of 48 ERC Grants since 2008 to support innovative projects.
Researchers at Gladstone Institutes and Xyphos Biosciences have developed convertibleCAR, a cell-based immunotherapy that reduces the latent HIV reservoir in infected patients on anti-retroviral therapy. The technology combines cytotoxic T cells with antibodies, offering a flexible approach to fighting the virus.
Researchers from Xyphos and Gladstone Institutes published preclinical data demonstrating that convertibleCAR cells can significantly reduce latent reservoirs of diverse HIV strains. This approach targets specific cells for destruction using bispecific MicAbodies, providing a promising solution to the HIV/AIDS cure.
A new study by University of Chicago researchers reveals how lactate regulates immune cell function and contributes to cancer growth. The discovery offers a potential breakthrough in developing targeted therapies for various types of cancer.
A new study reveals that PGV-1, an analogue of turmeric's curcumin, effectively suppresses tumor cell growth and causes cell death in various types of cancers. The compound's ability to selectively target cancer cells with minimal side effects may lead to breakthroughs in cancer treatment.
A study published in Nature Communications reveals that cell competition modulates morphogen gradients to eliminate unhealthy cells and maintain tissue patterning. The researchers found that aberrant Wnt/β-catenin signaling leads to changes in membrane expression levels of proteins, resulting in cell death via apoptosis.
Researchers at UNIGE have developed a new formula, C2, composed of four anti-cancer drugs that target and kill tumour cells while leaving healthy cells intact. The formula has shown promising results in reducing the risk of resistance and side effects associated with high-dose treatments.
Researchers have discovered fullerene compounds that can effectively kill non-small-cell lung carcinoma cells without harming healthy cells. The anti-tumor activity of these compounds has great potential for the development of new treatments for this aggressive form of cancer.
Researchers developed a targeted cancer treatment using biologically-inspired nanotubes that deliver chemotherapy drugs directly to fast-dividing lung cancer cells. The new technology reduces toxicity and effective kills cancer cells with lower doses, promising a precise approach for precision targeting.
Researchers have identified a new set of senolytic drugs that can selectively eliminate senescent cells, including those triggered by cancer and irradiation. These compounds, such as ouabain, are repurposed from existing heart medications to treat various diseases, including leukemia and lymphoma.
A unique immune system found in koalas protects their DNA from viruses, opening a new field of research. This 'immune response' helps prevent the spread of diseases like chlamydia and cancer.
Researchers discover that koala germ cells recognize and suppress retroviral invasion through a unique 'piRNA response' mechanism. This innate genome immune system can identify viral RNA and block its replication, providing a new understanding of how organisms defend against pathogen invasions.
A new treatment combination using stereotactic body radiotherapy and interleukin-12 has been shown to cure pancreatic cancer in mice by activating T-cells to attack cancer cells. The treatment also destroys pancreatic cells that have spread to the liver, a common site for metastatic disease.
A new compound has been developed that can prevent unwanted cell death, which could improve recovery from medical emergencies and procedures. The study's findings suggest the potential for using this 'cell death blocker' to treat conditions like cardiovascular diseases and degenerative disorders.
A new study has found that e-cigarette smoke caused lung cancer and bladder issues in mice exposed to nicotine. The study, published in the Proceedings of National Academy of Sciences, found that 22.5% of mice developed lung adenocarcinomas after exposure to e-cig smoke with nicotine for 54 weeks.
A novel transfection method called nano-electro-injection delivers DNA into immune cells two to three times more efficiently than conventional methods. This technique improves the process of generating high-quality genetically modified immune cells for cancer immunotherapy, reducing cell stress and improving cell health.
Researchers at UC Davis aim to deliver CRISPR genome editing machinery to gut cells to fix genes responsible for a rare form of familial cancer. They will use an engineered, non-infectious hepatitis E virus to orally deliver CRISPR into cells in the gastrointestinal tract of mice.
Researchers at Kyoto University have developed a method to selectively amplify the effect of X-ray radiation on cancer cells. The technique uses specially designed silica nanoparticles loaded with gadolinium, which releases low-energy electrons when hit by precisely tuned X-rays, damaging cancer cell vital components and killing them.
UT Dallas researchers have shown that hyperspectral imaging and AI can predict the presence of cancer cells with 80-90% accuracy in 293 tissue specimens. This technology, called a smart surgical microscope, aims to reduce operating time, lower medical costs, and save lives.
Researchers from the University of Seville have discovered a new mechanism that makes it possible to understand premature ageing in cells with asymmetrical cell division. This mechanism is related to the distribution of microtubule-organising centres (MTOCs) during cell division.
A recent study published in Aging Cell has discovered that human aging processes may actually hinder the development of cancer. In most human tissues, aging-related gene expression changes are contrary to those found in cancer, suggesting a protective effect on cell growth.
Researchers discovered that cancer cells in the brain communicate with healthy brain cells through synapses, stimulating growth and proliferation. Anti-epileptic medicine may hold a key to curbing this dangerous communication.
Researchers at King's College London have discovered that β-Galactoside-Binding Protein (βGBP) can selectively target and kill cancer cells while stimulating the immune system to provide long-term protection against cancer recurrence. The study presents a promising new strategy for treating aggressive forms of cancer.
A cluster of interacting proteins found in Tasmanian devil facial tumours and human cancers could guide the development of new drug combinations that improve immunotherapy treatment effectiveness. Researchers suggest that a class of EZH2 inhibitors may help overcome immune evasion in cancer cells.
A team of scientists developed a technique using light to activate an Iridium-based compound that cuts off the 'power source' in cancer cells, even under hypoxia. This method could reduce side effects and potentially immunize against future cancers.
Scientists uncovered novel signaling mechanisms in cancer cells and designed a new anticancer compound M-COPA to target defective biochemical pathways. The study found that the mutated KIT protein carries out cancer-specific signaling at the Golgi, which is activated by downstream proteins such as AKT, ERK, and STAT5.
Researchers use CRISPR gene editing and MICS to identify genes that can be targeted by drugs in cancer and regenerative medicine, revealing promising targets for cancer treatment. The technology also enables faster harvesting of desired cell types for therapy.
Scientists at UCL have developed a method to reactivate 'tumour suppressor' genes silenced by cancer cells. This finding could lead to new targeted biotherapies for cancer treatment.
Researchers at Medical College of Georgia have found a link between high levels of TIMP-1 and IL-6, two molecules that contribute to chemotherapy resistance in non-small cell lung cancer. The study's findings suggest that elevated levels of these molecules may be an indicator of poor prognosis and a potential target for improving treat...
Researchers at SMART developed a new confocal reflectance interferometric microscope to study nuclear membrane mechanics in intact cells. This label-free technology has the potential to revolutionize our understanding of metastatic cancers and genetic illnesses, enabling the identification of stem cells for therapeutic applications.
Research reveals that hypoxic conditions alter p53's shape, allowing it to bind with HIF and promote cancer cell survival. This discovery may lead to new therapeutic strategies for pancreatic cancer.
Researchers from the University of Cambridge have developed a platform that uses nanoparticles known as metal-organic frameworks to deliver a promising anti-cancer agent, siRNA, to cells. The study shows that MOFs can present a viable platform for delivering potent anti-cancer agents to target specific genes.
A new study in Nature explores the role of chromatin loops in V(D)J recombination, a gene assembly process that generates diverse antibodies. The research reveals how cells exploit loop formation to mix and match genetic code, leading to the creation of new antibodies.
Researchers at Vanderbilt University found that cancer cells prioritize wider, easier-to-navigate spaces over smaller, confined ones to reduce energy expenditure during metastasis. This discovery highlights the importance of energy metabolism in cancer cell migration and may lead to new strategies for preventing metastasis.
A new study reveals that many cancer drug candidates fail in clinical trials due to off-target effects, rather than targeting essential molecular mechanisms. This unexpected finding challenges over 180 previous reports on the importance of specific proteins for cancer cell survival.
Researchers at Yale Cancer Center have identified a key metabolic pathway that enables cancer cells to adapt to their microenvironment and respond to nutrient availability. The study suggests that targeting this pathway with drugs may help treat various forms of cancer by preventing cancer cells from growing in nutrient-rich environments.
Researchers found functional mosaicism, where individual cells use different protein molecules to carry out the same function, which could explain antibiotic resistance and cancer relapse. This discovery suggests that therapeutic treatments may not be effective against all cells of the same type.
Researchers have made a breakthrough in cancer treatment using nanoparticles that can be activated by radiation, resulting in statistically significant reductions in tumor size. This innovative approach builds on previous research and has the potential to effectively treat tumors throughout the body.
Scientists have identified a cellular pathway that allows acute myeloid leukemia cells to evade the effects of drugs. They then engineered a compound that targets this pathway, blocking a mutant protein and halting the cancer cells' ability to sidestep the compound's effects.
Researchers investigated how radiation damages DNA in cancer cells treated with 5-fluorouracil, identifying new fragment ions and their formation thresholds. The study could lead to new ways of protecting normal tissues from radiation damage caused by radiotherapy.
Scientists used single-cell transcriptomics to map cell types and molecular cascades driving medulloblastoma growth. They discovered new treatment targets, including the HIPPO-YAP/TAZ pathway, which can be targeted with an FDA-approved cancer drug.
A new study reveals pancreatic cancer cells invade and destroy nearby blood vessels, replacing them with tumor-lined structures. The process is driven by the interaction between the protein receptor ALK7 and the protein Activin, pointing to a possible target for future treatments.
Researchers identified a molecule called DCAF15 that makes cancer cells more susceptible to natural killer cells. Blocking this molecule could lead to better survival rates for patients with acute myeloid leukemia.
A University of Turku team has found that PIM kinases regulate the sense of smell in nematodes. The enzymes, previously linked to cancer cell motility and survival, also influenced olfactory neurons' ability to detect attractants or repellents.
A new study found that damaged mitochondria can pollute cells with reactive oxygen species, causing telomere damage and genetic instability. The researchers developed a technology to trigger this reaction, which ultimately led to the discovery of telomere fragility and breakage.
A Ludwig Cancer Research study reveals that MYC-driven cancers rely heavily on fatty acid synthesis and can be targeted for treatment. The research provides concrete information for the development of new therapies for a broad spectrum of malignancies.
Scientists at the Paul Scherrer Institute deciphered the structure of CCR7 receptor, which plays a crucial role in cancer cell migration. They identified an artificial molecule that blocks this receptor, preventing signaling protein from triggering a chain reaction leading to cell migration.
Researchers have discovered that natural killer cells interact with HLA class 2 proteins, which can activate them to attack cancer cells. This breakthrough may lead to new ways to harness the immune system to fight cancer and avoid attacking healthy tissues.
Researchers will investigate how solar UVB radiation triggers skin cancer and develop prevention and treatment strategies, including testing natural products and existing drugs.
Researchers have identified a new lipid signaling pathway that regulates T cell function and differentiation, leading to improved T cell-mediated immunotherapy against cancer cells. By depleting SphK1, the pathway inhibits Treg differentiation and promotes a Tcm phenotype, reducing tumor size and mortality in preclinical models.
Scientists at Huntsman Cancer Institute have discovered a way for cells to override genetic changes, potentially leading to more effective pancreatic cancer treatment. The study found that introducing PTF1A into normal cells prevented the formation of cancer cells and even reversed early-stage cancer cells back to healthy pancreas cells.
New research published in PNAS reveals that human epithelial cells form fractal-like branching structures under certain conditions, mirroring the self-assembly of particles suspended in a liquid. This discovery sheds light on tissue formation and cellular behavior.
As people age, the prostate grows, leading to an increased risk for prostate cancer and benign prostatic hyperplasia. A new UCLA study found that older mice have more luminal progenitor cells, which can generate new prostate tissue, helping explain why the prostate tends to grow with age.
Engineers create bone-like tissue in a dish to study disease processes and potential treatments for large bone injuries. The material has a 3D mineral structure populated with living cells, providing insights into cancer initiation, metastasis, and bone regeneration.
Two known gene mutations, KRAS and TP53, induce pathways that enhance pancreatic cancer's ability to invade tissues and evade the immune system. Mutations in these genes are closely linked to pancreatic ductal adenocarcinoma, a type of pancreatic cancer with a low five-year survival rate.
Researchers used Raman spectroscopy to differentiate between benign and cancerous thyroid cells, achieving 97 percent accuracy. The non-invasive technique could reduce the need for invasive procedures, minimizing surgical complications and healthcare costs.
Researchers found a significant association between vitamin A intake and reduced risk of cutaneous squamous cell cancer. The study followed nearly 125,000 health professionals for over 26 years.
Scientists have discovered a crucial protective role of Polo-like kinase (PLK1) in guarding against severe DNA damage during cell division. PLK1 is essential for maintaining chromosome rigidity and preventing chromosome rearrangements that can lead to cancers.
Researchers at the University of Groningen elucidated the human ASCT2 structure, providing unprecedented insight into its workings and potential as a target for new anti-cancer drugs. The 'one-gate elevator' mechanism reveals a surprising similarity in release and catch mechanisms on either side of the cell membrane.