Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
Researchers at the National University of Singapore have found that cells can attach to the fibrous protein meshwork surrounding them only if the fibres are spaced close enough. This finding has implications for understanding abnormal motility patterns in cancer cells and could lead to the development of new therapeutic targets.
A Drexel University study found that rapamycin cream can reduce wrinkles, sagging, and improve skin tone in human subjects over 40. The drug blocks the TOR protein and has anti-aging effects by reducing senescent cells associated with skin aging.
Researchers at the University of South Australia are developing a new radioimmunotherapy agent to target and kill pancreatic cancer cells, potentially minimizing side effects. The treatment uses alpha particles to deposit energy inside cancer cells while leaving healthy tissue intact.
Researchers at Duke University have developed DNA-based biomolecular reaction networks that can identify cancer cells by analyzing molecular signatures on their surface. The technology distinguishes cell types with higher specificity than previous methods, making it a promising step toward more accurate cancer screenings and therapies.
Researchers found that circular extrachromosomal DNA in cancer cells dramatically amplifies mutant oncogenes, promoting aggressive behavior and resistance to therapy. This unique shape enables tumor cells to generate massive amounts of growth-promoting oncogenes and evolve quickly.
Researchers at the University of Bern have found that killer cells without TRAIL become 'tamer', producing more messenger molecules to activate other immune cells, and resulting in better protection against viruses. This alternative signaling pathway could be used to reprogram killer cells for cancer immunotherapy.
Researchers identified Notch as a key molecule involved in cervical cancer progression, contrary to previous thought that Ras was the primary culprit. The review highlights the complex nature of cervical cancer progression, suggesting that local proliferation and metastasis occur through parallel routes.
Researchers developed a microfluidic device with tiny pillars to capture malignant plasma cells from blood samples. The device shows great potential as an early detection or monitoring tool for MM disease progression.
Scientists at UCLA Jonsson Comprehensive Cancer Center developed a new high-throughput screening system that identifies selective inhibitors of metabolic pathways. The approach revealed multiple kinase inhibitors block nucleotide metabolism and its targets.
Researchers at Rensselaer Polytechnic Institute developed a new deep neural network to improve fluorescence lifetime imaging, enabling rapid and detailed analysis of cellular interactions in cancer cells. This technique requires less light while producing detailed images, bringing the field closer to clinical use for precision medicine.
Researchers discover BRN4 overexpression drives neuroendocrine prostate cancer cell conversion in patients with recurrent cancer. Exosome inhibitors under study as potential treatment.
Researchers have discovered a way in which leukemia cells can change their identity to become macrophages, a process known as transdifferentiation. This transformation occurs through epigenetic changes that alter the cell's genetic material, allowing it to acquire new functions and behaviors.
Researchers at Lund University have discovered a protein, Lin28b, that allows self-reactive B-1 cells to develop in mice. These cells produce antibodies against the body's own substances, but are beneficial in cleaning up dead cells and preventing inflammation.
Researchers at Purdue University have developed a method to combine anthrax toxin with a growth factor to selectively kill bladder cancer cells and tumors. This promising treatment shows outstanding results, reducing tumor size without causing side effects in animal trials.
A study published in eLife reveals that an infectious cancer has spread to two different species of mussels on both sides of the Atlantic Ocean, likely due to accidental transport on ships. The cancer is believed to have originated from a single mussel with a primary cancer and has since infected multiple species across the globe.
Researchers developed a computational method to measure intercellular forces without disturbing cell activity. The approach combines biophysical modeling with data-driven modeling using microscopy images.
Researchers at Cornell University have developed a technique using fluorescent probes to study the performance of molecules inside living cells. The probes can accurately measure the rate at which linkers release drugs in cells, enabling pharmaceutical companies to make informed decisions about drug delivery systems.
Researchers at the University of Warwick have discovered a previously unknown cellular component called intracellular nanovesicles (INVs) that deliver proteins in heavy traffic. INVs are approximately 30 nanometres across and could provide clues to the process that allows cells, such as cancer cells, to migrate within the body.
Researchers developed a nondestructive TFM platform allowing for high-throughput cell measurements. The new platform uses a regular array of fluorescent markers to enable zero-stress state measurements, reducing the need for cell removal or relaxation.
Researchers at the Francis Crick Institute identified a key mechanism controlling tissue structure, which could help identify drugs that make it harder for cancer cells to spread. The study found that collisions between cells help create different tissue structures, some of which aid cancer progression and can be targeted by drugs.
Researchers at TU Dresden are working on understanding the metabolism of cancer cells, tracing the development of childhood leukemia, and developing novel electronic components using 2D materials. The institution has received a total of 48 ERC Grants since 2008 to support innovative projects.
Researchers at Gladstone Institutes and Xyphos Biosciences have developed convertibleCAR, a cell-based immunotherapy that reduces the latent HIV reservoir in infected patients on anti-retroviral therapy. The technology combines cytotoxic T cells with antibodies, offering a flexible approach to fighting the virus.
Researchers from Xyphos and Gladstone Institutes published preclinical data demonstrating that convertibleCAR cells can significantly reduce latent reservoirs of diverse HIV strains. This approach targets specific cells for destruction using bispecific MicAbodies, providing a promising solution to the HIV/AIDS cure.
A new study by University of Chicago researchers reveals how lactate regulates immune cell function and contributes to cancer growth. The discovery offers a potential breakthrough in developing targeted therapies for various types of cancer.
A new study reveals that PGV-1, an analogue of turmeric's curcumin, effectively suppresses tumor cell growth and causes cell death in various types of cancers. The compound's ability to selectively target cancer cells with minimal side effects may lead to breakthroughs in cancer treatment.
A study published in Nature Communications reveals that cell competition modulates morphogen gradients to eliminate unhealthy cells and maintain tissue patterning. The researchers found that aberrant Wnt/β-catenin signaling leads to changes in membrane expression levels of proteins, resulting in cell death via apoptosis.
Researchers at UNIGE have developed a new formula, C2, composed of four anti-cancer drugs that target and kill tumour cells while leaving healthy cells intact. The formula has shown promising results in reducing the risk of resistance and side effects associated with high-dose treatments.
Researchers have discovered fullerene compounds that can effectively kill non-small-cell lung carcinoma cells without harming healthy cells. The anti-tumor activity of these compounds has great potential for the development of new treatments for this aggressive form of cancer.
Researchers developed a targeted cancer treatment using biologically-inspired nanotubes that deliver chemotherapy drugs directly to fast-dividing lung cancer cells. The new technology reduces toxicity and effective kills cancer cells with lower doses, promising a precise approach for precision targeting.
Researchers have identified a new set of senolytic drugs that can selectively eliminate senescent cells, including those triggered by cancer and irradiation. These compounds, such as ouabain, are repurposed from existing heart medications to treat various diseases, including leukemia and lymphoma.
A unique immune system found in koalas protects their DNA from viruses, opening a new field of research. This 'immune response' helps prevent the spread of diseases like chlamydia and cancer.
Researchers discover that koala germ cells recognize and suppress retroviral invasion through a unique 'piRNA response' mechanism. This innate genome immune system can identify viral RNA and block its replication, providing a new understanding of how organisms defend against pathogen invasions.
A new treatment combination using stereotactic body radiotherapy and interleukin-12 has been shown to cure pancreatic cancer in mice by activating T-cells to attack cancer cells. The treatment also destroys pancreatic cells that have spread to the liver, a common site for metastatic disease.
A new compound has been developed that can prevent unwanted cell death, which could improve recovery from medical emergencies and procedures. The study's findings suggest the potential for using this 'cell death blocker' to treat conditions like cardiovascular diseases and degenerative disorders.
A new study has found that e-cigarette smoke caused lung cancer and bladder issues in mice exposed to nicotine. The study, published in the Proceedings of National Academy of Sciences, found that 22.5% of mice developed lung adenocarcinomas after exposure to e-cig smoke with nicotine for 54 weeks.
A novel transfection method called nano-electro-injection delivers DNA into immune cells two to three times more efficiently than conventional methods. This technique improves the process of generating high-quality genetically modified immune cells for cancer immunotherapy, reducing cell stress and improving cell health.
Researchers at UC Davis aim to deliver CRISPR genome editing machinery to gut cells to fix genes responsible for a rare form of familial cancer. They will use an engineered, non-infectious hepatitis E virus to orally deliver CRISPR into cells in the gastrointestinal tract of mice.
Researchers at Kyoto University have developed a method to selectively amplify the effect of X-ray radiation on cancer cells. The technique uses specially designed silica nanoparticles loaded with gadolinium, which releases low-energy electrons when hit by precisely tuned X-rays, damaging cancer cell vital components and killing them.
UT Dallas researchers have shown that hyperspectral imaging and AI can predict the presence of cancer cells with 80-90% accuracy in 293 tissue specimens. This technology, called a smart surgical microscope, aims to reduce operating time, lower medical costs, and save lives.
Researchers from the University of Seville have discovered a new mechanism that makes it possible to understand premature ageing in cells with asymmetrical cell division. This mechanism is related to the distribution of microtubule-organising centres (MTOCs) during cell division.
A recent study published in Aging Cell has discovered that human aging processes may actually hinder the development of cancer. In most human tissues, aging-related gene expression changes are contrary to those found in cancer, suggesting a protective effect on cell growth.
Researchers discovered that cancer cells in the brain communicate with healthy brain cells through synapses, stimulating growth and proliferation. Anti-epileptic medicine may hold a key to curbing this dangerous communication.
Researchers at King's College London have discovered that β-Galactoside-Binding Protein (βGBP) can selectively target and kill cancer cells while stimulating the immune system to provide long-term protection against cancer recurrence. The study presents a promising new strategy for treating aggressive forms of cancer.
A cluster of interacting proteins found in Tasmanian devil facial tumours and human cancers could guide the development of new drug combinations that improve immunotherapy treatment effectiveness. Researchers suggest that a class of EZH2 inhibitors may help overcome immune evasion in cancer cells.
A team of scientists developed a technique using light to activate an Iridium-based compound that cuts off the 'power source' in cancer cells, even under hypoxia. This method could reduce side effects and potentially immunize against future cancers.
Scientists uncovered novel signaling mechanisms in cancer cells and designed a new anticancer compound M-COPA to target defective biochemical pathways. The study found that the mutated KIT protein carries out cancer-specific signaling at the Golgi, which is activated by downstream proteins such as AKT, ERK, and STAT5.
Researchers use CRISPR gene editing and MICS to identify genes that can be targeted by drugs in cancer and regenerative medicine, revealing promising targets for cancer treatment. The technology also enables faster harvesting of desired cell types for therapy.
Scientists at UCL have developed a method to reactivate 'tumour suppressor' genes silenced by cancer cells. This finding could lead to new targeted biotherapies for cancer treatment.
Researchers at Medical College of Georgia have found a link between high levels of TIMP-1 and IL-6, two molecules that contribute to chemotherapy resistance in non-small cell lung cancer. The study's findings suggest that elevated levels of these molecules may be an indicator of poor prognosis and a potential target for improving treat...
Researchers at SMART developed a new confocal reflectance interferometric microscope to study nuclear membrane mechanics in intact cells. This label-free technology has the potential to revolutionize our understanding of metastatic cancers and genetic illnesses, enabling the identification of stem cells for therapeutic applications.
Research reveals that hypoxic conditions alter p53's shape, allowing it to bind with HIF and promote cancer cell survival. This discovery may lead to new therapeutic strategies for pancreatic cancer.
Researchers from the University of Cambridge have developed a platform that uses nanoparticles known as metal-organic frameworks to deliver a promising anti-cancer agent, siRNA, to cells. The study shows that MOFs can present a viable platform for delivering potent anti-cancer agents to target specific genes.
A new study in Nature explores the role of chromatin loops in V(D)J recombination, a gene assembly process that generates diverse antibodies. The research reveals how cells exploit loop formation to mix and match genetic code, leading to the creation of new antibodies.
Researchers at Vanderbilt University found that cancer cells prioritize wider, easier-to-navigate spaces over smaller, confined ones to reduce energy expenditure during metastasis. This discovery highlights the importance of energy metabolism in cancer cell migration and may lead to new strategies for preventing metastasis.
A new study reveals that many cancer drug candidates fail in clinical trials due to off-target effects, rather than targeting essential molecular mechanisms. This unexpected finding challenges over 180 previous reports on the importance of specific proteins for cancer cell survival.
Researchers at Yale Cancer Center have identified a key metabolic pathway that enables cancer cells to adapt to their microenvironment and respond to nutrient availability. The study suggests that targeting this pathway with drugs may help treat various forms of cancer by preventing cancer cells from growing in nutrient-rich environments.
Researchers found functional mosaicism, where individual cells use different protein molecules to carry out the same function, which could explain antibiotic resistance and cancer relapse. This discovery suggests that therapeutic treatments may not be effective against all cells of the same type.
Researchers have made a breakthrough in cancer treatment using nanoparticles that can be activated by radiation, resulting in statistically significant reductions in tumor size. This innovative approach builds on previous research and has the potential to effectively treat tumors throughout the body.
Scientists have identified a cellular pathway that allows acute myeloid leukemia cells to evade the effects of drugs. They then engineered a compound that targets this pathway, blocking a mutant protein and halting the cancer cells' ability to sidestep the compound's effects.
Researchers investigated how radiation damages DNA in cancer cells treated with 5-fluorouracil, identifying new fragment ions and their formation thresholds. The study could lead to new ways of protecting normal tissues from radiation damage caused by radiotherapy.