Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
A portable 'electronic nose' device detected Barrett's oesophagus with a sensitivity of 91% and specificity of 74%, comparable to breast and bowel cancer screening methods. The non-invasive technique shows high acceptability and low costs, making it a promising approach for primary care screening.
Research reveals some extra chromosomes in cancer cells can inhibit metastasis and even increase survival rates for patients. A study published in Developmental Cell found beneficial aneuploidies associated with increased survival, contrary to the long-held notion that aneuploidy always skews gene activity towards aggressive cancers.
Researchers found cancer cells can override mechanical regulation of energy use by sequestering TRIM21 protein, preventing its degradation and keeping metabolism high. This discovery could help understand how cancer cells adapt to their environment and lead to new therapeutic strategies.
Researchers have identified a novel mechanism for repairing genetic mistakes, which involve cross-talk between enzymes that read and correct DNA recipes. This discovery has significant implications for our understanding of cellular processes and the development of treatments for diseases such as cancer.
Researchers at Beckman Institute have developed a new probe named CoxFluor that selectively detects Cyclooxygenase-2, an enzyme driving cancer progression. The probe's ability to distinguish between COX-2 and COX-1 could lead to innovative anti-inflammatory and cancer therapy strategies.
Researchers at Sanford Burnham Prebys Medical Discovery Institute and Harvard University discovered that mitochondria trigger senescence in cells by communicating with the cell's nucleus. They identified an FDA-approved drug that helped suppress the damaging effects of senescence in cells and mice, providing a potential treatment for a...
Anna-Karin Gustavsson joins Rice University as a CPRIT Scholar, bringing expertise in single-molecule imaging to cancer research. She aims to develop 3D super-resolution microscopy techniques for understanding molecular mechanisms and potential targets for drug treatment.
Researchers developed a smart material that can analyze multiple environment parameters to ensure effective drug delivery. The material achieves high sensitivity in detecting low concentrations of DNA, making it promising for express DNA analysis and next-generation drugs.
Scientists have developed a new technique to analyze signaling molecules in individual cancer cells, revealing complex communication networks that contribute to tumor growth and treatment resistance. The technique, tested on bowel cancer cells, detected 28 key signaling molecules across six cell types in over 1 million cells.
Researchers at University of Helsinki identified tropomodulin as a key player in maintaining the balance between protrusive and contractile actin-filament machineries. The protein's depletion leads to severe problems in cell shape and force production, associated with various cancers.
Researchers at Stanford University have developed a CRISPR-Cas tool that can detect and debug faulty genetic circuits, facilitating more precise treatments for diseases like cancer. The technology allows for greater precision in identifying and eliminating diseased cells, with potential applications beyond cancer treatment.
A team of researchers at the Garvan Institute of Medical Research has identified individual cells that cause autoimmune disease from patient samples. They discovered how these cells 'go rogue' by evading checkpoints and accumulating genetic mutations that drive disease progression.
Scientists from the IPC PAS found that cell viscosity remains constant throughout its life cycle, defying intuitive expectations. This discovery has implications for developing new diagnostic and therapeutic methods, particularly in cancer treatment and neurodegenerative diseases.
Researchers report no negative side effects and persistent engineered T cells in advanced cancer patients. The study's findings suggest the gene editing approach is safe and feasible, paving the way for further development of this innovative cancer treatment.
The study analyzed 3,000 cancer patients' genomes to identify common mutation patterns, revealing a significant role for structural alterations in gene expression. By integrating genome and transcriptome data, researchers gained insight into the complex interplay between DNA mutations and RNA alterations.
Researchers break down amino acid glutamine when bombarded with different doses of electrons. This process has implications for understanding the effect of ionising radiation on human cells and improving cancer radiotherapy.
ITMO University researchers have developed a DNA-based nanorobot that can detect and destroy pathogenic RNA strands in cancer cells. The nanorobot, which costs $20 to produce, uses deoxyribozymes to cleave bonds in an RNA strand, effectively blocking the production of harmful proteins and killing cancer cells.
A new paper explores how bodies evolve to prevent cancer by making growth factors costly to use and limiting cell proliferation. Individual cancer cells are kept in check when there's a high energetic cost for creating growth factors that signal cell growth.
A team of researchers at KAIST has discovered a novel approach to reprogram healthy colon cells into non-cancerous ones by reducing the activity of a master regulator protein called SETDB1. This method could lead to more effective and less painful cancer treatment options.
Researchers discovered a death receptor pathway in cancer cells that prevents them from dying, leading to T cell dysfunction and resistance to CAR T cell therapy. The study's findings may provide guidance for future immunotherapies in patients resistant to CAR T therapy.
A study found that people who quit smoking have more genetically healthy lung cells than current smokers, with a lower risk of developing into cancer. These 'protective cells' can help protect against lung cancer and may even allow new, healthy cells to actively replenish the lining of airways.
Researchers have developed iron nanowires that can selectively kill cancer cells while minimizing harm to healthy tissue. These nanorobots use an external magnetic field to guide themselves to the tumor site and activate a three-step mechanism that releases chemotherapy and generates heat, leading to nearly complete cell ablation.
A new treatment approach for cutaneous T-cell lymphoma, a rare blood disease, has been proposed by University of Alberta researcher Robert Gniadecki. He found that cancer cells originate from the blood, not the skin, and suggests treating malignant clones in the blood rather than waiting until they reach the skin.
Cancer cells store lipids in vesicles called lipid droplets, making them more invasive and prone to forming metastases. The researchers found that TGF-beta2 is the switch responsible for both lipid storage and aggressive cancer cell behavior.
FerriIridium, a novel drug, can diagnose and treat gastric cancer by selectively activating in tumor cells. The iron-based compound reduces side effects by targeting cancer cell mitochondria, leading to their destruction.
Scientists at Tokyo Tech and Kyoto University create a PVA-BPA complex that allows boron to remain in cancer cells for longer periods, reducing the need for continuous infusion. This method enhances anti-cancer activities of BNCT and offers a simple solution for drug delivery
Researchers at Tokyo University of Science devise a new image analysis method that reveals how giant viruses infect amoebae and how the host reacts. The study uses time-lapse microscopy to track changes in cellular behavior, providing new insights into the life cycle of giant viruses and their impact on eukaryotes.
A new technique developed at the University of Michigan uses bacteria to produce billions of different drug candidates that won't fall apart quickly inside the body. The peptides on bacteria are so plentiful that researchers can see how well they work right on the bacterium, enabling them to test hundreds of millions of different designs.
UK scientists have discovered a potential new treatment strategy for pancreatic cancer by targeting energy production in cells, leading to an irreversible build-up of calcium and cell death. The approach involves inhibiting a specific enzyme called PKM2, which fuels calcium pumps on the cell surface.
Researchers found that cell-to-cell contacts are essential for human cells to survive protein-damaging conditions and stress. Impaired cell adhesion may make cancer cells more vulnerable to drug treatment.
Researchers used a label-free technique to investigate the metabolism of living biological tissues in fruit flies. They found that sperm had a highly glycolytic metabolism similar to that of cancer cells, which may contribute to their ability to remain fresh in female bodies. The study also suggests potential clinical applications for ...
Princeton researchers recreated a crucial cell division process outside a cell, uncovering the vital role of protein TPX2 in over 25% of all cancers. The team's findings reveal TPX2 facilitates efficient microtubule assembly and spindle formation by acting as a liquid-like molecule.
A study by University of Michigan researchers sheds light on the role of WDR5 and p53 proteins in influencing stem cell fate, with implications for cancer research and potential treatments for heart disease. The team found that inducing a short delay in WDR5 expression steered embryonic stem cells towards different tissue types.
Researchers found that leukemia cells are 'addicted' to vitamin B6, using it to accelerate cell division. By limiting this enzyme's activity, a new drug could slow or stop cancer growth without harming healthy cells.
A new mathematical model, ETFL, accurately models enzyme expression and its associated metabolic cost in living cells. The model integrates biochemistry, thermodynamics, and multi-omics data to predict enzyme activity and metabolism.
A team of scientists has identified a network of interaction partners for the juxtamembrane segment of the EGF receptor, which can influence cell growth and development. This breakthrough may lead to new therapeutic approaches for cancers that have become resistant to current active ingredients.
Researchers have successfully produced human immune cells in a lab dish, shedding light on the formation of these crucial cells. The breakthrough could pave the way for new cancer treatments and autoimmune disease interventions.
Researchers at University College London have identified a subset of immune cells that can kill cancerous cells, opening the door to new and more effective cancer treatments. The discovery builds on previous research and provides evidence for utilizing Blimp-1 to enhance anti-tumor activity in CD4+ T cells.
Researchers have developed a low-intensity ultrasound approach that exploits the unique physical and structural properties of tumor cells to target them. By tuning the frequency to match the target cells, they were able to break apart several types of cancer cells without harming healthy blood cells.
The study reveals syndecan-4's role in sensing environmental conditions outside cells, driving cellular processes behind cancer and diseases. Activating these cellular 'hands' triggers a pathway involving YAP, controlling apoptosis and blood vessel development.
The scTRIP method allows for the study of genetic variations within a single cell and measures genetic changes directly as they form in new cells. Researchers found four times more variants in patient-derived leukaemia cells using scTRIP compared to standard clinical diagnostics.
ATAD5 plays a crucial role in counteracting DNA replication stress by regulating PCNA unloading and promoting RAD51 recruitment. This study reveals ATAD5's fundamental mechanism of replication stress control, contributing to the development of cancer therapy.
Researchers have identified a new therapeutic strategy to combat chemotherapy resistance in ovarian cancer by targeting the NAD+ metabolic pathway. Combining cisplatin treatment with pharmacological inhibition of NAMPT suppresses the outgrowth of resistant cancer cells and prolongs survival in a preclinical model.
Scientists have discovered a new population of gamma delta T cells that recognize an MHC-like molecule called MR1. Using advanced imaging techniques, researchers found that these T cells bind to MR1 from underneath the molecule, rather than sitting atop it as previously thought.
Researchers have designed artificial sweetener derivatives that inhibit two tumor-associated enzymes, showing improved activity against cancer cells. These compounds selectively bind to enzymes CA IX and XII, making them potential anti-cancer drugs.
Scientists at University of Helsinki and Institut Jacques Monod have identified a molecular machinery that drives rapid depolymerisation of actin filaments and recycles resulting monomers. This discovery provides new avenues for developing therapeutics to inhibit cancer cell migration.
Researchers discovered a key factor, USF1, that inhibits p53 activity, promoting gastric cancer development. USF1 levels can indicate poor prognosis and help identify patients at higher risk of severe forms of gastric cancer.
A study found that silencing the KPNA4 gene reduces cell proliferation, migration ability and resistance to radiation in HNSCCs. Targeting disease-specifically altered transport systems may serve as promising therapeutic strategies for cancer treatment.
Scientists at the University of Bath have developed a new probe, AzuFluor, to detect reactive oxygen species in cells under the microscope. This probe uses a bright blue chemical found in mushrooms and has shown potential applications in cell biology and the pharmaceutical industry.
Researchers found that colon cancer cells deficient in p53 use the mevalonate pathway to survive, producing ubiquinone to synthesize new DNA. Statins inhibit this pathway, inducing apoptosis in cancer cells.
A new method called scPred uses single cell analysis techniques with machine learning algorithms to identify specific types of cells. This can help diagnose cancer and autoimmune diseases earlier, and personalize treatments for individual patients.
A new AI algorithm, ConvPath, uses artificial intelligence to classify cell types and quantify spatial distributions in tumor tissue. This allows pathologists to obtain accurate cancer cell analysis in a faster way.
Researchers developed a bispecific T-cell engager, AMG 701, to target myeloma cells. Administered with lenalidomide or pomalidomide, it showed promising pre-clinical results in mice implanted with human myeloma cells.
Scientists at Johns Hopkins Medicine developed a nanosize container made of biodegradable polymer to deliver protein-based medicines and gene therapies, including CRISPR, into specifically selected target cells. The invention could offer a way to efficiently ferry larger medical compounds into cells with fewer side effects.
Researchers at Stanford University School of Medicine have developed a new approach to programming CAR-T cells that can prolong their activity and increase their effectiveness against human cancer cells. The technique uses ATAC-Seq to understand what happens when T cells become exhausted, and modifying CAR-T cells to restore balance in...
Researchers discovered a new mechanism for detecting foreign material during early immune responses, which could help detect elusive cancers. ERAP1 protein can break down peptides bound to MHC I, allowing immune cells to recognize and destroy infected cells.
Researchers found that dichloroacetate treatment lowered lactate production and stopped abnormal cell growth in women with endometriosis. The study suggests a new non-hormonal treatment option for the condition, which affects millions of women worldwide.
Researchers at American Friends of Tel Aviv University have developed a new treatment that triggers the self-destruction of pancreatic cancer cells. The innovative therapy has shown promising results in its early stages, providing hope for patients with pancreatic cancer.
Researchers have created a new technique to deliver chemotherapy directly to malignant cells, bypassing healthy ones. This discovery could allow doctors to reduce chemo doses and alleviate side effects, improving treatment outcomes.
Scientists from the University of Pennsylvania School of Medicine have discovered a way to make sarcoma cells more susceptible to treatment by slowing down their growth through a key metabolic process. By reactivating the FBP2 enzyme, researchers were able to stop cancer cell proliferation and leave them vulnerable to targeted therapies.