Articles tagged with Cancer Cells
Researchers discovered a death receptor pathway in cancer cells that prevents them from dying, leading to T cell dysfunction and resistance to CAR T cell therapy. The study's findings may provide guidance for future immunotherapies in patients resistant to CAR T therapy.
A study found that people who quit smoking have more genetically healthy lung cells than current smokers, with a lower risk of developing into cancer. These 'protective cells' can help protect against lung cancer and may even allow new, healthy cells to actively replenish the lining of airways.
Researchers have developed iron nanowires that can selectively kill cancer cells while minimizing harm to healthy tissue. These nanorobots use an external magnetic field to guide themselves to the tumor site and activate a three-step mechanism that releases chemotherapy and generates heat, leading to nearly complete cell ablation.
A new treatment approach for cutaneous T-cell lymphoma, a rare blood disease, has been proposed by University of Alberta researcher Robert Gniadecki. He found that cancer cells originate from the blood, not the skin, and suggests treating malignant clones in the blood rather than waiting until they reach the skin.
Cancer cells store lipids in vesicles called lipid droplets, making them more invasive and prone to forming metastases. The researchers found that TGF-beta2 is the switch responsible for both lipid storage and aggressive cancer cell behavior.
FerriIridium, a novel drug, can diagnose and treat gastric cancer by selectively activating in tumor cells. The iron-based compound reduces side effects by targeting cancer cell mitochondria, leading to their destruction.
Scientists at Tokyo Tech and Kyoto University create a PVA-BPA complex that allows boron to remain in cancer cells for longer periods, reducing the need for continuous infusion. This method enhances anti-cancer activities of BNCT and offers a simple solution for drug delivery
Researchers at Tokyo University of Science devise a new image analysis method that reveals how giant viruses infect amoebae and how the host reacts. The study uses time-lapse microscopy to track changes in cellular behavior, providing new insights into the life cycle of giant viruses and their impact on eukaryotes.
A new technique developed at the University of Michigan uses bacteria to produce billions of different drug candidates that won't fall apart quickly inside the body. The peptides on bacteria are so plentiful that researchers can see how well they work right on the bacterium, enabling them to test hundreds of millions of different designs.
UK scientists have discovered a potential new treatment strategy for pancreatic cancer by targeting energy production in cells, leading to an irreversible build-up of calcium and cell death. The approach involves inhibiting a specific enzyme called PKM2, which fuels calcium pumps on the cell surface.
Researchers found that cell-to-cell contacts are essential for human cells to survive protein-damaging conditions and stress. Impaired cell adhesion may make cancer cells more vulnerable to drug treatment.
Researchers used a label-free technique to investigate the metabolism of living biological tissues in fruit flies. They found that sperm had a highly glycolytic metabolism similar to that of cancer cells, which may contribute to their ability to remain fresh in female bodies. The study also suggests potential clinical applications for ...
Princeton researchers recreated a crucial cell division process outside a cell, uncovering the vital role of protein TPX2 in over 25% of all cancers. The team's findings reveal TPX2 facilitates efficient microtubule assembly and spindle formation by acting as a liquid-like molecule.
A study by University of Michigan researchers sheds light on the role of WDR5 and p53 proteins in influencing stem cell fate, with implications for cancer research and potential treatments for heart disease. The team found that inducing a short delay in WDR5 expression steered embryonic stem cells towards different tissue types.
Researchers found that leukemia cells are 'addicted' to vitamin B6, using it to accelerate cell division. By limiting this enzyme's activity, a new drug could slow or stop cancer growth without harming healthy cells.
A new mathematical model, ETFL, accurately models enzyme expression and its associated metabolic cost in living cells. The model integrates biochemistry, thermodynamics, and multi-omics data to predict enzyme activity and metabolism.
A team of scientists has identified a network of interaction partners for the juxtamembrane segment of the EGF receptor, which can influence cell growth and development. This breakthrough may lead to new therapeutic approaches for cancers that have become resistant to current active ingredients.
Researchers have successfully produced human immune cells in a lab dish, shedding light on the formation of these crucial cells. The breakthrough could pave the way for new cancer treatments and autoimmune disease interventions.
Researchers at University College London have identified a subset of immune cells that can kill cancerous cells, opening the door to new and more effective cancer treatments. The discovery builds on previous research and provides evidence for utilizing Blimp-1 to enhance anti-tumor activity in CD4+ T cells.
Researchers have developed a low-intensity ultrasound approach that exploits the unique physical and structural properties of tumor cells to target them. By tuning the frequency to match the target cells, they were able to break apart several types of cancer cells without harming healthy blood cells.
The study reveals syndecan-4's role in sensing environmental conditions outside cells, driving cellular processes behind cancer and diseases. Activating these cellular 'hands' triggers a pathway involving YAP, controlling apoptosis and blood vessel development.
The scTRIP method allows for the study of genetic variations within a single cell and measures genetic changes directly as they form in new cells. Researchers found four times more variants in patient-derived leukaemia cells using scTRIP compared to standard clinical diagnostics.
ATAD5 plays a crucial role in counteracting DNA replication stress by regulating PCNA unloading and promoting RAD51 recruitment. This study reveals ATAD5's fundamental mechanism of replication stress control, contributing to the development of cancer therapy.
Researchers have identified a new therapeutic strategy to combat chemotherapy resistance in ovarian cancer by targeting the NAD+ metabolic pathway. Combining cisplatin treatment with pharmacological inhibition of NAMPT suppresses the outgrowth of resistant cancer cells and prolongs survival in a preclinical model.
Scientists have discovered a new population of gamma delta T cells that recognize an MHC-like molecule called MR1. Using advanced imaging techniques, researchers found that these T cells bind to MR1 from underneath the molecule, rather than sitting atop it as previously thought.
Researchers have designed artificial sweetener derivatives that inhibit two tumor-associated enzymes, showing improved activity against cancer cells. These compounds selectively bind to enzymes CA IX and XII, making them potential anti-cancer drugs.
Scientists at University of Helsinki and Institut Jacques Monod have identified a molecular machinery that drives rapid depolymerisation of actin filaments and recycles resulting monomers. This discovery provides new avenues for developing therapeutics to inhibit cancer cell migration.
Researchers discovered a key factor, USF1, that inhibits p53 activity, promoting gastric cancer development. USF1 levels can indicate poor prognosis and help identify patients at higher risk of severe forms of gastric cancer.
A study found that silencing the KPNA4 gene reduces cell proliferation, migration ability and resistance to radiation in HNSCCs. Targeting disease-specifically altered transport systems may serve as promising therapeutic strategies for cancer treatment.
Scientists at the University of Bath have developed a new probe, AzuFluor, to detect reactive oxygen species in cells under the microscope. This probe uses a bright blue chemical found in mushrooms and has shown potential applications in cell biology and the pharmaceutical industry.
Researchers found that colon cancer cells deficient in p53 use the mevalonate pathway to survive, producing ubiquinone to synthesize new DNA. Statins inhibit this pathway, inducing apoptosis in cancer cells.
A new method called scPred uses single cell analysis techniques with machine learning algorithms to identify specific types of cells. This can help diagnose cancer and autoimmune diseases earlier, and personalize treatments for individual patients.
A new AI algorithm, ConvPath, uses artificial intelligence to classify cell types and quantify spatial distributions in tumor tissue. This allows pathologists to obtain accurate cancer cell analysis in a faster way.
Researchers developed a bispecific T-cell engager, AMG 701, to target myeloma cells. Administered with lenalidomide or pomalidomide, it showed promising pre-clinical results in mice implanted with human myeloma cells.
Scientists at Johns Hopkins Medicine developed a nanosize container made of biodegradable polymer to deliver protein-based medicines and gene therapies, including CRISPR, into specifically selected target cells. The invention could offer a way to efficiently ferry larger medical compounds into cells with fewer side effects.
Researchers at Stanford University School of Medicine have developed a new approach to programming CAR-T cells that can prolong their activity and increase their effectiveness against human cancer cells. The technique uses ATAC-Seq to understand what happens when T cells become exhausted, and modifying CAR-T cells to restore balance in...
Researchers discovered a new mechanism for detecting foreign material during early immune responses, which could help detect elusive cancers. ERAP1 protein can break down peptides bound to MHC I, allowing immune cells to recognize and destroy infected cells.
Researchers found that dichloroacetate treatment lowered lactate production and stopped abnormal cell growth in women with endometriosis. The study suggests a new non-hormonal treatment option for the condition, which affects millions of women worldwide.
Researchers at American Friends of Tel Aviv University have developed a new treatment that triggers the self-destruction of pancreatic cancer cells. The innovative therapy has shown promising results in its early stages, providing hope for patients with pancreatic cancer.
Researchers have created a new technique to deliver chemotherapy directly to malignant cells, bypassing healthy ones. This discovery could allow doctors to reduce chemo doses and alleviate side effects, improving treatment outcomes.
Scientists from the University of Pennsylvania School of Medicine have discovered a way to make sarcoma cells more susceptible to treatment by slowing down their growth through a key metabolic process. By reactivating the FBP2 enzyme, researchers were able to stop cancer cell proliferation and leave them vulnerable to targeted therapies.
Researchers at the National University of Singapore have found that cells can attach to the fibrous protein meshwork surrounding them only if the fibres are spaced close enough. This finding has implications for understanding abnormal motility patterns in cancer cells and could lead to the development of new therapeutic targets.
A Drexel University study found that rapamycin cream can reduce wrinkles, sagging, and improve skin tone in human subjects over 40. The drug blocks the TOR protein and has anti-aging effects by reducing senescent cells associated with skin aging.
Researchers at the University of South Australia are developing a new radioimmunotherapy agent to target and kill pancreatic cancer cells, potentially minimizing side effects. The treatment uses alpha particles to deposit energy inside cancer cells while leaving healthy tissue intact.
Researchers at Duke University have developed DNA-based biomolecular reaction networks that can identify cancer cells by analyzing molecular signatures on their surface. The technology distinguishes cell types with higher specificity than previous methods, making it a promising step toward more accurate cancer screenings and therapies.
Researchers found that circular extrachromosomal DNA in cancer cells dramatically amplifies mutant oncogenes, promoting aggressive behavior and resistance to therapy. This unique shape enables tumor cells to generate massive amounts of growth-promoting oncogenes and evolve quickly.
Researchers at the University of Bern have found that killer cells without TRAIL become 'tamer', producing more messenger molecules to activate other immune cells, and resulting in better protection against viruses. This alternative signaling pathway could be used to reprogram killer cells for cancer immunotherapy.
Researchers identified Notch as a key molecule involved in cervical cancer progression, contrary to previous thought that Ras was the primary culprit. The review highlights the complex nature of cervical cancer progression, suggesting that local proliferation and metastasis occur through parallel routes.
Researchers developed a microfluidic device with tiny pillars to capture malignant plasma cells from blood samples. The device shows great potential as an early detection or monitoring tool for MM disease progression.
Scientists at UCLA Jonsson Comprehensive Cancer Center developed a new high-throughput screening system that identifies selective inhibitors of metabolic pathways. The approach revealed multiple kinase inhibitors block nucleotide metabolism and its targets.
Researchers at Rensselaer Polytechnic Institute developed a new deep neural network to improve fluorescence lifetime imaging, enabling rapid and detailed analysis of cellular interactions in cancer cells. This technique requires less light while producing detailed images, bringing the field closer to clinical use for precision medicine.
Researchers discover BRN4 overexpression drives neuroendocrine prostate cancer cell conversion in patients with recurrent cancer. Exosome inhibitors under study as potential treatment.
Researchers have discovered a way in which leukemia cells can change their identity to become macrophages, a process known as transdifferentiation. This transformation occurs through epigenetic changes that alter the cell's genetic material, allowing it to acquire new functions and behaviors.
Researchers at Lund University have discovered a protein, Lin28b, that allows self-reactive B-1 cells to develop in mice. These cells produce antibodies against the body's own substances, but are beneficial in cleaning up dead cells and preventing inflammation.
Researchers at Purdue University have developed a method to combine anthrax toxin with a growth factor to selectively kill bladder cancer cells and tumors. This promising treatment shows outstanding results, reducing tumor size without causing side effects in animal trials.
A study published in eLife reveals that an infectious cancer has spread to two different species of mussels on both sides of the Atlantic Ocean, likely due to accidental transport on ships. The cancer is believed to have originated from a single mussel with a primary cancer and has since infected multiple species across the globe.
Researchers developed a computational method to measure intercellular forces without disturbing cell activity. The approach combines biophysical modeling with data-driven modeling using microscopy images.
Researchers at Cornell University have developed a technique using fluorescent probes to study the performance of molecules inside living cells. The probes can accurately measure the rate at which linkers release drugs in cells, enabling pharmaceutical companies to make informed decisions about drug delivery systems.
Researchers at the University of Warwick have discovered a previously unknown cellular component called intracellular nanovesicles (INVs) that deliver proteins in heavy traffic. INVs are approximately 30 nanometres across and could provide clues to the process that allows cells, such as cancer cells, to migrate within the body.
Researchers developed a nondestructive TFM platform allowing for high-throughput cell measurements. The new platform uses a regular array of fluorescent markers to enable zero-stress state measurements, reducing the need for cell removal or relaxation.