Articles tagged with Cancer Cells
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Princeton researchers recreated a crucial cell division process outside a cell, uncovering the vital role of protein TPX2 in over 25% of all cancers. The team's findings reveal TPX2 facilitates efficient microtubule assembly and spindle formation by acting as a liquid-like molecule.
A new mathematical model, ETFL, accurately models enzyme expression and its associated metabolic cost in living cells. The model integrates biochemistry, thermodynamics, and multi-omics data to predict enzyme activity and metabolism.
Researchers found that leukemia cells are 'addicted' to vitamin B6, using it to accelerate cell division. By limiting this enzyme's activity, a new drug could slow or stop cancer growth without harming healthy cells.
A team of scientists has identified a network of interaction partners for the juxtamembrane segment of the EGF receptor, which can influence cell growth and development. This breakthrough may lead to new therapeutic approaches for cancers that have become resistant to current active ingredients.
Researchers have successfully produced human immune cells in a lab dish, shedding light on the formation of these crucial cells. The breakthrough could pave the way for new cancer treatments and autoimmune disease interventions.
Researchers at University College London have identified a subset of immune cells that can kill cancerous cells, opening the door to new and more effective cancer treatments. The discovery builds on previous research and provides evidence for utilizing Blimp-1 to enhance anti-tumor activity in CD4+ T cells.
Researchers have developed a low-intensity ultrasound approach that exploits the unique physical and structural properties of tumor cells to target them. By tuning the frequency to match the target cells, they were able to break apart several types of cancer cells without harming healthy blood cells.
The study reveals syndecan-4's role in sensing environmental conditions outside cells, driving cellular processes behind cancer and diseases. Activating these cellular 'hands' triggers a pathway involving YAP, controlling apoptosis and blood vessel development.
The scTRIP method allows for the study of genetic variations within a single cell and measures genetic changes directly as they form in new cells. Researchers found four times more variants in patient-derived leukaemia cells using scTRIP compared to standard clinical diagnostics.
ATAD5 plays a crucial role in counteracting DNA replication stress by regulating PCNA unloading and promoting RAD51 recruitment. This study reveals ATAD5's fundamental mechanism of replication stress control, contributing to the development of cancer therapy.
Scientists have discovered a new population of gamma delta T cells that recognize an MHC-like molecule called MR1. Using advanced imaging techniques, researchers found that these T cells bind to MR1 from underneath the molecule, rather than sitting atop it as previously thought.
Researchers have identified a new therapeutic strategy to combat chemotherapy resistance in ovarian cancer by targeting the NAD+ metabolic pathway. Combining cisplatin treatment with pharmacological inhibition of NAMPT suppresses the outgrowth of resistant cancer cells and prolongs survival in a preclinical model.
Researchers have designed artificial sweetener derivatives that inhibit two tumor-associated enzymes, showing improved activity against cancer cells. These compounds selectively bind to enzymes CA IX and XII, making them potential anti-cancer drugs.
Researchers discovered a key factor, USF1, that inhibits p53 activity, promoting gastric cancer development. USF1 levels can indicate poor prognosis and help identify patients at higher risk of severe forms of gastric cancer.
Scientists at the University of Bath have developed a new probe, AzuFluor, to detect reactive oxygen species in cells under the microscope. This probe uses a bright blue chemical found in mushrooms and has shown potential applications in cell biology and the pharmaceutical industry.
Scientists at University of Helsinki and Institut Jacques Monod have identified a molecular machinery that drives rapid depolymerisation of actin filaments and recycles resulting monomers. This discovery provides new avenues for developing therapeutics to inhibit cancer cell migration.
A study found that silencing the KPNA4 gene reduces cell proliferation, migration ability and resistance to radiation in HNSCCs. Targeting disease-specifically altered transport systems may serve as promising therapeutic strategies for cancer treatment.
Researchers found that colon cancer cells deficient in p53 use the mevalonate pathway to survive, producing ubiquinone to synthesize new DNA. Statins inhibit this pathway, inducing apoptosis in cancer cells.
A new method called scPred uses single cell analysis techniques with machine learning algorithms to identify specific types of cells. This can help diagnose cancer and autoimmune diseases earlier, and personalize treatments for individual patients.
A new AI algorithm, ConvPath, uses artificial intelligence to classify cell types and quantify spatial distributions in tumor tissue. This allows pathologists to obtain accurate cancer cell analysis in a faster way.
Researchers developed a bispecific T-cell engager, AMG 701, to target myeloma cells. Administered with lenalidomide or pomalidomide, it showed promising pre-clinical results in mice implanted with human myeloma cells.
Scientists at Johns Hopkins Medicine developed a nanosize container made of biodegradable polymer to deliver protein-based medicines and gene therapies, including CRISPR, into specifically selected target cells. The invention could offer a way to efficiently ferry larger medical compounds into cells with fewer side effects.
Researchers at Stanford University School of Medicine have developed a new approach to programming CAR-T cells that can prolong their activity and increase their effectiveness against human cancer cells. The technique uses ATAC-Seq to understand what happens when T cells become exhausted, and modifying CAR-T cells to restore balance in...
Researchers discovered a new mechanism for detecting foreign material during early immune responses, which could help detect elusive cancers. ERAP1 protein can break down peptides bound to MHC I, allowing immune cells to recognize and destroy infected cells.
Researchers at American Friends of Tel Aviv University have developed a new treatment that triggers the self-destruction of pancreatic cancer cells. The innovative therapy has shown promising results in its early stages, providing hope for patients with pancreatic cancer.
Researchers found that dichloroacetate treatment lowered lactate production and stopped abnormal cell growth in women with endometriosis. The study suggests a new non-hormonal treatment option for the condition, which affects millions of women worldwide.
Researchers have created a new technique to deliver chemotherapy directly to malignant cells, bypassing healthy ones. This discovery could allow doctors to reduce chemo doses and alleviate side effects, improving treatment outcomes.
Scientists from the University of Pennsylvania School of Medicine have discovered a way to make sarcoma cells more susceptible to treatment by slowing down their growth through a key metabolic process. By reactivating the FBP2 enzyme, researchers were able to stop cancer cell proliferation and leave them vulnerable to targeted therapies.
Researchers at the National University of Singapore have found that cells can attach to the fibrous protein meshwork surrounding them only if the fibres are spaced close enough. This finding has implications for understanding abnormal motility patterns in cancer cells and could lead to the development of new therapeutic targets.
A Drexel University study found that rapamycin cream can reduce wrinkles, sagging, and improve skin tone in human subjects over 40. The drug blocks the TOR protein and has anti-aging effects by reducing senescent cells associated with skin aging.
Researchers at the University of South Australia are developing a new radioimmunotherapy agent to target and kill pancreatic cancer cells, potentially minimizing side effects. The treatment uses alpha particles to deposit energy inside cancer cells while leaving healthy tissue intact.
Researchers at Duke University have developed DNA-based biomolecular reaction networks that can identify cancer cells by analyzing molecular signatures on their surface. The technology distinguishes cell types with higher specificity than previous methods, making it a promising step toward more accurate cancer screenings and therapies.
Researchers found that circular extrachromosomal DNA in cancer cells dramatically amplifies mutant oncogenes, promoting aggressive behavior and resistance to therapy. This unique shape enables tumor cells to generate massive amounts of growth-promoting oncogenes and evolve quickly.
Researchers at the University of Bern have found that killer cells without TRAIL become 'tamer', producing more messenger molecules to activate other immune cells, and resulting in better protection against viruses. This alternative signaling pathway could be used to reprogram killer cells for cancer immunotherapy.
Researchers developed a microfluidic device with tiny pillars to capture malignant plasma cells from blood samples. The device shows great potential as an early detection or monitoring tool for MM disease progression.
Researchers identified Notch as a key molecule involved in cervical cancer progression, contrary to previous thought that Ras was the primary culprit. The review highlights the complex nature of cervical cancer progression, suggesting that local proliferation and metastasis occur through parallel routes.
Scientists at UCLA Jonsson Comprehensive Cancer Center developed a new high-throughput screening system that identifies selective inhibitors of metabolic pathways. The approach revealed multiple kinase inhibitors block nucleotide metabolism and its targets.
Researchers have discovered a way in which leukemia cells can change their identity to become macrophages, a process known as transdifferentiation. This transformation occurs through epigenetic changes that alter the cell's genetic material, allowing it to acquire new functions and behaviors.
Researchers discover BRN4 overexpression drives neuroendocrine prostate cancer cell conversion in patients with recurrent cancer. Exosome inhibitors under study as potential treatment.
Researchers at Lund University have discovered a protein, Lin28b, that allows self-reactive B-1 cells to develop in mice. These cells produce antibodies against the body's own substances, but are beneficial in cleaning up dead cells and preventing inflammation.
Researchers at Rensselaer Polytechnic Institute developed a new deep neural network to improve fluorescence lifetime imaging, enabling rapid and detailed analysis of cellular interactions in cancer cells. This technique requires less light while producing detailed images, bringing the field closer to clinical use for precision medicine.
Researchers at Purdue University have developed a method to combine anthrax toxin with a growth factor to selectively kill bladder cancer cells and tumors. This promising treatment shows outstanding results, reducing tumor size without causing side effects in animal trials.
Researchers developed a computational method to measure intercellular forces without disturbing cell activity. The approach combines biophysical modeling with data-driven modeling using microscopy images.
A study published in eLife reveals that an infectious cancer has spread to two different species of mussels on both sides of the Atlantic Ocean, likely due to accidental transport on ships. The cancer is believed to have originated from a single mussel with a primary cancer and has since infected multiple species across the globe.
Researchers at Cornell University have developed a technique using fluorescent probes to study the performance of molecules inside living cells. The probes can accurately measure the rate at which linkers release drugs in cells, enabling pharmaceutical companies to make informed decisions about drug delivery systems.
Researchers at the University of Warwick have discovered a previously unknown cellular component called intracellular nanovesicles (INVs) that deliver proteins in heavy traffic. INVs are approximately 30 nanometres across and could provide clues to the process that allows cells, such as cancer cells, to migrate within the body.
Researchers developed a nondestructive TFM platform allowing for high-throughput cell measurements. The new platform uses a regular array of fluorescent markers to enable zero-stress state measurements, reducing the need for cell removal or relaxation.
Researchers at the Francis Crick Institute identified a key mechanism controlling tissue structure, which could help identify drugs that make it harder for cancer cells to spread. The study found that collisions between cells help create different tissue structures, some of which aid cancer progression and can be targeted by drugs.
Researchers at TU Dresden are working on understanding the metabolism of cancer cells, tracing the development of childhood leukemia, and developing novel electronic components using 2D materials. The institution has received a total of 48 ERC Grants since 2008 to support innovative projects.
Researchers at Gladstone Institutes and Xyphos Biosciences have developed convertibleCAR, a cell-based immunotherapy that reduces the latent HIV reservoir in infected patients on anti-retroviral therapy. The technology combines cytotoxic T cells with antibodies, offering a flexible approach to fighting the virus.
Researchers from Xyphos and Gladstone Institutes published preclinical data demonstrating that convertibleCAR cells can significantly reduce latent reservoirs of diverse HIV strains. This approach targets specific cells for destruction using bispecific MicAbodies, providing a promising solution to the HIV/AIDS cure.
A study published in Nature Communications reveals that cell competition modulates morphogen gradients to eliminate unhealthy cells and maintain tissue patterning. The researchers found that aberrant Wnt/β-catenin signaling leads to changes in membrane expression levels of proteins, resulting in cell death via apoptosis.
A new study reveals that PGV-1, an analogue of turmeric's curcumin, effectively suppresses tumor cell growth and causes cell death in various types of cancers. The compound's ability to selectively target cancer cells with minimal side effects may lead to breakthroughs in cancer treatment.
Researchers at UNIGE have developed a new formula, C2, composed of four anti-cancer drugs that target and kill tumour cells while leaving healthy cells intact. The formula has shown promising results in reducing the risk of resistance and side effects associated with high-dose treatments.
A new study by University of Chicago researchers reveals how lactate regulates immune cell function and contributes to cancer growth. The discovery offers a potential breakthrough in developing targeted therapies for various types of cancer.
Researchers developed a targeted cancer treatment using biologically-inspired nanotubes that deliver chemotherapy drugs directly to fast-dividing lung cancer cells. The new technology reduces toxicity and effective kills cancer cells with lower doses, promising a precise approach for precision targeting.
Researchers have discovered fullerene compounds that can effectively kill non-small-cell lung carcinoma cells without harming healthy cells. The anti-tumor activity of these compounds has great potential for the development of new treatments for this aggressive form of cancer.
Researchers have identified a new set of senolytic drugs that can selectively eliminate senescent cells, including those triggered by cancer and irradiation. These compounds, such as ouabain, are repurposed from existing heart medications to treat various diseases, including leukemia and lymphoma.
A unique immune system found in koalas protects their DNA from viruses, opening a new field of research. This 'immune response' helps prevent the spread of diseases like chlamydia and cancer.
Researchers discover that koala germ cells recognize and suppress retroviral invasion through a unique 'piRNA response' mechanism. This innate genome immune system can identify viral RNA and block its replication, providing a new understanding of how organisms defend against pathogen invasions.