Articles tagged with Cancer Cells
Researchers have identified silent ancient DNA elements in our genome that, when reactivated, stimulate the immune system to fight cancer. The discovery of ADAR1, an enzyme used by cancer cells to evade detection, opens up a new field of cancer therapies.
Researchers have discovered a novel mechanism by which cells detect and respond to mechanical stress, triggered by the deformation of their nuclei. This 'fight or flight' reflex allows cells to rapidly flee crowded environments, a process that is conserved across species and in adulthood.
A five-year, $10 million research effort will focus on understanding the three-dimensional structure of cell nuclei and its effects on cellular functions. Researchers aim to develop fundamental knowledge to provide insights into developmental disorders, aging, and other cell processes.
The study reveals that efavirenz alters the gene expression of important factors essential for genomic stability, particularly down-regulating S-phase and DNA replication genes. This suggests that efavirenz may be used in synergy with chemo/radiotherapy to treat lung cancer.
Scientists have identified the crucial role of RAD51 protein in recruiting TERRA molecules to telomeres, which helps prevent accidental loss or shortening of DNA. This mechanism is essential for maintaining healthy telomeres and preventing premature aging and age-related diseases.
The study finds that high miR-708 expression is associated with survival rates in lung squamous cell carcinoma patients. Additionally, miR-708 decreases proliferation, survival, and migration of lung cancer cells by inhibiting PGE2 signaling.
Researchers found that compressing cells can trigger cell growth and division, increasing stem-cell state. Squeezing intestinal cells activates specific proteins, leading to larger organoids with more stem cells on their surface.
Scientists created a 3D structural model of the BAF complex, which modifies DNA architecture and is frequently mutated in cancer. The new model provides critical insights into how mutations disrupt gene regulation and tumor growth.
Researchers successfully replicated Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) in various human cell lines, including liver, intestinal, and airway cells. This finding suggests that SADS-CoV has a broad host range and may pose a risk to human health.
Researchers observed cells moving through small channels to understand cell migration in 3D environments. The findings suggest that cancer cells may penetrate tissues and be blocked within small capillaries, potentially allowing them to metastasize.
A new molecular concept dubbed 'range selectivity' allows for targeted drug delivery to diseased cells with high specificity, reducing side effects. By identifying specific receptor densities, researchers can develop nano-sized drug carriers that attach only to diseased cells.
Researchers discovered that cancer mutations follow specific patterns, with internal factors leading to enriched mutations in active domains and external factors resulting in mutations in inactive domains. This understanding may lead to new therapeutic targets and treatment options.
Researchers at KAUST developed a cost-effective, ultrathin SRS lens using laser-based 3D printing, inspired by lighthouse design. The new lens rejects cross-phase modulation background signals, improving imaging efficiency for biological processes like cancer cell growth.
Researchers at Gladstone Institutes have mapped the genetic networks that control regulatory T cells, which act as a brake to suppress immune reactions. The findings could lead to therapies that strengthen or weaken the function of these cells to treat cancer and autoimmune diseases.
Researchers at IRB Barcelona have developed a new method to regulate cell plasticity by inhibiting the protein CDK8, strengthening gene expression for specific cell identities while reducing alternative identities. This approach holds promise for improving chemotherapy reactions and studying embryonic stem cells.
Cells utilize long-distance traveling waves in a self-organized manner to close wounds, guided by intricate interplay of cell movement, sensing, and protein activation. This coupled system enables robust communication of direction over large distances, promoting coordinated behavior for healing and growth.
Researchers from Aarhus University discovered that a circular RNA molecule, ciRS-7, is actually not found in cancer cells but contributes to cancer development through the tumor's microenvironment. This finding challenges previous conclusions and highlights the importance of spatial analyses of patient tumors.
TMDU researchers have engineered a material that can identify and target cancer cells using an antibody-supermolecule conjugate, potentially overcoming drug resistance. The new approach showed enhanced autophagic cell death with lower concentrations of the treatment.
Researchers have created the first atlas of human heart cells, detailing nearly half a million cells and their functions. The database provides a new basis for studying heart disease, which is the leading cause of death worldwide.
Dipanjan Pan and collaborators have developed a novel method to synthesize plasmonic gold nanoparticles within cancer cells, eliminating the need for traditional laboratory methods. The approach has potential applications in x-ray imaging and therapy, with possibilities for targeted drug delivery.
Scientists have developed a new method to combat cancer by using molecular fibers that target the acidic and reactive environment of cancer cells. The approach has shown promising results in laboratory tests, with cancer cells dying within four hours.
Researchers at City of Hope found that Andrographis paniculata, a natural botanical, is effective in killing chemo-resistant colon cancer cells when used in conjunction with chemotherapy. The study's goal was to develop a non-toxic treatment that could succeed in killing cancer cells.
Scientists have identified the SLC25A51 gene as a key player in transporting NAD+ to mitochondria, a critical step in cellular metabolism. This breakthrough could lead to new treatments for diseases such as neurodegenerative disorders and cancer by manipulating NAD+ levels in specific cells.
Researchers discovered that mutations in ARID1A and ARID1B genes lead to the disassembly of cBAF complexes, causing aggressive liver and skin cancer. This finding challenges a proposed strategy to target these proteins for cancer treatment, highlighting the importance of understanding SWI/SNF biology.
Scientists have identified a promising new system to attack tumors directly by combining a small biomolecule with a toxic metal complex. The molecule's luminescent properties allow for detection within cells and demonstrate its toxic effect, paving the way for further research into this innovative theranostic system.
Using tattoo ink and food dyes, researchers have developed new imaging contrast agents that can illuminate cancers, allowing for better differentiation between cancer cells and normal adjacent cells. This breakthrough aims to improve early cancer detection and localization.
Researchers found that UVB exposure expands regulatory T cells expressing proenkephalin and amphiregulin, promoting wound healing and keratinocyte growth. These PENK+UVB-skin Treg cells have a novel therapeutic potential for treating psoriasis and atopic dermatitis.
Researchers at Champalimaud Centre for the Unknown discover that changes in sex cells' nutritional requirements make female flies crave sugar, affecting their food choice and fertility. The study's findings suggest a novel mechanism by which metabolism controls feeding behaviour, potentially relevant to human fertility.
Scientists at Gladstone Institutes have performed a massive cellular energy audit to understand how cells regulate ATP levels. They identified genes and proteins that can be targeted to manipulate cellular energy and treat disease, including neurodegenerative disorders and cancer. The study reveals new pathways for boosting cellular en...
Cells use self-generated chemotaxis to create attractant gradients, allowing them to read local and global information about their surroundings. This process enables cells to navigate vast distances through the human body during embryogenesis and other biological events.
Researchers have used single-cell RNA sequencing to profile transcriptome-level changes in response to DNA damage across individual cancer cells. The study found three distinct groups of genes activated in response to chemotherapy, revealing new insights into why some cancer cells survive while others die.
A new small molecule treatment reduces colon cancer metastasis by locking up cancer cells' ability to change shape and move throughout the body. The treatment cut the rate of cancer metastasis in half, according to a study published in the Proceedings of the National Academy of Sciences.
A team of researchers has identified a novel drug target, 4-hydroxyacetophenone (4-HAP), that activates a protein motor and disrupts biomechanical processes essential to cell motility. In a mouse model, targeting this protein motor reduces the metastasis of colon cancer cells.
A new mechanism for anticancer drug resistance has been discovered in gastric cancer, involving a molecule called Annexin A6. The molecule is secreted by cancer-associated fibroblasts and taken up by gastric cancer cells, leading to increased resistance to treatment.
Scientists have developed a new tool to precisely target cancer cells by distinguishing them from neighboring cells. The Co-LOCKR system uses synthetic proteins to detect specific combinations of cell surface markers, allowing for more precise targeting and improved safety for cancer-killing CAR T cells.
PIM kinases promote metastatic growth by regulating actin fibre formation in the cytoskeleton, supporting PIM-targeted therapies to prevent metastasis. The study provides critical information on factors regulating cancer cell motility, essential for preventing cancer spread.
Researchers developed experimental drugs to lower alpha-ketoglutarate levels, which slowed cancer cell growth and extended mouse lifespans. Higher alpha-ketoglutarate levels were linked to epigenetic changes that kept genes vital for cancer cells active.
Researchers developed a comprehensive study on nanoprodrugs (NPDs) inside cancer cells, revealing their internalization rate, intracellular localization, and degradation. The study shows that NPDs consistently absorbed by cells as intact particles before being transported into lysosomes.
Researchers discovered that simultaneously targeting two energy-production pathways within cancer cells can help overcome the effects of a cancer-causing mutation in DIPG. In mouse models, inhibiting both pathways at once significantly improved survival rates compared to targeting each pathway individually.
Researchers at Weizmann Institute of Science develop new technology to see inside tens of thousands of individual cells at once, identifying a subset of innate immune cells that collaborate with cancer. This breakthrough may lead to immunotherapy treatment for cancer.
Researchers identify essential cohesin STAG2 in mouse embryonic development, while its inactivation is detrimental to adult health. The study provides substantial evidence of the specific functions performed by different cohesin subunits.
Scientists have developed a protocol to measure mitochondrial activity in living animals using a bioluminescent molecule found in fireflies. This method reveals impaired mitochondrial functions in diseases such as diabetes and cancer.
Researchers at Kumamoto University discovered that NSD2 enzyme prevents cellular senescence by maintaining cell growth and serum response. Reduced NSD2 leads to increased expression of genes related to cell aging and decreased activity of growth-promoting genes.
Researchers at The Wistar Institute identified a cell-surface glycomic signature associated with persistent HIV transcription in T cells. This signature, characterized by the presence of fucose and Sialyl-LewisX, may help target hidden HIV reservoirs during antiretroviral therapy.
Researchers developed an optically induced electrokinetics (OEK) microfluidic method for label-free separation and characterization of gastric cancer cells. The new technique, published in Science Advances, achieved purity up to 71% in separating cancer cells from ascites and demonstrated rapid and non-destructive capabilities.
Researchers discovered that stressed bacteria's damage-containment system can become overwhelmed, prompting cells to activate alternative pathways for DNA replication and growth. This response allows cells to maintain normal functions under stressful conditions.
A new study reveals a previously unknown protein called STEEP that plays a crucial role in the migration of STING protein within immune cells. This discovery provides valuable knowledge about how infectious diseases affect the immune system and could lead to new principles for understanding immune function.
Researchers have discovered that iron is internalised by CD44, a membrane protein known for its association with metastases. This allows cancer cells to acquire metabolites necessary for the metastatic state.
Researchers found that factors produced by bone marrow support cells helped leukemia cells survive treatment with quizartinib, a type of tyrosine kinase inhibitor. However, when quizartinib was combined with another TKI called dasatinib, the alternative survival pathways were shut down, leading to more effective leukemia cell death.
Researchers identified a group of cells regulating T lymphocyte development, preventing leukemia. Cell competition in the thymus is crucial for immune system development and cancer prevention.
Researchers used a genome database to identify the cell type from which cancers derive, revealing new insights into cancer development. By comparing cancer cells to normal human cells, they found that different cancers mostly closely matched specific cell types, shedding light on their origins and tumor behavior.
Researchers found that combining pan-Bcl-2 inhibitors with cancer treatments can cause healthy cells to die, leading to reproductive and developmental defects. The study highlights the need for awareness about adverse effects of certain drugs like navitoclax.
A new study describes a novel label-free imaging technique that can differentiate active T cells from those in a quiescent state. The method, which uses autofluorescence detection, is non-damaging and doesn't alter the behavior of the cell, offering advantages over traditional antibody-based methods.
A clinical trial led by UNC Lineberger Comprehensive Cancer Center found CAR-T cell therapy to be highly active and safe in patients with relapsed/refractory Hodgkin lymphoma. The treatment resulted in a complete disappearance of tumor in the majority of patients and had an overall survival rate of 94% one year after treatment.
Researchers found that chronic inflammation alters cell evolution in the colon, leading to a higher mutation rate and increased risk of colorectal cancers. The study also uncovered evidence of positive selection of mutations in genes associated with immune system regulation and cancer susceptibility.
Researchers have developed a new method for treating skin cancer that uses silica nanoparticles to deliver light-sensitive medication, potentially expanding its use to other types of cancer. This innovative approach could increase the effectiveness of photodynamic therapies by penetrating deeper into tissue.
Researchers at the University of Freiburg have identified a previously undiscovered domain of the T-cell receptor called RK motif. This discovery enables more precise control over T cells, potentially improving therapies for cancer and autoimmune diseases.
Scientists have tracked quadruple helix DNA formation in living human cells for the first time, allowing them to see how it works and its possible role in cancer. The discovery could reveal new targets for drugs that interrupt gene expression, a fundamental process in gene regulation.
Researchers at MU successfully treated bone cancer in dogs with a vaccine that stimulates the immune system against abnormal proteins specific to the patient's tumor. The treatment outperformed chemotherapy, resulting in over 400 days of cancer survival for dogs compared to about 270 days for those receiving traditional chemotherapy.
Researchers discovered that cancer cells with high-affinity iron collection systems collect iron more efficiently than healthy macrophages, allowing them to survive in nutrient-deprived CSF environments. This mechanism enables LM cells to evade immune attack by limiting the supply of vital iron to patrolling macrophages.