Articles tagged with Cancer Cells
Researchers at Technion-Israel Institute of Technology have discovered a new pathway that targets cancer cells specifically, minimizing damage to healthy cells. The folate cycle is essential for DNA and RNA production, and the team found that tumor cells relying on the cytosolic pathway are more susceptible to targeted treatments.
The study investigates the role of cell cycle progression on analyzing telomerase activity in cancer cells based on an AIEgen-based fluorescence detecting system. The results show that cancer cells exhibit increased fluorescence intensity during different stages of the cell cycle, while normal cells do not.
Researchers at the Max Delbrück Center used advanced microscopy to determine that CXCR4 receptor on cancer cells appears in both transient pairs and alone, depending on receptor density. This knowledge may lead to more effective cancer drugs with fewer side effects.
Researchers at the University of Seville have solved a long-standing enigma in basic biology by discovering how lipids distribute proteins within cells. Using a new microscopy technology, they found that membrane lipids select and direct specific proteins to correct exit doors.
Researchers have identified a key function of AIM2, a molecule that plays a vital role in regulating the adaptive immune system. The study reveals that AIM2 is expressed at higher levels in regulatory T cells, which prevent overzealous immune responses and mitigate autoimmune diseases.
Researchers develop innovative approach to treating bone tumors by starving cancer cells of their energy source, potentially replacing toxic chemo with a less harmful treatment. The two-drug combination showed promise in mice studies, outperforming a commonly used chemotherapy drug without severe side effects.
Researchers used XSEDE Stampede2 supercomputer to simulate polarized elongation of actin filaments, shedding light on their polymerization kinetics. The study's findings have potential applications in cancer treatment and development of self-healing materials.
A new method has been developed to identify peptides that inhibit histone deacetylases (HDACs), enzymes that play a role in cancer development and treatment. The researchers hope to use this method to develop more specific HDAC inhibitors with fewer side effects, leading to improved cancer therapy.
Researchers at Northwestern University have developed a novel therapy that uses synthetic nanoparticles to trigger the destruction of lymphoma cells by depriving them of cholesterol. This approach has potential for targeting other cancers with an appetite for cholesterol, such as kidney and ovarian cancer.
Researchers at Toyohashi University of Technology developed a low-cost method for intracellular delivery using titanium-oxide nanotubes and nanosecond pulse lasers. The study successfully delivered propidium iodide and fluorescent dextran into HeLa cells with high efficiency and cell viability.
Scientists have discovered a previously unknown enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, which could lead to new approaches for treating EBV-associated cancers. The study sheds light on how this protein helps replicate and maintain the viral genome in infected cells.
Using CRISPR, scientists have created 'scratchpad' cells that can be tracked in real-time as they proliferate and spread. This method reveals differences in tumor biology and identifies genes associated with metastasis.
Researchers at Sloan Kettering Institute found a new link between Warburg metabolism and PI3 kinase activity, challenging the long-held view that metabolism is secondary to cell signaling. The study suggests targeting metabolism could be an effective way to curb cancer growth.
A new method traces real-time cancer progression across thousands of cells, identifying rare events and distinct gene expression profiles associated with metastatic phenotypes. The approach could inform aspects of cellular cancer biology, including genetic mutations, microenvironment adaptation and resistance to therapeutic agents.
Researchers at Moffitt Cancer Center discovered that cancer cells can fuse and recombine their genetic material, leading to increased diversity and adaptability. This mechanism, similar to parasexual recombination in pathogenic microbes, enables cancer cells to rapidly evolve and acquire resistance to treatments.
A new method, D2O-CANST-R, allows for rapid and precise tracking of metabolic changes in cancer cells at the single-cell and single-organelle level. This approach has the potential to reveal the metabolism in a cancer cell with very fine details and distinguish between effective and ineffective drugs.
Cell velocity depends on surface stickiness, and researchers have figured out the precise mechanics. A mathematical model captures forces involved in cell movement, matching experimental results for various cell types. The findings could provide new targets to interrupt tumor metastasis.
Researchers from UC3M and UCM developed a mathematical model to understand how cancer cells invade healthy tissue, using topological data analysis techniques. The model simulates the collective movement of cells in tissues and can be used to track the progression of tumor growth.
Researchers created nanodiamond sensors that can act as both heat sources and thermometers, allowing for the measurement of thermal conductivity inside living cells. This breakthrough may lead to new diagnostics tools and cancer therapies, as well as a better understanding of metabolic disorders such as obesity.
Researchers at UNH discovered a new inhibitor drug combination that effectively reduces growth and kills WM cancer cells, offering more treatment options. Adding venetoclax or panabinostat to BET inhibitors shows improved efficacy in treating Waldenström macroglobulinemia.
Researchers at Moffitt Cancer Center have identified a novel biochemical pathway that protects cells from ferroptosis, a type of cell death caused by oxidation imbalance. The discovery involves the activation of the protein GCLC, which leads to the production of gamma-glutamyl-peptides that shield cells against ferroptosis.
Researchers discovered that ovarian cancer cells undergo structural changes in their mitochondria to survive and proliferate in the peritoneal cavity. This adaptation enables aggressive cancerous cells to grow and spread, making it harder to detect and treat. Understanding these cellular adaptations could lead to new targeted therapies.
Scientists have created glowing probes to visualize four-stranded DNA in living cells, revealing its interaction with molecules and shedding light on its role in cancer and other diseases. The discovery opens up new avenues for research and potential drug development.
This issue of APSB features studies on the anticancer effects of berberine, baicalein's potent antivirus ability against HSV-1, and a new class of PDE10A inhibitors for treating PAH. Additionally, several articles explore innovative drug delivery systems and novel targets for cancer therapy.
Scientists have created a new method for combating non-Hodgkin's lymphomas by equipping immune cells with an antenna that targets the CXCR5 receptor on cancer cells. In laboratory experiments and mouse models, this approach showed promising results in fighting follicular lymphoma and chronic lymphocytic leukemia.
Scientists at the University of Southampton have discovered that modifying antibodies to target OX40 can enhance immune responses against cancer cells. By adjusting the antibody's isotype, researchers found that one type can delete suppressive Treg cells and another can stimulate killer T-cells, leading to improved anti-tumor effects.
Researchers at UCSF have discovered a new method to control immune responses using CD47-expressing hypoimmune stem cells. These cells can silence natural killer cells via the SIRPα checkpoint, paving the way for novel cell therapies and tissue implants that can evade immune rejection.
Researchers have found that cancer cells can enter a slow-dividing state to survive chemotherapy, similar to an embryonic survival program in mammals. Targeting these sleeping cells with novel therapies may prevent cancer regrowth and overcome drug resistance.
A biologist has created software tools to model cancer pathways and predict the efficacy of cancer drugs. The project aims to develop targeted treatments that target specific signaling networks in cancer cells, reducing harm to normal cells.
Researchers at Kyoto University's iCeMS have discovered how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells. This mechanism, driven by ATP energy, facilitates the export of toxic compounds and confers drug resistance.
Researchers found that chromothripsis breaks up chromosomes, leading to the formation of rearranged genomes and extra-chromosomal DNA that promotes cancer cell growth and drug resistance. This phenomenon enables cancer cells to evade treatment and become more aggressive.
Researchers discovered SETD2 modifies actin cytoskeleton, regulating cell migration and autophagy. Defects in SETD2 lead to impaired delivery of chromosomes and separation of daughter cells during cell division.
Researchers found that reduced amounts of p120ctn contribute to resistance in cancers with high EGFR levels, leading to poorer treatment outcomes. Testing for p120ctn levels may help clinicians identify patients at risk for therapy resistance or relapse.
Researchers have developed nanoparticles that can breach cell barriers and kill tumor cells, reducing tumor sizes by 40-70% in mice. The highly selective toxicity of the particles offers new hope for treating aggressive cancers.
Studies found that DNA leakage from cell nuclei triggers an immune response in cancer cells, making them more susceptible to immunotherapy. Delivering radiation before immunotherapy may be an effective way to fight challenging-to-treat cancers.
A team of researchers has identified a protein called RFWD3 that plays a critical role in recruiting DNA repair and signaling factors. The discovery could lead to new methods to inhibit these repair processes, making chemotherapy more efficient and reducing side effects.
Researchers developed inhibitors targeting mitochondrial DNA, affecting only rapidly dividing cells like cancer cells. Treatment stopped cell proliferation and reduced tumour growth without harming healthy cells.
Researchers at Scripps Research Institute have successfully modified natural killer cells to selectively target and destroy lymphoma cells, a promising breakthrough in cancer treatment. The innovative approach uses glycans, sugar-like molecules that play crucial roles in disease, to steer the cells to malignant B-cells.
Tumor cells produce excess complement protein iC3b to mask abnormal proteins, evading immune cell attack. The immune system relies on a flexible receptor CR3 to distinguish between 'I belong' and 'I don't belong' tags.
A recent study published in Oncogenesis suggests that a compound derived from the thunder god vine can attack 'super-enhancers' in the DNA of cancer cells, as well as the stroma surrounding the tumor. This disruption leads to accelerated cancer cell death and improved clinical outcomes for pancreatic cancer patients.
A recent in vitro study published in Journal of Dietary Supplements found that ergothioneine helped preserve telomere length and reduce oxidative stress. The study suggests that ergothioneine as part of a healthy diet could potentially mitigate the negative effects of oxidative stress and support healthy aging by preserving telomeres.
Scientists studying DNA damage repair process aim to identify a protein that can help healthy cells avoid dying or becoming cancerous. ATF3, a sensor of cell stress, has been shown to be essential to efficient DNA repair and may be the key to developing new cancer therapies.
Researchers found that women with low levels of senescence-associated secreted phenotypes (SASPs) had higher survival rates than those with high levels. Brachytherapy greatly improved survival in patients with high SASP levels, but had little impact on those with low levels.
A machine learning model developed in Finland can identify best cancer drug combinations to selectively kill specific cancer cells with unique genetic or functional profiles. The AI model accurately predicts how different drug combinations inhibit particular cancer cells, paving the way for more effective cancer treatments.
Scientists have developed a procedure, SCENITH, that identifies the energy status of immune and cancer cells within tumors to personalize treatment. This method uses protein synthesis as an indicator of cell activity, enabling clinicians to predict patient response and improve therapy efficacy.
A new imaging technology allows researchers to see multiple intracellular signals simultaneously, revealing their relationships and interactions. This breakthrough could illuminate complex processes like learning and memory, as well as diseases such as Alzheimer's and cancer.
A novel targeted therapy, POMHEX, has been developed to block metabolic pathways in brain cancer cells with specific genetic defects. The study found that the small-molecule enolase inhibitor effectively killed brain cancer cells missing ENO1, and showed promise in animal models of this type of cancer.
Researchers studied fruit fly ovaries to understand cellular motion, discovering that tissue geometry creates a path of least resistance. The team found that cells choose central paths despite multiple side paths available, and this choice is influenced by the physical space, not just chemical signals.
Researchers at Tel Aviv University developed a CRISPR-Cas9 system that specifically targets cancer cells, destroying them by genetic manipulation. The system improved the average life expectancy of mice with glioblastoma tumors by 30% and increased overall survival rate in metastatic ovarian cancer mice model by 80%.
Scientists at St. Jude Children's Research Hospital have identified how metabolic signaling pathways influence key immune cells, including eTreg cells. Understanding this regulation may aid in developing more specific drugs to target these pathways and treat diseases such as lupus, rheumatoid arthritis, and cancer.
A team of scientists at Tokyo University of Science has developed a novel synthesis method to create phenazinones, which show high cytotoxicity towards cancer cells. This breakthrough could lead to the creation of new anticancer drugs with minimal side effects.
Researchers at CeMM have developed a scalable method to study hundreds of proteins in parallel, enabling the observation of changes in protein levels and localization in real-time. This approach has potential applications in discovering new drug treatments and understanding proteome dynamics.
Researchers found a ubiquitin ligase complex that degrades miR-7 and other miRNAs in cells. This discovery sheds light on how cells dispose of genetic molecules regulating protein production.
Researchers at WPI will develop computational models to understand cellular forces and geometry during cell division. The study aims to identify factors that lead to defective spindle structure in cells, which can be targeted to promote cancer cell death.
A team of researchers has discovered how an enzyme called UCH37 helps cells get rid of damaged proteins. By removing branchpoints from ubiquitin chains, UCH37 allows proteins to be degraded more efficiently, which could lead to new cancer treatments.
Purdue University engineers have developed a microfluidic device that allows scientists to test drugs on multiple tumor cell subtypes, revealing new insights into drug resistance. The technology mimics the behavior of pancreatic cancer cells within a tumor, enabling researchers to identify effective treatment strategies.
Scientists have discovered a new role for the cancer-fighting gene p53 in preventing retrotransposons from hopping around the human genome, potentially leading to new ways of detecting or treating cancers. The study found that cells without functional p53 had higher rates of retrotransposon movement and multiplication.
Researchers from the University of Copenhagen have discovered how MCM proteins regulate DNA replication pace and preserve essential skill for life continuation in cells. Their findings suggest a potential way to exploit cancer weaknesses by manipulating molecular roadblocks that slow down DNA replication.
A new study by Brown University scientists has identified vimentin as a potential target for treating aggressive cancer cells known as polyploidal giant cancer cells (PGCCs). PGCCs have been found to rely on vimentin to migrate and invade surrounding tissues.
Researchers have developed a new cancer-specific anticancer drug that can prevent drug resistance and reduce side effects. The drug is designed to release an anticancer agent along with a drug-resistance inhibitor in cancer cells, effectively treating cancers without recurrence or treatment failure.