Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
University at Buffalo researchers have discovered a way to easily and effectively fasten proteins to nanoparticles, showing promise for developing an HIV vaccine and targeting cancer cells. The new biotechnology uses modified proteins and nanoparticles made of natural pigments and metal, and has been tested with impressive results.
Research reveals FGFR1 amplification in 22.7% of small cell lung cancer tumors, implying applicability to non-small cell lung cancer treatments
Researchers have discovered a protein called LEM that promotes the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses. The discovery could lead to new gene therapies designed to boost infection-fighting cells and provide a robust treatment for patients.
Alessandro Vindigni's research reveals four-way junctions as a critical mechanism for resolving DNA lesions, enabling cells to resume replication and maintain genetic stability. New enzymes, including DNA2, play a key role in this process.
Researchers discovered a previously invisible biological process that may be implicated in the rapid growth of some cancers. The new study reveals that a well-known cancer protein called mTOR can hand off its work to another protein, CDK1, when cells are dividing.
Researchers have developed a method to increase radiation's effectiveness in killing cancer cells by using gold nanoparticles tethered to acid-seeking compounds. The approach, published in PNAS, shows promising results and may improve radiation treatment for cancer patients.
A new study has found a significant link between muscle-building supplements and an increased risk of developing testicular cancer. Men who used these supplements were more than 65% likely to develop the disease compared to those who did not use them.
A recent study published in the JNCI: Journal of the National Cancer Institute found a surprising association between shorter telomeres and decreased cancer mortality. The researchers analyzed data from two prospective cohort studies involving over 64,000 individuals and discovered that those with longer telomeres had higher genetic sc...
Researchers at the University of York have found a potential new treatment for organ-confined prostate cancer using low-temperature plasmas. The study, published in the British Journal of Cancer, suggests LTPs may be a viable alternative to current radiotherapy and photodynamic therapy treatments.
Acute myeloid leukemia (AML) cells exhibit high genetic diversity, driven by convergent evolution and mutation rates, leading to increased treatment resistance. Researchers are exploring a new paradigm that leverages cancer's evolveability to develop more effective treatments.
A new molecule designed to specifically target a cancer-causing transcription factor has shown potential to extend survival in some leukemia patients. The small molecule, AI-10-49, inhibits the progression of acute myeloid leukemia (AML) by sequestering an oncogenic mutant, leaving normal transcription factor activity intact.
Researchers at the University of Missouri-Columbia found that 6-Thioguanine can change how certain cancer cells function, weakening them so they can be killed by other drugs. This discovery could lead to future cancer treatments using combination therapy.
A new MRI technique can detect cancerous cells by identifying telltale sugar molecules shed by the outer membranes of cancerous cells. This method could potentially replace or enhance current imaging tests like mammograms and CT scans, allowing for earlier diagnosis and more effective treatment.
This special issue delves into the latest research on molecular gastronomy, perception of food, growing crops, obesity, and diet's impact on the circadian clock. Researchers discuss the science behind cooking techniques, flavor creation, and how chefs are pioneering new fermentation reactions.
Dr. Sara A. Courtneidge is being recognized by the American Association for Cancer Research (AACR) for her groundbreaking research on Src-family kinases and their role in cancer development. Her work has also focused on promoting women in science, leadership, and mentorship.
Low is being recognized for his pioneering development of low molecular weight ligands to deliver attached therapeutic and imaging agents selectively into pathologic cells such as cancer cells. This targeted therapeutic approach improves potency and reduces toxicity.
Researchers at the University of Virginia have developed a promising drug that targets a specific altered cellular protein driving acute myeloid leukemia. The compound kills cancerous cells while sparing healthy ones, offering a new paradigm for treating leukemia.
Cells sort out hairpin-loop structures meant to encode small RNAs, known as microRNAs, using a specific chemical tag. The discovery has wide-ranging implications for development, health and disease, including cancer.
Researchers discover that combining Sodium Formate with metal-based cancer treatment JS07 can greatly increase its effectiveness against ovarian cancer cells. The potent form of JS07 disrupts cancer cell's energy generation mechanism, leading to cell shutdown and potential reduction in side effects.
Researchers discovered that minor clones present at low levels in leukemia cells often drive relapse, contradicting the assumption that mutated cells with more mutations are more likely to survive therapy. The study's findings have implications for monitoring patients in remission and detecting signs of relapse.
Researchers in Berlin have successfully generated human T cell receptors that specifically recognize and destroy cancer cells. The breakthrough, published in Nature Biotechnology, could lead to new cancer therapies by training the immune system to attack tumor cells.
Scientists have created buckybombs, nanoscale explosives that could target and eliminate cancer cells at the cellular level without affecting surrounding tissue. The new explosives were built by attaching nitrous oxide molecules to a Bucky-Ball and then heating it, triggering a controlled explosion.
Researchers at the University of Leeds have discovered a rare African bush that may help treat kidney cancer. The Phyllanthus engleri plant contains a chemical called Englerin A, which activates specific proteins in renal cancer cells, leading to their death.
Researchers develop a novel approach to drug design using diabodies to tune cytokine receptor signaling. The method shows promise in targeting cancer cells and has the potential to reduce side effects by selectively blocking pathologic signals.
Researchers at the University of Sydney have discovered a key RNA mechanism that helps plants adapt to their environment, which could lead to improved crop yields and gene therapies for diseases like cancer. The findings also suggest similar mechanisms exist in humans, providing new avenues for medical research.
Researchers at Walter and Eliza Hall Institute developed a new genome-editing technology to target and kill blood cancer cells. The CRISPR/Cas9 system was used to delete an essential gene for cancer cell survival, showing promise for treating human diseases arising from genetic errors.
Two proteins critical for maintaining healthy day-night cycles also protect against mutations that could lead to cancer. The study found that these proteins have an unexpected role in DNA repair, stabilizing a protein called Cry1 and preventing errors in DNA transcription.
Scientists studying human cervical epithelial cells found that distinct fractal patterns emerge only at the point of progression towards cancer. These findings could inspire targeting specific weak points in pathways leading to cancer development. Fractal patterns may hold importance in understanding cancer metastasis, where cancer cel...
Theoretical chemists generate maximally random, jammed states using a computer algorithm, revealing new insights into the nature of randomness. These findings have implications for materials science and photonics, where randomly dispersed patterns can create unique properties.
Intermediate filaments of vimentin 'insulate' mitochondria in cancer cells from destruction, preserving energy reserves. This discovery may lead to the development of new drugs that effectively treat cancer.
Chemists at Bielefeld University develop copper-based anti-tumor agent that targets DNA phosphates, disrupting cellular processes and killing cancer cells. The new agent shows higher efficacy than cisplatin in killing cancer cells at lower concentrations.
Researchers identified a genetic variation associated with increased risk and severity of peripheral neuropathy in young leukemia patients treated with vincristine. The high-risk CEP72 variant may allow for reduced vincristine doses without compromising cancer treatment efficacy.
A study by Brigham and Women's Hospital researchers uses epigenomic maps to predict a cancer's cell type of origin, providing new insights into early cancer events. This discovery could help guide treatment decisions for patients with unknown primary sites, which pose significant challenges.
A new study suggests that understanding species extinction can help drive cancer cells to annihilation. The authors identify two critical factors governing species resistance to extinction: evolveability and robustness to perturbations. These characteristics may have important correlates among some types of cancer cells.
Scientists have created a new model organism for studying aging in the naturally short-lived African turquoise killifish. The researchers developed a genome-editing toolkit, allowing them to rapidly manipulate genes and study aging-related diseases.
A new approach, called an evolutionary trap, steers cells into one evolutionary path while shutting off others, then knocks out the cell population for good. The strategy may be applied to various clinical scenarios where drug resistance is a problem.
Researchers at McGill University developed a powerful new intraoperative probe for detecting cancer cells in real time during surgery. The Raman spectroscopy probe has a greater than 92% accuracy in identifying invasive brain cancers, and its use may improve patient outcomes by reducing cancer recurrence and extending survival times.
Scientists have created a conjugate molecule that targets and suppresses prostate cancer growth in mice, using a near-infrared dye and MAO-A inhibitor. The compound NMI shows promise as a therapeutic and diagnostic tool for prostate and other cancers.
Researchers at the University of Chicago Medical Center have created a new screening tool for ovarian cancer that can rapidly test compounds to block metastasis. The three-dimensional cell-culture system mimics human tissue and has identified small molecules that inhibit adhesion and invasion.
Researchers have visualized the molecular process behind a protein that punches holes into cancer cells, using edible oyster mushrooms as inspiration. The findings could lead to new treatments for autoimmune diseases, malaria, and pests in agriculture, while also introducing a powerful tool against infectious diseases.
Researchers discovered that lab-grown cells undergo rapid changes within three days of adaptation to their new environment. This finding affects the interpretation of past studies and provides clues for improving cell cultures.
Scientists at TU Dresden have presented a novel method, real-time deformability cytometry (RT-DC), to mechanically screen large populations of cells quickly and accurately. This technology enables the continuous, on-the-fly mechanical screening of hundreds of cells per second.
Fox Chase researchers discovered that pancreatic cancer cells sidestep chemotherapy by hijacking the vitamin D receptor, a key mechanism driving chemotherapeutic effectiveness against pancreatic cancer. The findings raise hopes for developing new treatments that can selectively kill cancer cells while leaving healthy cells unharmed.
Researchers at UMD have developed a technology platform for creating targeted drug and vaccine delivery vehicles using customized soap bubbles. The technology can produce 1,000 doses of vaccines in just 72 hours.
Researchers used game theory to model cooperation among cancer cells, finding that free-riding cells can outcompete producing ones. Computer simulations and experiments with pancreatic cancer cells validated the predictions, suggesting new insight into cancer dynamics.
A green tea compound may trigger a process in the mitochondria that leads to cell death, reducing cancer cell defenses. Researchers found EGCG selectively targets sirtuin 3 in cancer cells, causing oxidative stress and programmed cell death.
A new protein-based therapy has been developed to target drug-resistant leukemia cells, with promising results in mouse models and potentially amplifying the potency of standard treatment options. The fusion protein CD19L-sTRAIL selectively binds and delivers a 'death signal' to leukemia cells.
Researchers at the University of Copenhagen have discovered that Ras protein misregulation is linked to cell shape. By targeting changes in membrane curvature, they hope to develop new ways to diagnose and treat cancers.
Researchers have found that cooperation between cancer cells leads to the evolution of resistance and relapses after therapy. A new treatment approach involves genetically modifying cancer cells to remove growth factor-producing genes, potentially eliminating tumor heterogeneity.
Researchers have discovered that highly efficient DNA methyl transferase 1 (DNMT1) enzymes found in cancer cells are responsible for the abnormal turning on and off of genes. The findings suggest that a drug targeting this enzyme may be beneficial for cancer treatment, potentially reducing cancer relapse.
Researchers propose a novel approach to cancer therapy by subtly hardening cancer cells to prevent metastasis. They've identified a compound, 4-HAP, that shows promise in fighting pancreatic cancer.
A new study identifies pyruvate carboxylase as a key metabolic enzyme that drives proliferation in non-small cell lung cancer. Elevated PC expression was found in cancerous tissues and decreased growth rates when PC was reduced or inhibited.
A new statistical method for RNA-seq analysis has identified and corrected for hidden structure between cells, revealing new subtypes that may have distinct functions. This breakthrough allows researchers to create more accurate gene-expression profiles and explore cell types in cancers and diseases.
The Damon Runyon-Rachleff Innovation Award funds novel approaches to fighting cancer, enabling exceptionally creative thinkers to develop high-risk/high-reward ideas that lack preliminary data. The awardees have the potential to significantly impact cancer prevention, diagnosis, and treatment.
Researchers have discovered that targeting a cell 'survival' protein could help treat some lymphomas, including those cancers with genetic defects that make them resistant to many existing therapies. Removing MCL-1 causes the death and elimination of lymphoma cells that had become resistant to conventional cancer treatments.
Researchers at UCSB's Reich Group have developed a method for spatially and temporally controlling the release of proteins inside cells using near-infrared laser-activated nanocarriers. This technology allows for targeted protein delivery, enabling new avenues for basic research and therapeutic applications.
Researchers developed a drug delivery technique using graphene strips to sequentially deliver two anticancer drugs, TRAIL and doxorubicin, targeting distinct parts of the cell. The technique significantly improved treatment efficacy compared to isolated therapies in mouse models targeting human lung cancer tumors.
Researchers have identified a novel cellular biomarker that can determine if a tumor has a potentially lethal mutation in the p53 protein, which is often referred to as the 'guardian of the genome'. The new biomarker can be used to assess p53 status in as little as 15 minutes.
Researchers developed a system to selectively insert compounds into cancer cells, identifying malignant tissues for precise surgery. The technology uses near-infrared light to kill remaining cancer cells, promising a more accurate and effective approach to cancer surgeries.
Scientists discovered a small molecule, 6-thiodG, that can stop cancer cell growth and shrink tumors in mice. The compound works by disrupting the normal way cells maintain telomere length, triggering cell death.