Articles tagged with Cancer Cells
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The study identifies tiny differences in protein sequences between cancer cells and healthy tissue, enabling the creation of personalized vaccines. The research aims to improve treatment outcomes for patients with ovarian cancer, which often responds well to surgery and chemotherapy but returns lethally within a year or two.
A team of scientists has uncovered a new mechanism controlling actin-rich protrusions that aid in cell migration, a process essential for development, wound healing, and immunological responses. GMF protein plays a key role in regulating these protrusions.
Researchers at Imperial College London have developed a new cancer drug, DTP3, that selectively kills multiple myeloma cells without causing toxicity. The drug works by stopping the NF-kB pathway, which allows cancer cells to multiply, and has been awarded funding for clinical trials in patients with multiple myeloma.
Researchers at North Carolina State University have developed a DNA-based drug delivery system that targets cancer cells using nano-cocoons made of DNA. The system uses self-assembling DNA techniques and specifically delivers anticancer drugs to cancer cells, releasing them quickly once inside.
Researchers discovered that chromosome rearrangements can induce additional errors in cell division, leading to genetic instability. The study found that misplaced DNA segments can lead to the formation of extra cohesion sites, causing abnormal chromosome stretching during cell division.
Researchers found that nuclear factor kappa B (NF-kB) enables cancer cells to evade the immune system by suppressing genes that inhibit the immune response. Inhibiting NF-kB may make tumor cells more vulnerable to elimination by the immune system.
Researchers created a computer model that captures the exosomal exchange between cancer cells, dendritic cells, and other immune system cells. This new approach aims to find a better balance between cancer and the immune system, potentially leading to reduced side effects and improved treatment outcomes.
A $470,350 NSF award will support research on how proteins form groups or clusters within cells, which is associated with cancer and heart arrhythmias. The project aims to gain a better understanding of normal and abnormal protein grouping to prevent or correct abnormalities.
Researchers created a novel method for cell migration by mimicking the connective tissue environment, allowing cells to move in a controlled direction. This breakthrough could lead to new approaches in combating cancer metastasis and inflammation.
A new study reveals that individual cells' migration speed changes randomly through successive generations, despite the population's average speed remaining constant. This finding has significant implications for cancer treatment and tissue repair, suggesting a target for drugs to modulate cell migration speed.
Researchers have found that protein AIM can prevent liver cancer development by triggering the complement cascade to eliminate cancerous cells. AIM accumulates on the surface of HCC cells, leading to their destruction.
Researchers at the University of Missouri have discovered a molecule that effectively treats oxidative stress, which is linked to cancer, Alzheimer's, and Parkinson's disease. The compound, HPP-4382, has shown promise in fighting free radicals and could eventually be developed into a drug.
Phase II data showed dabrafenib has significant anti-tumour activity in patients with advanced BRAF V600E mutant non-small cell lung cancer. HER2 inhibition also shows promise in HER2-positive non-small cell lung cancer, with a 21% overall response rate in patients treated with neratinib and temsirolimus.
Researchers at the University of Missouri have discovered that a molecule used by bacteria can prevent cancer cells from spreading and even kill them. The 'stop spreading' bacteria molecule was found to stop multiplying, migrate, and begin dying in human pancreatic cancer cells.
Researchers have identified a better measure of predicting cancer neoepitopes, which are specific protein sequences recognized by immune cells. This new approach has the potential to improve current methods for generating anticancer vaccines, increasing their effectiveness in combating cancer.
Researchers at the Salk Institute have discovered a 'switch' in cells that can be turned on and off to control telomerase activity. This switch could help keep telomerase levels low, potentially slowing aging and regenerating vital organs.
A new technique uses perfluorocarbon tracers in combination with MRI to track therapeutic immune cells injected into patients with colorectal cancer. The study found that only half of the delivered cell vaccine remained at the inoculation site after 24 hours, but the technology shows promise for tracking other cell types and diseases.
The NIH has awarded over $64 million to six institutions to create a database of human cellular responses, known as the Library of Integrated Network-based Cellular Signatures (LINCS). This will improve scientists' understanding of cell pathways and aid in the development of new therapies for many diseases.
Ovarian cancer cells use mesothelial cells to spread through the body via fibronectin secretion. The study suggests that mesothelium is an active participant in the spread of ovarian cancer.
Researchers at Thomas Jefferson University have discovered a novel approach to killing colon cancer cells by using an antibody that targets the GUCY2C receptor, which is over-produced and exhibited on the surface of cancer cells. The immunotoxin selectively destroys colon cancer cells while sparing surrounding tissue.
A new cancer drug targeting mitochondrial function has been proven safe and showed some efficacy in a Phase I clinical trial for leukemia patients. The drug selectively shut down energy production in cancer cells, which can reproduce faster and repair damage from chemotherapy.
Researchers have developed an innovative algorithm that identifies synthetic lethal interactions in cancer, enabling personalized treatment and predicting patient prognosis. The study's findings show promise for repurposing existing drugs to target specific cancer types.
Yale Cancer Center researchers have found that lupus antibodies can selectively attack and kill cancer cells with defective DNA repair mechanisms. The study, led by James E. Hansen, suggests that harnessing these antibodies could be a new approach to targeted cancer therapy.
A new study confirms the role of invadopodia in cancer spread, showing that preventing their formation can stop cancer entirely. The study identifies a potential therapeutic target for drug development to prevent invadopodia formation.
Cells with oncogenic H-RAS activate ROS, which inactivates PTP1B, leading to AGO2 phosphorylation and gene silencing. This results in the accumulation of p21 proteins and halting the cell cycle.
Researchers have created an online analytic platform called CellNet to aid stem cell engineering. The tool uses network biology methods to analyze and predict cell fate and corresponding engineering strategies, offering a reliable shortcut for drug development and individualized cancer therapies.
Researchers at Virginia Commonwealth University Massey Cancer Center have developed a novel cancer therapy that leverages the autophagy defense mechanism to induce cell death in multiple myeloma cells. By targeting the p62 protein, the therapy disrupts autophagy and triggers apoptosis, resulting in increased effectiveness compared to t...
Researchers at Duke University have uncovered a 'roving detection system' on cell surfaces that may lead to new cancer therapies. The system involves receptors that search for signals to guide cell movement, potentially allowing for the prevention of metastasis and other diseases.
Researchers found BIM deletion independently predicts overall and progression-free survival in advanced NSCLC patients, particularly in those treated with EGFR TKIs or chemotherapy. The study suggests considering BIM deletion as a clinical trial stratification factor for Asian NSCLC patients.
Researchers at Children's Hospital Los Angeles have developed a method to multiply natural killer cells from patients with leukemia in the lab. These autologous NK cells can be used to destroy cancer cells, potentially providing a less toxic and more effective treatment for pediatric leukemia.
The MGH device tracks the movement of cells passing through a comb-like array, allowing researchers to study epithelial-mesenchymal transition and its role in tumor metastasis. This process enables cancer cells to break off from primary tumors and invade other tissues.
Researchers have shed new light on the epithelial-mesenchymal transition (EMT) process in cancer cells, using a microengineered device that acts as an obstacle course for cells. The study reveals that EMT upgrades cancer cells from an economy model to a fast sports car, allowing them to migrate aggressively to distant locations.
The NIH Follow that Cell Challenge seeks tools to monitor a cell's behavior and function over time, potentially leading to earlier diagnosis and improved therapies for diseases. The challenge aims to generate creative ideas and methods for following a single cell's behavior, using multiple integrated measures.
Researchers at the Salk Institute have identified a key control mechanism on regulatory T cells that maintain immune system balance. Removing a specific genetic sequence in Foxp3 destabilizes these cells, leading to autoimmune disease in animal models.
Chloroquine has been shown to inhibit tumor growth and metastases by normalizing abnormal blood vessels in tumors. This results in an increased barrier function blocking cancer cell dissemination and enhanced tumor perfusion increasing the response of the tumor to chemotherapy.
Researchers have created a synthetic ion transporter that can cause cancer cells to self-destruct by disrupting the delicate balance of ions within their cell membranes. The molecule, which was discovered after two decades of research, confirms a hypothesis that could lead to new anticancer drugs and benefit patients with cystic fibrosis.
Researchers at Duke University have successfully used CRISPR gene-editing to target and destroy two HPV genes responsible for cervical cancer cell growth. By hijacking the bacterial defense system, they were able to selectively kill cancer cells while leaving normal cells intact.
Researchers have identified a specific gene required for human cells to survive chromosomal defects that occur as cells divide over time. The discovery sheds light on the mechanisms behind cancer cell survival and holds promise for developing new treatments.
Researchers at Cardiff University have identified a specific gene, Ligase 3, that human cells require to survive chromosomal defects and evade death. This discovery has significant implications for understanding the development of cancer and could lead to new therapeutic targets.
A team of international researchers, led by Professor Wayne Brodland from the University of Waterloo, found that wounds knit together through a complex process involving cellular crawling and contraction. This discovery has potential applications in addressing major health issues such as birth defects and cancer
University of Michigan researchers identified a protein called TRIP13 that enables cancer cells to repair themselves and survive despite chemotherapy. The team found an existing chemical compound that can block this process, potentially increasing the effectiveness of cancer treatment and improving patient survival rates.
Scientists at the University of Kent have discovered how cells regulate internal structures, known as actin filaments. The research could lead to new therapies for diseases like cancer.
Researchers at EPFL discovered that cancer cells with high sugar intake and mobility have a similar mechanism, promoting metastasis and influencing patient survival. The intensity of this phenomenon significantly impacts survival rates, making GLUT3 a potential target for future therapies.
Cancer cells can divide even without sufficient oxygen by manipulating the protein HIF-1alpha. Lysosomes play a crucial role in regulating this process by marking or degrading HIF-1alpha. The study suggests that inhibiting Cdk2 may be an effective treatment strategy for certain types of cancer.
Researchers found a significant reduction in cervical cancer risk after removing squamocolumnar junction (SCJ) cells, which are implicated as the origins of cervical cancer. The study showed that removal of SCJ cells altered recurrence patterns and may prevent precancerous growths.
Researchers reveal detailed images of anaphase-promoting complex (APC/C), a protein that controls mitosis. The discovery could lead to new cancer drugs by identifying binding sites for future treatments.
A new study suggests that cancer metastasis, the spread of tumors from one part of the body to another, may occur through pure chance. Researchers used statistical models to show that 'common' cancer cells circulating in the bloodstream could, on rare occasions, cause metastasis.
University of Houston researchers have developed a technique to extract biomolecules from live cells without killing them. The method uses magnetized carbon nanotubes to retrieve molecular information, allowing researchers to study single cells. This breakthrough could provide new avenues for diagnosing cancer and other diseases.
Researchers developed a novel technique to extract molecular information from live cells using magnetized carbon nanotubes, allowing for the study of individual cells without cell death. This breakthrough has potential applications in cancer drug screening and biomedicine.
A new study has identified a previously unknown mechanism used by neurons to survive, which is also hijacked by brain cancer cells. The discovery may lead to new investigations of brain cancer treatments and provide insight into Parkinson's disease.
A team of researchers has created a way to induce normally mild-mannered cells to gobble up their undesirable neighbors by exploiting a molecular signal. This breakthrough could lead to therapies that enlist patients' own cells to better fend off infection and even cancer.
Researchers developed software to identify cancer cells in tissue sections and detect specific biomarkers. The tool reduces inter-observer variability, leading to more accurate diagnoses and suitable treatment options.
Research identifies TOR signalling pathway as key driver of endoplasmic reticulum expansion in cancer cells, enabling constant protein and lipid production. The findings may uncover future targets for cancer treatment.
A review article by scientists from VIB and KU Leuven suggests that thorough research into the cell metabolism of stromal cells, endothelial cells, and immune cells could result in new treatment options for these diseases. This would also improve current cancer treatments.
Researchers at the University of Georgia have developed a new formulation of cisplatin that significantly increases its ability to target and destroy cancerous cells. The modified version of cisplatin, called Platin-M, is designed to overcome resistance by attacking mitochondria within cancerous cells.
Researchers at University College London have discovered a way to block the movement of cancer cells by targeting chemical signals that trigger their transformation into an invasive, liquid-like state. This breakthrough could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumours.
A new anti-EGFR antibody has been successfully tested on canine cancer cells, offering a promising approach to diagnosis and treatment. The antibody, developed from its human counterpart, demonstrates high specificity and is expected to improve cancer treatment outcomes for dogs.
A new protease, Wss1, has been identified as a safeguarding factor that removes DNA-protein crosslinks, enabling cells to duplicate their genome. Cells lacking Wss1 are highly sensitive to damage and suffer from genomic instability.
A new study found that cancer cells' thick sugar coating enhances their survival by altering cell signaling pathways. The coating causes the cell membrane to change shape, leading to unchecked growth and increased lethality for cancer patients.
Researchers 'remote-controlled' cancer cell behavior with light, finding that activation can cause changes in morphology, proliferation, and gene expression. This breakthrough applies optogenetics to cancer research, offering a precise method for targeting specific cells.