Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
Researchers found BIM deletion independently predicts overall and progression-free survival in advanced NSCLC patients, particularly in those treated with EGFR TKIs or chemotherapy. The study suggests considering BIM deletion as a clinical trial stratification factor for Asian NSCLC patients.
Researchers at Children's Hospital Los Angeles have developed a method to multiply natural killer cells from patients with leukemia in the lab. These autologous NK cells can be used to destroy cancer cells, potentially providing a less toxic and more effective treatment for pediatric leukemia.
The MGH device tracks the movement of cells passing through a comb-like array, allowing researchers to study epithelial-mesenchymal transition and its role in tumor metastasis. This process enables cancer cells to break off from primary tumors and invade other tissues.
Researchers have shed new light on the epithelial-mesenchymal transition (EMT) process in cancer cells, using a microengineered device that acts as an obstacle course for cells. The study reveals that EMT upgrades cancer cells from an economy model to a fast sports car, allowing them to migrate aggressively to distant locations.
The NIH Follow that Cell Challenge seeks tools to monitor a cell's behavior and function over time, potentially leading to earlier diagnosis and improved therapies for diseases. The challenge aims to generate creative ideas and methods for following a single cell's behavior, using multiple integrated measures.
Researchers at the Salk Institute have identified a key control mechanism on regulatory T cells that maintain immune system balance. Removing a specific genetic sequence in Foxp3 destabilizes these cells, leading to autoimmune disease in animal models.
Chloroquine has been shown to inhibit tumor growth and metastases by normalizing abnormal blood vessels in tumors. This results in an increased barrier function blocking cancer cell dissemination and enhanced tumor perfusion increasing the response of the tumor to chemotherapy.
Researchers have created a synthetic ion transporter that can cause cancer cells to self-destruct by disrupting the delicate balance of ions within their cell membranes. The molecule, which was discovered after two decades of research, confirms a hypothesis that could lead to new anticancer drugs and benefit patients with cystic fibrosis.
Researchers at Duke University have successfully used CRISPR gene-editing to target and destroy two HPV genes responsible for cervical cancer cell growth. By hijacking the bacterial defense system, they were able to selectively kill cancer cells while leaving normal cells intact.
Researchers have identified a specific gene required for human cells to survive chromosomal defects that occur as cells divide over time. The discovery sheds light on the mechanisms behind cancer cell survival and holds promise for developing new treatments.
Researchers at Cardiff University have identified a specific gene, Ligase 3, that human cells require to survive chromosomal defects and evade death. This discovery has significant implications for understanding the development of cancer and could lead to new therapeutic targets.
A team of international researchers, led by Professor Wayne Brodland from the University of Waterloo, found that wounds knit together through a complex process involving cellular crawling and contraction. This discovery has potential applications in addressing major health issues such as birth defects and cancer
University of Michigan researchers identified a protein called TRIP13 that enables cancer cells to repair themselves and survive despite chemotherapy. The team found an existing chemical compound that can block this process, potentially increasing the effectiveness of cancer treatment and improving patient survival rates.
Scientists at the University of Kent have discovered how cells regulate internal structures, known as actin filaments. The research could lead to new therapies for diseases like cancer.
Researchers at EPFL discovered that cancer cells with high sugar intake and mobility have a similar mechanism, promoting metastasis and influencing patient survival. The intensity of this phenomenon significantly impacts survival rates, making GLUT3 a potential target for future therapies.
Cancer cells can divide even without sufficient oxygen by manipulating the protein HIF-1alpha. Lysosomes play a crucial role in regulating this process by marking or degrading HIF-1alpha. The study suggests that inhibiting Cdk2 may be an effective treatment strategy for certain types of cancer.
Researchers found a significant reduction in cervical cancer risk after removing squamocolumnar junction (SCJ) cells, which are implicated as the origins of cervical cancer. The study showed that removal of SCJ cells altered recurrence patterns and may prevent precancerous growths.
Researchers reveal detailed images of anaphase-promoting complex (APC/C), a protein that controls mitosis. The discovery could lead to new cancer drugs by identifying binding sites for future treatments.
Researchers developed a novel technique to extract molecular information from live cells using magnetized carbon nanotubes, allowing for the study of individual cells without cell death. This breakthrough has potential applications in cancer drug screening and biomedicine.
University of Houston researchers have developed a technique to extract biomolecules from live cells without killing them. The method uses magnetized carbon nanotubes to retrieve molecular information, allowing researchers to study single cells. This breakthrough could provide new avenues for diagnosing cancer and other diseases.
A new study suggests that cancer metastasis, the spread of tumors from one part of the body to another, may occur through pure chance. Researchers used statistical models to show that 'common' cancer cells circulating in the bloodstream could, on rare occasions, cause metastasis.
A team of researchers has created a way to induce normally mild-mannered cells to gobble up their undesirable neighbors by exploiting a molecular signal. This breakthrough could lead to therapies that enlist patients' own cells to better fend off infection and even cancer.
A new study has identified a previously unknown mechanism used by neurons to survive, which is also hijacked by brain cancer cells. The discovery may lead to new investigations of brain cancer treatments and provide insight into Parkinson's disease.
Researchers developed software to identify cancer cells in tissue sections and detect specific biomarkers. The tool reduces inter-observer variability, leading to more accurate diagnoses and suitable treatment options.
A review article by scientists from VIB and KU Leuven suggests that thorough research into the cell metabolism of stromal cells, endothelial cells, and immune cells could result in new treatment options for these diseases. This would also improve current cancer treatments.
Research identifies TOR signalling pathway as key driver of endoplasmic reticulum expansion in cancer cells, enabling constant protein and lipid production. The findings may uncover future targets for cancer treatment.
Researchers at the University of Georgia have developed a new formulation of cisplatin that significantly increases its ability to target and destroy cancerous cells. The modified version of cisplatin, called Platin-M, is designed to overcome resistance by attacking mitochondria within cancerous cells.
Researchers at University College London have discovered a way to block the movement of cancer cells by targeting chemical signals that trigger their transformation into an invasive, liquid-like state. This breakthrough could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumours.
A new anti-EGFR antibody has been successfully tested on canine cancer cells, offering a promising approach to diagnosis and treatment. The antibody, developed from its human counterpart, demonstrates high specificity and is expected to improve cancer treatment outcomes for dogs.
A new protease, Wss1, has been identified as a safeguarding factor that removes DNA-protein crosslinks, enabling cells to duplicate their genome. Cells lacking Wss1 are highly sensitive to damage and suffer from genomic instability.
Researchers 'remote-controlled' cancer cell behavior with light, finding that activation can cause changes in morphology, proliferation, and gene expression. This breakthrough applies optogenetics to cancer research, offering a precise method for targeting specific cells.
A new study found that cancer cells' thick sugar coating enhances their survival by altering cell signaling pathways. The coating causes the cell membrane to change shape, leading to unchecked growth and increased lethality for cancer patients.
Scientists have discovered that Lassa virus uses a two-step process to enter cells, involving the transport of the virus to a lysosome and the binding to an interior cell receptor called LAMP1. This finding could lead to new approaches for preventing the disease.
Researchers have found a way to deliver proteins directly into live human cells, bypassing the need to damage or kill the cell membrane. This breakthrough has the potential to revolutionize medical research and treatment of diseases, including cancer and regenerative medicine.
Researchers at UT Arlington have developed a method using laser technology and magnetic carbon nanoparticles to deliver drugs and genes directly into cancer cells. The new photothermal delivery method has shown promise in lab experiments, offering an alternative to viruses for gene therapy and potentially treating genetic conditions, c...
A team of researchers at UT Arlington has developed a low-cost, non-invasive device to detect bladder cancer cells in urine. The device uses nanotechnology and can identify as few as two cancer cells in a full liter of urine, making it a promising tool for early detection.
A computer-designed protein, BINDI, was engineered to trigger self-destruction of Epstein-Barr-infected cancer cells. It suppressed tumor growth and enabled mice with EBV-positive lymphoma to live longer.
Researchers have developed a new technique to observe and report on the behavior of kinase signaling proteins in living cells. This allows for the tracking of multiple kinases functioning in living cells, enabling the observation of healthy versus diseased cell comparison and experimental drug effects.
Researchers have discovered the mechanism by which NEDD8 attaches to cells' protein machinery, enabling them to adapt to changing conditions. This breakthrough provides new understanding of how cells regulate proteins and could lead to cancer prevention strategies.
Researchers developed a nanoshell to protect foreign enzymes used in chemotherapy, shielding them from the immune system. The nanoshell acts like a filter in the bloodstream, allowing amino acids to feed cancer cells while trapping enzymes that starve cancer cells.
Researchers have found that cancer cells decide whether to live or die after a short period of intense exposure to targeted therapy. This discovery presents a new treatment strategy with significant potential for reducing side effects in patients.
Iowa State researchers discovered long-lived, force-induced hydrogen bonds are the key to forming catch bonds between cadherin proteins. This discovery is essential for maintaining tissue integrity and may help prevent cancer cells from breaking away and spreading.
Scientists have developed a liver cancer vaccine that is effective in preventing the disease in mice, with the goal of improving patient survival rates. The vaccine targets a specific protein expressed by most liver cancer cells, allowing the immune system to recognize and attack them.
A preclinical study of Rice University's quadrapeutics technology found that it can detect and kill cancer cells instantly, without harming surrounding normal organs. The technology uses a combination of existing clinical treatments and mechanical events triggered by nano-explosions to target cancer cells.
A recent study published in Metabolomics found that EGCG, a green tea extract, disrupts the balance of metabolic pathways in pancreatic cancer cells, reducing their growth and increasing the risk of cancer. Researchers also identified an enzyme inhibitor, oxamate, which operates in a similar manner.
A study found that removing JAK2 from healthy hematopoietic stem cells accelerates leukemia in mice, causing a rapid increase in cancerous cells. Healthy cells, however, are severely impaired and often disappear due to the loss of JAK2.
Cancer cells utilize a protein called Aiolos, which allows them to acquire blood cell characteristics and spread throughout the body. Researchers have discovered how this mechanism works, offering hope for future treatments.
Scientists used a new technology called GRO-Seq to map the genes directly regulated by p53, a tumor suppressor gene that helps prevent cancer. The study identified dozens of new genes that are activated by p53, which could lead to new strategies for fighting cancers.
A research team led by Dr. Bing Hu aims to understand a cell defect that contributes to diseases like cancer and develop effective drug therapies.
Researchers are studying the role of protein kinase D (PKD1) in non-melanoma skin cell damage and death. The study aims to understand how PKD1 protects skin cells from UV damage and explore ways to reduce its activity for cancer prevention.
A team of researchers suggests that an epigenetic switch could control rapid growth and differentiation in cancer cells, leading to the development of various cancers. This switch is thought to be reversible, allowing cells to change their characteristics and differentiate into new cell types.
Researchers at MIPT have developed an algorithm to predict the impact of various substances on signaling pathways, which can help speed up the search for longevity drugs and decrease their cost. The new algorithm is based on comparing gene expression in young and elderly patients' cells.
Detailed studies at St. Jude Children's Research Hospital reveal the structural details of how p53 attaches to its regulatory protein BCL-xL, enabling scientists to design drugs that release p53 in cancer cells, triggering apoptosis. The findings have significant implications for developing new cancer-fighting treatments.
Researchers at Duke University developed a chip-like device that can sort, store, and retrieve hundreds of thousands of individual living cells in minutes. This technology revolutionizes research by allowing fast and efficient control of individual cells, enabling the study of small but significant differences within populations.
Researchers at Children's Hospital Los Angeles have discovered a novel target, B-cell activating receptor (BAFF-R), for chemotherapy-resistant leukemia cells. By targeting this receptor, the team was able to selectively kill cancer cells in mouse models and increase killing of leukemia cells by natural killer cells and macrophages.
Using a novel bioinformatics approach, researchers have found that the approved antimicrobial drug pentamidine may help treat advanced kidney cancer. The study identified gene expression patterns that suggest an antimicrobial may be effective against clear cell renal cancer, a common and highly malignant subtype of kidney cancer.
Researchers at Johns Hopkins University discovered a novel method cancer cells use to migrate through the body by leveraging a propulsion system based on water and charged particles. The Osmotic Engine Model reveals how sodium-hydrogen ions, aquaporins, and water create a flow that propels cells forward.
Researchers have identified DAZAP1 as a 'master regulator' of gene expression in cancer cells, inhibiting the progression of several types of cancer cells. The discovery sheds new light on the protein's potential as a drug target for cancer treatment.
Researchers at Binghamton University will study biofilms implicated in 80% of infectious diseases using a new fluorescence-activated cell sorter. The machine allows for separation and analysis of subpopulations of cells without killing them.
Researchers discovered a new water-soluble fluorescent detection system that is extremely sensitive to pyrophosphate, which plays a key role in energy transduction and DNA replication in cancer cells. The discovery may lead to improved cancer diagnostics.