Articles tagged with Cancer Cells
University of Houston researchers have developed a technique to extract biomolecules from live cells without killing them. The method uses magnetized carbon nanotubes to retrieve molecular information, allowing researchers to study single cells. This breakthrough could provide new avenues for diagnosing cancer and other diseases.
A new study suggests that cancer metastasis, the spread of tumors from one part of the body to another, may occur through pure chance. Researchers used statistical models to show that 'common' cancer cells circulating in the bloodstream could, on rare occasions, cause metastasis.
A team of researchers has created a way to induce normally mild-mannered cells to gobble up their undesirable neighbors by exploiting a molecular signal. This breakthrough could lead to therapies that enlist patients' own cells to better fend off infection and even cancer.
A new study has identified a previously unknown mechanism used by neurons to survive, which is also hijacked by brain cancer cells. The discovery may lead to new investigations of brain cancer treatments and provide insight into Parkinson's disease.
Researchers developed software to identify cancer cells in tissue sections and detect specific biomarkers. The tool reduces inter-observer variability, leading to more accurate diagnoses and suitable treatment options.
A review article by scientists from VIB and KU Leuven suggests that thorough research into the cell metabolism of stromal cells, endothelial cells, and immune cells could result in new treatment options for these diseases. This would also improve current cancer treatments.
Research identifies TOR signalling pathway as key driver of endoplasmic reticulum expansion in cancer cells, enabling constant protein and lipid production. The findings may uncover future targets for cancer treatment.
Researchers at the University of Georgia have developed a new formulation of cisplatin that significantly increases its ability to target and destroy cancerous cells. The modified version of cisplatin, called Platin-M, is designed to overcome resistance by attacking mitochondria within cancerous cells.
Researchers at University College London have discovered a way to block the movement of cancer cells by targeting chemical signals that trigger their transformation into an invasive, liquid-like state. This breakthrough could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumours.
A new anti-EGFR antibody has been successfully tested on canine cancer cells, offering a promising approach to diagnosis and treatment. The antibody, developed from its human counterpart, demonstrates high specificity and is expected to improve cancer treatment outcomes for dogs.
A new protease, Wss1, has been identified as a safeguarding factor that removes DNA-protein crosslinks, enabling cells to duplicate their genome. Cells lacking Wss1 are highly sensitive to damage and suffer from genomic instability.
Researchers 'remote-controlled' cancer cell behavior with light, finding that activation can cause changes in morphology, proliferation, and gene expression. This breakthrough applies optogenetics to cancer research, offering a precise method for targeting specific cells.
A new study found that cancer cells' thick sugar coating enhances their survival by altering cell signaling pathways. The coating causes the cell membrane to change shape, leading to unchecked growth and increased lethality for cancer patients.
Scientists have discovered that Lassa virus uses a two-step process to enter cells, involving the transport of the virus to a lysosome and the binding to an interior cell receptor called LAMP1. This finding could lead to new approaches for preventing the disease.
Researchers have found a way to deliver proteins directly into live human cells, bypassing the need to damage or kill the cell membrane. This breakthrough has the potential to revolutionize medical research and treatment of diseases, including cancer and regenerative medicine.
Researchers at UT Arlington have developed a method using laser technology and magnetic carbon nanoparticles to deliver drugs and genes directly into cancer cells. The new photothermal delivery method has shown promise in lab experiments, offering an alternative to viruses for gene therapy and potentially treating genetic conditions, c...
A team of researchers at UT Arlington has developed a low-cost, non-invasive device to detect bladder cancer cells in urine. The device uses nanotechnology and can identify as few as two cancer cells in a full liter of urine, making it a promising tool for early detection.
A computer-designed protein, BINDI, was engineered to trigger self-destruction of Epstein-Barr-infected cancer cells. It suppressed tumor growth and enabled mice with EBV-positive lymphoma to live longer.
Researchers have developed a new technique to observe and report on the behavior of kinase signaling proteins in living cells. This allows for the tracking of multiple kinases functioning in living cells, enabling the observation of healthy versus diseased cell comparison and experimental drug effects.
Researchers have discovered the mechanism by which NEDD8 attaches to cells' protein machinery, enabling them to adapt to changing conditions. This breakthrough provides new understanding of how cells regulate proteins and could lead to cancer prevention strategies.
Researchers developed a nanoshell to protect foreign enzymes used in chemotherapy, shielding them from the immune system. The nanoshell acts like a filter in the bloodstream, allowing amino acids to feed cancer cells while trapping enzymes that starve cancer cells.
Researchers have found that cancer cells decide whether to live or die after a short period of intense exposure to targeted therapy. This discovery presents a new treatment strategy with significant potential for reducing side effects in patients.
Iowa State researchers discovered long-lived, force-induced hydrogen bonds are the key to forming catch bonds between cadherin proteins. This discovery is essential for maintaining tissue integrity and may help prevent cancer cells from breaking away and spreading.
Scientists have developed a liver cancer vaccine that is effective in preventing the disease in mice, with the goal of improving patient survival rates. The vaccine targets a specific protein expressed by most liver cancer cells, allowing the immune system to recognize and attack them.
A preclinical study of Rice University's quadrapeutics technology found that it can detect and kill cancer cells instantly, without harming surrounding normal organs. The technology uses a combination of existing clinical treatments and mechanical events triggered by nano-explosions to target cancer cells.
A recent study published in Metabolomics found that EGCG, a green tea extract, disrupts the balance of metabolic pathways in pancreatic cancer cells, reducing their growth and increasing the risk of cancer. Researchers also identified an enzyme inhibitor, oxamate, which operates in a similar manner.
A study found that removing JAK2 from healthy hematopoietic stem cells accelerates leukemia in mice, causing a rapid increase in cancerous cells. Healthy cells, however, are severely impaired and often disappear due to the loss of JAK2.
Cancer cells utilize a protein called Aiolos, which allows them to acquire blood cell characteristics and spread throughout the body. Researchers have discovered how this mechanism works, offering hope for future treatments.
Scientists used a new technology called GRO-Seq to map the genes directly regulated by p53, a tumor suppressor gene that helps prevent cancer. The study identified dozens of new genes that are activated by p53, which could lead to new strategies for fighting cancers.
A research team led by Dr. Bing Hu aims to understand a cell defect that contributes to diseases like cancer and develop effective drug therapies.
Researchers are studying the role of protein kinase D (PKD1) in non-melanoma skin cell damage and death. The study aims to understand how PKD1 protects skin cells from UV damage and explore ways to reduce its activity for cancer prevention.
A team of researchers suggests that an epigenetic switch could control rapid growth and differentiation in cancer cells, leading to the development of various cancers. This switch is thought to be reversible, allowing cells to change their characteristics and differentiate into new cell types.
Researchers at MIPT have developed an algorithm to predict the impact of various substances on signaling pathways, which can help speed up the search for longevity drugs and decrease their cost. The new algorithm is based on comparing gene expression in young and elderly patients' cells.
Detailed studies at St. Jude Children's Research Hospital reveal the structural details of how p53 attaches to its regulatory protein BCL-xL, enabling scientists to design drugs that release p53 in cancer cells, triggering apoptosis. The findings have significant implications for developing new cancer-fighting treatments.
Researchers at Duke University developed a chip-like device that can sort, store, and retrieve hundreds of thousands of individual living cells in minutes. This technology revolutionizes research by allowing fast and efficient control of individual cells, enabling the study of small but significant differences within populations.
Researchers at Children's Hospital Los Angeles have discovered a novel target, B-cell activating receptor (BAFF-R), for chemotherapy-resistant leukemia cells. By targeting this receptor, the team was able to selectively kill cancer cells in mouse models and increase killing of leukemia cells by natural killer cells and macrophages.
Using a novel bioinformatics approach, researchers have found that the approved antimicrobial drug pentamidine may help treat advanced kidney cancer. The study identified gene expression patterns that suggest an antimicrobial may be effective against clear cell renal cancer, a common and highly malignant subtype of kidney cancer.
Researchers at Johns Hopkins University discovered a novel method cancer cells use to migrate through the body by leveraging a propulsion system based on water and charged particles. The Osmotic Engine Model reveals how sodium-hydrogen ions, aquaporins, and water create a flow that propels cells forward.
Researchers have identified DAZAP1 as a 'master regulator' of gene expression in cancer cells, inhibiting the progression of several types of cancer cells. The discovery sheds new light on the protein's potential as a drug target for cancer treatment.
Researchers at Binghamton University will study biofilms implicated in 80% of infectious diseases using a new fluorescence-activated cell sorter. The machine allows for separation and analysis of subpopulations of cells without killing them.
Researchers discovered a new water-soluble fluorescent detection system that is extremely sensitive to pyrophosphate, which plays a key role in energy transduction and DNA replication in cancer cells. The discovery may lead to improved cancer diagnostics.
Researchers at Virginia Tech developed a novel method to detect the subcellular location of proteins, which will enable improved patient monitoring and drug development. The technique allows for rapid screening of large cell populations with high resolution, revealing heterogeneity among cells.
Researchers at VCU Massey Cancer Center have identified a critical protein called Noxa, which helps regulate the function of MCL-1 and makes cancer cells more sensitive to ABT-737. This breakthrough may lead to improved therapies for small cell lung cancer, overcoming resistance to conventional chemotherapies.
Scientists at the University of Texas at Dallas are investigating the potential human health effects of multi-walled carbon nanotubes, tiny structures used in various products. The researchers will use advanced microscopy techniques to track how these nanotubes interact with human cells and determine their impact on health.
Using the subway analogy, a physicist is applying queuing theory to study protein traffic jams in cells. By understanding these bottlenecks, he aims to discover mechanisms for alleviating them and develop new tools for synthetic biology. This research has the potential to impact areas such as development, inflammation and cancer.
Researchers at Beth Israel Deaconess Medical Center have identified a key enzyme responsible for lactate production in cancer cells, which they inhibit to halt tumor growth and even cause regression. The study's findings offer promising results for new treatments targeting cancer metabolism.
Researchers at UC Davis have identified the atomic structure of kinesin-5, a protein essential for mitosis in virtually all eukaryotic cells. The newly discovered structure reveals unique pockets that could be exploited as targets for new anti-cancer drugs.
Researchers develop a new strategy to kill bladder cancer cells by attaching gold nanorods to EGFR proteins, which are overexpressed on these cells. The application of low-intensity laser heat the nanorods, killing the cancer cells without harming healthy tissue.
A University of Colorado study shows that cancer cells can outlive chemotherapies by using autophagy, a process where cells recycle damaged parts. This finding has implications for developing drugs that inhibit autophagy to sensitize cancer cells to chemotherapy.
Researchers at Lund University have developed a technique using magnetically controlled nanoparticles to selectively kill cancer cells while sparing healthy tissue. This method has the potential to revolutionize cancer treatment by reducing side effects associated with traditional therapies.
A new study published in the journal Cancer has identified a novel biomarker, CCTα, associated with improved survival rates in patients with head and neck cancers and non-small cell lung cancer. The findings suggest that CCTα may be a more important predictor of patient outcomes than previously established ERCC1.
A comprehensive 'roadmap' of blood cells has been presented by researchers, pinpointing the location of key genetic regulators that determine cell development and function. This robust genetic catalog will enable hematologists to trace the development of blood cells and identify potential triggers for malignancies.
Researchers discovered that p53 acts to prevent cancer cell invasion by initiating a chain of events that ultimately prevents the formation of lamellipodia. This process involves the activation of a mitochondrial protease called Omi, which cleaves actin filaments and suppresses the activity of focal adhesion signaling protein p130Cas.
Researchers at Massachusetts General Hospital have identified a path to safer drugs for heart disease and cancer. By analyzing the structure of an extracellular matrix protein and its interaction with an integrin, they have discovered a high-affinity version that can bind strongly without inducing unintended receptor activation.
Scientists at Northwestern University have discovered that cancer cells rely on the FAS receptor and its binding component for survival, making them vulnerable to elimination. The team created a cancer cell completely devoid of CD95, which resulted in DNA damage and cell death, offering a promising new approach to kill cancer cells.
A team of biologists and engineers at the University of California, San Diego has discovered how white blood cells generate traction forces to propel themselves forward by coordinated action of contractile proteins. This finding is crucial for developing new pharmacological strategies to treat chronic inflammatory diseases.
Researchers have identified a key pathway that helps cancer cells survive in low-glucose environments, and found that certain diabetes drugs can inhibit this pathway to kill cancer cells. The study provides new insights into how anti-cancer properties of diabetes drugs like metformin may work.
Researchers found that just a handful of genetic mutations give E. coli the capacity to withstand ionizing radiation, making them similar to Deinococcus radiodurans. The study demonstrates active DNA repair mechanisms that allow organisms to resist radiation damage.
Researchers have developed a versatile mouse that expresses a fluorescent biosensor, enabling the tracking of diseased cells and drugs in real-time. This technology has been used to monitor Rac activation in various organs in response to drug treatment, providing valuable information on cancer progression.
A recent study reveals that a key protein called IRSp53 plays a crucial role in regulating cell movement, which is necessary for wound healing and immune response. However, when cancer cells break away from tumors and migrate to other tissues, this regulation can be disrupted, leading to metastasis.