Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
Researchers at UT Southwestern Medical Center identified BRD4 as a potential therapeutic target for MPNST, a rare and aggressive type of soft-tissue cancer. Inhibiting BRD4 caused cancer cells to die in a mouse model, providing new hope for patients with this incurable disease.
Researchers develop new treatment for pancreatic cancer by using a drug that breaks down the protective barrier surrounding cancer tumours. The approach enables T cells to get through and kill cancer cells, resulting in almost complete elimination of cancer cells in initial tests.
A study in the Journal of Dairy Science found that polyphenol EGCG in milk can reduce colon cancer cell proliferation and inhibit tumor formation. Milk's casein protein micelles may enhance bioavailability and efficacy of these compounds.
Research reveals that fusion between cancer cells and macrophages empowers cancer cells to spread, forming tumors more rapidly. The study's findings suggest a new mechanism by which cancer progression is driven.
Researchers identify two therapeutic targets to block cancer cell growth: PAK and STAT5. The shutdown of either target significantly delays leukemia progression in mice, offering new hope for cancer treatment.
A research group at Lund University has shown that the 'avalanche effect' theory of cancer development is not correct. Cancer cells can have over 100 chromosomes, but a single initial change does not lead to unstoppable further mutations.
A toxin linked to brentuximab vedotin has shown compelling antitumor activity in patients with non-Hodgkin lymphomas, including diffuse large B cell lymphoma. The study found that 40% of DLBCL patients had an objective response, with a median duration of 36 weeks.
Scientists at VTT Technical Research Centre of Finland have discovered a novel DNA repair mechanism in cancer cells that allows them to survive DNA damage. This finding provides valuable insights into how cancer cells evade programmed cell death and can be targeted by new cancer therapies.
A new optical sensor created at MIT can track zinc within cells, shedding light on its functions and helping researchers study zinc trafficking in prostate cells. The sensor supports the theory that cancerous prostate cells banish zinc from mitochondria to produce extra energy.
A personalized cell therapy reprograms a patient's immune system to eliminate tumors in blood, showing complete responses in 89% of patients with high-risk ALL. The treatment has also been shown to persist in circulation and prevent cancer recurrence.
Researchers have discovered that tumour cells adopt the 'break-induced replication' (BIR) pathway to repair damaged replication forks, allowing for genome duplication. This pathway is common in cancer cells but rare in healthy cells, revealing a significant difference between these two types of cells.
Researchers at the University of Colorado have synthesized the most active component of grape seed extract, B2G2, which induces apoptosis in prostate cancer cells while leaving healthy cells unharmed. The findings suggest that B2G2 is a promising lead compound for future clinical trials and preclinical studies.
Researchers found that inhibiting antioxidant proteins reduced tumor growth and induced cell death in lung cancer cells. In a mouse model, the inhibitor ATN-224 also reduced tumor sizes when combined with another drug.
Researchers discovered a unique leukemia-specific DNA enhancer element that enables cancerous blood cells to proliferate in Acute Myeloid Leukemia (AML), a devastating and incurable cancer. The study also reveals how a new class of promising drugs, including JQ1, halt the growth of cancer cells by targeting this enhancer element.
Researchers have unveiled a biological process that explains how DNA can be damaged during genome replication, which relies on protein RPA. Cells use this protein as 'band aids' to protect DNA temporarily during replication, but if they run out, DNA breaks severely and cells cannot divide.
A new technique, deformability cytometry, can analyze over 1,000 cells per second and provide more accurate diagnoses than traditional methods. The test uses fluid flow to 'squeeze' individual cells, allowing for detailed analysis of cell properties.
Researchers at the University of Adelaide have discovered a gene that plays a crucial role in suppressing lymphoma, a type of blood cell cancer. Caspase-2 helps maintain healthy chromosome numbers in cells, preventing them from becoming cancerous.
Researchers used DNA sequencing to create a family tree for individual cancer cells, revealing unique branching patterns and distinct sub-populations. This technique could help identify key mutations driving tumor growth and develop targeted treatments more effectively.
Researchers have identified FOX01 as a critical molecule in the wound-healing process, providing a possible new target for pharmaceuticals. The study found that FOX01 plays an integral role in activating key growth factor TGF-β1 and protecting cells against oxidative stress.
A CNIO team has discovered that senescence, which makes cells stop dividing, also takes place during embryo development to eliminate unnecessary cells. This process, known as programmed senescence, helps shape the body's tissues and organs.
A peptide fragment derived from cow's milk, lactoferricin B25, exhibits potent anticancer capability against human stomach cancer cell cultures. This finding provides support for the potential therapeutic agent for gastric cancer treatment.
Whitehead Institute scientists report that the FLCN protein acts as a trigger to activate the mTORC1 pathway, which regulates cell growth in response to nutrient levels. This unexpected finding may provide insight into how cancer cells distort normal cellular functions to maintain their own harmful ways.
Researchers at the University of Nottingham have found a type of archaea that can reproduce without normal replication processes, growing faster in its absence. This discovery challenges existing understanding of DNA replication and has implications for cancer research.
Researchers at Boston University School of Medicine suggest epigenetics as a target for cancer therapy. Epigenetic changes mediate the development of cancer progenitor cells, which can grow rapidly to become full-fledged cancer.
The Cell-CT platform detected lung cancer in patient sputum samples with a sensitivity of over 95% and specificity of 99.8%. The technology creates comprehensive 3D digital images of cells, making it possible to determine the presence or absence of cancer with great accuracy.
Researchers discovered that individual molecular muscles within cells respond differently to various forces, shedding light on how cells 'feel' their environment. A computer model predicts cell behavior in response to altered levels of these molecules, with implications for understanding cellular disorders like cancer and neurodegenera...
Researchers at UCSF have discovered a new way to target cancer by controlling cell growth and boosting protein production during the S phase of the cell cycle. This study has implications for the development of new cancer therapies.
Researchers discovered distinct EBV subtypes with varying public health risks, including a strain associated with nasopharyngeal carcinoma. This finding highlights the importance of tailoring prevention efforts to specific viral strains.
Researchers at CNIO's Cell Division & Cancer Group have discovered that the protein Greatwall is essential for preventing mitotic collapse in mammals. By inhibiting Greatwall, cells can no longer divide properly, which may lead to slowed-down cancer growth and potentially reactivated tumour suppressor PP2A
A study finds that chronic myeloid leukemia cells with activating beta-catenin mutations are highly aggressive and resistant to Imatinib. Combined treatment with drugs restoring IRF8 expression and inactivating beta-catenin may prevent fatal leukemia progression.
A team of engineers has developed a new approach that marries computer vision and hardware optimization to sort cells up to 38 times faster than current techniques. The approach improves on imaging flow cytometry, which uses camera mounted on a microscope to capture cell features.
A study at the Weizmann Institute suggests that in a quarter of all leukemias, cancer cells use a balance between a mutated gene and its normal counterpart to keep going. The healthy RUNX1 gene plays a crucial role in blood cell development and maintenance.
A phase I clinical trial has shown that an anti-PD-L1 monoclonal antibody can produce striking responses in non-small cell lung cancer patients with metastatic disease who have failed to respond to previous chemotherapy. Smokers and former smokers are more likely to benefit from this treatment.
Researchers found that men with variable telomere length in cancer cells and shorter telomeres in stromal cells were more likely to develop metastatic disease and die sooner from their prostate cancer. This combination could be a marker for prostate cancer prognosis.
Cancer researchers at UC San Diego isolated and characterized early-stage prostate cancer cells, which may drive recurrent disease. The study suggests that these cells could be targeted for new treatments, potentially reducing cancer progression.
A team of U-M neuroscientists reports that SIRP alpha plays a critical role in stabilizing the most active synaptic connections between brain cells. This finding may aid research on conditions like autism, schizophrenia, and intellectual disability, which are linked to abnormal synapse function.
The circadian clock enables cells to use stored fuel efficiently when we fast, with NAD+ and Sirtuin 3 playing a critical role. Disrupting the clock leads to metabolic disorders, but providing NAD+ supplements can restore mitochondrial function.
A study published in the Journal of the National Cancer Institute found that proteins delivering leucine to prostate cancer cells are therapeutic targets. Inhibition of these proteins inhibits nutrient signaling pathways and over 100 metastasis-related genes, leading to cell cycle inhibition and reduced tumor growth.
Scientists at A*STAR's Singapore Immunology Network have discovered a new mechanism involving p53, the famous tumor suppressor, to fight against aggressive cancers. The strategy works by sabotaging cancer cells' ability to hide from the immune system, opening a new avenue for targeted therapy.
Scientists at the University of Copenhagen have identified a specific sugar molecule that aids in the growth of cancer cells. The discovery, published in PNAS, could lead to new ways to diagnose and treat cancer.
Cancer cells exploit a vicious cycle of mucus production to protect themselves from the immune system and promote tumor growth. Researchers at Rice University have identified a potential therapeutic target in rosiglitazone, a diabetes medication that can attenuate this cycle.
Researchers have discovered a network of genes in stem cells that foster cooperation, which is essential for the development and function of multicellular organisms. The study suggests that understanding this genetic mechanism could lead to new ways to address diseases such as cancer and immune system dysfunction.
Researchers at Dartmouth's Geisel School of Medicine discovered that cyclin A plays a crucial role in ensuring faithful chromosome segregation during cell division. In contrast to normal cells, cancer cells often fail to correct errors, leading to abnormal numbers of chromosomes and resistance to chemotherapy treatments.
Researchers developed a new system to test how viruses interact with cells in the body, revealing insights that will improve viral therapy. The technology allows for the use of real viruses in real environments, enabling scientists to study host targets for antiviral drugs.
Medical scientists at the University of Alberta have made a key discovery about how the immune system kills healthy cells while attacking infections. Their research could lead to better solutions for cancer and anti-viral treatments by manipulating the immune system response to block collateral damage.
Scientists discovered a new weakness in cancer cells that makes them more susceptible to chemotherapy by targeting the HDAC5 protein. Cancer cells with longer telomeres tend to be resistant to therapies, while shorter telomeres make them more vulnerable to treatment.
St. Jude Children's Research Hospital scientists have identified a protein that blocks death of high-risk acute lymphoblastic leukemia cells, leading to a new two-drug combination therapy approach. The study shows promise for treating Ph-positive ALL, a high-risk cancer with limited treatment options.
Researchers uncover how ABL regulatory unit controls cell fate in CML, with implications for cancer treatment. The study finds that anchoring ABL on the cell membrane is essential for apoptosis, highlighting a potential target for novel therapies.
Research reveals that chromosomal rearrangements, such as inversions or translocations, can be beneficial in certain environments, leading to improved growth abilities. This discovery sheds light on how natural selection shapes chromosome structure to favor specific conditions.
Researchers found that a combination of calorie restriction and targeted therapy may increase cancer survival. Calorie restriction decreased Mcl-1 protein activity, sensitizing lymphoma cells to treatment. This study suggests a potential new approach to improve cancer treatment efficacy.
Researchers found that flavonoids in celery, artichokes and Mexican oregano can kill human pancreatic cancer cells by inhibiting the GSK-3β enzyme. This pre-treatment approach may prolong life without curing the disease, while preventing it could reduce cancer risk with chronic flavonoid exposure.
Researchers at CWRU School of Dental Medicine have discovered the link between an oral bacterium and colorectal cancer. They found that Fusobacterium nucleatum can trigger cancerous cell growth by modulating E-cadherin/ß-catenin signaling.
Researchers have produced detailed descriptions of human folate receptor proteins, aiding in the design of new drugs that can target cancer cells without harming healthy ones. The findings could lead to effective treatments for ovarian cancers and inflammatory diseases such as rheumatoid arthritis.
Researchers have discovered a key role played by TACC3-ch-TOG-clathrin in forming inter-microtubule bridges that stabilise kinetochore fibres during mitosis. Removing this protein team can induce cells to arrest and die, potentially providing a new approach to cancer treatment.
Researchers at Columbia University Medical Center created DNA nanorobots that can identify and tag specific human cells based on multiple surface proteins. This allows for precise targeting of cancer cells with minimal impact on healthy cells, potentially revolutionizing cancer treatment.
Researchers at Mayo Clinic have made a breakthrough discovery about the origin of inflammation-driven pancreatic cancer. They found that chronic inflammation in the pancreas can push acinar cells to transform into duct-like cells, which can then acquire mutations leading to further progression of pancreatic cancer. The study identified...
Researchers found cancer cells can reverse replication forks using 'fork reversal' repair after DNA damage caused by topoisomerase I inhibitors. This process is controlled by proteins PARP and RECQ1, which could be targeted for effective treatment with lower toxic side effects.
UPCI researchers discovered that targeting 'cell sleep' can kill a larger fraction of cancer cells, increasing the effectiveness of cancer drugs. This finding has implications for gastrointestinal stromal tumors (GISTs), which are often treated with targeted therapy drug imatinib.
Scientists at Cancer Research UK have discovered a new molecule that prevents cancer cells from responding to low oxygen levels, targeting the master switch HIF-1. The researchers developed this approach using synthetic biology and testing over 3.2 million potential compounds.
Researchers have identified a new therapeutic target by linking protein translation to heat shock response in cancer cells, which slows tumor growth and makes drug-resistant tumors vulnerable to other therapies. A compound called Rohinitib disrupts this link, normalizing metabolism and killing cancer cells.