Articles tagged with Cancer Cells
Researchers used advanced mathematical modelling to devise strategies for making cancer cells exquisitely sensitive to virus infection, killing them without affecting normal cells. The models were remarkably accurate, predicting experimental outcomes in a mouse model of the disease and creating a useful framework for further research.
Researchers at Uni Basel have discovered Sox4 as a key player in cancer metastasis, triggering the epithelial-mesenchymal transition (EMT) process. The study found that Sox4 promotes the expression of genes involved in EMT and metastasis, leading to changes in gene expression and cell behavior.
Researchers at the University of Copenhagen have discovered a new way cells communicate with each other using antennae-like structures called primary cilia. This breakthrough sheds light on the causes of debilitating diseases such as heart defects and birth defects, highlighting the importance of TGFβ signalling in fetal development.
Researchers at UCLA have isolated a new population of pluripotent stem cells, called Multi-lineage Stress-Enduring (Muse-AT) cells, from fat tissue that can differentiate into virtually every cell type in the human body. These cells are stress-resistant and may even be activated by severe stress, making them potentially superior source...
Researchers at the University of California, San Diego School of Medicine discovered a novel mechanism that suppresses tumor growth by stabilizing heterochromatin, a form of chromosomal DNA. This finding suggests a potential new approach to inhibit cancer gene expression and may represent a new class of tumor suppressors.
Researchers have captured the first three-dimensional crystalline snapshot of the initial step in actin filament formation, crucial for understanding cell shape and cancer. The study's dual-mutant approach helped overcome challenges in forming crystals, revealing critical contacts involved in nucleation.
Researchers at Monash University have identified a sub-group of cells that can contribute to prostate cancer recurrence, opening up new treatment options. These previously unidentified cells are potential targets for future therapies and may be targeted before the cancer reaches an incurable stage.
Researchers developed a novel approach to make ovarian cancer cells susceptible to an antitumor drug, potentially improving treatment outcomes. The strategy targets telomeres and shows promise in treating other epithelial cancers.
Researchers have identified two ruthenium-based complexes that target cancer cells more effectively and are less toxic than current chemotherapies. The complexes, which seem to target cells in hypoxic states, could complement widely used platinum-based therapies like cisplatin.
Researchers at the University of Montreal have discovered how rapamycin prevents cells from dividing, potentially slowing cancer progression and other diseases of abnormal growth. The study reveals that TOR sends a signal to shut down B cyclin production through an intermediary protein.
Researchers at LMU discover how cellular respiration generates reactive oxygen species that can cause DNA mutations, leading to cell dysfunction and cancer. The study highlights the importance of improving treatment options for cancer by inhibiting DNA repair processes in tumor cells.
Researchers successfully targeted doxorubicin to mitochondria, killing cancer cells even those with developed pumps. The study suggests this approach could work with other nucleus-targeting anti-cancer drugs.
Mayo Clinic researchers found that positively charged gold nanoparticles can be effective against ovarian cancer cells when their cellular stress is increased. This is achieved by inhibiting calcium uptake into the mitochondria, which helps to make the nanoparticles more effective in destroying cancer cells.
Scientists discovered that a molecule called BRD4 recognizes a specific amino acid on NF-kappa B and activates it, preventing its degradation in cancer cells. This interaction is critical in the development of cancer, and blocking it may lead to new cancer treatments.
A new computational method called viSNE enables scientists to analyze high-dimensional cancer data, revealing distinct cell subpopulations and detecting minimal residual disease. This breakthrough technology has the potential to improve cancer diagnosis and treatment.
Researchers at Memorial Sloan-Kettering Cancer Center have discovered that expression of TRAIL in transplanted hematopoietic stem cells is critical for an effective anti-tumor response. This finding has led to the development of new therapeutic strategies to suppress graft-versus-host disease while maintaining anti-tumor activity.
Researchers at MIT have identified ALKBH7 as a key protein involved in programmed necrosis, a cell death pathway that can help prevent cancer cells from surviving DNA damage. By mimicking the effects of this protein, drugs may be able to induce necrosis in resistant cancer cells, providing a new potential target for cancer treatment.
A team of researchers at NYU School of Medicine has made a breakthrough in understanding how pancreatic tumor cells feed themselves. By identifying the role of macropinocytosis in delivering nutrients to Ras-transformed cancer cells, they have uncovered a potential new target for treating this lethal disease.
A new study reveals distinct characteristics between inducible and natural IL17-producing T cells, with different signals required for cytokine production. The findings suggest a specific role of Akt protein complex in regulating cytokine production by these cell types.
A University of Colorado Boulder study suggests that a tumor suppressor gene helps cells fend off stress and survive under starvation conditions. The research found that the Rb gene regulates the expression of multiple genes to help organisms survive longer when encountering starvation.
Researchers at Walter and Eliza Hall Institute discover that p53 protein can prevent cancer formation even without regulating cell death or division after DNA damage. The study sheds new light on the complex functions of p53, which was previously believed to have a straightforward role in preventing cancer.
Researchers found that the egg genome is reprogrammed to match sperm DNA with or without paternal contribution. The mother's genes undergo extensive changes to prepare for differentiation.
Researchers at Stanford University School of Medicine developed a new technique to visualize cell interactions in living mice, pinpointing metastatic cancer cells' locations after breaking off from initial tumor sites. The method uses light-emitting proteins and has potential applications in studying various cell interactions.
Researchers developed powerful data-sifting algorithms to assemble the most complete genetic profile of acute myeloid leukemia, an aggressive form of blood cancer. The work aims to lead to new AML treatments based on the genetics of each patient's disease.
Researchers found that a combination of chemoradiation therapy and surgery improves overall survival in stage 3 non-small cell lung cancer patients. Five-year survival rates were twice as high for those who received chemoradiation followed by surgery compared to those who only had chemoradiation.
Researchers at Karolinska Institutet have obtained detailed images of how the transport protein GLUT transports sugars into cells. The study's findings could lead to new strategies to fight cancer cells by blocking fuel pumps that introduce sugars and other nutrients required for cell metabolism.
Researchers at Mount Sinai identified new targets for abnormal cell division, finding that blocking CDK7 can inhibit the activity of other critical enzymes CDK4 and CDK6. This discovery suggests turning off these enzymes may be an effective therapeutic target for preventing cancer cell proliferation.
CNIO researchers have successfully mapped the proteins involved in human DNA replication, a process targeted by many chemotherapeutic agents. The study provides new insights into the mechanisms underlying cancer cell division and holds promise for developing new therapeutic strategies.
Researchers used high-quality video imaging to investigate why a particular cancer drug is effective at killing cells. The study found that the drug creates a cluster of protein molecules on one side of the cell, making it easier for natural killer cells to kill it.
A Northwestern University study has developed a pioneering biophotonics technology to detect ovarian cancer by analyzing cells from the cervix or uterus. The partial wave spectroscopic microscopy technique shows diagnostic changes in these cells even when they appear normal under a microscope, offering a potential breakthrough in early...
Scientists have developed a new chemical compound, WEHI-539, that inhibits BCL-XL protein in cancer cells. This could lead to the design of potential anti-cancer agents that restore cell death and improve treatment outcomes for patients with various types of cancer.
Researchers have discovered that protein machines that copy DNA pause frequently during the process, creating potential for dangerous mutations. Efficient repair of these breakdowns is crucial to prevent corruption of the genetic code.
Scientists at NIH and Pitt School of Medicine discovered a method to grow large numbers of stem cells by blocking CD47 membrane protein, increasing expression of four genes essential for iPS cell formation and allowing directed differentiation into various tissue types.
Researchers at the University of Helsinki discovered that the Myc oncoprotein makes cancer cells vulnerable to cell death by activating AMPK, a biochemical sensor. This leads to the activation of tumor suppressor protein p53, which promotes apoptosis in cancer cells.
Scientists have developed GUMBOS-based materials with targeted properties for medical use, such as selectively toxic to cancer cells and non-toxic to normal cells. The technology also has potential uses in solar cells and biomedical imaging.
The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells, suggesting potential for improved cancer treatments. By promoting the expression of Rev-erbα and NAMPT, Myc upregulates genes that suppress circadian oscillations, leading to altered metabolism and potentially increased replication rates in cancer cells.
New research reveals chemotherapy activates the body's immune system to target and destroy cancer cells. The treatment converts dying tumors into therapeutic vaccines, boosting the host's immune response against cancer.
Researchers envision cell-based therapeutics as a promising approach to treat critical diseases. Cells can adapt and respond better than small-molecule drugs, offering a more predictable treatment option.
A new form of radiation therapy, BNCT, has been developed by University of Missouri researchers, putting cancer into remission in mice without harmful side effects. The technique targets cancer cells by delivering boron chemicals that shatter and destroy cancer cells from the inside out.
Researchers at the University of Colorado Cancer Center have developed a new technology that uses cholesterol rafts to deliver genetic payloads into cancer cells. This innovative approach overcomes the long-standing challenge of delivering nucleic acids across cell membranes.
Researchers at University of California, San Diego Moores Cancer Center identified a humanized monoclonal antibody targeting CD44, directly killing chronic lymphocytic leukemia (CLL) cells. The antibody, RG7356, induces apoptosis in CLL cells expressing ZAP-70, a protein found in roughly half of CLL patients.
Researchers will use photoacoustic microscopy to measure oxygen consumption rates of individual cells, mapping distributions of cellular metabolism. The technology has potential applications in gauging cellular health and metabolic state for stress response and toxicity studies.
Researchers at the University of Washington have developed a new method to analyze single cells using quantum dots, allowing for the simultaneous testing of up to 100 biomarkers. This breakthrough enables more accurate diagnosis and treatment of cancer by examining a cell's unique behavior at its molecular level.
A team of Chilean researchers, with collaboration from Carnegie's Wolf Frommer, has devised a molecular sensor to detect lactate levels in individual cells in real-time. This breakthrough provides an unprecedented sensitivity and range of detection for non-invasively detecting cancer.
GW researcher Xiaoyan Zheng is studying the mechanism involved in the hedgehog signaling pathway's regulation of cell-cell adhesion and segregation. The goal is to find better ways to treat diseases related to these interactions, such as cancer.
Researchers at the University of New Mexico Cancer Center have identified a first-in-class chemical compound, CID2950007, that inhibits Cdc42 GTPase activity, controlling cell migration and adhesion. This novel compound shows promise in preventing cancer metastasis and may also be effective against infectious diseases.
Researchers have identified a carbohydrate modification on leukaemic cells that can be targeted to eradicate cancer. The study, published in Journal of Experimental Medicine, offers hope for new treatment options against drug-resistant forms of acute lymphoblastic leukaemia.
Researchers have found that inhibiting the Mer receptor increases sensitivity to chemotherapy in leukemia cells, reducing toxic side effects while maintaining effectiveness.
Researchers identified protein MCM that changes DNA topology, forming 'supercoils.' This can lead to cancer cells growing out of control. The study provides new insight into MCM's role in gene regulation and cancer.
University of Central Florida chemist Kevin Belfield uses acid reflux to kill certain cancer cells by making them more acidic when exposed to specific wavelengths of light. This technique could provide a way to target cancer cells deep within human tissue with minimal side effects.
Researchers found that threonyl tRNA synthetase (TARS) plays a critical role in angiogenesis, the formation of new blood vessels, to support cancer growth. A potent inhibitor of TARS activity blocks its induction of angiogenesis.
A line of special liver cells called PICM-19 has the potential to perform many of the same functions as a human liver. The immortal cell line can be used to study various diseases, including liver cancers and cystic fibrosis, and may enable the development of artificial liver devices.
A new microscopy technique has allowed scientists to observe protein clusters in living cancer cells, enabling direct measurement of drug effects on target proteins. This breakthrough could significantly improve cancer treatment by reducing collateral damage associated with traditional therapies.
A modified Newcastle disease virus has been developed to target prostate cancer cells without harming normal cells, offering a new treatment option for hormone-refractory patients. This oncolytic virus uses a retargeted design to minimize off-target losses and reduce the amount of virus needed for treatment.
A new study by researchers at the University of Pennsylvania School of Medicine found that minimally invasive therapies can effectively remove damaged cells from patients with Barrett's esophagus, reducing cancer progression. In over two-thirds of cases, patients had no signs of disease return for years.
A natural product called genistein-combined polysaccharide (GCP) may help patients with metastatic prostate cancer live longer by blocking a key mechanism used by prostate cancer cells to survive. GCP is expected to be effective in treating patients with low response to androgen-deprivation therapy.
Researchers at Northwestern University developed a mathematical model that sheds light on the mechanisms causing bulges in cells' nuclear membranes. This study may provide potential therapies for related diseases by preventing bleb formation.
A Melbourne-based research team has discovered a genetic defect that can halt cell growth and force cells into a death-evading survival state. The finding reveals an important mechanism controlling rapidly-dividing cells, which may lead to the development of new treatments for diseases including cancer.
New materials mimic mussel adhesive proteins to deliver self-setting antibacterial hydrogels, seal fetal membrane defects, and target cancer cells with precision. Researchers collaborate on in-vivo testing of these innovative biomedical applications.
A team from the University of Pennsylvania School of Medicine has identified a molecular master switch for pancreatic cancer, which could serve as a potential predictor of treatment outcome. The researchers found that Prrx1 and Sox9 regulate the emergence of an intermediate cell type that can give rise to cancer.