Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
Researchers at Medical College of Georgia Cancer Center have developed a cancer cell line that is resistant to histone deacetylase (HDAC) and heat shock protein 90 (hsp90) inhibitors, two promising cancer treatments.
Researchers found that a specific hormone, TNF-alpha, drives the JAK2 enzyme to cause an often deadly red blood cell cancer called polycythemia vera. The study showed mice with normal TNF-alpha production developed severe bone marrow fibrosis within weeks.
Scientists at Johns Hopkins Medicine discovered that epigenetic changes in gene activation can lead to cancer development, and found a way to block the 'addiction' to growth factors, preventing cancer growth. The study shows that blocking this response can greatly reduce precancerous lesions in animals.
Researchers identify key cellular components that carry out protein disposal and shed light on how proteasome inhibitors interfere with this process. The discovery could lead to novel cancer drugs targeting the protein disposal mechanism.
A team of researchers at the University of Michigan has developed a nano-scale voltmeter that can measure electric fields deep within cells. The device, which is 1,000-fold smaller than existing voltmeters, reveals surprisingly high electric field strengths in cytosol, challenging conventional wisdom about cellular processes.
A team of researchers has discovered a tumor-suppressor gene called Par-4 that kills cancer cells but not normal cells. The mice born with this gene live longer and have no toxic side effects, making it a potentially therapeutic application for treating cancer without harming patients.
The S.T.A.R. Program brings together researchers from top cancer centers to explore the role of targeted heat in cancer therapy for prostate cancer. The program aims to selectively heat cancer cells while preventing damage to adjacent healthy tissues.
A new study led by USC researchers identifies distinct changes in DNA structures that silence cancer cell genes. The findings enable the exploration of new therapies to switch genes back on, potentially leading to novel treatments for human cancers.
A recent study elucidates the relationship between environmental stress and cancer by revealing how stress-inducing agents reduce SIRT1 enzyme activity, leading to increased cell survival. By targeting this process, researchers aim to develop new treatments that increase SENP1 activity to promote programmed cell death in cancer cells.
Researchers have discovered a new potential cancer therapy that targets angiogenesis, the formation of blood vessels that feed tumor cells. Anti-PLGF inhibits the growth of VEGF(R)-resistant tumors without affecting healthy vessels, offering a promising alternative to existing treatments.
Researchers at Albert Einstein College of Medicine successfully treated cancers by targeting viruses that cause them, slowing tumor growth and even causing tumors to regress. The approach holds promise for preventing cancer by destroying virus-infected cells before they become cancerous.
Researchers developed a new virotherapeutic targeting cancer cells expressing E2F and EGFR proteins, showing antitumor effects in mice and rabbits. The virus demonstrated high selectivity for cancer cells in tumor-bearing rabbits and human tissue samples.
A new study suggests that viruses may contribute to cancer by causing excessive death to normal cells while promoting the growth of surviving cells with cancerous traits. The Phoenix Paradigm model proposes a separate mechanism where viral infection selects pre-existing mutated clones, promoting their further growth and multiplication.
A team of Johns Hopkins scientists found that topical application of broccoli sprout-derived extract can protect human skin against UV radiation-induced damage. The extract works by boosting protective enzymes in cells, providing long-lasting protection even after the extract is removed from the skin.
A new heparanase inhibitor has shown promising results in animal models, indicating its potential as a cancer drug. The enzyme heparanase splits polysaccharides into shorter fragments, which can promote tumor growth. By inhibiting this enzyme, researchers hope to develop a new treatment for cancer.
Researchers detected androgen-synthesizing proteins in prostate cancer cells, which may explain why some cancers become resistant to therapies. This discovery offers new directions for research into future treatments that could block the development of androgens in cancer cells.
Scientists at Johns Hopkins Medicine have developed a novel way to fight colorectal cancer using tiny molecules to deliver potent radiation inside cancer cells. The new system proved able to specifically target colon cancer cells, reducing unwanted side effects.
Scientists have identified a key gene called Bub 1 that plays a critical role in normal cell division, and deactivating it has been shown to prevent cells from dividing successfully. The team hopes that targeting this gene may selectively kill cancer cells and develop new treatments.
Researchers discovered that telomeric RNA is transcribed from DNA on the telomere, challenging previous theories. This finding may uncover new targets for attacking telomere function in cancer cells.
Researchers at UVA Health System discovered how cells protect themselves from DNA damage caused by UV rays, involving an unexpected connection between proteins. The study reveals part of a pathway inside human cells that regulates when and how cells repair damage to their DNA.
Researchers at UCSD School of Medicine discovered a novel PLC-epsilon enzyme subtype that activates a second signaling pathway for cell proliferation. This finding may enable targeting the enzyme's second function to prevent pathological responses while preserving its critical physiological roles.
A study suggests that patients with non-squamous histology achieve statistically significant higher survival when treated with ALIMTA in the second-line setting compared to those with squamous histology. The analysis also identified other predictive factors for potential benefit from treatment, including adenocarcinoma histology and go...
A recent study published in Cell describes a chemical chain reaction, known as the Hippo pathway, that controls organ growth and may contribute to cancer. The researchers found that this pathway is altered in 20-30% of human cancer cells, suggesting a potential new target for cancer therapy.
A study found that heat-shock transcription factor HSF1 enables normal cells to become cancerous by orchestrating proliferation and survival processes. Depriving cancer cells of HSF1 strongly suppresses their growth and survival, offering a potential new approach to fighting cancer.
Researchers have uncovered a new pathway that regulates killer proteins called caspases, which are essential for trimming down heavy sperm to make them better swimmers. This discovery provides insights into the causes of human infertility and opens up opportunities for developing drugs that can alter cell death for therapeutic purposes.
Research reveals ultraconserved non-coding RNAs may play a role in cancer development and could help diagnose the disease, determine prognosis, and even guide treatment. The study found specific activity patterns for these molecules in different types of cancer, suggesting they might serve as genetic markers.
A new study reveals that RNA polymerase II constantly scans the cell's DNA for damage, sending a stress signal to p53, a master protein that responds to DNA damage. This discovery sheds light on how cells protect themselves against cancer-producing DNA lesions.
Researchers at Ohio State University found that extracts from Hass avocados kill or stop the growth of pre-cancerous cells leading to oral cancer. The study highlights the potential health benefits of consuming phytonutrient-rich foods like avocados.
Researchers have identified a protein on the surface of platelets that plays a key role in cancer-induced platelet aggregation, allowing cancer cells to evade the immune system and spread throughout the body. By blocking the interaction between podoplanin and CLEC-2, it may be possible to prevent tumor metastasis.
A recent study from Michigan Medicine researchers reveals that specific 'junk' RNA genes, known as microRNA34, work with the protective gene p53 to regulate cell growth and prevent cancer. The loss of these microRNAs is linked to common lung cancer.
Researchers are working on a £18 million project to change the social habits of living cells, which could help fight diseases like cancer and diabetes. By adjusting cell networking, they aim to reduce disease occurrence and improve health outcomes.
Researchers at Rice University have developed a way to package radioactive particles inside DNA-sized carbon tubes to target tiny tumors. The alpha-emitting nanocapsules are designed to deliver a single, direct hit to cancer cells, making them potentially more effective than traditional beta-particle radiation.
Researchers at the University of Georgia are working on a new approach to detect pancreatic cancer using subtle changes in proteins and sugars. They believe that these biomarkers can be found in pancreatic fluid and blood, which could lead to earlier detection and improved treatment outcomes.
Researchers at UGA discovered that pectin reduces prostate cancer cell count by up to 40% through apoptosis. The study found pectin's anti-cancer properties under different treatment conditions, suggesting potential for developing pharmaceuticals or health-enhancing foods.
Researchers at Carnegie Mellon University have developed nanogels that can uniformly release encapsulated carbohydrate-based drugs, enabling targeted delivery to specific tissues like cancer cells. The nanogels are biodegradable and non-toxic, allowing for prolonged circulation time within the bloodstream.
Researchers found that anthocyanins from purple corn, chokeberries, and bilberries can slow the growth of colon cancer cells. The compounds were tested on human colon cancer cells and rats with colon cancer, showing promising results. Further studies are needed to understand how these compounds interact with other food components.
Researchers found that bursts of waves drive immune system 'soldiers' toward invaders, using a signaling protein to direct cell movement. The discovery may lead to strategies to block cancer growth and treat heart disease.
Two new studies provide insight into the molecular mechanisms underlying aberrant NF-κB activity in MM tumor cells. The research reveals diverse mutations that lead to pathological activation of NF-κB signaling in MM, highlighting its role as a target for therapy development.
Researchers at MIT have developed a technique to create 3D images of living cells, revealing internal structures and enabling the study of cellular function in its native state. The method uses interferometry and refractive index properties, producing high-resolution images with resolutions as low as 150 nanometers.
Researchers found that acid reflux disease can lead to Barrett's esophagus, a condition where normal skin-like cells turn into tougher, more acid-resistant cells. This transformation may increase the risk of cancer, particularly adenocarcinoma of the esophagus.
A recent study by MUHC and McGill University has shed light on the mechanisms triggering cancer cell growth, potentially leading to targeted therapies. The research discovered that ubiquitin promotes interactions between proteins Cb-b, which plays a crucial role in mitigating uncontrolled cell proliferation.
Researchers at Florida State University have developed a new approach to targeting cancer cells using light-activated molecules that can induce apoptosis in both strands of DNA. By exploiting the unique property of these molecules, they can selectively kill cancer cells while sparing healthy ones.
Researchers at Tufts University have identified a specific DNA sequence that increases chromosome breakage and stalls replication, which can lead to cancer. The study's findings suggest that this sequence may be responsible for the fragility in human chromosomes associated with common fragile sites.
Researchers found that low doses of THC can facilitate infection of skin cells and promote cellular events leading to malignancy, raising concerns for those with lowered immune systems. The study emphasizes the need for caution when using marijuana medicinally or recreationally among vulnerable populations.
Researchers at the University of York have developed urothelial cell sheets that regenerate to repair damage, paving the way for engineered bladders. Pharmaceutical companies will soon be able to test therapies using these models.
Researchers at the University of Texas M.D. Anderson Cancer Center discovered that a protein called IKK-alpha protects an important cell defense mechanism from silencing in skin cancers. The protein prevents DNA methylation, which normally silences the checkpoint gene 14-3-3-sigma.
Researchers at the University of Florida have developed a new method to detect subtle differences in leukemia cells using molecular probes called aptamers. This technique has the potential to improve diagnosis and treatment for cancer patients by providing more precise and personalized care.
Scientists have discovered that cancer cells eliminate the enzyme protein kinase G (PKG), leading to uncontrolled cell proliferation. Reintroducing PKG into cancer cells has been shown to inhibit tumor growth and angiogenesis, suggesting a potential new avenue for targeted cancer treatment.
A Penn State research team discovered that blocking km23, a traffic cop protein, disrupts the transport of a signaling component to the nucleus, leading to reduced gene expression and cell growth. The findings may lead to diagnostic tools and earlier treatments for ovarian cancer.
Scientists have identified a specific pathway, reactive-oxygen species (ROS), that allows cancer cells to evade the immune system. By targeting this pathway, researchers hope to develop new therapies that can break through the 'escape hatch' and accelerate or slow down T-cell activity.
Researchers at the University of Pennsylvania School of Medicine identified a combination therapy that selectively eliminates cancer cells while leaving healthy cells intact. The therapy combines TRAIL and sorafenib, reducing tumor size in mice with few side effects, demonstrating its potential effectiveness on human colon cancers.
Researchers developed a new cancer treatment called Chlorotoxin:Cy5.5, which can illuminate tumor cells in the operating room, making it easier for surgeons to remove all cancerous cells without injuring surrounding healthy tissue. This technology has the potential to improve cancer therapy and save lives.
Scientists at Fred Hutchinson Cancer Center discovered a modified version of antimycin that selectively kills cancer cells with high levels of survival proteins Bcl-2 and Bcl-xL. The compound's unique mechanism provides a therapeutic window, making it a potential targeted molecular therapy to enhance cancer treatment effectiveness.
Researchers characterized transformation mechanisms in APL, revealing the importance of higher-order RXR homotetrameric complexes and recruitment. These findings suggest that disrupting these pathways may be a viable strategy for treating RARA fusion-mediated cancers.
Researchers at Virginia Tech and UC Berkeley developed irreversible electroporation (IRE) to target cancer cells, successfully abling tissue in rat livers. IRE preserves vessel architecture and kills cells with minimal damage to surrounding healthy tissue.
USC researchers applied nanoscale imaging to study Anabaena oscillarioides, clarifying the mechanism of nitrogen fixation. The study revealed a key step in the nutrient cycle, allowing for better understanding of global carbon and nitrogen dynamics.
Delft scientists observe topotecan's effect on DNA molecule loops, revealing mechanism of TopoIB protein in cell division. They use magnetic spheres and magnets to manipulate a single DNA molecule, allowing them to study the enzyme's action live.
Researchers have developed multifunctional nanoparticles that target and image cancer cells by exploiting overexpression of folic acid receptors. These dendrimer-based systems can accumulate in diseased cells and retain bright fluorescence, allowing for easy visualization via confocal microscopy.
Researchers at Goethe University Frankfurt have identified a novel Ub conjugation reaction that allows for more efficient manipulation of key proteins in the treatment of cancer and other diseases. This discovery provides a basis for novel therapeutic approaches that are more specific than existing drugs like Bortezomib.
Scientists create a new adenovirus that selectively targets cancer cells with high dNTP concentrations, potentially delivering genetic materials to destroy malignant cells. The approach has shown promise in testing mice and human pancreatic cancer cells.