Custom-made cancer cell attacks
Researchers at TRIUMF are developing custom radioisotopes to target cancer cells more efficiently. They aim to create tailor-made treatment programs for each patient, reducing radiation doses and treatment sessions.
Cancer Cells
Articles tagged with Cancer Cells
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HIV protein enlisted to help kill cancer cells
Researchers have found a way to deliver a messenger into cancer cells that forces them to respond to death signals using an HIV protein. This approach has shown promise in killing cancer cells and could provide new treatment options for patients with deadly cancers.
Oxidative stress stimulates p38 MAPK-mediated tumor suppression
A new study finds that p38-alpha MAPK inhibits tumor formation by sensing oxidative stress and triggering apoptosis. Cancer cells may evade this mechanism by desensitizing p38-alpha to ROS, highlighting potential therapeutic targets for cancer treatment.
Scientists use nanoparticle to discover disease-causing proteins
Purdue University researchers use dendrimers to label specific proteins in living cells, allowing them to determine protein functions and diagnose diseases. This new method provides a more reliable alternative to existing methods, which require small sample amounts and damage the natural environment.
New medical technique punches holes in target cell membranes to treat tumors
A new medical technique using microsecond electrical pulses has been shown to create permanent nanoscale holes in target cell membranes without harming surrounding tissue. This technique, called irreversible electroporation (IRE), has the potential to revolutionize minimally invasive surgical treatments for tumors.
The multi-tasking reovirus
Researchers at Oncolytics Biotech have developed a harmless virus that not only kills tumor cells but also primes the immune system to mount a powerful defense against cancer. Studies have shown that reovirus exposure can activate dendritic cells, which then educate natural killer cells and T cells to attack the tumor.
New protein inhibitor impedes growth of cancerous cells
Researchers developed a small-molecule inhibitor of Plk1, a key kinase controlling cell division. The compound BI 2536 effectively halts cancerous cell growth in culture and in animal models, causing cell death and tumor regression. This discovery has therapeutic potential for patients with locally advanced or metastatic cancers.
Brown cancer biologists identify major player in cell growth
Researchers at Brown University have identified GABP as a critical transcription factor that restarts cell division, a process fundamental to development, renewal, and cancer growth. Disrupting GABP may lead to new cancer treatments.
FISH-ing for links between cancer and aging
Scientists have linked telomere loss to both cancer and aging by visualizing chromosomes of cells from patients with Werner Syndrome. Rebuilding structures called telomeres significantly blocks genetic damage seen in cells of patients with Werner Syndrome.
Lipid plays big role in embryonic development
Researchers discovered that ceramide helps stem cells organize into primitive ectoderm, which further differentiates into embryo tissues. The lipid's presence is essential for cell polarity and differentiation.
Drug strategy makes cancer genes get lost in translation
A new strategy for fighting cancer aims to make its genes get lost in translation, silencing oncogenes by targeting weak messenger RNAs. The researchers discovered a small molecule that effectively inhibits the translation of these weak mRNAs, leading to the decline of cancer-promoting proteins.
Molecular link between inflammation and cancer discovered
Researchers at University of California, San Diego found a molecular link between chronic inflammation and cancer development. The protein p100 enables communication between inflammatory response and normal cell growth, but excessive levels may overactivate developmental pathways, leading to cancer.
New test predicts blood cancer's sensitivity to experimental cancer drug
A new test developed by Dana-Farber Cancer Institute scientists identifies malignant blood cells that are highly vulnerable to an experimental cancer drug. The drug works by neutralizing the Bcl-2 action, unleashing molecules that trigger suicide in the cancer cells.
Buckyballs used as 'passkey' into cancer cells
Researchers at Rice University have developed a novel way to deliver drugs directly into cancer cells using buckyball nanoparticles as passkeys. The technique, which mimics viral proteins, shows promise in penetrating the defenses of liver and neuroblastoma cancer cells, two types often difficult to treat.
UCF scientists' molecular discovery could help drugs target unhealthy cells
Researchers have made a breakthrough in molecular technology that could help deliver life-saving drugs directly to cancer-ridden cells. The discovery involves attaching therapeutic drugs to molecules using tiny molecules that can travel through the bloodstream.
Jefferson scientists find guardian gene's choices crucial to stopping cancer process
Researchers found that the p53 gene's ability to direct a damaged cell to stop growing or commit suicide depends on turning on separate groups of target genes. Alterations in an amino acid, lysine 120, can influence this decision, potentially leading to new strategies in chemotherapy drug development.
Hybrid molecule causes cancer cells to self-destruct
Researchers at Johns Hopkins University have developed a hybrid molecule that combines a sugar with a short-chain fatty acid to kill cancer cells in lab tests. The molecule triggers cellular suicide and orchestrates the expression of genes responsible for halting uncontrolled growth.
AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
The study found that AVN944 significantly inhibited the IMPDH enzyme and induced biomarkers associated with cancer cell death. The gene HspA1A marker was elevated even at low doses of the drug, indicating potential for tumor cell apoptosis.
Blame our evolutionary risk of cancer on body mass
Scientists discovered that higher body mass, not lifespan, increases the risk of cancer due to telomerase expression. Rodents from various species showed a correlation between body size and telomerase activity, while human's don't express it in somatic cells, suggesting evolution prioritized cancer prevention over healing.
UCF researcher's 3-D Digital Storage System could hold a library on 1 disc
A new technology allows users to record and store massive amounts of data onto a single disc, such as the Smithsonian National Air and Space Museum's entire collection or 500 movies, maintaining excellent quality without damage. The UCF team's Two-Photon 3-D Optical Data Storage system uses lasers to compact information onto a DVD.
Children's Hospital Oakland Research Institute -- cancer study
Researchers at Children's Hospital Oakland Research Institute identified a specific enzyme called sphingosine phosphate lyase (SPL) that can cause the death of cancer cells. The study found that SPL makes cancer cells more vulnerable to chemotherapy, while removing the enzyme makes the cells more resistant to treatment.
DNA repair teams' motto: 'To protect and serve'
Researchers at the Salk Institute reveal how cellular repair proteins recruit a second machinery to create a protective structure at chromosome ends, maintaining chromosomal stability. Telomeres exist to prevent damage and ensure cell division integrity.
JCI table of contents: November 16, 2006
Researchers suggest repairing abnormal blood vessels in retinopathy using adult bone marrow–derived myeloid progenitor cells. Dendritic cells form part of granuloma walls containing Listeria monocytogenes, maintaining integrity through immunosuppressive protein IDO.
Tailored treatments: Promising designer drug provides new insight into cancer biology
ABT-737, a BH3 mimetic, targets Bcl-2 proteins to induce apoptosis in cancer cells. The treatment has shown effectiveness against acute myeloid leukemia (AML) cells and can be combined with MCL-1 inhibitors for improved results.
Antiprotons 4 times more effective than protons for cell irradiation
The ACE experiment found that antiprotons are four times more effective at terminating live cells than protons, with the potential to reduce damage to healthy tissue. Researchers plan further tests to assess the effectiveness of antiprotons for cancer therapy and ensure minimal harm to surrounding tissues.
White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells
Researchers found that white blood cells in cancer-resistant mice can sense and kill cancer cells through a multi-step process, involving migration, recognition, and physical contact. The discovery suggests that some cancers may share common characteristics that make them vulnerable to this type of immune response.
New insight into cell division
Researchers at Max Planck Institute for Molecular Genetics in Berlin have explained the molecular principles of cell division control mechanisms. The study found that checkpoint kinases interact with a different category of proteins involved in developing the cell division spindle.
New cancer drug hope
Researchers at the University of Manchester have made a breakthrough in developing a new class of cancer drugs that target the Aurora B enzyme, which helps cells divide and can lead to uncontrolled cell growth in cancer. Early clinical trials suggest the drug's toxicity is mild, offering a revolutionary new way to treat cancer.
Scientists find a key to immune system's ability to remember
A team of researchers identified a protein, Lck, that plays a crucial role in stimulating immune cells to recall past encounters with pathogens, enabling quick responses to reinfection. This discovery may aid in the development of vaccines against diseases like AIDS and autoimmune disorders.
Grape seed extract halts cell cycle, checking growth of colorectal tumors in mice
A study found that grape seed extract significantly inhibits the growth of colorectal tumors in both human cells and mice. The extract works by increasing the availability of a critical protein called Cip1/p21, which freezes the cell cycle and often pushes cancer cells to self-destruct.
Potential new therapeutic target for asthma, allergies and cancer
Researchers at VCU University have identified a new therapeutic target for asthma, allergies, and cancer by uncovering the transport mechanism of bioactive molecule S1P out of mast cells. The study may lead to the development of new treatments for these conditions.
Mayo discovers protein as potential tactic to prevent tumors
Researchers at Mayo Clinic have discovered a protein pair that could be used to prevent tumors. The study found that CDK2 modifies FOXO1 in damaged cells, triggering apoptosis and potentially halting cancer cell growth. This breakthrough provides new hope for the development of targeted anti-tumor therapies.
Molecular 'signature' protects cells from viruses
Cells use a molecular signature to distinguish their own RNA from viral RNA, triggering an immune response and cell suicide. This discovery opens up new possibilities for therapy, including using triphosphate-end RNAs to trigger anti-viral responses and gene therapy.
Fantastic Voyage: A new nanoscale view of the biological world
A new technique called multi-isotope imaging mass spectrometry (MIMS) allows researchers to image and quantify molecules at a subcellular level. This enables the tracking of individual donor cells after transplantation and the measurement of cancer treatment drug efficacy within cells.
Antibiotic inhibits cancer gene activity
Researchers at the University of Illinois Chicago have identified an antibiotic that specifically targets the FoxM1 gene, which is responsible for cancer cell proliferation. The antibiotic, siomycin A, was found to induce cancer cells to commit suicide in a process called apoptosis, with no effect on normal cells.
Scientists use gene signatures to match cancer and other diseases with potentially effective drugs
Researchers have unveiled a new systematic approach to drug discovery that matches diseases with potential treatments using gene signatures. The 'Human Connectivity Map' allows scientists to compare disease signatures with those of treated cells, identifying effective treatments for cancer, obesity and Alzheimer's disease.
UVa receives $35.7 million grant renewal from NIH
The University of Virginia School of Medicine has received a $35.7 million grant renewal from the National Institute of General Medical Sciences to continue its Cell Migration Consortium research. The consortium, comprising nearly 40 researchers globally, aims to understand cell migration and its role in diseases like cancer.
Two-faced protein can stop metastasis or promote it, researchers say
Researchers at Mayo Clinic found that the protein p120 catenin can both suppress and promote metastasis, depending on its interaction with cadherin proteins. The study suggests that a future designer drug could block the beginning of metastasis or stop it once it starts.
Structure determined for key molecular complex involved in long-term gene storage
Researchers at The Wistar Institute have determined the three-dimensional structure of a key two-molecule complex involved in long-term gene storage, primarily in non-growing cells. This discovery provides important insights into how cells protect genes that could trigger cancers and other disorders.
Newly discovered behavior in cancer cells signals dangerous metastasis
Newly discovered behavior in cancer cells reveals a toggle switch that enables them to morph into highly mobile cells, invade other tissues, and adapt comfortably. This understanding could lead to finding ways to stop metastasis, the most deadly trait of cancer.
The sweet science: Viruses switch grip to gain upper hand
Researchers discovered that viruses can infect cells more efficiently by attaching to different carbohydrates on the cell surface. This finding helps explain how flu and other viruses evade the immune system and may be useful for developing gene therapies for cancer and brain diseases.
Over the edge: New therapeutic strategy takes advantage of stressed cancer cells
Researchers successfully exploited oxidative stress in cancer cells to preferentially kill malignant cells while exhibiting minimal toxicity in normal cells. The study found that a naturally occurring compound called PEITC can be used to achieve such activity.
Distinguishing friend from foe in the battle against cancer
Researchers at Salk Institute discover that cancer cells use NF-kB survival factor to stay alive when attacked by chemotherapeutic drugs. This finding suggests a strategy to enhance the effectiveness of rapamycin-based therapies by inhibiting NF-kB signaling.
Researcher lights the way to better drug delivery
A Purdue University researcher has shed light on the details of one mechanism by which targeted drug therapy is achieved. The understanding of how to deliver and unload a cancer drug can be extrapolated to other diseased cells, including those involved in arthritis, multiple sclerosis, and Crohn's disease.
PNP gets a pass to enter cells
Scientists have found a way to get purine nucleoside phosphorylase (PNP) into the cells of mice lacking the enzyme, which could lead to a treatment for individuals with PNP deficiency. The PTD-PNP fusion protein corrected most immune defects in Pnp-deficient mice.
Molecular motor helps cells tell which way is up
Researchers at the University of Illinois Chicago discovered a molecular motor that helps cells determine which way is up by transporting a key lipid. This process is essential for maintaining cell polarity and preventing cancerous metastasis. The study sheds light on the trafficking and disposition of polarity determinants.
Synthetic molecule causes cancer cells to self-destruct
Researchers identify small synthetic molecule PAC-1 that directly activates procaspase-3 and induces apoptosis in cancer cells. This discovery offers a promising approach for personalized anti-cancer therapy by bypassing the broken signaling pathway in cancer cells.
One-two particle punch poses greater risk for astronauts
Human cells exposed to high-energy protons and then iron or titanium particles showed a significant increase in anchorage-independent growth, a characteristic of early cancer development. The timing of the particle exposure was critical, with cells responding more strongly when hit by protons first.
New lab technique churns out fungus' potential cancer fighter
Researchers have developed a method to synthesize rasfonin, a cancer-killing compound derived from a fungus, in enough quantity to conduct proper biological tests. The new process produces 67 times more rasfonin than previous methods, offering a promising lead for the development of a potential anticancer drug.
Smoking out the links between nutrition and oral cancer
Researchers investigated nutritional links between smoking and oral cancer, finding folate levels lower in smokers' blood and cheek cells. Smokers also had altered forms of folate distribution, while antioxidants like carotenoids and vitamin E showed similar trends. More studies are needed to clarify these findings.
Failure of 'scout cells' may lead to cancer in transplant patients
A new study suggests that post-transplant lymphoproliferative disorder (PTLD) arises when immune cells called scout cells become weakened, allowing the Epstein-Barr virus to cause cancer. The study identifies a mechanism that may explain why some patients develop PTLD and others don't.
Mayo Clinic researchers enhance safety and effectiveness of therapeutic virus that fights cancer
Researchers at the Mayo Clinic have engineered a modified measles virus that specifically targets and kills cancer cells by recognizing unique protein secretions. This breakthrough enhances the safety and effectiveness of oncolytic virotherapy, reducing the risk of unintended infections while improving cancer treatment outcomes.
No cell walls, no new cancer cells
Researchers at the Ludwig Institute for Cancer Research discovered that SREBP1 regulates both lipid synthesis and cell cycle progression. Disrupting SREBP1 activity can prevent lipid production, which is essential for new cell wall construction.
Scientists develop new, molecular approach to early cancer detection
Researchers at the University of Florida have successfully tested a new method to detect leukemia cells and believe it can be used to diagnose cancer at the molecular level. The technique uses aptamers, short strands of DNA that can recognize cancerous cells without prior knowledge of molecular changes associated with the disease.
Researchers uncover how prostate cancer cells defy death
Prostate cancer cells resist hormone treatment by activating three survival strategies involving the protein BAD. The discovery may lead to new treatments or ways to monitor treatment's intended effect, such as developing a drug to prevent BAD inhibition.
Heat therapy for cancer may be key to 'Lance Armstrong Effect'
Scientists at Johns Hopkins believe that heat therapy can selectively target and kill cancer cells by disrupting their nuclear protein scaffolding. Preliminary research suggests that this approach could be effective in treating solid tumors, with the goal of improving cure rates.
Study pinpoints protein's role in cancer spread
MDM2 overproduced leads to unbalanced p53 regulation, promoting cancer cell growth. The study identifies protein fragments binding to MDM2, inhibiting its destructive effect on p53.
OHSU Cancer Institute researchers use shortcut to identify new treatment target for leukemia
Using mass spectrometry, researchers identified three activating mutations of the tyrosine kinase JAK3 in AML cells, leading to a potential new treatment target. The study's fast and affordable approach could help analyze cancer cells for mutations in just weeks.
New strategy rapidly identifies cancer targets
Researchers developed a new strategy to identify genetic mutations that drive cancerous growth by analyzing proteins instead of genes. This approach allows for rapid identification of molecular abnormalities vulnerable to specific drug treatments, enabling personalized medicine and potential targeted therapies.
Cell survival depends on chromosome integrity
Researchers at Johns Hopkins have discovered protein machinery essential for maintaining chromosome integrity in cells. Removing sirtuin proteins causes yeast cells to become hypersensitive to chemical agents and spontaneously break chromosomes.