Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
An analysis of a phase III clinical trial showed that VIDAZA can improve patient responses, achieving an overall response rate of 51% in higher-risk MDS patients. Continued treatment with VIDAZA led to better outcomes for almost half of responders.
A subset analysis of the AZA-001 trial demonstrated that Vidaza significantly improved overall survival in patients with WHO-defined acute myeloid leukemia (AML) compared to conventional care regimens. The study also showed reduced infections, hospitalizations, and red blood cell transfusions.
Scientists identified a protein called Akt as the key to exploiting a vulnerability in cancer cells. By targeting this protein, researchers were able to selectively kill cancer cells while sparing normal cells.
Researchers found that cancer cells' chromatin packaging, including Polycomb group proteins, plays a crucial role in deactivating tumor suppressor genes. By disrupting this packaging, demethylating agents can restore gene expression and potentially lead to new cancer therapies.
A new study reveals that cellular senescence, a natural process for fighting cancer in younger persons, can actually promote cancer in older individuals by triggering the secretion of proteins that cause inflammation. This process is linked to almost every major disease associated with aging, including many cancers.
A new study found that senescent cells secrete proteins into their environment, causing inflammation and setting conditions for the development of age-related diseases, including cancer. The research provides a molecular description of how this process drives aging and age-related disease.
Scientists at St. Jude Children's Research Hospital identified distinctive genetic changes in cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse. The study found that the majority of ALL relapse cases arise from a cell already present at diagnosis, providing a potential target for treatments.
Researchers at the Rong Li Lab discovered that yeast cells can adapt to disruptions in cell division machinery by increasing their chromosome number and modifying gene expression patterns. This ability may contribute to cancer cell evasiveness and could be used to predict evolutionary paths and outcomes.
A team of researchers found that a tiny protein called alpha-catenin is essential for forming strong bonds between cells. Cancer cells with dysfunctional alpha-catenin can break free and spread the disease, but scientists may be able to develop therapies to repair or replace this protein and prevent cancer's progression.
Researchers at Joslin Diabetes Center have identified pancreatic progenitors that can form into insulin-producing cells after birth or injury, contradicting earlier studies. This finding offers new hope for treating and potentially curing diabetes through replacement therapy.
UT Southwestern researchers have developed a new strategy for broad-spectrum anti-viral drugs that targets a lipid molecule on infected cells, triggering the immune system to attack and destroy infected cells. The treatment, bavituximab, shows promise in treating viral diseases, including Lassa fever and cytomegalovirus.
Researchers have discovered that cells can turn on tumor-promoting growth circuits as a result of misreading damaged DNA without copying it. The results suggest that DNA damage, if it hits certain critical genes in a cell, could lead to transcriptional mutagenesis that spurs the cell to divide.
A new class of compounds, phosphaplatins, can effectively kill various types of cancer cells, including ovarian, testicular and head and neck cancer cells, with potentially fewer side effects than conventional drugs like cisplatin and carboplatin.
Research reveals vitamin D's role in regulating colon cancer cell behavior by modulating gene expression and cytoskeleton structure. The study highlights a previously unknown pathway governing vitamin D's diverse effects on cancer cells.
A study by Fox Chase Cancer Center researchers reveals that BubR1 protein plays a crucial role in chromosome distribution during mitosis. Mutating this protein may cause genetic shuffling similar to that seen in cancer cells, making it a potential target for cancer treatment enhancement.
A study found that pemetrexed-based treatment is more effective in patients with non-squamous histology than those with squamous histology, indicating improved survival benefits for some lung cancer patients.
A recent study by MIT biologists has found that DNA packaging plays a crucial role in directing stem cells towards becoming specific types of adult cells. The researchers discovered that chromatin structure, specifically the variant histone H2AZ, influences gene expression and cell fate.
Researchers identified a peptide sequence that acts like a drug to break apart the MLL molecular switch, potentially slowing or stopping abnormal white blood cell production. The discovery may lead to more effective treatments with fewer side effects for some types of leukemia.
Scientists have discovered a way to silence a protein that helps leukemia cells survive by blocking its signals. The breakthrough could lead to more efficient treatments for the disease and potentially even reverse its effects.
Researchers at Dana-Farber Cancer Institute identified a trigger point on a naturally occurring death protein that helps the body get rid of unwanted or diseased cells. The newly found trigger may be exploited as a target for designer drugs that force malignant cells to commit suicide.
A new study found that self-induced DNA breaks in immune cells activate genes responsible for their migration and homing to fight invaders. This discovery sheds light on a rare genetic disorder, ataxia telangiectasia, and may have implications for cancer research.
Researchers at Burnham Institute have created a peptide that converts Bcl-2, a protein protecting cancer cells from programmed death, into a pro-apoptotic molecule. This breakthrough may lead to novel cancer therapies, as the peptide induces cell death in cancer cells.
Researchers discovered a molecule called ACF7 that helps regulate and power cell movement along the extracellular matrix. Without ACF7, cellular movement slows down, suggesting its importance in preventing cancer cell migration and metastasis.
Researchers at Memorial Sloan-Kettering Cancer Center found that vitamin C supplements reduce the effectiveness of a wide range of anti-cancer drugs in laboratory cancer cells and mice. Vitamin C appears to protect mitochondria, which are essential for cell survival.
Researchers found that when a single telomere is lost, it can cause many abnormalities in a cell's chromosomes, leading to cancer. A new treatment route for cancer may be possible by interfering with the process of adding new telomeres.
Researchers discovered that existing anti-obesity drugs can inhibit viral replication by targeting fatty acid metabolism. The study found a thousand-fold reduction in HCMV replication when using drugs like TOFA and C75. This approach may provide an exciting antiviral treatment option.
Researchers found that ellagic acid increases programmed cell death and decreases proliferation of pancreatic cancer cells. The compound also reduces the activity of the pro-survival transcription factor NF-kB, which may help overcome resistance to radio and chemotherapies.
Researchers developed a secretory Apoptin fusion protein that induces apoptosis in hepatocellular carcinoma HepG2 cells, offering new potential for cancer gene therapy. The study's findings suggest the therapeutic usage of Apoptin may be increased with its secretory characteristic.
A team of researchers at M. D. Anderson Cancer Center has discovered a biomarker for bladder cancer using fluorescence in situ hybridization (FISH) tests on urine samples, identifying all 23 cancer cases and correctly characterizing six of seven controls as not having bladder cancer.
Research finds that anti-apoptotic Bcl-2 proteins, such as Bcl-xL and Mcl-1, contribute to apoptosis resistance in colorectal cancer cells. Knockdown of these proteins sensitizes CRC cells to chemotherapy and targeted therapies, suggesting a potential new approach to improving treatment outcomes.
Researchers developed a 'suicide gene' delivery approach that successfully kills pancreatic cancer cells by over 95 percent, targeting only cancer cells with minimal harm to normal ones. This innovative strategy uses mesothelin DNA linked to diphtheria toxin, effectively hijacking cancer cell machinery.
Scientists have developed a new imaging technique that enables the identification of proteins in cells by analyzing their energy flow. This technique, known as coherent two-dimensional infrared spectroscopy (2DIR), has been successfully tested in laboratory experiments and holds promise for improving protein analysis and discovery.
A unique case of gastric cancer combined with adenocarcinoma, choriocarcinoma, and neuroendocrine cell carcinoma has been reported. The prognosis for this rare type of gastric cancer is poor, as seen in the case where the patient died due to hepatic failure.
Duke University scientists have developed a new microscopy technique that enables peeking so deep into living tissue as to see molecules interacting. By combining optical coherence tomography with miniscule particles of gold, researchers can achieve higher resolutions than traditional methods.
Researchers at Max Planck Institute of Neurobiology found that tiny pores on the cell surface allow granzymes to enter cells, providing a new target for therapeutic methods. The discovery could lead to improved treatments for chronic virus infections and cancer.
Researchers have developed new therapies targeting out-of-control growth circuits in cancer cells, leading to improved survival rates. Advances in understanding head and neck cancer have also allowed doctors to better preserve organ function and increase early detection strategies.
A new study has resolved a 50-year-old debate on cell division, finding that both polar relaxation and equatorial stimulation mechanisms exist in cells. This discovery may aid cancer research and provide insights into genetic diseases.
Researchers at Ohio State University's Comprehensive Cancer Center discovered that mice can develop normally with just one of the four E2f genes. The study suggests that the location and timing of gene activity play a crucial role in development, contradicting previous assumptions about cancer-causing gene regulation.
Scientists at the University of York have discovered a new role for Natural Killer cells, which can make diseases worse in certain cases. The research suggests that these cells produce chemicals that inhibit immune responses, leading to potential breakthroughs in treating chronic infections and cancer.
Researchers found a significant association between ACE inhibitor and ARB use and reduced incidence of basal cell carcinoma and squamous cell cancers in U.S. veterans. The study revealed a 39% relative reduction in basal cell cancer and 33% relative reduction in squamous cell cancers among users compared to non-users.
Ohio State University researchers have developed coatings that encourage neurons in the body to grow and connect with electrodes, boosting implant effectiveness. The coatings, which release neurotrophins over time, show promise for treating conditions such as Parkinson's disease and macular degeneration.
Researchers at UNC are developing a unique way to deliver a nucleic acid derived from bacteria to tumors, allowing the body's immune system to recognize and attack cancerous cells. The goal is to create a reliable delivery method for immunotherapy, which has shown promise but faces challenges in consistency.
A protein complex regulating primary cilia formation has been identified by NYU researchers. The complex involves three proteins: CEP290, CP110, and Rab8a, which work together to promote cilia formation on mature cells. This discovery may lead to new drug targets for diseases such as polycystic kidney disease, retinal degeneration, and...
Researchers at Rockefeller University amplify cell death signals to induce self-destruction in precancerous cells. By inactivating a protein called IAP, they found that mice without the RING domain lived twice as long as those with it, highlighting a potential breakthrough in cancer therapy.
Researchers at the University of Texas Medical Branch have found that shutting down gastrin-releasing peptide receptors can dramatically suppress neuroblastoma tumor formation and slow its spread. This breakthrough could lead to the development of new therapies for this devastating disease.
Researchers have developed irreversible electroporation (IRE), a minimally invasive technique that uses electric pulses to destroy cancer tissue without heat. The technology has shown promising results in laboratory testing and preclinical mouse models, with complete regression achieved in 92% of treated tumors.
Researchers use ruthenium as a catalyst to increase oxidant levels in infected cells, ultimately destroying cancerous cells. The study offers a promising alternative to traditional cancer treatments, which often adapt quickly to targeted drugs.
Researchers discuss the difficulties in diagnosing and treating Barrett's oesophagus, a pre-cancerous condition often associated with chronic acid reflux. The authors suggest improving detection and treatment by developing standardized indicators, less costly screening methods, and laboratory animal models.
The Scripps Research Institute team has identified a protein called Nrm1 that plays a crucial role in regulating the cell cycle. When DNA replication stalls, Nrm1's repression of certain genes is blocked, allowing those genes to be expressed again, which enables the production of proteins needed to correct the problem.
Researchers develop powerful tool for investigating gene function using siRNA and lentiviral vectors. The method enables long-term down-regulation of specific target genes in various cell types, facilitating cancer cell biology studies.
Researchers have discovered that methadone has surprising killing power against leukemia cells, including those resistant to chemotherapy and radiation. The agent activates the mitochondrial pathway, inducing apoptosis in cancer cells without harming non-leukemic blood cells.
A new study reveals that dividing cells exhibit an unprecedented level of regulation, with over 1,000 proteins becoming highly phosphorylated. This discovery has significant implications for understanding cell cycle disorders and developing therapeutic targets.
Scientists at NYU Langone Medical Center have identified a new cellular pathway that responds to DNA damage and is linked to the development of cancer. The pathway involves a process that targets proteins for disposal, which could potentially be used to sensitize cancer cells to treatment.
Scientists are using cyanobacteria and plant materials to identify anticancer lead compounds that may be more effective than current treatments. The goal is to develop naturally occurring substances that target key cellular targets such as the proteasome and histone deacetylase.
Researchers have developed a novel therapy that utilizes magnetic nanoparticles to target and capture cancer cells, which can then be removed from the body. This technology shows promise in treating ovarian cancer, where free-floating cancer cells spread throughout the abdominal cavity.
Researchers at DKFZ have developed a new simulation method to predict the molecular targets that control cell behavior. This breakthrough may lead to new treatments against cancer metastasis by targeting specific genetic changes.
Researchers at UGA's Franklin College of Arts and Sciences have identified a mechanism that explains how telomerase enzymes are recruited to chromosome ends in cancer cells. The study highlights the potential for targeting telomerase as a means to stop cancers from spreading, providing new avenues for investigation into cancer growth.
Research by VIB-K.U.Leuven scientists finds that location in cell affects carcinogenicity of NUP214-ABL1 protein, a kinase linked to T-cell acute lymphoblastic leukemia. This discovery opens new avenues for targeted therapies and potential treatment approaches.
Scientists at the University of Pennsylvania School of Medicine found that myosin-I motors sense minute changes in force to regulate cellular processes. This discovery has implications for understanding hearing, balance, glucose uptake, and more.
Researchers at Washington University School of Medicine discovered a single protein, HS1, that enables key functions of natural killer (NK) cells. The protein allows NK cells to pursue targets, latch on, and kill them. Further study of HS1 may open new possibilities for revving up NK cells to fight infections and cancer.