Articles tagged with Cancer Cells
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Researchers have found that cancer cells use glucose to avoid programmed cell death and maintain survival through the protein Akt. By exploiting this mechanism, cancer cells can bypass normal safeguards and continue to grow even without growth factors.
Researchers have discovered novel methods for delivering drugs directly to cancer tumors, including the use of peptides and nanotechnology. These methods show promise in reducing malignant tumors in mice and increasing survival rates.
A University of Central Florida scientist has secured $1 million in NIH funding to research the death protein, BAX, which could lead to breakthroughs in treating cancer and heart disease. By understanding how BAX triggers cell death, she hopes to develop a peptide-based therapeutic approach to stimulate or protect healthy cells.
Scientists at Northwestern University successfully blocked the communication between inflammatory cells and prostate cancer cells, reducing their invasive activity. The findings suggest using existing anti-inflammatory drugs to control cancer spread and metastasis.
Researchers observed a group of six enzymes forming a cluster in living cells, which are essential for cell replication and DNA production. This discovery could lead to new cancer treatments by disrupting purine synthesis and halting cancer cell replication.
Researchers found that microRNA miR-200 is a consistent marker of cancer cells expressing E-cadherin but lacking Vimentin. Altering miR-200 levels induced changes consistent with either inducing EMT or the reverse process.
Researchers at USC have found that fasting for two days protects healthy cells from chemotherapy, while leaving cancer cells vulnerable. This discovery holds promise for developing more selective and less toxic chemotherapy treatments.
Researchers have created a novel nanomachine, called nanoimpeller, that can capture and store anticancer drugs inside tiny pores and release them into cancer cells in response to light. The device has strong implications for cancer treatment and may open a new avenue for drug delivery under external control.
Researchers at Uppsala University created a new method to film blood vessel cells moving in response to signals, enabling the study of cancer cell migration and nerve control. The technique can also be used to understand how desirable vessel formation occurs during wound healing.
Researchers found that resveratrol induces pancreatic cancer cell death by crippling the mitochondria's energy function, leading to apoptosis. The study suggests that moderate red wine consumption may not be contraindicated during chemotherapy or radiation treatment.
Dr. Adam Marcus receives $80,000 award to study lung cancer cell invasion and mutations of the LKB1 protein. This research could lead to novel diagnostic and prognostic approaches to control lung cancer malignancy.
The HPV vaccine GARDASIL has been shown to reduce abnormal Pap test results by 43% in women, preventing the development of cell changes that lead to cervical disease. This reduction also translates to fewer invasive procedures like cervical biopsies, with a 42% decrease observed in GARDASIL recipients.
Researchers at MIT have devised a simple and inexpensive method for sorting different types of cells, which could lead to low-cost tools for diagnosing diseases like cancer. The new device relies on the way cells interact with a surface by rolling along it, allowing specific types of cells to be separated.
Researchers discovered that roundworms use both G and C motifs to protect chromosomes, each uniquely attached to the DNA
Researchers at Rockefeller University discovered a tiny RNA molecule that helps skin cells form a protective barrier. MicroRNA-203 plays a crucial role in regulating genes outside the cell's nucleus, specifically suppressing the activity of p63 to prevent stem cells from proliferating excessively.
Researchers developed artificial cell-like particles made of biodegradable material that can target specific diseases or infections. The new method enhances T cell activation by up to 45 times, addressing limitations of previous immunotherapy procedures.
Researchers at Virginia Tech are developing a treatment for prostate cancer using the Newcastle Disease virus. The virus targets specific proteases secreted by cancer cells, generating apoptosis and killing diseased cells. This is a promising new approach to fighting cancer.
Researchers at UCSD developed a gene therapy protocol that successfully activated the immune system in six patients with chronic lymphocytic leukemia. The protocol introduced a gene with potential to activate an immune response and resulted in the production of antibodies reacting against leukemia cells.
Researchers at the University of Wisconsin-Madison found that administering interleukin-7 during a specific stage of infection can increase the number of killer cells capable of destroying virus-infected cells, enhancing immune memory. This discovery may lead to improved vaccine efficacy against HIV and cancer.
Researchers at the University of Minnesota have discovered a novel pathway to turn off immune system cells in humans, which could lead to new treatments for autoimmune diseases like rheumatoid arthritis and lupus. The study also identified a potential target for preventing cancer cell division.
Researchers at Dartmouth Medical School have discovered that the adenomatous polyposis coli (APC) gene plays a dual role in regulating cell growth, acting as both a tumor suppressor and a gas pedal in cell signaling. This new understanding may help identify therapeutic targets for colon cancer treatment.
Researchers studied yeast cells to understand actin network regulation, which is crucial for cell movement. The study found that Arp2/3 regulatory proteins have distinct roles in actin assembly and endocytosis, shedding light on the immune system's ability to target disease-causing invaders and cancer cells' migration.
An international team of scientists discovered 480 genes that regulate human cell division and identified over 100 genes with abnormal patterns of activation in cancer cells. These findings provide insights into how cancers develop and potentially lead to new treatments.
Researchers have discovered a new platinum-based compound that is up to 80 times more powerful than current anti-cancer drugs and can target cancer cells with high accuracy using light activation. The compound's stability and non-toxicity in the dark make it an attractive alternative for treating surface cancers.
A new study published in PLOS Computational Biology suggests that the inefficient process of replacing worn-out cells is a defense against cancer. The researchers found that multicellular organisms use a complex system to replace lost cells, which suppresses mutations that could lead to uncontrolled cell growth.
Researchers at Stanford University School of Medicine have isolated a human blood cell called the multipotent progenitor, which is thought to be the great-grandparent of all cells in the blood. This finding could lead to new treatments for blood cancers and other blood diseases.
Researchers found that a specific protein-protein interaction, involving the rogue Ras protein and its binding partner Raf, blocks the switch from being turned off, leading to uncontrolled cell proliferation. The study resolves a paradox in the behavior of Ras mutants in cells versus solution.
Researchers at Medical College of Georgia Cancer Center have developed a cancer cell line that is resistant to histone deacetylase (HDAC) and heat shock protein 90 (hsp90) inhibitors, two promising cancer treatments.
Researchers found that a specific hormone, TNF-alpha, drives the JAK2 enzyme to cause an often deadly red blood cell cancer called polycythemia vera. The study showed mice with normal TNF-alpha production developed severe bone marrow fibrosis within weeks.
Scientists at Johns Hopkins Medicine discovered that epigenetic changes in gene activation can lead to cancer development, and found a way to block the 'addiction' to growth factors, preventing cancer growth. The study shows that blocking this response can greatly reduce precancerous lesions in animals.
Researchers identify key cellular components that carry out protein disposal and shed light on how proteasome inhibitors interfere with this process. The discovery could lead to novel cancer drugs targeting the protein disposal mechanism.
A team of researchers at the University of Michigan has developed a nano-scale voltmeter that can measure electric fields deep within cells. The device, which is 1,000-fold smaller than existing voltmeters, reveals surprisingly high electric field strengths in cytosol, challenging conventional wisdom about cellular processes.
A team of researchers has discovered a tumor-suppressor gene called Par-4 that kills cancer cells but not normal cells. The mice born with this gene live longer and have no toxic side effects, making it a potentially therapeutic application for treating cancer without harming patients.
The S.T.A.R. Program brings together researchers from top cancer centers to explore the role of targeted heat in cancer therapy for prostate cancer. The program aims to selectively heat cancer cells while preventing damage to adjacent healthy tissues.
A new study led by USC researchers identifies distinct changes in DNA structures that silence cancer cell genes. The findings enable the exploration of new therapies to switch genes back on, potentially leading to novel treatments for human cancers.
A recent study elucidates the relationship between environmental stress and cancer by revealing how stress-inducing agents reduce SIRT1 enzyme activity, leading to increased cell survival. By targeting this process, researchers aim to develop new treatments that increase SENP1 activity to promote programmed cell death in cancer cells.
Researchers have discovered a new potential cancer therapy that targets angiogenesis, the formation of blood vessels that feed tumor cells. Anti-PLGF inhibits the growth of VEGF(R)-resistant tumors without affecting healthy vessels, offering a promising alternative to existing treatments.
Researchers at Albert Einstein College of Medicine successfully treated cancers by targeting viruses that cause them, slowing tumor growth and even causing tumors to regress. The approach holds promise for preventing cancer by destroying virus-infected cells before they become cancerous.
Researchers developed a new virotherapeutic targeting cancer cells expressing E2F and EGFR proteins, showing antitumor effects in mice and rabbits. The virus demonstrated high selectivity for cancer cells in tumor-bearing rabbits and human tissue samples.
A new study suggests that viruses may contribute to cancer by causing excessive death to normal cells while promoting the growth of surviving cells with cancerous traits. The Phoenix Paradigm model proposes a separate mechanism where viral infection selects pre-existing mutated clones, promoting their further growth and multiplication.
A team of Johns Hopkins scientists found that topical application of broccoli sprout-derived extract can protect human skin against UV radiation-induced damage. The extract works by boosting protective enzymes in cells, providing long-lasting protection even after the extract is removed from the skin.
A new heparanase inhibitor has shown promising results in animal models, indicating its potential as a cancer drug. The enzyme heparanase splits polysaccharides into shorter fragments, which can promote tumor growth. By inhibiting this enzyme, researchers hope to develop a new treatment for cancer.
Researchers detected androgen-synthesizing proteins in prostate cancer cells, which may explain why some cancers become resistant to therapies. This discovery offers new directions for research into future treatments that could block the development of androgens in cancer cells.
Scientists at Johns Hopkins Medicine have developed a novel way to fight colorectal cancer using tiny molecules to deliver potent radiation inside cancer cells. The new system proved able to specifically target colon cancer cells, reducing unwanted side effects.
Scientists have identified a key gene called Bub 1 that plays a critical role in normal cell division, and deactivating it has been shown to prevent cells from dividing successfully. The team hopes that targeting this gene may selectively kill cancer cells and develop new treatments.
Researchers discovered that telomeric RNA is transcribed from DNA on the telomere, challenging previous theories. This finding may uncover new targets for attacking telomere function in cancer cells.
Researchers at UVA Health System discovered how cells protect themselves from DNA damage caused by UV rays, involving an unexpected connection between proteins. The study reveals part of a pathway inside human cells that regulates when and how cells repair damage to their DNA.
Researchers at UCSD School of Medicine discovered a novel PLC-epsilon enzyme subtype that activates a second signaling pathway for cell proliferation. This finding may enable targeting the enzyme's second function to prevent pathological responses while preserving its critical physiological roles.
A study suggests that patients with non-squamous histology achieve statistically significant higher survival when treated with ALIMTA in the second-line setting compared to those with squamous histology. The analysis also identified other predictive factors for potential benefit from treatment, including adenocarcinoma histology and go...
A study found that heat-shock transcription factor HSF1 enables normal cells to become cancerous by orchestrating proliferation and survival processes. Depriving cancer cells of HSF1 strongly suppresses their growth and survival, offering a potential new approach to fighting cancer.
A recent study published in Cell describes a chemical chain reaction, known as the Hippo pathway, that controls organ growth and may contribute to cancer. The researchers found that this pathway is altered in 20-30% of human cancer cells, suggesting a potential new target for cancer therapy.
Researchers have uncovered a new pathway that regulates killer proteins called caspases, which are essential for trimming down heavy sperm to make them better swimmers. This discovery provides insights into the causes of human infertility and opens up opportunities for developing drugs that can alter cell death for therapeutic purposes.
Research reveals ultraconserved non-coding RNAs may play a role in cancer development and could help diagnose the disease, determine prognosis, and even guide treatment. The study found specific activity patterns for these molecules in different types of cancer, suggesting they might serve as genetic markers.
A new study reveals that RNA polymerase II constantly scans the cell's DNA for damage, sending a stress signal to p53, a master protein that responds to DNA damage. This discovery sheds light on how cells protect themselves against cancer-producing DNA lesions.
Researchers at Ohio State University found that extracts from Hass avocados kill or stop the growth of pre-cancerous cells leading to oral cancer. The study highlights the potential health benefits of consuming phytonutrient-rich foods like avocados.
Researchers have identified a protein on the surface of platelets that plays a key role in cancer-induced platelet aggregation, allowing cancer cells to evade the immune system and spread throughout the body. By blocking the interaction between podoplanin and CLEC-2, it may be possible to prevent tumor metastasis.
Researchers are working on a £18 million project to change the social habits of living cells, which could help fight diseases like cancer and diabetes. By adjusting cell networking, they aim to reduce disease occurrence and improve health outcomes.
A recent study from Michigan Medicine researchers reveals that specific 'junk' RNA genes, known as microRNA34, work with the protective gene p53 to regulate cell growth and prevent cancer. The loss of these microRNAs is linked to common lung cancer.
Researchers at Rice University have developed a way to package radioactive particles inside DNA-sized carbon tubes to target tiny tumors. The alpha-emitting nanocapsules are designed to deliver a single, direct hit to cancer cells, making them potentially more effective than traditional beta-particle radiation.
Researchers at the University of Georgia are working on a new approach to detect pancreatic cancer using subtle changes in proteins and sugars. They believe that these biomarkers can be found in pancreatic fluid and blood, which could lead to earlier detection and improved treatment outcomes.