Articles tagged with Cancer Cells
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Researchers discovered that lung cancer cells can persist in the presence of cigarette smoke due to a protein pump called ABCG2, which clears damaging molecules from the cells. This mechanism could also contribute to resistance to pharmaceutical treatments in cancer cells.
A study published in Cancer Research Communications reveals a potential genetic marker associated with better survival outcomes in patients with head and neck cancer. The researchers found that the presence of a specific genetic variant and higher expression of the GAN gene product gigaxonin may contribute to improved survival rates.
A new nanocarrier has been developed that can selectively release drugs in cancer cells through controlled endosomal escape. The approach exploits the unique enzymatic activity of cancer cells, allowing for targeted delivery and reduced harm to healthy cells.
Researchers have discovered a new way to target chemotherapy-resistant ovarian cancer cells by depriving them of cholesterol, leading to significant tumor growth reduction. The nanoparticles starve the cells of cholesterol, triggering cell death through oxidation of lipids in the cell membrane.
A recent study used AI trained on cell-to-cell communication networks to predict drug responsiveness in immunotherapy for cancer. The model demonstrated high accuracy in analyzing samples from 700 patients with four types of cancer, identifying key communication pathways related to responsiveness and resistance.
USC researchers have designed nanoparticles that can target and highlight cancer cells in lymph nodes, allowing for earlier detection of metastasis. The particles work by hitchhiking on immune cells to reach the lymph nodes, where they can amplify the signal detected by MRI scans.
Researchers identified a group of proteins that help cancer cells maintain genetic stability and avoid immune system detection. By depleting these proteins, they triggered an inflammatory response and made the cancer cells visible to the immune system.
Researchers have engineered T cells with a mutation found in malignant lymphoma cells, making them more than 100 times potent at killing cancer cells. The new approach shows promise against solid tumors and could provide long-term immunity against cancer.
Scientists at Northwestern University and UCSF have developed a new technique to enhance the potency of human T cells against cancer. By studying mutations in malignant T cells, they were able to create T cells that can kill tumors derived from skin, lung, and stomach cancers in mice.
Scientists at City of Hope discovered a new cellular mechanism that plays a key role in cancer cells' ability to cause disease. The study identified integrin αV and β5 as crucial proteins that partner to spur cancer cell growth, offering a promising target for new therapies.
Researchers have identified mechanisms of resistance to tazemetostat in epithelioid sarcoma and rhabdoid tumors, leading to the development of a combination therapy strategy. The therapy uses an epigenetic treatment approach to target specific mutations that drive cancer growth.
Researchers discovered that depletion of the protein DPYSL5 can restore drug-responsive neuroendocrine prostate cancer cells, promoting cell transformation and lineage plasticity. This finding could lead to the development of new cancer drugs.
A low-cost, DIY device using a coin-vibrating motor has been developed to rapidly generate uniform tumor spheroids. These 3D tumor models exhibit clinically typical responses to chemotherapy and can help overcome limitations of traditional cell cultures.
Researchers at the University of Oklahoma Health Sciences have developed a new imaging technique that can detect pancreatic cancer cells approximately 10 times more magnificently than current options. The approach combines contrast agent recognition with Multispectral Optoacoustic Tomography, enabling real-time detection and surgery pl...
A new CRISPR-based technology, TRED-I, has been developed to increase visibility of cancer cells to the immune system by augmenting MHC class I molecules. This technology has shown promising results in animal cancer models, reducing tumor sizes and enhancing treatment efficacy when used with existing immunotherapy.
Researchers studied how epithelial cells sense small changes in their environment using ion channels. They found that even small movements can trigger rapid intracellular calcium changes via mechanosensitive cation channels, which play a key role in touch sensation and other physiological functions.
A recent study published in Cell Reports reveals that cancer cells can prevent the immune system from attacking them by inhibiting key checkpoints. Researchers found that monotherapy agents targeting these checkpoints may not be effective without an inflammatory trigger, explaining why some immunotherapies work while others fail.
A new study published in Oncogene highlights the effectiveness of MDX-124, a therapeutic drug targeting annexin-A1, which promotes tumour progression. High annexin-A1 expression levels correlate with poorer overall survival in various cancers.
Researchers have revealed CD4+ T cells can work effectively on their own to control melanoma, challenging conventional understanding. Harnessing their potential therapeutically holds great promise for improving current cancer immunotherapies.
Researchers developed a new photosensitizer, polphylipoprotein (PLP), to improve photodynamic therapy (PDT) efficacy. PLP selectively induces necrosis in cancer cells by exploiting the autophagy mechanism under starvation, leading to high selectivity and potential efficacy.
Sezáry syndrome patients face a vicious circle where cancer and treatment weaken the immune system, allowing bacteria like S. aureus to thrive. Eliminating these bacteria may make cancer cells more susceptible to anti-cancer drugs.
A systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types. Researchers used machine learning methods to find promising targets and linked them to specific biological markers and genetic features.
A team of scientists has identified a previously unrecognized control point in DNA repair processes, which could lead to novel cancer therapies by inhibiting the repair of damaged cancer cells. The newly discovered GSE1-CoREST complex contains three enzymes that control DNA repair and may form the basis for improved cancer treatments.
Researchers have found a way to control MYC's hyperactivity using a peptide compound with sub-micro-molar affinity. This breakthrough offers hope for more effective treatments for cancer patients.
Researchers found that a rare type of T cell, Vd1-gd T cells, can predict patient response to immunotherapy treatments. The presence of these cells is highly predictive of positive responses in cancers with few mutations, and they may be more resistant to suppression from cancer cells.
Researchers have developed nanodrones that target and eliminate cancer cells by recruiting natural killer cells to tumor sites. The study offers a potential solution for intractable types of cancers, with promising results in suppressing tumor growth without causing side effects.
Researchers have developed a novel method to produce a selective anticancer precursor substance. The synthesis involves the reaction of metal-active oxygen species with nitrile, utilizing cost-effective metals at lower temperatures. This breakthrough opens up new possibilities in developing innovative drugs against cancer.
Researchers have made significant progress in understanding the enzyme SMYD3's involvement in prostate cancer's progression to a more aggressive stage. The study found that adding methyl groups to the MAP kinase protein is likely SMYD3's role in driving metastasis, and compounds that can inactivate SMYD3 are already available
A new study found that removing the RUNX1 transcription factor and its target gene can lead to a network collapse, causing cancer cell death in a type of aggressive leukemia. This breakthrough identifies specific protein targets for potential treatments.
Researchers developed a novel cancer sensor using viral enhancement and nanomaterials, achieving ultra-high sensitivity in detecting breast cancer cells. The new P-DBS technology outperformed existing electrical-based sensors in terms of sensitivity and signal contrast.
Researchers at the University of Gothenburg have developed a way to distinguish different types of structural changes in glycan molecules linked to various cancers. The AI-enhanced method uses mass spectrometry to identify patterns in data sets, providing a precise answer to what will change for a specific disease.
Researchers explore the properties of cytostatic persisters in cancer treatment, highlighting their therapeutic potential and challenges. The study suggests that targeting these persisters before resistance emerges can reduce cancer recurrence.
Researchers at Mass General Brigham have developed a new class of proteasome inhibitors that specifically target the β2 active site in cancer cells. The newly synthesized compounds effectively inhibit multiple myeloma cell growth and show promise for reducing therapeutic resistance and side effects when combined with existing drugs.
A new study from Indian Institute of Science finds that certain types of cancer cells respond well to IFN-γ activation, while others don't. The researchers suggest approaches to make non-responsive cancer cells better respond to immunotherapy by targeting their metabolism.
The Tokyo University of Science team has created a device that enables the simultaneous evaluation of many cancer cells, allowing for rapid and accurate analysis. The system, called cROT, increases throughput to 2,700 cells per hour, making it more than 100 times faster than traditional methods.
A new study in mice shows that a hybrid treatment combining a drug and a protein fragment can prevent the growth of blood cancer cells by targeting the RAS gene mutation. The treatment, which blocks cell division and multiplication, has shown promising results in live animals with multiple myeloma tumors.
Researchers at the University of Turku found that bexmarilimab therapy alters macrophage behavior to promote anti-tumor immune defense. The therapy was well-tolerated and stabilized disease progression in patients with advanced-stage cancer, inducing tumor-associated macrophage and lymphocyte activation.
A new study found that a type of white blood cell called tumour-associated macrophages can promote the formation of lymphatic vessels, facilitating cancer cell transport to other organs. However, these cells also reduce breast cancer spread to the lungs while increasing it to the lymph nodes.
Researchers Haval Shirwan and Esma Yolcu design a molecule, SA-4-1BBL, that mobilizes immune cells to target cancer cells. The molecule shows promising results in preventing lung cancer by triggering the immune system's defense mechanism.
Researchers discovered that Osteopontin induces mitochondrial biogenesis in deadherent breast tumor cells, which aids metastatic success. The study suggests a possible mechanism and targets for treating cancer metastasis by increasing ATP levels and mitochondrial mass.
Researchers discovered an alternative immune response involving NK and CD4+ T cells that can recognize and attack cancer cells when the usual recognition marker B2M is missing. This finding holds potential for developing more effective combination cancer immunotherapy treatments.
Researchers developed GraphNovo, a program that provides accurate understanding of peptide sequences in cells, improving immunotherapy for unique cases. The AI model enhances de novo peptide sequencing accuracy, filling gaps with precise mass data.
A new study by Tulane University has identified a previously unknown molecular pathway that could halt lung cancer growth. The research found that protein RBM10 can suppress lung cancer by targeting the function of c-Myc, a protein that drives cancer cell growth and proliferation.
Researchers at Duke University have developed a new computational model called Adaptive Physics Refinement (APR) that can simulate the movement of individual cancer cells across long distances within the entire human body. This approach captures detailed cellular interactions and their effects on cellular trajectory, providing valuable...
Researchers found that cancer cells are more vulnerable to radiotherapy when using the less common 'YC' first-base-cytosine site instead of the usual 'YR' adenine or guanine start sites. This discovery enables further understanding of gene regulation in cancers and potential targets for treatment.
Researchers at the University of Pennsylvania School of Medicine found that lidocaine activates the bitter taste receptor T2R14, which triggers apoptosis in cancer cells. This mechanism could lead to improved treatment options for patients with head and neck cancers, particularly those associated with human papillomavirus.
Researchers found that cancer cells with multiple mutations alter cell competition, allowing them to infiltrate and form highly invasive tumors. The study identified a key mechanism, MMP21, which promotes the production of diffusely invasive cancer cells.
Researchers at Purdue University have developed a novel cancer immunotherapy compound that targets the enzyme TC-PTP, found in both cancer cells and T cells. Deleting this enzyme promotes antigen presentation, alerting the immune system to tumor cells, while stimulating T-cell activation enhances their ability to fight and destroy tumors.
A new study by Cleveland Clinic researchers reveals significant differences in cell communication between breast tissue with and without BRCA1/2 gene mutations. This discovery provides a foundation for personalized medicine approaches to prevent and treat breast cancer in mutation carriers.
Scientists from Tokyo Medical and Dental University created a synthetic polymer biomaterial that mimics the pancreatic adenocarcinoma microenvironment, enabling them to identify potential therapeutic targets. The study successfully recapitulates the complex interactions between cancer stem cells and their niche.
Researchers discovered narrow-spectrum Wnt signaling inhibitors can suppress breast cancer tumors and reduce chemo-resistant cells in mice. The treatment, derived from a bacterial toxin, targets specific receptors to minimize bone density side effects.
Researchers at UCLA have developed a new method to engineer more powerful immune cells that can potentially be used for 'off-the-shelf' cell therapy to treat challenging cancers. Gamma delta T cells with high expressions of CD16 surface marker exhibited increased ability to recognize and kill cancer cells.
Researchers developed a technique to capture extracellular vesicles using sustainable wood cellulose-based nanofiber sheets, revealing new insights into cancer treatment. The technology has the potential to revolutionize early cancer diagnosis and open up personalized medicine.
Researchers identified a mechanism that fuels cancer cell growth and developed a new strategy to restrict this process. By restricting glucose in lung cancer cells, they found it caused the cells to lose their specialized features, making them more aggressive.
Researchers at the University of Leicester have received a significant financial boost to advance their cancer treatment research. The team will investigate 'liquid biopsies' to reveal vital clues about cancer genetic makeup, aiming to predict how cancer changes and which treatment works best for individual patients.
The study found that SPT5 plays an important role in the development of MYC-dependent tumors, with reduced levels leading to significant regression of tumors. The researchers suggest that SPT5 could be a potential target for pharmacological inhibitors to combat cancer.
Researchers used spatial transcriptomics to analyze cancer cells at the edge and center of tumors, finding distinct gene expression patterns that can predict clinical outcomes and response to therapy. These findings hold promise for improving treatment strategies across various cancer types.
A phase 1 trial of the radiopharmaceutical 225AC-J591 demonstrated promising antitumor activity against advanced metastatic prostate cancer, reducing PSA levels by at least half for 47% of patients. The treatment was well-tolerated, with only temporary low blood cell count side effects.
Researchers at Duke University developed an innovative antibody approach to target and kill tumor-promoting molecules found in cancer cells. The study revealed notable reductions in tumor growth and minimal side effects, making it a promising new treatment option for various types of cancer.
Researchers have discovered a novel biomarker that enables the evaluation of near-infrared photoimmunotherapy (NIR-PIT) treatment success. The biomarker uses microbubbles to track tumor vessels and measure the effectiveness of NIR-PIT, which combines antibodies and near-infrared light to destroy cancer cells.