Articles tagged with Cancer Stem Cells
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Trapping prostate cancer stem cells with self-assembling nanomaterials inhibits colony formation and cell division in vitro. The approach may offer a new treatment strategy for metastatic hormone-refractory prostate cancer by targeting cancer stem cells, which are thought to be the origin of tumor metastasis.
Researchers found that oestrogen can reduce the proportion of breast cancer stem cells, explaining a better prognosis for tumours expressing the oestrogen receptor. This study presents new insights into oestrogen's effect on cancer stem cells and opens doors to developing tools for preventing breast cancer.
Researchers at the University of Wisconsin-Madison have successfully reprogrammed diseased blood cells into pluripotent stem cells, allowing for the observation of leukemia's onset in a laboratory dish. This breakthrough enables scientists to pinpoint the earliest stages of cancer development.
Researchers at Cold Spring Harbor Laboratory have identified a new role for the sister gene of p53, p63, in skin cancer and stem cell biology. The study reveals that increased activity of Ras combined with overly exuberant activity of ΔNp63α stimulates skin stem cells to promote carcinoma development.
Researchers have developed a mathematical model to assess the growth of stem cells and their malignant counterparts. The method, published in PLOS ONE, may aid in developing stem cell therapies for diseases like Alzheimer's and Parkinson's.
U-M researchers found that breast cancer stem cells are regulated by mesenchymal stem cells from the bone marrow, creating a 'niche' for the cancer cells to replicate. By blocking signals from this niche, researchers hope to target and kill breast cancer stem cells using existing medications.
Researchers found a strong correlation between high levels of gene expression associated with leukemia stem cells and poor outcomes in patients. The study suggests that targeting these self-renewing cells could lead to more effective treatments and improved patient survival.
Researchers at Tufts University discovered that estrogen stimulates breast cancer stem cells through a pathway mirroring normal stem cell development. By disrupting this signaling mechanism, they were able to halt the expansion of breast cancer stem cells and prevent tumor growth.
Researchers found that functional cardiac stem cells can be isolated from aged and damaged hearts, with women producing more CSCs than men. The study suggests that these stem cells have the potential to regenerate heart muscle and vessel tissue, potentially treating heart failure.
Researchers found that most melanoma cells can drive disease progression and cannot be cured by targeting rare sub-populations. The study suggests that all melanoma cells have the ability to form tumors and change genes on the fly.
University of Pittsburgh researchers have developed a 3D system to mimic colon cancer stem cell growth patterns. They found that some cancer stem cells produce differentiated cells, while others produce self-renewing cells, paving the way for testing new therapies.
Researchers at NC State University found that elevated SP2 protein in stem cells causes them to form cancerous tumors. Overproduction of SP2 stops stem cells from producing mature descendants, leading to uncontrolled proliferation and tumor formation.
A study published in The Lancet Oncology found that some CML patients can survive up to 2 years without relapse after stopping imatinib treatment, suggesting a potential cure with tyrosine-kinase inhibitors. The study suggests that indefinite treatment may not be necessary and that imatinib can be safely discontinued in some cases.
Researchers at Rockefeller University identified a gene called Sept4 that regulates programmed cell death in precursor cells, which can increase the risk of developing cancer. The study found that mice lacking the Sept4 gene had twice as many hematopoietic stem cells and were more susceptible to tumors.
For the first time, researchers have identified and isolated adult mammary stem cells in mice using a genetically modified mouse model. The tagged stem cells exhibit bright green fluorescence under a microscope, representing a new alternative to induced pluripotent stem cells for various medical applications.
Walter and Eliza Hall Institute researcher Dr Marie-Liesse Asselin-Labat is unraveling the mysteries of breast stem cells, their development, and influence by oestrogen and steroids. Her groundbreaking studies aim to uncover how breast cancer progresses and why it sometimes returns.
Researchers from Massachusetts General Hospital identified a microRNA molecule that increases the number of hematopoietic stem cells, which can give rise to all blood and immune system cells. This discovery may lead to improved cancer treatment by expanding stem cell populations.
Cancer stem cells have been identified in a model of human lung cancer, but their uniqueness varies between tumors depending on the tumor's genetic signature. The study suggests that targeting specific cancer cell populations based on the tumor genotype may lead to personalized and effective treatments.
A study found that sulforaphane from broccoli limits breast cancer stem cells in mice and cell cultures, preventing tumor growth. Researchers believe eliminating these cells is key to controlling cancer, suggesting a potential new treatment approach.
A new study has found that genetically short-circuiting the ability of cancer stem cells to absorb a key nutrient can kill many colon cancer cells. The approach targets tumor cell 'factories' and could potentially reduce recurrence rates of colon cancer. However, further research is needed to ensure the treatment does not harm normal s...
A Phase I clinical trial demonstrated early signs of a strong safety profile and clinical activity for BBI608, a first-in-class cancer cell stemness inhibitor. Nine patients achieved stable disease for at least two months with early signs of tumor regression.
Researchers discovered yeast cells can decide to mate within two minutes of meeting due to a chemical change on a single protein. This process is controlled by the concentration of pheromones in the environment, which triggers mating if sufficient.
A new study by Johns Hopkins scientists found that Notch-blocking drugs can kill brain cancer stem cells in mice, with a 70% reduction rate. However, further experiments suggested that additional therapies or increased dosage of Notch-blocking drugs may be necessary to target all cancer stem cells.
Researchers at Yale University have discovered that stopping the expression of two genes Lin28 and Oct4 can reduce ovarian cancer cell growth and survival. This could lead to more effective treatments for this deadly form of cancer, which has a high recurrence rate and resistance to treatment.
Researchers from M.D. Anderson Cancer Center discovered that cancer stem cells inhibit T cell response and evade immune attack on glioblastoma multiforme. Differentiation of these cells into other neural types can restore the immune response, offering new hope for treatment.
A recent study identifies CXCR1 as a crucial protein in targeting human breast cancer stem cells. Inhibiting this protein selectively depletes the cancer stem cell population, leading to reduced tumor growth and metastasis. The findings suggest that strategies targeting CXCR1 may offer a promising approach for treating breast cancer.
A U-M study reveals that a specific receptor, CXCR1, triggers growth of breast cancer stem cells in response to inflammation and tissue damage. Researchers found that blocking this receptor using an existing anti-inflammatory drug repertaxin kills breast cancer stem cells and prevents metastasis in mice.
Researchers identified a strategy to target human breast cancer stem cells by blocking the protein CXCR1. The approach selectively depleted cancer stem cells in mice xenotransplanted with human breast cancer cells, leading to reduced tumor growth and metastasis. This finding provides hope for women with breast cancer.
Researchers at Johns Hopkins Medicine have discovered a protein called Twist that accurately distinguishes stem cells driving aggressive breast cancer from other cancer cells. The protein's presence alone can flag a tumor cell as a breast cancer stem cell, suggesting new potential for early detection and treatment strategies.
Duke University researchers have found a way to increase the effectiveness of radiation therapy against glioma brain tumors by blocking a specific signaling pathway in cancer stem cells. This breakthrough could lead to more effective treatment options for patients with glioblastoma and other brain cancers.
A study published in Stem Cells reveals human stem cells can immunize against colon cancer by tricking the immune system. The discovery builds upon a century-old theory and opens up new possibilities for cancer vaccine research.
Stem cell biology faces challenges in defining molecular characteristics, with potency and self-renewal not exclusive to stem cells. A new perspective suggests considering 'stemness' as a system property, rather than individual cell traits, which may lead to improved understanding of cancer stem cells.
Researchers at Penn State College of Medicine have identified a population of cancer stem cells in the liver prior to tumor formation. These malignant stem cells have been found to be resistant to chemotherapy and are thought to play a key role in driving liver cancer formation. The study suggests that targeting these cells could poten...
Researchers at the Mayo Clinic have discovered that the lung cancer oncogene PKCiota is necessary for the proliferation of lung cancer stem cells. The study found that an agent called aurothiomalate substantially inhibits growth of these cancer stem cells, suggesting a potential new treatment target.
A phase 3 trial found that anti-T cell globulin (ATG) reduces the incidence of both acute and chronic graft-versus-host disease (GVHD) in transplant patients. This results in improved survival rates and reduced complications without compromising overall survival or increasing relapse rates.
Researchers discovered a first compound that targets cancer stem cells directly, reducing breast cancer stem cells by over 100-fold. Salinomycin slows tumor growth and seed tumors in mice, highlighting a new avenue for cancer therapy development.
Researchers discover a chemical that selectively kills cancer stem cells, which enable cancers to spread and reemerge after treatment. The compound, salinomycin, shows surprising potency against laboratory-created and naturally occurring cancer stem cells.
Researchers found that STAT3 inhibits the growth and self-renewal of glioblastoma stem cells, suggesting a promising target for cancer therapy. The study demonstrates the potential of STAT3 inhibitors to stop tumor formation and offers a new approach to treating this devastating brain cancer.
Researchers found stem-like cancer cells that share characteristics with healthy stem cells, including unlimited lifespan and migration properties. These cells were localized in the same tissue location as bladder stem cells and showed increased activity in genes related to cell proliferation and metastasis.
Researchers at Stanford University School of Medicine have discovered a common molecular pathway used by breast cancer stem cells and normal breast stem cells when reproducing. Increasing the levels of miR-200c suppresses their ability to divide and reproduce.
Researchers at Stanford's School of Medicine identified human bladder cancer stem cells and revealed how they work to escape the body's natural defenses. The discovery may be a valuable therapeutic target for many types of cancers.
Researchers have discovered a protein on the surface of leukemia stem cells that helps them evade macrophage immune cells. Targeting this protein, called CD47, may help increase the body's appetite for killing cancer cells.
Researchers have developed a new leukemia therapy targeting cancer stem cells that drive acute myeloid leukemia (AML) growth. The antibody therapy, which specifically targets the CD123 protein, has shown promising results in laboratory models and clinical trials.
Researchers propose that cancer stem cells could provide an important avenue for controlling cancer if targeted by new treatments. The subpopulation of malignant cells may be the root cause of cancer, offering a potential new approach for therapy.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a unique model to isolate and study lung cancer stem cells. The model uses patient specimens and autologous tumor microenvironments to identify markers associated with cancer stem cells, providing proof-of-concept for the existence of these cells in lung cancer.
Researchers identified a gene involved in inflammatory response that could hold key to treating CML, a lethal cancer. A drug combination targeting this gene showed improved therapeutic effect on CML in mice.
A protein that maintains cell 'stemness' has been linked to various advanced human cancers, including liver cancer, ovarian cancer, and Wilm's tumor. Increasing its production can prevent mature tumor-suppressing microRNAs from maturing, leading to a more cancerous state.
Researchers identified cancer stem cells in breast cancer patients' bone marrow, which correlated with tumor's lymph node involvement and worse prognosis. The study suggests a need for novel biological therapies targeting these cells, and may lead to better monitoring of patients needing additional treatment.
Researchers found a novel combination therapy using tigatuzumab and gemcitabine that reduces pancreatic cancer stem cells, achieving tumor remission and preventing recurrence. The treatment significantly increased time-to-tumor progression in treated cases, offering new hope for patients with this deadly disease.
Researchers discovered that growing mouse skin cells in spheres can lead to generation of cells with properties of cancer stem cells. The study found that mutation of the retinoblastoma tumor suppressor gene family led to reprogramming of differentiated cells into cancer stem cells.
Scientists at McMaster University have identified a key communication pathway that triggers stem cells to specialize and become blood cells in humans. The noncanonical Wnt pathway works by organizing cells to respond to signals for blood development, providing an efficient way to produce blood cells.
A genome-wide expression analysis identified 3,005 differentially expressed genes, including a ribosome and T-cell receptor signaling pathway. The study provides critical insight into the differences between leukemic stem cells and normal blood stem cells, potentially leading to targeted therapies.
Cancer stem cells are more resistant to radiation due to a protective pathway that shields normal stem cells from DNA damage. By blocking this pathway, cancer stem cells become more susceptible to killing by radiation.
Researchers at McMaster University have discovered a way to distinguish between healthy stem cells and cancer stem cells in humans. This breakthrough could lead to more effective cancer treatments that spare healthy cells.
Scientists at St. Jude Children's Research Hospital have discovered that normal stem cells can give rise to tumors in mature solid tissues, including the intestine. The study identifies Prominin1 as a molecular marker for normal stem cells, which can act as the source of cancerous tumors.
Researchers at the University of Michigan found that a quarter of melanoma cells are 'tumorigenic' and can form new tumors, contradicting previous estimates. The study suggests that targeting these rare cancer stem cells may not be effective in treating melanoma.
A new study reveals that therapy targeting cyclin D1 can block the expansion of breast cancer cells, which are involved in therapy resistance and tumor recurrence. The findings provide a potential new treatment approach for targeted therapies at cancer stem cells in humans.
Researchers identified a molecular mechanism involved in the development of cancer stem cells, which can lead to malignant brain tumors. Targeting this signaling pathway with gene therapy may prevent tumor recurrence.
Scientists have identified distinct gene combinations that define different stem cell types, revealing a single key factor controlling their behavior. This breakthrough has significant implications for manipulating and engineering stem cells to treat human degenerative disorders.
Studies in mice reveal that women who have children young have fewer mammary stem cells, which could contribute to lower breast cancer risk. Researchers plan to investigate further to determine the mechanism behind this protective effect and explore potential treatments.