Articles tagged with Cancer Stem Cells
Scientists at UCSB have discovered a protein called vacuolar ATPase that naturally prevents inappropriate cell fusion, which can lead to cancer metastasis. This finding may pave the way for new treatments to enhance organ regeneration by stem cells, prevent cancer progression, and control fertility.
A plant derivative called parthenolide selectively kills leukemia stem cells while sparing normal cells, offering a promising new therapy for leukemia. This breakthrough research identifies molecular pathways that allow parthenolide to induce cancer cell death.
Researchers found that beta-arrestin2 activates the hedgehog signaling pathway, which can lead to cancerous tumors. The study suggests potential new drugs to block tumor growth by disrupting beta-arrestin2's function.
Recent studies suggest that two chemical signals, Hedgehog and Wnt, play a key role in the development of certain cancers. These signals are also active in normal stem cells that repair damaged tissue, raising the possibility that some cancers may start from these cells with accumulated mutations.
Researchers at Sick Kids confirm that cancer stem cells are responsible for initiating and growing brain tumors in a mouse model. This discovery opens the door for new therapeutic targets to conquer brain tumors.
Researchers at Stanford Medicine have identified leukemia stem cells in chronic myelogenous leukemia, a breakthrough that could lead to new targeted therapies. The discovery reveals that normal adult cells can mutate into cancer stem cells, which are resistant to chemotherapy and require a specific protein called Wnt to self-renew.
Researchers at the University of Pittsburgh Medical Center have discovered a molecular mechanism that enhances the ability of stem cells to fight disease. By blocking the function of p18, a molecule critical for cell cycle control, scientists found improved long-term engraftment of stem cells in bone marrow tissue.
Brain tumours are difficult to cure despite advances in surgery and drug treatments. Researchers have identified a cancer stem cell that drives tumour growth, leading them to design therapies targeting these cells., The discovery sheds light on metastases and may lead to new targets for brain tumour therapy.
University Health Network researchers have identified a new class of human stem cells that rapidly rebuild the blood system, allowing for faster recovery from cancer treatment. The discovery holds significant implications for transplant patients who are vulnerable to infections during their weakened state.
U of MN researchers identified proteins FRGY2a and FRGY2b that disassemble nucleoli without other protein help. This discovery may lead to understanding normal cell development and human diseases.
Researchers discovered a novel gene, nucleostemin, crucial for maintaining stem cells' proliferative capacity. Its expression is linked to self-renewal and proliferation in both embryonic and adult stem cells, as well as some human cancer cell lines.
A study led by Dr. William Bensinger found that patients undergoing stem-cell transplantation lived longer than those receiving marrow transplants, especially for high-risk blood cancers. The study also showed lower rates of acute and chronic graft-versus-host disease with stem cells.
A team of researchers at The Hospital for Sick Children has discovered two distinct types of stem cells within the blood system, short-term repopulating and long-term repopulating stem cells. These stem cells have different functions and could lead to improved cancer treatment and gene therapy outcomes.
A study by University of Pennsylvania researchers found that the hair follicle and epidermis may originate from the same cache of cells. The finding suggests that daughter cells in the upper follicle migrate upward to form and maintain the new epidermis, and down to form the hair shaft.
Researchers at NYU Langone Health and the University of Pennsylvania School of Medicine have discovered that hair follicles are the source of new cells for the skin's outermost layer, the epidermis. These stem cells reside in a protected area called the bulge, which migrates to the epidermis, replenishing the skin throughout life.
Researchers at Massachusetts General Hospital have identified a molecular switch, the protein p21, that controls the development and proliferation of hematopoietic stem cells. The discovery may solve a major limitation to using these stem cells in transplants and gene therapies.
Researchers found that stem cells provide a higher two-year survival rate (70%) compared to marrow transplants (45%) for certain high-risk blood cancer patients. The study suggests that stem cell transplants may offer fewer relapses with fewer complications.
Researchers at Thomas Jefferson University have isolated hematopoietic stem cells using a specific marker, enabling laboratory production of all types of blood cells. This breakthrough has the potential to alleviate blood shortages for transfusions and develop innovative approaches to bone marrow transplants and gene therapy.
Researchers at the Weizmann Institute developed a molecule that allows blood stem cells to multiply without differentiation in the test tube, improving bone marrow transplantation and gene therapy research. This breakthrough could enable scientists to insert genes into human stem cells for treating genetic disorders.
Researchers discovered that human stem cells use a specific receptor, CXCR4, to migrate to bone marrow. Treating stem cells with growth factors increased their ability to express this receptor and migrate successfully, improving transplant success rates from 25% to over 90%.
A clinical trial demonstrates that TPO, administered with G-CSF, boosts stem cell migration and increases the number of patients eligible for autologous stem cell transplantation. The treatment significantly improves re-growth of blood cells after chemotherapy.
Researchers at Duke University Medical Center have identified a cell component called the spectrosome that guides reproductive cells to self-renew and mature differentiated cells in fruit flies. The finding may help explain how men continuously produce sperm and why some stem cells lose control, forming cancerous tumors.