Articles tagged with Cell Cycle Progression
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
A University of Tsukuba-centered study reveals that nucleolar integrity during interphase is essential for proper cell cycle progression. The study's findings suggest that the maintenance of nucleolar structure regulates the activity of Cdk1, a kinase that controls mitotic entry.
Researchers found that high zinc levels inhibit cell growth, upregulate growth arrest and DNA damage-induced gene (Gadd45) expression, and block cell cycle progression in normal human bronchial epithelial cells. Gadd45 plays a crucial role in maintaining genomic stability and apoptosis.
Researchers at Cold Spring Harbor Laboratory investigate the concept of return to normalcy in genetic systems. They uncover new insights into how cells can re-establish normal gene expression after perturbations.