Articles tagged with Cell Division
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A recent study using cutting-edge super-resolution microscopy has shed light on the role of cohesin in cell division. The research revealed multiple populations of cohesin complexes, each playing a specific role in faithful genetic material segregation during cell division.
Research reveals micro- and nanoplastics can persist in the human body for longer than previously thought, being passed on to newly formed cells during cell division. The study also suggests these tiny plastic particles may promote the spread of cancer by increasing tumor migration.
A long non-coding RNA called lncREST has been identified as a crucial component of the stress response during DNA replication. Its absence leads to impaired stress signalling, resulting in severe DNA defects and cell death. The discovery opens up new avenues for developing anti-tumour therapies.
Researchers at CNIO have discovered a new protein that prevents DNA triplication, reducing the risk of cancer. The RAD51 protein ensures that DNA is copied only once, preventing errors and damage.
Scientists have discovered two new end-replication problems in DNA replication, affecting both the leading and lagging strands. This revelation changes our understanding of telomere biology and may hold clinical implications for individuals with telomere disorders, such as Coats plus syndrome.
For the first time, scientists have visualized the process of microtubule formation in human cells at an atomic scale. The study reveals how microtubules are triggered to form during cell division, providing new insights into their role in cellular biology and potential therapeutic applications.
Scientists have imaged microtubule formation in unprecedented detail, revealing a complex process that involves the gamma-tubulin ring complex and a newly-discovered latch mechanism. The findings hold promise for developing targeted therapies for various diseases, including cancer and neurodevelopmental disorders.
Scientists have successfully replicated QS-21, a potent vaccine adjuvant, in an alternative plant host for the first time. This breakthrough enables the production of this highly valued compound in a more sustainable manner.
Researchers have developed a new technique that provides a previously unattainable view of the mechanical properties inside the cell nucleus. The study reveals the peculiar dynamic structural features in living cells, which appear to be crucial for cell function.
Scientists unravel DnaA's role in DNA replication initiation, shedding light on bacterial cell growth and reproduction. The discovery reveals a previously unknown binding pocket within DnaA, enabling the capture of single DNA strands.
The study identifies FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A, regulating its activity and cellular location. This finding may provide potential clinical insights into treating Down syndrome and related diseases.
Researchers identified key factors in DNA repair, revealing the 'proofreading' portion of polymerase epsilon helps prevent strand breakage. This knowledge arms scientists with ways to enhance anti-cancer drug effectiveness and develop new diagnostic methods.
Researchers identified a novel bacterial protein, MceF, that can prolong cell longevity by acting directly on mitochondria. The discovery could lead to new treatments for diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders.
A preclinical study by Weill Cornell Medicine researchers reveals that activating a pathway to promote cell division can expand insulin-producing cells without impairing their function. The study's findings support the concept that beta cell mass can be expanded without compromising function.
The study reveals that CENP-E binds to protein complexes, forming a scaffold for the fibrous corona's development. This discovery sheds light on errors during cell division and could contribute to cancer treatment strategies.
A new study reveals that autophagy plays a crucial role in the gradual loss of DNA content in diploid Saccharomyces cerevisiae cells undergoing chronological aging. The researchers found that only diploids survived, and autophagy induction was responsible for the DNA loss.
Researchers discovered that a single mutation in a key synaptonemal complex protein can cause infertility in mice and is likely to have the same effect in humans. This finding may lead to new technologies for treating male infertility by pinpointing the exact location of the defect.
Researchers have developed a lab-grown human skin model that effectively replicates mpox virus infections, providing insights into the virus's mechanisms of attack on skin cells. The study reveals how the virus causes disease and identifies potential therapeutic targets, including an antiviral drug called tecovirimat.
Researchers discovered that targeting TUG1 can control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors. By inhibiting TUG1, the therapy significantly suppressed tumor growth and improved survival rates when combined with standard treatment.
New plant cell walls exhibit significantly different mechanical properties compared to surrounding parental walls, enabling cells to alter their local shape and influence the growth of plant organs. Researchers have discovered that new cell walls in some plants are 1.5 times stiffer than the parental cell walls.
Researchers identified two SARS-CoV-2 protein mutations linked to severe COVID-19 symptoms and increased inflammation. The mutations, known as KR, were found in patients with higher viral loads and more severe symptoms.
A study using engineered mice found that BA.5, a contagious omicron subvariant, replicates rapidly early during infection, causing significant weight loss and high levels of inflammatory cells and cytokines in lungs.
Researchers discovered NSMF protein's role in alleviating DNA replication stress by displacing weakly bound RPA proteins and promoting phosphorylation. This mechanism accelerates relief of replication stress, offering a new direction for treating various diseases, including cancer and age-related conditions.
A Kyoto University team reveals the Dumpy protein as the key factor in controlling 3D tissue structures through external cues. This finding challenges traditional understanding of morphogenesis and opens up new avenues for manufacturing controllable 3D tissue folding with coordinated cell behaviors.
Researchers at the Centre for Genomic Regulation have discovered how proteins work together to regulate treadmilling, a critical mechanism in cell division. The discovery highlights the importance of protein KIF2A and its role in maintaining tension between chromosomes during cell division.
Researchers discovered that bacteria employ 'surfing' proteins called ParA/MinD ATPases to transport cargo across the cell. These systems interact with each other, enabling complex movements before cell division. The findings provide a basis for developing synthetic biology tools and understanding bacterial pathogens.
A team of researchers developed a computational simulation that explains key mechanism of DNA segregation, providing new insights into the distribution of genetic information during bacterial cell division. The study reveals fundamental biochemical principles relevant to synthetic biology and medical applications.
Scientists have found several genes that produce minimal RNA fluctuations, shedding light on gene expression and noise. These ultra-low noise genes provide a unique window into understanding how cells function optimally.
Researchers discovered a central regulator, DipM, controlling multiple autolysins and promoting cell constriction in Caulobacter crescentus. The study reveals DipM's role in coordinating bacterial cell wall remodeling and division processes.
Researchers have discovered how MCV initiates DNA replication in host cells, allowing the virus to make hundreds of new copies of itself. This process is different from normal cellular DNA replication and can lead to cancer if not controlled.
Researchers at Johns Hopkins Medicine have identified a new target for treating HIV infection by blocking the neutral sphingomyelinase-2 (nSMase2) enzyme. Inhibiting this enzyme can prevent HIV replication and kill infected cells, offering a promising therapeutic approach.
Researchers at UC San Diego have discovered that shattered DNA fragments are tethered together during cell division, allowing them to be reassembled in a different order. Destroying the tether may help prevent cancerous mutations and is now being explored as a therapeutic target.
A team at Osaka University identified a crucial protein facilitating proper chromosome movement when cells divide. The research revealed that the Cupin domain of CENP-C is essential for its function, supporting centromere/kinetochore assembly and maintaining genomic integrity.
Researchers investigate the γ-TuRC complex, a key player in microtubule formation and stabilization. The study reveals that γ-TuRC can cap microtubules independently of nucleation, contributing to their formation outside of centrosomes during mitosis.
Researchers at the University of Missouri identified occludin protein as a mediator for cell-to-cell transmission of coronavirus. The study found that damaged occludin protein enables virus replication and spread to neighboring cells, worsening symptoms.
Acute myeloid leukemia is a cancer that affects blood cells and can lead to infection, anemia, and easy bleeding. The Georgia Cancer Center has received a $2.3 million grant to study how cancer cells resist treatment and propose new options to improve patient survival.
Researchers assembled the largest atlas of post-zygotic genome mutations in healthy human tissue, providing insight into genetic underpinnings of disease. The study found that most detectable mutations occurred later in life, but some arose systematically and predictably as people age.
Researchers at the CNIO have elucidated a key point about how cohesin attaches to DNA and forms loops. The study suggests that NIPBL is not necessary for cohesin to bind to DNA, but only for it to move and form DNA loops. This finding may be important in understanding Cornelia de Lange syndrome.
Researchers identified over 1,000 genes with age-related methylation changes in human sperm. These changes are associated with increased offspring disease susceptibility for neurodevelopmental disorders. The study found no correlation between paternal BMI or semen quality and age-related methylation changes.
A cross-disciplinary team developed a convolutional neural network to analyze microscopy images of chromosomes with cohesion defects. The algorithm achieved 73.1% accuracy in classifying new images, streamlining experiments with chromosome analysis.
Scientists discovered the molecular basis of CAMSAP3's role in stabilizing microtubules, which is critical for cell survival and various cellular processes. The findings provide a key concept to understanding how microtubule dynamics control cellular phenomena.
Researchers at the University of Copenhagen have discovered a new mechanism, called H2A-H2B mediated epigenetic memory, that helps cells preserve their information and functionality during division. This discovery could lead to new treatments for cancer and aging by modulating cellular processes.
Researchers at Osaka University used cryogenic electron microscopy to study the structural change of the centromere during cell division. The study revealed a complex interaction between proteins involved in cell division, providing new insights into the correct division of chromosomes.
Etoposide's impact on DNA structure has been untangled by Cornell researchers using optical tweezers and magnetic tweezers. The study found that etoposide promotes DNA loop trapping and barrier formation by topoisomerase II, enabling the creation of sensitive screening tools for improving patient treatment.
Researchers at IRB Barcelona have discovered the ch-TOG protein's key role in microtubule initiation, crucial for cell functions and division. The protein facilitates the binding of tubulin molecules, enabling microtubule formation and growth.
Researchers at Weill Cornell Medicine have identified a crucial mechanism that prevents cells from replicating extra DNA, reducing the risk of cancer and genome instability. The study reveals that a licensing protein called CDT1 acts as a brake on DNA replication, preventing it from progressing once licensed sites are established.
Researchers identified 17 clusters of single cells in peripheral blood, showing upregulation of antigen processing and presentation pathways and downregulation of genes involved in ribosome pathways with age. The study also found senescent T cells resistant to apoptosis, potentially targeted for treatment.
A new method, iDEMS, uses quantitative mass spectrometry to measure DNA modifications on purified, replicated DNA. This approach reveals that DNA methylation levels increase steadily after replication and are eventually diluted by cell division.
Researchers from Washington University in St. Louis and Purdue University used single-cell data to develop a new framework for understanding the relationship between cell growth, DNA replication, and division in bacteria. They found that individual cells can exquisitely coordinate these processes, despite the 'noisiness' of each process.
Researchers uncover new mechanism of human MCM2-7 complex in regulating replication initiation, offering novel anticancer strategy for selective killing of cancer cells. The study provides high-resolution structural and mechanistic information on the human pre-initiation complex.
Researchers discovered two polarity proteins that accumulate on opposite sides of a cell, acting as a cellular compass to control the development of helper cells. This helps grasses form efficient stomata, optimizing gas exchange and saving water.
Researchers discovered a smart molecular glue formed by proteins clinging to microtubules, enabling nucleus positioning during cell division. The 'glue' enables mechanical forces to be transduced as desired, with flexible properties allowing it to withstand tension.
Researchers discovered that Dis1 protein promotes microtubule shortening in fission yeast through catastrophe, a process where growing microtubules suddenly shorten. This finding challenges the conventional view of microtubule stabilization and has long-term applications for therapy and artificial cell segregation.
G-Quadruplex DNA structures play a crucial role in regulating genes and cell processes, but their visualization is challenging due to the dynamic nature of double standard DNA. Fluorescence-active small molecule probes have emerged as a real-time visualization method, enabling researchers to detect G-quadruplexes with high selectivity.
In a complex process, germ cells produce GRIF-1 protein to mark and degrade maternal RNA molecules, gaining access to their own genetic material. This allows for the development of an entire organism without maternal control.
Researchers have identified a potential new cancer therapeutic target in the cell division enzyme TTLL11. Microtubule polyglutamylation by TTLL11 is crucial for faithful chromosome segregation. In cancer, TTLL11 levels are significantly downregulated, leading to unstable microtubules that favor aneuploid cells.
Researchers found that reducing SAMHD1 levels made brain tumor cells sensitive to chemotherapy drugs and slowed cell growth. They also suspect that glioblastoma alters SAMHD1's function to aid its own survival and treatment resistance.
A new experimental drug has shown promising results in treating liver cancer, with two patients experiencing a partial response to the treatment. The drug, NMS-01940153E, targets an enzyme that plays a critical role in cell division and growth, and its side effects are manageable.
Researchers at the University of Bonn have identified a mechanism that helps dendritic cells migrate more quickly to lymph nodes. The discovery reveals that forming multiple centrosomes enables these immune cells to stay on course longer before continuing their search.
Researchers used Raman spectroscopy to identify and analyze Escherichia coli persister cells, finding they have enhanced metabolic activities despite being in a dormant state. This new understanding could lead to the development of novel therapeutic strategies.