Articles tagged with Cell Migration
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A report by University of Illinois professor Susan Schantz highlights dozens of common chemicals posing risks to fetal and child neurodevelopment. The report criticizes regulatory lapses allowing toxic chemicals into everyday products.
Researchers have found that mixtures of equally sized particles in solution will demix, or sort themselves, if they differ in their diffusion constants. This phenomenon, known as the Brazil Nut effect, was simulated and explained by a theoretical model, showing that random particle motions play a key role in the process.
A recent study found that the presence of Epidermal Growth Factor (EGF) promotes the motility of elongated mesenchymal tumour cells in breast cancer cells, which migrate along collagen fibres. This increased persistence and moderate speed suggests that EGF contributes to modulating the mobility of tumour cells.
Researchers compared two patches, human umbilical cord and biocellulose film, in a rat model of spina bifida. The study found that the umbilical cord patch promoted cellular migration with minimal inflammation, suggesting a potential regenerative material for antenatal spina bifida repair
A prehistoric code on cell surface adhesion molecules regulates cell motility, explaining how cells fine-tune migration in response to different tissue determinants. This discovery has significant implications for understanding cellular processes in cancer and inflammation.
Researchers create spatiotemporal genomic analysis (SAGA) technique to study differences in cellular behavior, including cell migration and response to chemotherapy. This approach may lead to new treatments that hamper metastasis.
High levels of saturated fat in the blood can lead to monocytes migrating into tissues, exacerbating inflammation and tissue damage. This research suggests that maintaining high concentrations of saturated fats may worsen cardiovascular disease outcomes.
E-Cad protein facilitates coordinated movement of diverse cell types, enabling them to migrate together and distribute at their destination. This new function may explain why tumours with intermediate E-Cad levels have a poorer prognosis, highlighting the protein's role in cancer metastasis.
Scientists at McGill University have made a breakthrough in understanding the role of Netrin1, a protein that brings cells together and maintains their healthy relationships. The study used genetic technology to remove all Netrin1 from mouse embryos, revealing a greater disruption of the nervous system than previously thought.
Researchers found that constructing organic solar cells on a 'non-wetting' plastic surface increased efficiency, allowing for larger grain growth and reduced barriers to electricity production. The technique has potential applications in other technologies like faster transistors and more sensitive photodetectors.
Researchers discovered a new protein, Callipygian, which aids in cell migration by shutting off proteins at the front edge of cells. The protein helps create the back of a cell, allowing it to move directionally.
Researchers at the University of Helsinki discovered that cytoplasmic intermediate filaments interact with specific contractile actin filament structures called arcs, which transport intermediate filaments towards the nucleus. Disruption of these interactions leads to defects in cell morphogenesis and shape abnormalities.
Researchers discovered that immune cells are drawn to damaged sites via hydrogen peroxide and a well-established immune signaling pathway. This knowledge could help design therapies to control immune cell behavior and prevent diseases like autoimmunity and chronic inflammation.
Researchers at Kobe University have discovered that membrane tension stress plays a key role in regulating cell motility. This finding has significant implications for treating infections and malignant tumors, as it may help identify new approaches to cancer treatment.
Researchers at the University of Arizona discovered how cells know to rush to a wound and heal it, shedding light on mechanisms of cell migration. They found that biomechanical stress and biochemical signaling orchestrate this process, which can be regulated and manipulated to create new tissues.
Researchers at CNIC identified the molecular mechanism regulating transport of Rac1 between nucleus and cytoplasm. Sustained presence of Rac1 in nucleus promotes nuclear deformation to facilitate cell migration through confined spaces. The study provides potential targets for future therapies.
A PhD student at Brunel University London created a low-cost inverted microscope by adapting a cheap instrument to measure cell motility and study the immune system of snails. The instrument, costing around £160, is significantly cheaper than high-quality equipment that can stretch to hundreds of thousands of pounds.
A team of scientists has uncovered a new mechanism controlling actin-rich protrusions that aid in cell migration, a process essential for development, wound healing, and immunological responses. GMF protein plays a key role in regulating these protrusions.
Researchers created a novel method for cell migration by mimicking the connective tissue environment, allowing cells to move in a controlled direction. This breakthrough could lead to new approaches in combating cancer metastasis and inflammation.
A new study reveals that individual cells' migration speed changes randomly through successive generations, despite the population's average speed remaining constant. This finding has significant implications for cancer treatment and tissue repair, suggesting a target for drugs to modulate cell migration speed.
The MGH device tracks the movement of cells passing through a comb-like array, allowing researchers to study epithelial-mesenchymal transition and its role in tumor metastasis. This process enables cancer cells to break off from primary tumors and invade other tissues.
Researchers discovered a novel conceptual framework that explains how neurons establish spatial polarity and direction using netrin and Wnt signaling pathways. The study found that these pathways work redundantly in guiding cell migrations along different axes.
EPFL scientists have discovered a new relationship between cell shape and migration efficiency, explaining how cells move using a simple model of liquid droplets. The study found that spherical cells are faster movers, and this phenomenon is influenced by surface characteristics.
Physicists Luca Giomi and Antonio DeSimone simulated the spontaneous emergence of cell motility and division in artificial cells using a simplified model. They found that by controlling one physical parameter, they could reproduce similar effects observed in experimental observations.
Researchers at Fox Chase Cancer Center have identified FAK as a potential target for epithelial ovarian cancer treatment. By inhibiting the activity of FAK, they found that STAT3 activation was reduced, suggesting that targeting this enzyme could also inhibit the action of STAT3 in epithelial ovarian cancer cells.
Researchers used Drosophila flies to unravel the signalling mechanism involved in cell movement regulation. A new molecular component controls FGF expression, which is crucial for processes like embryonic development, wound healing and tumour invasion.
Researchers at Johns Hopkins Medicine identified a protein that plays a surprising role in cell migration, which is crucial for cancer cells to spread. The study found that deleting this 'Velcro protein' does not cause single-celled migration, but rather disrupts the organization of epithelial cells.
Researchers at the University of California, Berkeley, used electrical current to direct the movement of epithelial cells, a breakthrough that could lead to controlled forms of tissue engineering. The study demonstrates the potential for 'smart bandages' that use electrical stimulation to aid wound healing.
Researchers at Yale University have made a breakthrough in understanding the cellular mechanisms behind pulmonary hypertension, a life-threatening condition that affects millions. The study identified specific cells responsible for the disease's progression and suggests potential targets for therapy.
Penn researchers found that nuclear stiffness, controlled by lamin-A, affects cell migration and survival. Softer nuclei are more susceptible to DNA damage, leading to cell death, while stiffer nuclei allow for easier migration but compromise DNA protection.
The discovery sheds light on how SecA pushes proteins out of the cell through a series of mechanical steps. This understanding is crucial for developing specific antibiotics and optimizing biotechnological production of human biopharmaceuticals.
Researchers at NUS have discovered that outer skin cells can form suspended bridges during wound healing, paving the way for better wound treatment and artificial skin design. The study sheds light on how skin cells migrate over regions devoid of support from the extracellular matrix.
Researchers at IRB Barcelona discover that a single cell can act as leader during multiple cell migrations in Drosophila melanogaster, dragging others with it. This discovery sheds light on angiogenesis, a critical process in cancer development.
Manipulating protein PRH can hinder the ability of cancer cells to penetrate into neighboring environments, potentially preventing their spread. The findings suggest that PRH regulation of Endoglin may represent a novel method for controlling migration and treating multiple cancers.
A study by IDIBELL researchers has identified a mechanism inducing tumor cell migration in liver cancer, suggesting that patients with overactivated TGFb and high CXCR4 levels may benefit from TGFb inhibitory therapy. The findings provide new insights into the molecular mechanisms underlying liver cancer progression.
A multi-disciplinary study by University of Pennsylvania researchers has illuminated a crucial step in the process of cell movement. The protein Exo70 induces a reshaping of the cell's plasma membrane, necessary for cell migration from one location to another.
Researchers at Scripps Research Institute found a crucial molecular signal guiding brain development in the neocortex. The discovery may aid research on autism, schizophrenia, and other psychiatric conditions by understanding how molecules like reelin regulate neuron migration.
Researchers at the University of Oregon have made breakthroughs in understanding the complex interactions between actin filaments and regulatory proteins. They discovered how tiny synthetic molecules disrupt the activity of a key molecular machine, potentially leading to new therapeutic targets for diseases such as cancer and HIV.
A team of international researchers has identified a self-perpetuating signaling circuit in connective tissue cells that allows them to form a front and back and propel themselves in a particular direction. This propulsion is similar to the movement used by tumor cells to invade healthy tissue during cancer metastasis.
Researchers used X-ray diffraction to image soft tissues in living frog embryos, resolving individual cells and analyzing single-cell migration. The technique provides new insights into embryonic development and its underlying molecular biology.
Researchers at WashU Medicine successfully manipulate immune cells using light to move them towards a beam of light, holding potential for controlling insulin secretion or heart rate. The study uses genetic engineering techniques to introduce a light-sensitive protein into immune cells, enabling them to sense and respond to light signals.
Studies on zebrafish embryos reveal that the protein Nodal triggers a signaling cascade, allowing cardiac progenitor cells to migrate faster and form an asymmetric heart. The research also shows that another signaling molecule, Bmp, reduces cell migration on the left side of the heart.
Scientists at the University of Montreal's IRIC have identified a key mechanism that enables cancer cells to coordinate their movement, allowing them to disseminate efficiently in the body. By understanding this mechanism, researchers hope to develop molecular targets to disrupt collective cell migration and fight metastasis formation.
Adult stem cells have been identified that can migrate to the intestine and produce intestinal cells, suggesting their potential to treat inflammatory bowel disease. The cells were found to express high levels of a receptor involved in tissue repair and wound closure.
Researchers at Stanford have developed a light-emitting probe that can be injected into individual cells without harm. The device uses photonic cavities to amplify light and detect specific biomolecules, paving the way for real-time sensing and monitoring of cellular biology.
Researchers identify new gene associated with Hirschprung Disease and demonstrate how deficiencies in two candidate genes synergize to halt gut nervous system formation. Understanding this genetic basis may lead to better diagnostics and treatment for the condition.
Researchers investigated five cell types in CNS transplantation, finding none showed significant repair benefits. Despite differences in immune responses, only a few cells survived, highlighting the need for further research to better understand cell graft induced tissue damage.
Researchers at Penn State College of Medicine found that targeting km23-1, a motor protein involved in cell migration, can slow the spread of cancer cells. By inhibiting km23-1, cancer therapies may be developed to prevent tumor cells from migrating to other parts of the body.
A team led by Professor Z. Josh Huang has revealed the birth timing and embryonic origin of critical inhibitory brain cells called chandelier cells, tracing their specific paths into the cerebral cortex of mouse brains. This breakthrough sheds light on the genetic programming of brain development and the role of these cells in balancin...
Researchers at Caltech used Caenorhabditis elegans to study cell migration, identifying genes that are active during this process. These findings may lead to the development of new drugs that block cell migration, which is linked to tumor formation and metastatic cancer.
Stem cells found in cord blood have the ability to migrate to the intestine and contribute to its cell population, suggesting a potential treatment for inflammatory bowel disease. The cells' innate ability to form blood vessels may also improve vessel abnormalities found in IBD.
A new model system explores how cells' functional structures assemble through self-organisation. The study reveals that actin filaments, held together by cross-linking proteins and molecular motors, can rapidly compact into highly ordered fibres.
Researchers at the Stowers Institute for Medical Research found that the Arp2/3 complex is essential for forming lamellipodia, which are crucial for cell migration. The study used genetic disruption to investigate the function of Arp2/3 in fibroblast cell motility.
Research reveals that bacteria can cause disease through frontal attack or stealthy manipulation of the host's immune system. Bacteria that destroy phagocytes have low infectivity, while those with high growth rates and quorum-sensing capabilities are more infectious.
The study reveals that Raf-1 regulates cell adhesion, enabling cells to form new bonds and new blood vessels. The discovery may lead to cancer treatment approaches by targeting Raf-1 and disrupting tumor environments.
A new study has found that stomach cells from the cardia region may give rise to esophageal adenocarcinoma, a particularly lethal form of esophageal cancer. The research suggests a link between chronic inflammation and bile acid reflux in the development of this disease.
Researchers at Stowers Institute for Medical Research discovered that oocytes rely on an intracellular flow to push the meiotic spindle into place, setting the stage for asymmetric cell division. This finding may lead to improvements in selecting promising oocytes for in-vitro fertilization.
Researchers at the Trudeau Institute have identified a previously unknown link between the migration of white blood cells to infected tissues and their ability to survive as long-lived memory cells. This discovery aims to improve vaccine efficacy, particularly for the elderly population.
Researchers at Scripps Research Institute found a way to disrupt a critical enzyme interaction that prevents cell death, potentially leading to new treatments for heart attack and stroke. The discovery could provide a new therapeutic target against conditions including neurodegenerative diseases like Parkinson's.
Scientists at Harvard School of Public Health discovered that cells exert forces on their neighbors, leading to a cooperative yet chaotic migration. The study found that collective cellular migration is not a smooth process, but rather an 'organized chaos' with pushing and pulling in all directions.