Articles tagged with Cell Migration
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A study by Fred Hutchinson Cancer Center researchers reveals a signaling protein called Reelin helps brain cells navigate during development. This finding may hold clues to understanding how cancer cells migrate within the body.
Researchers at University of Pennsylvania have discovered a new understanding of how the heart forms in frog embryos. They found that the blood separation comes from an entirely different part of the embryo, known as the 'second heart field'. This finding has implications for human health, particularly for patients with DiGeorge Syndrome.
Scientists have discovered that a gene regulating neuronal cell migration also plays a crucial role in liver organogenesis. The navigation gene nav3a optimizes cytoskeletal modulation, guiding cells to form the liver. Dysregulated expression of nav3a may be involved in human liver diseases.
A new study has provided insight into the evolutionary scenario guiding sensory information projections in different species. Researchers discovered that subtle changes in the migration of 'guidepost' neurons underlie major differences in brain connectivity between mammals and nonmammalian vertebrates.
Researchers studied avian embryos to understand mechanisms of epiboly, a developmental process linked to wound healing and cancer. They discovered new molecules and protein expression patterns that may be unique to the avian embryo.
A study by Albert Einstein College of Medicine researchers found that an enzyme family, katanin, regulates cell motility. Treating this enzyme can encourage cells to migrate in a particular direction to heal wounds. This discovery could lead to new therapeutic agents for conditions like diabetic ulcers and metastatic cancer.
Researchers at North Carolina State University have found a compound that induces intestinal birth defects in frog embryos and also inhibits the growth of cancerous tumors. The compound, dubbed 'heterotaxin,' disrupts asymmetry in organ development and prevents normal blood-vessel formation, cell migration, and adhesion.
Applied physicists found that migrating tissues exhibit similar behavior to colloidal glass, with cells flowing like a liquid until they reach a certain density threshold. This finding has significant implications for biological processes, including wound healing, cancer metastasis, and embryonic development.
A recent IRCM breakthrough reveals a novel molecular mechanism that regulates cell motility, a key factor in tumour spread. The study identifies the ELMO protein's regulatory feature as critical in preventing uncontrolled cell migration.
Robert Langer will receive the Founders Award for his contributions to drug delivery and tissue engineering, while Anita Jones will receive the Arthur M. Bueche Award for leadership in science and technology policy. The awards recognize outstanding achievements that have benefited society.
Researchers at Johns Hopkins Medicine used a laser beam to activate a protein that makes a cluster of fruit fly cells behave like a school of fish, following the lead of one stimulated with light. This study holds potential importance for understanding embryonic development and tumor metastasis.
Researchers at Beth Israel Deaconess Medical Center have identified palladin as a critical regulator of cell motility and migration in breast cancer. By inhibiting these processes, palladin helps suppress breast cancer invasion and metastasis.
A research team investigated S1P receptor expression profiles in human esophageal cancer cells, finding that S1P5 inhibits cell proliferation and migration. This study suggests that S1P5 or its associated signaling molecules may serve as a future biotherapy strategy for esophageal cancer.
Researchers identify Decapentaplegic protein as key player in cell migration, found in healthy Drosophila melanogaster cells. The protein triggers cell mobility and invasion, benefiting metastasis.
Researchers discovered that cell shape influences stem-cell fate, with star shapes promoting bone formation and flower shapes promoting fat production. The study offers a promising direction for further investigation into stem-cell therapies.
Glioblastoma cells use miR-451 to sense glucose availability, slowing cell proliferation and increasing migration. High miR-451 levels correlate with shorter survival, suggesting the molecule as a biomarker for predicting patient prognosis.
Researchers found that human cells follow a bimodal correlated random walk pattern when moving in search of nutrients and growth factors. This discovery provides a general framework for analyzing cell movement, with potential applications in predicting the effectiveness of untested therapies.
Researchers discovered that sceptrin reduces cancer cell motility and limits cell contractility, a critical function for cell movement. The naturally-derived compound and its synthetic version showed effectiveness in combating metastasis in various cancer types.
Researchers at Stanford University School of Medicine have found a protein controlling DNA accessibility responsible for the cells' developmental flexibility, offering insights into CHARGE syndrome and cancer metastasis. The study suggests that increased CHD7 levels may enhance metastasis in certain cancers.
A study by the Cell Transplantation Center of Excellence found that autologous brain cell transplants can provide brain protection and repair neural damage in donor primates. The cells survived at an impressive 50% rate for four months post-implantation, offering a promising new approach to treating neurological disorders.
Researchers discovered that reactive oxygen species are necessary for invadopodia formation, allowing cancer cells to become metastatic. Inhibiting reactive oxygen reduces invadopodia formation and limits cancer cell invasion.
The study reveals that a specific protein, srGAP2, plays a crucial role in controlling the migration and branching of neurons during brain development. By manipulating this protein's activity, researchers were able to observe its effects on filopodia formation and neuronal behavior.
Researchers funded by NIH have found a key factor in the spread of aggressive brain cancer glioblastoma multiforme (GBM). A small designer protein can block the activity of a protein fragment that stimulates GBM cell migration, suggesting a potential new therapy target.
Researchers linked the Disc1 gene to schizophrenia, showing that its disruption affects brain cell migration and development. The study suggests that impaired brain connectivity may contribute to the disease.
Researchers identified the Myosin II-actin machinery powering neuronal migration, revealing how glial cells guide neurons to their correct place in the developing brain. This finding offers new insights into brain organization and could lead to better understanding of disorders like epilepsy and mental retardation.
Research team investigates effect of TGF-beta 1 on intestinal fibroblast migration and differentiation. Short-term incubation enhances migration, while long-term treatment reduces it, with increased FN production.
Researchers identified proepithelin as a protein that encourages cell growth and migration in prostate cancer cells, especially androgen-independent ones. Proepithelin overexpression may serve as a clinical marker for prostate cancer diagnosis and a therapeutic target.
The primary cilium is a vital cellular sensor that detects signals to guide cells toward wounds, promoting efficient healing. Defective cilia impede wound closure and lead to uncontrolled cell migration, potentially contributing to invasive cancers and fibrosis.
A study by University of Utah researchers reveals that interaction between Wnt and Fgf growth factor signaling pathways is crucial for proper collective cell migration. Proper division of labor between the two pathways enables cells to migrate directionally, but defects in these interactions may lead to cancer progression.
Research reveals that blocking avb3 integrin leads to a5b1's increased trafficking and association with EGFR1, activating the Akt pathway and promoting random migration and invasive ability. This study sheds light on the mechanisms underlying metastatic movement in tumor cells.
A study led by Yuntao Wu reveals how HIV triggers a cell process that activates cofilin, allowing the virus to cross the cell membrane. This fundamental understanding may lead to the development of new therapeutic tools to block viral interaction.
Researchers discovered how filopodia extensions are generated and integrated with lamellipodia/ruffles in human cancer cells. The study reveals a complex interplay between these actin-based structures, suggesting that suppression of filopodia is needed for efficient cell migration.
Researchers at University of California and University of Virginia develop novel technique to quantify molecular concentrations and aggregation states in real-time. This new method, N and B analysis, enables fast and spatially resolved imaging of protein interactions in complex cellular processes.
Researchers at the Salk Institute found that early-stage breast cancer cells with high motility pose an increased risk of metastasis. These cells can wander along milk ducts and seed new tumors within the same breast, suggesting a need for earlier intervention.
Researchers found that molecule Sdf plays a crucial role in dictating the pattern of at least one stripe in zebrafish. By studying the effects of Sdf on melanophores, they discovered how this molecule influences their migration and positioning.
A new study by Hopkins researchers reveals that the DISC1 protein plays a critical role in guiding newly made nerve cells into the brain's neural network, allowing them to integrate seamlessly. Abnormalities in this process may contribute to psychiatric disorders like schizophrenia.
Scientists at UC San Diego discovered how cells of higher organisms change their movement speed, a discovery that may help prevent cancer cells from spreading. The study found that the frequency of the cell's motility cycle determines its crawling speed.
Researchers at K-State are examining how nonsteroidal anti-inflammatory drugs damage the gastrointestinal tract. They found that in addition to blocking COX, NSAIDs also affect calpains, important enzymes required for cell maintenance.
Researchers at Deakin University have identified a rogue cell type that may contribute to the spread of breast cancer. By studying a cell model mimicking human breast tissue, they found that abnormal fibroblasts can trigger breast cells to change and migrate.
Researchers have successfully observed cell migration in real-time using a specialized liquid culture medium, shedding light on the nuances of organized cell movement. This breakthrough could lead to strategies for regulating both normal growth and cancer progression.
Scientists have observed paxillin moving from cell surface hubs to the nucleus, highlighting its role in signaling and controlled cell growth. This discovery sheds light on paxillin's interactions with other proteins and its potential involvement in diseases such as cancer.
The University of Virginia School of Medicine has received a $35.7 million grant renewal from the National Institute of General Medical Sciences to continue its Cell Migration Consortium research. The consortium, comprising nearly 40 researchers globally, aims to understand cell migration and its role in diseases like cancer.
Researchers at EMBL track individual cells in transparent fish embryos using advanced microscope techniques to find that they migrate to the right place to form eyes. This discovery suggests that other organs might be formed by individual cell migration rather than sheets of tissue.
Researchers discovered that Snail family genes play a consistent role in controlling body asymmetry in mice and birds, but have a different function in neural crest cell formation. This finding provides surprising new insights into the evolution of developmental biology across species.
Researchers found that compounds binding to CB2 receptor suppress white blood cell migration, a key step in fighting infections and inflammation. This discovery suggests potential therapeutic applications for cannabinoids in treating inflammatory diseases.
Joan A. Steitz and Thomas D. Pollard, two Yale biologists, have been awarded the 2006 Gairdner International Award for their groundbreaking discoveries in understanding autoimmune disease and cell motility. Their work has significant implications for improving human quality of life.
A study published in Developmental Cell identified several hundred genes involved in cell migration and material transport, shedding light on the mechanisms of human cancer spread. The research found that these genes share similarities with those found in human metastatic breast cancer cells.
Researchers at UCSB discovered a genetic pathway that could lead to new treatments for ADPKD. The polycystin-1 protein plays a key role in the disease, and its inhibition may have beneficial effects. This finding opens up new avenues for drug development.
A study published in Nature reveals that a molecular mechanism directs cells to migrate to the correct location within the developing neural tube of vertebrates. The research, conducted by Mount Sinai School of Medicine, identifies specific molecules involved in restoring polarity and guiding cell migration.
Research reveals that tiny biophysical forces play a critical role in tissue formation, enabling cells to migrate and organize into functional structures. The study used computational models and in vitro experiments to demonstrate the importance of slow biophysical flows in establishing morphogen gradients.
Researchers at University of Illinois Chicago have found a new connection between the signaling protein Raf Kinase Inhibitor Protein (RKIP) and cell migration. By studying the compound locostatin, they identified RKIP as a key player in controlling cell movement, suggesting it as a potential target for anti-cancer strategies.
Researchers at UNC have discovered that CIB1 inhibits cell migration in cancer cells by activating PAK1, a kinase that adds phosphate groups to other proteins. This finding suggests that CIB1 may be a potential target for developing new treatments to decrease tumor metastasis.
A new study has identified a protein called DOCK180 that senses chemicals inducing cell migration. This finding may lead to treatments halting cancer metastasis and immune disorders like arthritis and asthma by inhibiting inappropriate cell movement.
Chronic wounds like bedsores affect millions in US, causing widespread infections and limb amputations. Researchers found skin cells get stuck in healing process due to overabundance of c-myc, a molecule that suppresses cell migration and causes thickened layers around the wound.
The study found that PTEN and PI3K are required for cell migration and division, raising hopes for new treatments in cancer and inflammatory disorders. The researchers also discovered a novel mechanism by which cells regulate PIP3 levels to control cell migration.
Researchers discovered that n-cofilin is critical for regulating cell movement. The molecule is essential for cells to migrate and form proper tissues during embryonic development. Its absence can lead to conditions like Spina bifida, where cells fail to reach their destinations.
The Journal of Dental Research (JDR) is now featuring manuscripts from Critical Reviews in Oral Biology & Medicine, enhancing its content and Scientific Impact Factor. The journal will also be made freely available online after 12 months.
Researchers discovered that Thymosin beta-4 prevents cell death after a heart attack and limits scar tissue formation in mice. The protein promotes survival and migration of heart muscle cells, which could lead to new treatments for heart disease in humans.
Researchers at Rockefeller University discovered that the protein Par6-alpha plays a crucial role in spurring the centrosome to action, allowing brain cells to migrate and form the brain's outer layer. The study overturned long-held assumptions about adhesion as the primary mechanism for neuronal migration.
A recent study has identified Wunen2 as a crucial guidance molecule in Drosophila germ cell migration, requiring maternal activity to sustain pole cells during migration. The research suggests a new paradigm for explaining the function of lipid phosphate phosphatases in developmental processes.