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Rapid reactivation of gene expression after thermal stress

Researchers from the University of Osaka have found a way for cells to quickly reactivate gene expression after being stressed by heat. They discovered that the CLK1 protein is regulated by phosphorylation and dephosphorylation, which controls its localization to nuclear stress bodies.

SourceThe University of Osaka·JournalMolecular Cell·TypeExperimental study·DateJul 17, 2026
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Ion and lipid transporters specialize for their niche

Researchers have discovered that ion and lipid transporters have evolved distinct structural features to optimize the transport of their respective substrates. Crystal structures reveal a pump primed for dephosphorylation in Ca2+-ATPase, while a novel mechanism is uncovered in P4-ATPases, enabling efficient lipid flippase activity.

SourceAarhus University·JournalJournal of Molecular Biology·DateJun 10, 2021

Stopping smad

Researchers discovered pyruvate dehydrogenase phosphatase as a key player in the dephosphorylation of MAD, a Drosophila Smad protein. This finding offers new insights into how BMP signals can be downregulated in various physiological contexts.

SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateFeb 27, 2006