Dephosphorylation

The mystery of a neuron-selective staining fluorescent probe, NeuO, has been finally solved after a decade of investigation

Researchers at POSTECH and Korea Brain Research Institute unveil NeuO's mechanism of selective neuron staining through PAK6 kinase phosphorylation. This breakthrough opens path for precise tracking and study of living neurons in brain.

Phosphorylation and dephosphorylation enzyme groups regulate sleep and wakefulness in mammals

A study reveals that protein kinase A promotes wakefulness, while protein phosphatase 1 and calcineurin promote sleep in mammals. The balance between sleep and wakefulness is regulated by multiple enzymes, including PKA, PP1, and calcineurin.

Ion and lipid transporters specialize for their niche

Researchers have discovered that ion and lipid transporters have evolved distinct structural features to optimize the transport of their respective substrates. Crystal structures reveal a pump primed for dephosphorylation in Ca2+-ATPase, while a novel mechanism is uncovered in P4-ATPases, enabling efficient lipid flippase activity.

Sony Alpha a7 IV (Body Only)

Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.

Stopping smad

Researchers discovered pyruvate dehydrogenase phosphatase as a key player in the dephosphorylation of MAD, a Drosophila Smad protein. This finding offers new insights into how BMP signals can be downregulated in various physiological contexts.