Articles tagged with Erythrocytes
A large study of over 1 million patients found no association between red blood cell donation from previously pregnant women and increased risk of death among recipients. The research adds to the growing body of literature on blood donor characteristics and transfusion outcomes.
Researchers tracked and quantified blood cell production from hematopoietic stem cells, revealing that red blood cells are the default pathway for all myeloid progenitors. This finding has important implications for understanding disorders such as anemia and blood cancers.
Researchers at Lobachevsky University discovered that the electrophoretic mobility of red blood cells and buccal epithelium cell analysis can effectively assess stress response severity. These indicators reflect engagement of stress-implementing systems and immune system effectiveness.
Researchers found that icefish have evolved transparent blood, increased energy production, and specialized proteins to protect against cold damage. These adaptations enable them to thrive in Antarctica's frigid waters.
Researchers from Lobachevsky University have discovered that erythrocytes undergo changes in their nanostructure when subjected to stress, which can lead to programmed cell death. This finding has significant implications for the development of optimal treatment regimens for patients with atherosclerosis and coronary heart disease.
Researchers found that infected red blood cells from cerebral malaria patients bind more strongly to brain-derived cells than those from uncomplicated malaria patients. This suggests that specific PfEMP1 proteins on the infected red blood cells allow for efficient binding to brain vessels, a key feature of cerebral malaria.
A first-in-human clinical trial found sutimlimab to be effective in treating severe hemolytic anemia in cold agglutinin disease. The investigational drug rapidly halted red blood cell destruction, increased hemoglobin levels, and eliminated the need for blood transfusions.
A new study found that transfusions of packed red blood cells stored for 22 days or more are associated with a 5% increase in mortality risk in trauma patients. The study suggests that patients who require massive transfusions may benefit from receiving fresh stored packed red blood cells, or those stored for 14 days or less.
A Duke University research team has found a way to detect autologous blood transfusions, a method used by athletes to boost oxygen-carrying capacity. By analyzing RNA changes, researchers can identify stored red blood cells and detect self-transfusions.
Research reveals that malaria parasites exhibit elevated cyto-adhesion during fever, which contributes to microvasculature obstruction and splenic clearance issues. The study found a significant increase in phosphatidylserine expression on infected red blood cells at febrile temperatures.
A study published in PLOS Pathogens reveals how malaria infection triggers the immune system's first line of defense by activating natural killer cells through the MDA5 receptor. Treatment with a small molecule that activates MDA5 restores the ability of non-responder natural killer cells to clear infected red blood cells.
Researchers found that natural killer cells fail to respond to malaria infection in some patients, leading to more severe disease outcomes. By identifying key genes involved, they discovered a potential therapeutic target using poly I:C treatment.
Researchers discovered a mechanism that determines whether immature blood cells differentiate into red or subtypes of white blood cells. The study found that repression of Bach factors contributes to the development of anemia of infection/inflammation, highlighting potential therapeutic targets for treating bone marrow and blood disord...
A new drug-delivery technology called RBC-hitchhiking has been found to dramatically increase the concentration of drugs in specific organs, potentially decreasing side effects and improving efficacy. The technology uses red blood cells to transport nano-scale drug carriers, achieving a 40-fold increase in drug uptake in the lungs.
Researchers at Lobachevsky University explore the use of ozonized erythrocyte mass to correct acute blood loss. The study reveals that ozone treatment improves the rheological properties of blood and microcirculation, reducing tissue hypoxia and promoting rapid recovery.
Scientists have discovered a protein called HRI that regulates hemoglobin production in red blood cells, potentially leading to a breakthrough treatment for sickle cell disease. Blocking the activity of this enzyme reduces characteristic sickling and improves red blood cell function.
Researchers have mapped the first contact between Plasmodium vivax malaria parasites and human red blood cells using cryo-EM technology. The discovery provides critical information for developing potential new antimalarial drugs and vaccines.
A recent study found that receiving a red blood cell transfusion before, during, or after surgery significantly increases the risk of developing postoperative blood clots. The research analyzed data from over 750,000 surgical patients and revealed that these transfusions were associated with an elevated risk of venous thromboembolism.
Researchers at the University of Tsukuba and the University of Dayton discovered a novel gene, Newtic1, expressed in red blood cells that may contribute to adult newt limb regeneration. The study found that Newtic1-expressing erythrocytes play a crucial role in releasing growth factors into regenerating blood vessels.
Researchers developed a new computer model predicting blood flow through capillaries, finding that vessels can switch between even and uneven flow. This study has significant implications for understanding healthy and disease states, and may lead to better prediction of drug transport in microvascular networks.
Researchers at the University of Bristol have developed a method to enhance red blood cell transfusion compatibility using CRISPR-Cas9 gene editing. By altering specific blood group genes, they can prevent immune reactions in patients with rare blood types or those requiring frequent transfusions.
Scientists have engineered red blood cell lines to express fewer antigens, making them less immunogenic for patients with rare blood types. This breakthrough could lead to the development of more universal blood sources for transfusion patients.
The Bajau people's larger spleens enable them to dive longer and deeper by injecting more oxygenated red blood cells into the circulation. Genetic analysis reveals a link between increased thyroid hormone levels and enhanced diving ability in this Southeast Asian group.
A recent study published in Cell reveals that disruptions in blood cell production can lead to anemia, specifically Diamond-Blackfan anemia. The research found that reduced ribosome levels and impaired translation processes contribute to the disorder's development.
Researchers found that a protein called myosin IIA contracts to give red blood cells their distinctive dimpled shape, shedding light on sickle cell diseases and other disorders. The discovery could lead to new treatments for conditions where red blood cells are deformed.
A NIH study found that extra iron interferes with ferroportin, a protein preventing toxic iron buildup and protecting red blood cells against malaria. The researchers also identified a mutant form of ferroportin, Q248H, which appears to protect against malaria in African populations.
A single high-fat milkshake can quickly transform healthy red blood cells into small, spiky cells that wreak havoc inside blood vessels. This study found that such a meal can lead to impaired ability of blood vessels to relax and an immune response similar to one provoked by an infection.
Researchers have discovered that reduced ribosome quantity impairs GATA1 production in blood stem cells, leading to Diamond-Blackfan anemia. This finding supports gene therapy as a potential treatment approach.
A team of researchers used a state-of-the-art simulation code to study the behavior of red blood cells flowing through physiologically realistic microvascular networks. They observed that red blood cells frequently jam for brief periods before proceeding downstream, causing temporary increases in vascular resistance. The findings have ...
A recent study found that transfusing older stored red blood cells can lead to adverse effects in critically ill patients. Free heme, a breakdown product from degraded red blood cells, is thought to be the key culprit behind this toxicity.
Researchers discover first mutation in EPO gene causing increased production of EPO hormone, leading to abnormally high red blood cell mass. The mutation reprograms a second mRNA in the EPO gene, resulting in biologically active EPO production and increased symptoms.
A study of US hospital inpatient discharges from 1993 to 2014 found a decrease in red blood cell and plasma transfusions between 2011 and 2014. This trend may be attributed to the implementation of restrictive transfusion practices aimed at improving patient outcomes and conserving blood.
Researchers at NIH have cured mice with Chuvash polycythemia, a life-threatening disorder that involves overproduction of red blood cells. The study suggests that Tempol or a similar drug may treat polycythemias in humans, such as mountain sickness.
Researchers identified two key proteins crucial for malaria parasites' escape from red blood cells and infection of fresh cells. The discovery offers potential new treatment targets against the deadliest malaria parasite, Plasmodium falciparum.
Researchers found that removing worms allows malaria to grow denser, while worm presence reduces malaria density. Ecological thinking revealed the key to understanding co-infections, offering insights into treating malaria and worm infections.
Scientists use super-resolution microscopy to reveal the fine detail of red blood cells' cellular mesh underlying the cell membrane. They discover that the mesh is a triangular structure composed of proteins, allowing for flexibility and elasticity in squeezing through narrow capillaries.
A study published in Mayo Clinic Proceedings reports significant improvements in HHT patients with severe bleeding treated with intravenous bevacizumab. The treatment reduced nose and gastrointestinal bleeds, allowing patients to stop or reduce blood transfusions, improving quality of life.
Researchers at UVA School of Medicine have discovered a 'complicated symphony' controlling the production of oxygen-carrying red blood cells, shedding light on iron-restricted anemias and potential new treatments. The study identified key proteins and mechanisms involved in the development of anemia.
Researchers studied black carbon aerosols from biomass burning under different combustion conditions, finding varying mixing states. The study revealed intense coagulation during flaming combustion, resulting in a thicker coating on rBC particles.
A new study has identified potassium as the critical component of circadian rhythms in red blood cells. Researchers found that varying potassium levels affected the cell's rhythmic activity, with higher levels impeding the rhythm and lower levels extending its duration.
Researchers announce innovative tools and therapies for hard-to-treat blood disorders, including gene editing platform CRISPR/Cas9. Interim results from a Phase I/II clinical study show restoration of all immune cell types in infants with X-linked severe combined immunodeficiency.
Researchers discovered vasopressin's role in stimulating red blood cell production, with implications for treating anemia after traumatic injuries or chemotherapy. The hormone's effectiveness was demonstrated in mouse models and clinical data from patients with central diabetes insipidus.
Scientists have discovered five new targets that can help create an effective malaria vaccine by reducing the parasite's ability to invade red blood cells. The study suggests combining these multiple factors could lead to a more effective vaccine.
A new deep learning approach has been developed to classify the shapes of red blood cells in a patient's blood, which could help monitor people with sickle cell disease. The system successfully classified red blood cell shape for both oxygenated and deoxygenated cells.
Receiving a blood transfusion from an ever-pregnant female donor is associated with increased mortality among male recipients, but not among female recipients. Transfusion-related acute lung injury (TRALI) is also linked to transfusions from female donors, particularly those with pregnancy history.
A study published in JAMA found that receiving a red blood cell transfusion from an ever-pregnant female donor was associated with an increased risk of death among male recipients compared to male donors. In contrast, mortality rates were similar for female recipients of transfusions from pregnant or non-pregnant female donors.
Even modest oil exposure can cause problems for individual birds and bird populations. The study found damage to circulating red blood cells and anemia in birds, affecting reproduction and survival.
Researchers developed a portable blood analyzer that can detect hemoglobin levels in whole blood samples using optical absorbance. The device is smaller than a toaster and can be used anywhere to monitor anemia prevalence and diagnose related conditions.
A landmark trial found that older stored red blood cells are safe and associated with fewer side effects, including transfusion reactions. The study, published in the New England Journal of Medicine, challenged common practice of allocating the oldest available compatible blood.
A NASA study found that astronaut blood parameters, such as red blood cells and oxygen-carrying proteins, remained higher than pre-flight levels even after adapting to microgravity. The study collected whole blood samples from 31 astronauts over up to six months on the International Space Station.
A recent study found 60 gene variants that affect hemoglobin A1c levels, including one variant unique to African Americans. This variant can reduce the accuracy of A1c blood testing, increasing the risk of underdiagnosis in a population already disproportionately affected by type 2 diabetes.
Scientists have discovered the key trigger molecule that helps mature red blood cells. By removing a hydrophobic molecule from serum using charcoal filters, researchers found that adding back just thyroid hormone triggers red blood cell maturation.
Researchers at Harvard Medical School have identified the mechanism behind red blood cell specialization, controlled by the enzyme UBE2O. The study reveals that UBE2O marks proteins for destruction, allowing precursor red blood cells to become specialized and well-nourished with oxygen.
Researchers at the University of British Columbia developed a novel method to assess malaria progression using RBC deformability, which can indicate hemin-induced oxidative stress. This simple microfluidic device can determine RBC rigidity in minutes, providing a valuable tool for disease diagnosis and treatment.
Researchers used X-ray fluorescence microscopy and soft X-ray tomography to study malaria parasites in liquid nitrogen, gaining insights into their ravaging mode of operation. The findings suggest a potential mechanism controlling the speed of hemoglobin digestion and crystallization, which could be targeted with new medication.
Researchers developed computer models that simulate the assembly of polymer fibers in sickle red blood cells, revealing new details about how different fiber structures produce abnormal cell shapes. The models can also be used to test new approaches to stopping the disease.
Research reveals that naturally produced testosterone in some elite female athletes gives them a competitive advantage in athletics events that depend on stamina and visuospatial abilities. Women with high levels of free testosterone performed significantly better in certain events, such as the 400m sprint and hammer throw.
A newly described protein, PfAP2-I, regulates a number of genes involved with the parasite's invasion of red blood cells, making it an effective target for new antimalarial drugs. Preventing PfAP2-I from binding to DNA and initiating the expression of invasion genes could stop an infection before it reaches the red blood cell stage.
A recent study has shown that a gene variant in Duffy-negative individuals leads to a relative paucity of circulating neutrophils. This phenomenon may provide a selective advantage against infections such as malaria. Researchers believe that the specific properties of these neutrophils have a positive impact on innate immune responses.
A study identified a genetic rearrangement of red blood cell glycophorin receptors that confers a 40% reduced risk from severe malaria. The hybrid GYPB-A Dantu gene is found in some people from East Africa, but not in West African populations.