Articles tagged with Induced Pluripotent Stem Cells
A new study found that schizophrenia's neurobiological mechanisms vary between males and females, with many genes related to the illness expressed differently in each. This suggests that sex-specific treatments may be necessary to address the different underlying causes of schizophrenia in males and females.
Researchers at University of Wisconsin-Madison find pIC accelerates cellular maturation, leading to more mature and functional cardiac muscle cells. The compound activates epigenetic changes, including increased expression of the JAG1 gene, resulting in improved contractility and electrical efficiency.
Researchers find that human iPSCs can efficiently produce highly purified extracellular vesicles for treating aging-related diseases. These vesicles contain proteins and other treatments that can help repair damaged cells, and may one day be used to treat progeria and ALS.
Researchers at Helmholtz Munich discover key molecules in the cell nucleus that orchestrate paraspeckles formation, a structure linked to ALS progression. The discovery provides new insights into pluripotency and differentiation processes, potentially leading to breakthroughs in regenerative medicine and therapeutic strategies for ALS.
Researchers used time-lapse imaging to show that mouse induced pluripotent stem cells differentiated into cardiomyocytes significantly faster at microgravity. The study, published in Stem Cells and Development, suggests a promising area of research for regenerative medicine and manned space travel.
Researchers at Mayo Clinic have created a more efficient method for reprogramming induced pluripotent stem cells, reducing the process from four factors to one. The new system combines genetic cocktails into a single measles virus vector, making it faster and safer for clinical translation.
A study from Osaka University reveals how human pluripotent stem cells can be differentiated into corneal and retinal cells by growing them on specific forms of the protein laminin. The findings show that different laminin isoforms affect cell behavior, density, and interactions, which in turn influence the types of ocular cells produced.
Researchers have discovered a potential treatment for chronic epilepsy using human induced pluripotent stem cells. The study found that grafting these cells into the hippocampus can alleviate symptoms of chronic epilepsy, including reduced seizure frequency and improved cognitive function.
Researchers discovered a link between SCN1A gene mutations and cardiac arrhythmias in epilepsy patients with Dravet syndrome, which may trigger sudden unexpected death. The study found that even after removing the mutated gene, an increase in sodium current occurred, leading to potential heart problems.
Scientists identified and characterized specific types of mutations in individual cell lines, including clonal mutations and subclonal mutations caused by ultraviolet radiation damage. This study aims to improve the therapeutic potential of iPSCs for treating human diseases.
Researchers have developed a new protocol to produce mature human podocytes from induced pluripotent stem cells, offering a robust source for scientific studies and potential cell therapies for kidney diseases. The method has been confirmed to exhibit transcriptomic and protein expression profiles matching those of mature podocytes.
Researchers at University of California San Diego School of Medicine and University of Minnesota have developed a new CAR-T immunotherapy using natural killer cells engineered from human induced pluripotent stem cells. These cells demonstrated heightened activity against ovarian cancer with less toxicity, offering potential advantages ...
Male and female cells behave differently after being reprogrammed into stem cells due to their number of X chromosomes. This affects DNA methylation, a process that changes DNA activity without changing its sequence.
Researchers at Cedars-Sinai Medical Center have developed a new method to study the brain's role in obesity by recreating brain neurons from obese patients' cells. The study found significant differences between super-obese and normal-weight neurons, suggesting genetic mutations may contribute to weight gain.
Researchers at Washington University in St. Louis have developed a new process to generate NP-like cells from human induced pluripotent stem cells (hiPSCs). The team mimicked the embryonic development process to produce nucleus pulposus cells, which could potentially be used to treat degenerative disc disease.
Researchers at Kyoto University developed a gene editing method called MhAX, which creates genetically matched stem cell 'twins' for studying disease-related mutations. The technique guides the cell's own repair mechanisms and allows for precise removal of reporter genes, leaving only the modified SNP behind.
Researchers created human cardiac-muscle patches that significantly improved recovery from heart attack injury in large animals. The patches also reduced infarct size, wall stress, and apoptosis, while preventing arrhythmia.
Researchers used CRISPR-Cas9 to pinpoint epigenetic signals driving cocaine addiction and shed light on rare genetic disorders. They also developed a cellular disease model to probe the neurobiological causes of schizophrenia and identified changes in neural stem cells caused by Zika virus.
A Kyoto-Osaka team uses hiPSCs to develop biodegradable aligned nanofibers as a scaffold for culturing cardiomyocytes, forming robust and functional cardiac tissue-like constructs. These CTLCs show excellent operability leading to favorable heart function recovery in injured rat hearts.
Researchers at Ohio State University Wexner Medical Center created a phenogenetic map for induced pluripotent stem cell models of neurological diseases, linking cell characteristics to genotype. The iPhemap online database shares knowledge and develops new therapies.
A synthetic DNA-targeting molecule called PIP-S2 has been developed to guide human induced pluripotent stem cells into specific cell types. This breakthrough overcomes challenges in current approaches and offers a promising strategy for tissue regeneration.
Scientists have successfully generated dopaminergic neurons in a non-human primate model using induced pluripotent stem cells (iPSCs) derived from adult marmoset monkeys. This breakthrough advances the use of marmosets as a model for Parkinson's disease, enabling the development of regenerative medicine approaches.
Researchers have developed a new approach to create integration-free, Myc- and Lin28-free human induced pluripotent stem cells. This breakthrough method reduces the neoplastic risk associated with IPSC generation, enabling their utility in regenerative medicine and personalized medicine.
Scientists have created a comprehensive, high-quality reference set of human induced pluripotent stem cell lines from 301 healthy volunteers. The resource is available for independent research and will help researchers study common genetic variation to put disease variations in context with healthy people.
Researchers at Boston University's Center for Regenerative Medicine have developed a way to grow and purify the earliest lung progenitors from human stem cells, creating tiny 'bronchospheres' that model cystic fibrosis. The breakthrough could lead to new personalized medicine approaches for treating lung disease.
Researchers have developed a new collection of induced pluripotent stem cells (iPSCs) to study human genetic variation. The iPSCORE collection includes 222 iPSC lines from diverse ethnic groups, enabling researchers to investigate the segregation of traits and their molecular mechanisms.
A collaborative effort analyzed iPS cells to understand how individual mutations contribute to polygenetic diseases, revealing that smaller collections of cells can produce results and identifying small changes in gene expression with dramatic effects on cells. The study also found that some effects manifest before cell differentiation.
Researchers at the University of Tsukuba found that KLF4 promotes metabolic shift towards glycolysis and inhibits oxidative phosphorylation, enabling cells to acquire pluripotency. This discovery sheds light on the mechanisms underlying induced pluripotent stem cell generation.
Researchers at the University at Buffalo have discovered a common genomic pathway that may be responsible for schizophrenia. By studying skin cells from four adults with schizophrenia, they found a dysregulated gene program that affects over 1,000 genes and can lead to the development of the disease.
Researchers have discovered that schizophrenia-linked gene deletions alter the brain's ability of stem cells to differentiate into neurons and astrocytes. HiPSCs from patients with schizophrenia exhibit reduced neurogenesis and increased glial cell production compared to healthy controls.
Researchers at Gladstone Institutes identify a gene mutation that enhances the efficiency of stem cell reprogramming, improving the number of induced pluripotent stem cells (iPSCs) generated from skin cells. This breakthrough could have significant implications for regenerative medicine and drug discovery.
Researchers used Real-time intraoperative magnetic resonance imaging (RT-IMRI) to guide the transplantation of induced pluripotent stem cell (iPSC)-derived neurons into brains modeled with Parkinson's disease. The study found that RT-IMRI guidance enhances cell survival and improves procedure efficacy and safety.
Researchers generated induced pluripotent stem cells from Nijmegen breakage syndrome patients and found that the P53 gene plays a crucial role in neural development, leading to cancer and neurological impairments. The study provides a powerful tool for understanding the disease and may lead to new treatments.
Scientists have developed a technique to convert diabetic foot ulcer cells into induced pluripotent stem cells (iPSCs), which can be used to study new therapeutic approaches and develop disease models. This breakthrough has significant implications for the treatment of non-healing chronic wounds.
Scientists developed guidelines to evaluate laboratory-generated stem cells, finding that no current methods produce truly naïve embryonic cells. The new criteria may aid researchers in achieving this goal, which could benefit both basic research and medical applications of stem cells.
Researchers from Sanford Research successfully modeled Smith-Lemli-Opitz syndrome using induced pluripotent stem cells, highlighting the role of Wnt/β-catenin defects in cholesterol synthesis. The study provides new insights into the underlying cellular mechanisms of this rare developmental disorder.
Scientists create method to differentiate patient-derived stem cells into retinal ganglion cells, which can help combat neurodegeneration in glaucoma. This breakthrough enables personalized medicine prospects for patients with glaucoma.
Researchers have identified a new genetic mutation responsible for Spinocerebellar ataxia (SCA), a degenerative and fatal movement disorder. The mutated Cav3.1 protein, encoded by the CACNA1G gene on Chromosome 17, was found to cause abnormal Calcium ion flow in nerve cells.
Researchers at MUSC have discovered a safe method for producing retinal pigment epithelial-like cells using human proteins, which can be transplanted to treat macular degeneration. The study also found an effective way to repair the damaged Bruch's membrane beneath these cells, rejuvenating the tissue.
Researchers found Activin-A as a candidate drug target for treating Fibrodysplasia ossificans progressive (FOP), a genetic disease where bone grows in soft tissue. The study uses induced pluripotent stem cells and suggests that inflammation could be the key to preventing diseased bone growth.
Researchers successfully transplanted human-induced pluripotent stem cell-derived kidney tissues into mouse kidneys, where the animal's blood vessels connected to the human tissue. The advance allows for the creation of urine-producing kidneys through regenerative medicine.
Researchers at Harvard Medical School have found that some human induced pluripotent stem cells (iPS cells) are genetically identical to human embryonic stem cells (ES cells), suggesting they may be used interchangeably.
Researchers discovered 16 RNA-binding proteins whose depletion affects stem cell pluripotency and identified six RBPs making up the critical protein complex called small subunit processome (SSUP). Enhanced translational activity is crucial for ESC maintenance, while precise regulation of translation rates may influence stem cell determ...
A new method for testing human induced pluripotent stem cells (iPSCs) has been developed, allowing for the evaluation of their differentiation potential. This approach uses pathway activation profiling to identify impaired iPSC lines and predict in vitro differentiation capabilities.
Researchers have identified a histone deacetylase inhibitor that reverses MECP2 alterations in mutant neurons, offering hope for treating the devastating neurological disorder. The breakthrough uses stem cell-derived 'mini-brains' to screen potential drug libraries, providing an efficient method for finding effective treatments.
Researchers at the Centre for Genomic Regulation have discovered a unique genetic switch that guides stem cells into developing specialized heart muscle. The discovery of the Mel18 protein is expected to reveal underlying causes of heart defects and potentially lead to new methods for controlling stem cells in the laboratory.
Researchers discovered that human induced pluripotent stem cells can be differentiated into retinal pigment epithelial cells without immune rejection. This finding provides hope for the development of human stem cell therapies to treat macular degeneration, a condition affecting 30-50 million people globally.
Researchers have designed a model that reprograms fibroblasts to study Duchenne muscular dystrophy development using induced pluripotent stem cells. The study reveals that calcium ion channels may cause muscle degeneration in DMD patients, providing a clear drug target for treatment.
Researchers at MIT and Case Western Reserve University will collaborate to advance understanding of Down syndrome, aiming to improve quality of life for those born with it. The collaboration will focus on developing personalized human stem cell models and testing potential therapeutic treatments.
Researchers at the University of Cambridge have successfully grown 'mini-lungs' using induced pluripotent stem cells derived from skin cells of patients with cystic fibrosis. These mini-lungs can be used to test potential new drugs and provide a more reliable alternative to traditional animal models.
A new study published in The Lancet reports the first evidence of medium-term to long-term safety and tolerability of human embryonic stem cell transplants in humans. hESCs restored sight in more than half of patients with severe vision loss, and no safety concerns were detected after up to 3 years post-transplant.
Cedars-Sinai is part of a 5-center consortium collecting and analyzing thousands of pieces of data to develop molecular signatures for motor neuron disorders. The goal is to create a 'cloud' of information that shows relationships between proteins, genes, and RNA in cells.
Researchers found that neurons from schizophrenia patients secrete higher amounts of dopamine, norepinephrine, and epinephrine. This discovery offers a new insight into the chemical basis of schizophrenia, potentially leading to new drug targets and therapies.
Researchers have shown that stem cells created using different methods produce differing cells, with nuclear transfer ES cells being more similar to real ES cells. The findings could lead to improved stem cell therapies and ultimately, the development of personalized treatments.
A team of researchers led by Professor Kenneth Lee attempted to replicate a controversial stem cell acid bath study published in Nature, but were unable to induce pluripotency in mouse somatic cells. The full experimental results are now available online, providing an open and transparent record of the attempt.
A study reveals that SIRT1 is required for correct and safe cell reprogramming, ensuring healthy functioning of induced pluripotent stem cells. The protein helps maintain telomeres and prevents chromosome aberrations and DNA damage.
Scientists at A*STAR's IMCB develop a method to generate human induced pluripotent stem cells from a single drop of finger-pricked blood. This technique enables donors to collect their own blood samples, potentially boosting recruitment and diversities of donors for large-scale hiPSC banks.
Researchers have found a way to create platelets without donated blood, potentially solving supply shortages and ensuring treatments for all who need them. The new method involves deriving functional platelets from human induced pluripotent stem cells, offering an alternative to traditional blood donations.
Researchers from RIKEN in Japan have identified a duo of histone proteins, TH2A and TH2B, that dramatically enhance the generation of induced pluripotent stem cells (iPSCs). The study demonstrates that these proteins function as substitutes for two Yamanaka factors and increase iPSC cell generation by twentyfold and speed up the process.
A study by Johns Hopkins Medicine found that patients overwhelmingly support stem cell research with induced pluripotent stem cells (iPSCs), despite ethical concerns. Patients prioritize full disclosure of anticipated uses and informed consent to alleviate concerns about privacy and commercialization.