Articles tagged with Lysosomes
A team of researchers at Osaka University has identified a specific enzyme complex that initiates the removal of damaged lysosomes from cells. The complex, composed of CUL4A, DDB1, and WDFY1 proteins, acts preferentially during lysophagy to facilitate the degradation process.
Researchers at the University of Pittsburgh have identified a universal mechanism for lysosomal repair, known as the PITT pathway, which helps maintain cellular longevity. The study reveals that damaged lysosomes are quickly repaired through the PITT pathway, but defects in this process can contribute to age-related diseases such as Al...
Researchers at the University of Würzburg have found that fluoxetine and its analogue AKS466 can inhibit SARS-CoV-2 coronavirus replication by trapping it in lysosomes and suppressing acid ceramidases, a new potential target for antiviral therapy.
University of Cincinnati researchers have discovered a technique using light-activated proteins to normalize dysfunctional mitochondria in cells. This method has the potential to treat certain diseases, including cancer and neurodegenerative disorders.
Researchers have discovered a common thread between multiple neurodegenerative diseases, including Alzheimer's, dementia with Lewy bodies, and frontotemporal lobar degeneration. A protein called TMEM106B forms fibrils in diseased brain tissue, potentially hobbling cells.
Researchers from NYITCOM are using a new imaging technique to study diabetic heart failure and its causes. They hope to develop new treatments by tracing how lysosomes, the body's defense system, are impaired in heart muscle cells.
Researchers at University of Cincinnati develop a new probe and imaging technique to study lysosomes, aiding in cancer and neurodegenerative disease research. The probe, known as EC Green, enables multidimensional analysis of lysosome dynamics and provides stable tracking capabilities.
Researchers discovered nine genes in S. mansoni's autophagy pathway inhibited by the primate's immune system, preventing parasite multiplication and contaminating the host. The study suggests a potential novel therapy and vaccine against schistosomiasis.
Researchers have discovered a new pathway of cell death, lysoptosis, which can be triggered in cervical cancer cells by the absence of SERPINB3 protein. This process is different from apoptosis and can be activated by chemotherapy and radiation stress.
Researchers at Japan Advanced Institute of Science and Technology develop a novel strategy to quickly separate intact lysosomes with high purity using magnetic-plasmonic hybrid nanoparticles. The technique allows for rapid extraction of lysosomes from cells, reducing the time required compared to existing methods.
Researchers discover that a slightly acidic environment is conducive to the formation of Alzheimer's disease-causing toxic protein aggregates, known as Aβ oligomers. The study also reveals that endosomes and lysosomes play a crucial role in their development.
Researchers found that α-syn fibrils spread through lysosomes, impairing their function and allowing the seeding of soluble α-syn. This process creates a hub for the propagation of disease pathology, shedding light on a crucial mechanism in Parkinson's disease.
The research team established a single lysosome mass spectrometry platform to analyze the metabolic heterogeneity of various lysosome types in cell aging. They found that each type of lysosomal subset exhibited distinct metabonomics changes, indicating lysosome type specificity in cellular aging.
A new study using expanded genetic code technologies uncovers the structural aspect of how one protein functions in lysosomes for intracellular clearance. The research reveals that the homophilic interaction between LAMP2 molecules is crucial for their function on the lysosome membrane.
A rare PLD3 mutation in Alzheimer's patients disrupts lysosomal recycling, leading to fewer β-amyloid plaques and less cognitive decline. Boosting PLD3 may have a protective effect against the disease.
A new study reveals a close link between proteins causing Alzheimer's disease and age-related sight loss, with findings showing toxic molecules accumulate in retina cells. The research also suggests that anti-amyloid beta drugs may be repurposed to treat age-related macular degeneration.
A new study reveals that genetic variations associated with Parkinson's disease alter the action of ion channels within lysosomes, a cellular organelle responsible for waste removal and recycling. These variations increase or decrease disease risk by influencing the function of an ion channel in cells' recycling centers.
G3BP proteins inhibit MTOR, a key signaling protein in tumor diseases and developmental disorders, preventing excessive metabolic activity and cell growth.
Scientists have identified G3BP proteins as a crucial molecular mechanism that inhibits MTOR activity, leading to cancer cell migration and neuronal hyperactivity. Inhibiting MTOR with existing drugs shows promise in treating breast cancer and neurological disorders, such as epilepsy.
Tiny components within cells, such as lysosomes, drive the movement of the endoplasmic reticulum (ER), a key organelle responsible for protein production. This discovery has significant implications for understanding and treating neurodegenerative diseases like Parkinson's and Alzheimer's.
A mutation in the CLCN6 gene has been identified as a cause of a novel, severe neurodegenerative disease affecting three unrelated children. The condition is characterized by developmental delay, intellectual disability, and progressive brain atrophy.
Scientists discovered that radioresistant cancer cells' invasiveness increases following radiotherapy, thanks to upregulated lysosome trafficking. The Arl8b molecule plays a key role in this process, while the BORC complex is required for its interaction with lysosomes.
A UNIGE team discovers that a single gene mutation affects every skin color in corn snakes, storing both pigments and crystals in lysosome-related vesicles. This study marks a significant step forward in understanding the origin of colors and patterns in vertebrates.
A team of researchers from Osaka University has identified the crucial role of lipids, lysosomes, and autophagy in preventing kidney injury. By understanding how calcium, lipids, and lysosomal degradation interact, scientists can develop new treatments for kidney damage caused by crystal-induced injuries.
Researchers have identified a gene, TMEM106B, as a risk factor for neurodegenerative diseases such as Alzheimer's and frontotemporal dementia. The study found that a mutation in this gene disrupts the formation of myelin sheaths around nerve fibers, leading to neurological defects.
Researchers discovered that lysosomes are active during mitosis and selectively degrade specific proteins, leading to a toroidal nucleus morphology that may indicate chromosomal instability. This finding provides a new perspective on the connection between autophagy and cell division in cancer and other diseases.
A study by Baylor College of Medicine researchers reveals that defective CLN6 causes toxic waste accumulation in cells, leading to progressive degeneration and cell death. The researchers found that CLN6 works together with CLN8 to transport enzymes to lysosomes, and when CLN6 is defective, this process is impaired.
Researchers have developed a CRISPR-Cas9 method to optimize proteins in mammalian cells, producing the fluorescent protein mCRISPRed that labels lysosomes. This technique enables targeted protein diversification and validation within organelles, opening new possibilities for biosensors, receptors, and therapeutic proteins.
Researchers found that increased lysosome numbers lead to hyperactivation of mTOR, stimulating abnormal cell growth. The study identified Rap1 as a regulator of lysosomal network organization and lysosome number, highlighting the central role of lysosomes in cancer progression.
Researchers have discovered a novel approach to selectively target and kill several types of cancer cells using nanoparticles that assemble into crystals. The crystals induce lysosomal swelling, loss of membrane integrity, and cell death in cancer cells but do not harm non-cancerous cells.
Researchers Alyssa Johnson and Adam Bohnert have discovered a new class of lysosomes, dubbed 'tubular lysosomes,' which can form complex networks that affect aging, disease, and stressors. Their findings could lead to medical therapies and treatments to extend health and longevity in humans and animals.
A recent study by KU Leuven researchers has discovered a link between a defective ATP13A2 gene and cell death in Parkinson's disease. The study found that the gene plays a crucial role in transporting polyamines, essential molecules supporting various cellular functions.
Researchers discovered that a rise in pH within lysosomes causes iron depletion, leading to cell death and inhibition of proliferation. This finding has implications for understanding and treating diseases, including cancer.
FerriIridium, a novel drug, can diagnose and treat gastric cancer by selectively activating in tumor cells. The iron-based compound reduces side effects by targeting cancer cell mitochondria, leading to their destruction.
Researchers found that beta-blockers can cause psoriasis by interfering with the breakdown of defective cell components and disrupting autophagy. This leads to the release of inflammatory messengers, resulting in skin problems. The study suggests that fat-soluble beta-blockers are more likely to cause inflammation.
Researchers found that RNA granules use Annexin A11 to hitch a ride on lysosomes, which are highly mobile organelles. This transportation method is crucial for RNA to reach its destination and translate into proteins, but mutations in annexin A11 have been linked to ALS.
Researchers found that neurons use annexin A11 to ship internal housekeeping instructions via a 'hitchhiking' system, which may lead to new treatments for ALS. Disease-causing mutations tie up deliveries at the cell's loading docks, preventing RNA delivery to neurons.
Researchers at UC Riverside propose a new theory for Alzheimer's disease, pointing to lysosomal storage as the underlying cause. Long-lived proteins like beta-amyloid and tau undergo spontaneous modifications that make them undigestible by lysosomes, leading to cellular damage.
A defective degradation enzyme leads to the accumulation of gangliosides, causing deterioration in patients with storage diseases. Researchers have discovered that genetic disorders can trigger a cascade of consequential damages.
A collaborative study improves understanding of ALS by identifying a key role for ubiquilin proteins in regulating cellular waste. The researchers found that mutated ubiquilins fail to regulate lysosomes, leading to excess waste buildup and disease development.
A new study by Baylor College of Medicine researchers discovered two independent mechanisms contributing to tuberous sclerosis, a rare genetic disease. Glycogen accumulation is linked to mTORC1 hyperactivity in some cases, while other TSC2 mutations trigger defects in lysosome formation and glycogen digestion.
Researchers at Baylor College of Medicine have discovered a new mechanism for neuronal ceroid lipofuscinosis 8, a form of Batten disease. The study found that the CLN8 protein plays a crucial role in facilitating the transfer of lysosomal enzymes from the endoplasmic reticulum to the lysosome.
A University of Colorado Cancer Center study reveals that inhibiting the action of lysosomes can efficiently kill metastatic cancer cells. Researchers found that the level of a protein called ID4 predicts which cancer patients will benefit most from treatment with chloroquine.
Researchers have developed a gene therapy approach to treat GM2 gangliosidosis, a devastating neurodegenerative disease. The treatment has shown promising results in mouse models and is now being tested in clinical trials using recombinant Adeno-associated viruses for gene transfer.
Researchers developed a technique to visualize mitophagy, the process by which cells recycle their energy factories, with a new bioimaging technology. The study could provide diagnostic information for degenerative brain diseases.
Scientists at Northwestern University discovered that mitochondria and lysosomes directly contact each other in cells to regulate their functions. This rare finding has important implications for understanding normal aging and diseases such as Parkinson's and cancer.
A study has found a connection between genetic mutations in lysosomal storage disorders and an increased risk of developing Parkinson's disease. Researchers analyzed the largest available Parkinson's disease genetic dataset, discovering that nearly half of those with the disease carried damaging mutations in these genes.
Researchers have uncovered a critical connection between cellular nutrient sensing and cell growth, implicating a new protein SLC38A9 as a potential therapeutic target for pancreatic cancer. By probing lysosomal biochemical content, the team identified SLC38A9's role in regulating amino acid availability.
Researchers detect granulins inside cells for the first time, suggesting a potential FTD treatment strategy by targeting lysosomal function. The discovery may have therapeutic potential for Alzheimer's disease and Parkinson's disease as well.
Researchers found that impaired lysosome transport contributes to protein aggregate buildup in brains of mice with Alzheimer's. Developing ways to restore lysosome transport could represent a new therapeutic approach.
A team of scientists at UC San Diego has found that lysosomes can travel to distant parts of neurons' dendrites and branch-like areas, playing a key role in remodeling and plasticity. This discovery may provide new insights into the development of neurodegenerative diseases.
Scientists at LMU Munich have developed a method to study ion channels in membrane vesicles with greater specificity. They screened compounds that selectively induce the enlargement of early and late endosomes, allowing them to characterize TRPML3 and TRPML1 channels.
Researchers at DGIST have identified a mechanism to reverse cellular aging and promote recovery through the inhibition of ATM protein. By activating lysosomal functions, they were able to restore cell division capacity and induce wound healing in aging animal models.
A team of researchers has discovered a novel approach to treating juvenile Batten disease by activating a protein called TFEB, which stimulates the cell to produce more lysosomes and degrade cellular waste. This breakthrough may lead to improved neurological symptoms in patients with the condition.
Researchers found that a manufactured version of progranulin reverses most effects of Gaucher's disease in mouse and human cell studies, including GBA accumulation. Progranulin must bind to other molecules to transport the enzyme to lysosomes.
Researchers at the Babraham Institute successfully tagged a protein in the mTORC1 complex to observe its movement in real time. The discovery sheds light on how mTORC1 regulates cell growth and ageing, revealing new insights into its dynamics and signalling pathways.
A new therapeutic strategy targeting a shared Achilles' heel of all Ebola viruses has shown promising results. Two monoclonal antibodies blocked the invasion of human cells by all five ebolaviruses, and one protected mice exposed to lethal doses of Ebola Zaire.
Researchers have identified a critical protein associated with Alzheimer's disease symptoms, suggesting a new target for therapy. The study shows that increasing p62 levels may reverse the effects of damaging plaques in the brain through autophagy.
A study by Duke Health and Duke-National University of Singapore Medical School reveals bladder cells' secreted chemicals can clear urinary tract infections. The research suggests new targets for developing remedies and provides insights into the herb Forskolin's impact on UTIs.
Researchers at the University of Michigan have discovered a protein that acts as a powerful protectant against free radicals, which cause cell damage and death. The protein is activated by excessive free radicals and helps to regulate autophagy, a process that reduces oxidative stress and slows down aging.