Articles tagged with Lysosomes
Researchers discovered that saposin B binds to the anti-malarial drug chloroquine, potentially leading to toxicity due to prolonged binding instead of removing damaged lipids. This finding opens up new avenues for investigating saposin B's role in other conditions, such as lysosomal storage diseases.
Researchers at the Tata Institute of Fundamental Research found that cholesterol-rich domains on phagosome membranes facilitate the transport of pathogens to lysosomes for degradation. This process is disrupted by certain parasites, potentially allowing them to survive and spread infection.
Research from the Buck Institute suggests that excess iron impairs cellular recycling in Parkinson's disease, resulting in toxic oxidative stress. The study highlights the importance of maintaining a healthy balance of iron within cells to prevent neurodegeneration.
Dendritic cells (DCs) process and present antigens to cytotoxic T cells through cross-presentation. Researchers found that a delayed fusion between phagosomes and lysosomes enhances antigen presentation. This mechanism helps DCs induce effective immunity against pathogens, while preventing the uptake of 'self' antigens.
Mutations in calcium channel genes disrupt autophagy in neurons, leading to neurodegeneration. Calcium channels play a key role in regulating autophagic vesicle fusion with lysosomes, maintaining neuronal homeostasis.
Scientists have discovered a new role for voltage-gated calcium channels (VGCCs) in neurons, which play a critical role in cellular 'garbage disposal' processes. VGCCs are found not only on the synaptic membrane but also in lysosomes, where they facilitate lysosomal fusion and autophagy.
Researchers at The Scripps Research Institute have identified a new cellular pathway affected in cystinosis, which could lead to new drug treatments for reducing or preventing renal failure. The study found that concentrations of LAMP2A, a lysosomal surface protein, were down by 50-80% in cystinotic cells.
Researchers found that B cells from mutant mice with M6P deficiency and patients with mucolipidosis II present similar defects in antibody synthesis, indicating a critical role of M6P in B cell function. Other immune cells, such as dendritic cells and T cells, were less severely affected.
Scientists at Washington University School of Medicine have identified a rare genetic disease caused by the misplacement of a normal protein, phosphotransferase. The protein ends up in the lysosomes, causing a shortage of enzymes and leading to skeletal and heart abnormalities.
A team of researchers led by Professor Jean Gruenberg has identified an exit in the cellular garbage truck, a structure responsible for sorting molecules and ensuring inter-cell digestion and regulation. The study reveals how Alix protein uses this route to avoid cellular digestion and how vesicular stomatitis uses it to infect cells.
Researchers at VIB and Oxyrane have created a new technology that produces enzymes for metabolic disorders like Pompe disease more efficiently than current treatments. The novel method uses yeast cells instead of mammalian cells, resulting in 17 times more efficient absorption by patient cells.
Researchers at Imperial College London have identified a way in which Salmonella bacteria counteract human cell defenses. The study found that Salmonella injects a protein that prevents cells from recycling transport carriers, effectively cutting off the supply line of toxic enzymes.
A new transport protein, ABCD4, has been identified as responsible for the transfer of vitamin B12 from lysosomes into cells. This discovery provides evidence for another cause of hereditary vitamin B12 deficiency and enables diagnosis and treatment.
Scientists have discovered a 'constant cloud' of potent inflammatory molecules surrounding the cells responsible for diseases like thickening of the arteries and rheumatoid arthritis. Monocytes, a type of white blood cell, were found to be surrounded by this constant cloud, which was propelled through the cell wall by lysosomes.
A University of Michigan team has identified a synthetic small molecule that can activate lysosome calcium channels, potentially treating rare inherited metabolic disorders and neurodegenerative diseases. The discovery could also provide insights into the aging process.
A new study found that mutations in a gene called NAGPA, which affects lysosomal function, are associated with persistent stuttering. The research provides evidence that impairment in cellular recycling centers may play a role in causing some people to stutter.
A recent study by Dr. Andrea Ballabio and colleagues discovered a key role for transcription factor EB (TFEB) in regulating lysosomal exocytosis, which can rescue cells from toxic waste buildup. The findings suggest an innovative approach to treating metabolic disorders associated with lysosomal storage diseases.
Researchers have identified a master gene controlling lysosome and autophagosome function, shedding light on rare genetic diseases and neurodegenerative disorders. The discovery may lead to new therapeutic approaches for inherited conditions like Tay-Sachs and Alzheimer's disease.
Researchers developed a new infrared light probe to study lysosomes, which could help diagnose and treat tumors. The breakthrough allows for longer periods of imaging without limitations.
The study reveals that chloride ion accumulation in lysosomes is crucial for protein degradation, rather than just acidification. This finding has significant implications for understanding kidney stone disease and neurodegeneration.
Researchers at IDIBAPS and University of Barcelona discover a new breakdown pathway for the KRas protein, which is actively transported from cell membrane to lysosomes. This finding could lead to new therapeutic strategies against cancer and diseases involving abnormal lysosome formation.
A glitch in iron transport may underlie Type IV mucolipidosis (ML4) and related symptoms like mental retardation and diminished motor abilities. The same deficit is also implicated in aging and neurodegenerative diseases such as Alzheimer's and Parkinson's, leading to potential new avenues for treatment.
A new study reveals that protein SRP-6 can regulate cell death and potentially halt the progression of cancer, stroke, and heart disease. The research team discovered that SRP-6 can target the lysosome, protecting cells from stress and injury.
Researchers at Yale University have discovered how Campylobacter jejuni enters intestinal cells and avoids destruction. The bacteria creates its own intracellular network of vacuoles, diverting from the conventional endocytic pathway.
A new task for IgG has been discovered, helping cells capture germs and dispose of them. The antibody aids in the formation of phagolysosomes that kill off invading microbes.
Certain bacteria, such as Rhodococcus equi, have evolved strategies to survive and even multiply within macrophages, which are intended to digest pathogens. This occurs when the bacteria prevent phagosome development, avoiding acidification and lysosomal digestive enzymes.
Researchers identified mutations in the sialin protein, responsible for transporting sialic acid out of lysosomes. The study found that even milder forms of the disease involve reduced transport activity and potential therapeutic targets.
A team of researchers at the University of Rochester Medical Center discovered that a genetic defect affects lysosome protein arginine regulation, causing Batten disease. This condition leads to lysosomes malfunctioning and cells swelling with waste, ultimately killing brain cells and resulting in severe medical problems.