Articles tagged with Muscle Cells
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Researchers have discovered that adult hearts contain stem cells capable of regenerating muscle tissue lost due to disease or wear. These findings open the possibility for the development of restorative therapies following heart attacks and other cardiovascular diseases.
Researchers found that supplementation with whey isolate and creatine increased muscle fiber size and strength gains, particularly in fast-twitch fibers. The study suggests that dietary strategies enhancing resistance training outcomes have significant implications for athletes and individuals with muscle-wasting conditions.
Researchers have successfully transformed mouse stem cells into heart muscle cells using vitamin C, a breakthrough that could lead to new treatments for heart failure. The study found that the cells exhibited cardiac myosin and actin, and beat spontaneously, suggesting a potential path forward for clinical applications.
Researchers have found that red blood cells cannot repair tears in their surfaces due to the lack of internal membranes, confirming a decade-old hypothesis. In contrast, muscle cells can rapidly repair tears by sealing them with a large internal membrane.
The FKHR gene helps myoblasts fuse into muscles, but a deficiency contributes to muscle cancer. FKHR's dual role is regulated by different processes depending on the cell context.
Researchers have pinpointed a genetic defect in the phospholamban protein as the cause of inherited dilated cardiomyopathy. The discovery may lead to targeted treatment for this disorder, which affects 4.7 million Americans and costs $17.8 billion annually.
Dr. Rossant and colleagues find that Flk1 and Tal1 proteins steer embryonic cells towards endothelial, hematopoietic, or smooth muscle fates. The study provides further evidence for a common hemangioblast progenitor cell, which can differentiate into the three cell types.
Researchers create device that measures muscle cell forces by measuring displacement of individual needles. The study reveals the relationship between cell shape and contraction force, as well as resolving conflicting scientific reports on cellular forces.
Researchers have successfully transmitted electrical signals in rat hearts using tissue-engineered cells, which may lead to a new treatment for heart block. The cells formed connections with cardiac cells and developed an electrical pathway within 10 weeks of implantation.
A recent study has provided the first direct evidence that transplanted muscle cells can form muscle fibers and blood vessels in damaged hearts. Satellite cells from patients' thigh muscles were injected into their heart tissue, surviving and differentiating into mature muscle fibers without triggering an immune reaction.
Researchers have found that deacetylase inhibitors enhance muscle gene expression and formation in human and mouse myoblasts. This discovery may lead to methods to induce muscle growth, regeneration, and repair in adults with muscular dystrophy.
Penn researchers have identified a key gene, Hop, that plays a vital role in regulating the development of heart cells. By inhibiting the expression of another important regulator, serum response factor (SRF), Hop protects cardiac muscle cells from over-development and fatal abnormalities.
Researchers at Johns Hopkins Medicine have successfully created a biologic pacemaker using gene therapy in guinea pigs. The new pacemaker allows heart cells to regulate their own rhythm, potentially providing an alternative to traditional electronic pacemakers for patients at high risk of infection or with limited space for implantation.
A boy with Duchenne muscular dystrophy (DMD) and severe combined immune deficiency (SCID) had bone marrow donor cells present in his muscle fibers 13 years after a transplant. Mesenchymal stem cells from the donor's bone marrow may be continuing to produce muscle cells, potentially reducing disease severity.
Researchers successfully converted circulating smooth muscle progenitor cells into functional smooth muscle cells, which could help address interventional cardiology problems. The study may pave the way for therapeutic angiogenesis by preventing or eliminating the adhesive properties that contribute to plaque formation.
Researchers at Dana-Farber Cancer Institute discovered a chemical switch called PGC-1 that can transform fast-twitch fibers into slow-twitch fibers, increasing muscular endurance. This finding could lead to the development of a new drug to manipulate muscle fiber type and improve muscular function in patients with medical conditions.
Researchers at the University of Pittsburgh School of Medicine have developed a promising new therapy for urinary incontinence using muscle-derived cells. The therapy, which uses genetically engineered muscle cells to replace damaged bladder muscles, shows long-term effectiveness in improving bladder function.
Researchers at the University of Pittsburgh have discovered a unique population of muscle stem cells that can be transplanted into mice with Duchenne muscular dystrophy, delivering the key protein dystrophin and improving muscle regeneration. The study suggests these cells may hold promise for treating the genetic disease.
Research on Fas signaling reveals its involvement in the development of cardiac hypertrophy, a condition characterized by abnormal heart growth. Understanding this mechanism is crucial for developing effective treatments to manage cardiac hypertrophy and associated diseases.
Researchers at USC have discovered an increase in BACE enzymes in patients with inclusion-body myositis (IBM), a crippling muscle disease. The findings suggest that cholesterol may play a role in the production of toxic amyloid-ß protein, which could lead to new treatment options for both IBM and Alzheimer's disease.
A study by Michigan Medicine researchers found that high oxygen levels can be toxic to stem cells, converting muscle cells into fat cells. This discovery has important clinical implications for the treatment of obesity and diabetes, as it may be related to aging and oxidative stress conditions.
QSulf1 enables embryonic cells to express muscle-specific proteins by modifying signaling co-factors. This discovery sheds light on the complex process of cell differentiation and has implications for regenerative medicine.
A new enzyme increases the number and size of heart muscle cells in mice, allowing them to live longer. This discovery could lead to gene-based therapies for heart disease, with potential benefits for millions of Americans affected by the condition.
Early atherogenesis is characterized by the infiltration of lymphocytes into atherosclerotic plaques. Lymphocytes contribute to the development and progression of atherosclerosis through various mechanisms, including inflammation and immune response activation.
Researchers successfully produce widespread transfer of corrective genetic material into muscle cells using a naturally-occurring hamster model. The technique, developed by Penn researchers, overcomes the existing problem of accessing millions of muscle cells requiring genetic re-engineering.
A new study at Ohio University found that changes in muscle cells with aging limit muscle growth, and the number of special cells required for muscle growth decreases as people age. This reduction limits how much a muscle can grow.