Articles tagged with Muscle Cells
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Researchers at Stanford University School of Medicine confirmed that satellite cells harbor an elusive muscle stem cell, which can self-renew and give rise to specialized progeny. This discovery has profound therapeutic implications for disorders like muscular dystrophy and muscle wasting due to aging.
A study published in PLoS One found that a restricted-calorie diet can reduce iron accumulation in muscle cell mitochondria, which can contribute to muscle loss in aging adults. The research suggests that reducing caloric intake early on may help limit muscle wasting in later years.
A new study reveals that laminin influences post-synaptic patterning by corraling cell surface receptors on the muscle side of the synapse. Maturation of the muscle side was slowed in mice lacking specific laminin chains, highlighting the protein's role in coordinating nerve and muscle fiber development.
Researchers at Dana-Farber Cancer Institute discovered a molecular switch that can convert muscle precursor cells into brown fat cells, which burn calories and release energy. The breakthrough could lead to new treatments for obesity by activating the calorie-burning process in the body.
Researchers focus on two muscle fibre types to achieve tastier cuts of meat without sacrificing production values. The study aims to identify genes important in slow muscle growth, enabling farmers to breed naturally flavorful and succulent meat.
Researchers have shown that purified stem cells isolated from adult skeletal muscle can restore healthy muscle and improve muscle function in mice with muscular dystrophy. The injected cells also replenished the pool of regenerative cells normally found in muscle, allowing the treated muscle to undergo subsequent rounds of injury repair.
Researchers have developed a novel gene delivery approach that targets smooth muscle cells in blood vessels, offering a new paradigm for cell-specific gene delivery. The approach uses an electric field to transiently permeabilize plasma membranes and a specific DNA sequence to control nuclear entry.
A recent study published in Circulation has uncovered the mechanisms by which low blood flow contributes to vascular disease. The research found that cyclophilin A plays a dual role in promoting inflammation and pathogenic growth, highlighting its potential as a target for developing new treatments against atherosclerosis.
A team of Japanese scientists has designed the world's first optical pacemaker for laboratory research, utilizing powerful laser pulses to regulate heart muscle cell contractions. This breakthrough technique may aid in understanding uncoordinated heart contractions and developing anti-fibrillation drugs.
Researchers from Germany and Austria used muscle-derived stem cells to repair damaged sphincters. Patients showed significant improvements in continence, with some being completely continent after treatment.
Researchers discover that myoepithelial cells play a critical role in regulating breast tumor progression and can act as 'gatekeepers' for the transition from in situ to invasive carcinoma. Understanding their pathways may open new avenues for cancer therapy and prevention.
Researchers at University Medical Center Utrecht have successfully grown large numbers of stem cells from adult human hearts into new heart muscle cells. The stem cells can be used to study cardiac arrhythmia, test new medicines, and potentially repair damaged heart tissue. This breakthrough in stem cell research could move forward res...
Scientists at the University of North Carolina at Chapel Hill found that not all heart cells respond equally to the same cue before differentiating. This discovery may lead to advances in understanding and treating congenital heart disease and heart attacks by identifying multiple types of heart cell progenitors.
Researchers at the University of Pennsylvania School of Medicine have discovered that leiomodin (Lmod) promotes the assembly of actin in heart muscle cells, directing it to form the pumping unit of the heart. The findings suggest Lmod could be relevant to cardiac muscle disease and require further study.
The SEISMIC study found that injecting muscle cells into scarred areas of the heart improved patients' symptoms, including increased walking distance, but did not improve heart function or size. Researchers concluded that cell therapy is feasible and may provide symptom relief for heart failure patients.
Researchers found that ranolazine shortens the QT interval by about 5 percent and improves myocardial relaxation in patients with LQT3 mutation, providing a potential treatment for two conditions. The drug also showed benefits in improving left ventricular relaxation and increasing mitral E-wave velocity.
Researchers found a significant decline in muscle fibers in the diaphragm after just 18 hours of mechanical ventilation. The study's results suggest that intervening in the molecular pathway responsible for muscle wasting could lead to the development of a new pharmacological approach to safely wean patients off ventilators.
Researchers tested Debio-025, an antiviral drug, on mice with muscular dystrophy and found it reduced mitochondrial swelling and cell death. The study suggests a new treatment strategy for Duchenne muscular dystrophy and may have implications for other degenerative disorders.
Dr. Lin Mei received the 2008 Mathilde Solowey Lecture Award for his groundbreaking research on neural circuitry formation and synaptic plasticity. His studies have revealed potential causes of schizophrenia and seizures, as well as new treatment targets for psychiatric diseases.
Gastrointestinal polyps can arise from mutations in smooth muscle cells surrounding epithelial tissue, not just the epithelium itself. This discovery opens new avenues for treatment strategies targeting intercellular signaling.
Oregon researchers have identified a key switch that allows embryonic cells to form into muscles in zebrafish, revealing the importance of protein interaction and timing control. The discovery of Smarcd3 proteins forms a chromatin-remodeling complex that alters DNA shape, triggering muscle development.
Researchers have developed a technique to sort embryonic stem cells to preserve only the desired muscle-type cells, avoiding tumor formation and improving muscle strength and coordination. The study shows significant improvements in muscle function and quality of life for mice with Duchenne muscular dystrophy.
Researchers at Ohio State University identified a genetic link between the profilin 1 gene and increased risk of high blood pressure in older adults. The gene affects vascular remodeling, which can lead to structural and functional changes in blood vessels, ultimately causing hypertension.
Scientists at Boston Children's Hospital have created a new technology that uses magnetic fields to control cellular signaling, mimicking the binding of drugs or hormones. This innovation has the potential to lead to finely-tuned but noninvasive treatments for various diseases.
Researchers discovered that a transient and local rise in interleukin-6 (IL-6) is essential for the growth of muscle fibers. This finding could lead to new treatments for reversing or improving muscle loss in diseases such as cancer and AIDS, as well as normal aging.
Researchers have found a naturally occurring protein called CnAß1 that permanently activates calcineurin, increasing muscle stem cell proliferation and regeneration. This uncouples the protein's activity from injury signals, making it a promising candidate for treating muscle damage and wasting.
A Northwestern University study found that overexcited neurons can cause protein damage in muscle cells due to neurotransmitter imbalance. This imbalance can lead to various diseases, including neurodegenerative disorders and cancer.
Researchers have successfully reprogrammed human adult stem cells to correct the genetic mutation causing muscular dystrophy. The corrected cells were then transplanted into mice with the disease, resulting in significant recovery of muscle morphology and function.
Researchers found that skeletal myoblasts can help improve urinary incontinence in female rats with urethral sphincter deficiency when transplanted into their nerve-damaged muscles. The transplanted muscle cells increased urethral pressure, leading to significant improvement in incontinence and near-normal urethral closure pressures.
A recent study by Dr. Dorit Hanein at the Burnham Institute for Medical Research provides new insights into Familial Hypertrophic Cardiomyopathy (FHC), a deadly genetic disorder affecting young people and athletes. The research reveals that a specific point mutation in myosin heavy chain causes myocardial disarray, leading to changes i...
Researchers at Children's Hospital of Pittsburgh have identified a unique population of adult stem cells derived from human muscle tissue that can be used to treat muscle injuries and diseases. The myoendothelial cells are easily isolated, proliferate rapidly, and can differentiate into muscle, bone, and cartilage cells.
Researchers at Penn School of Medicine have discovered a potential new target for treating muscular dystrophy by targeting the 'brake' on utrophin gene expression. The study proposes using drugs to remove this brake, increasing utrophin production as a possible therapy for Duchenne muscular dystrophy.
Researchers have discovered two types of satellite cells in muscle that behave like stem cells, allowing them to regrow and repair muscle tissue. These findings could lead to new treatments for muscle-wasting diseases and potentially even help maintain muscle mass with age.
A study by Frank de Paoli and colleagues reveals that lactic acid and adrenaline work together to protect muscles from potassium ion imbalance. This finding contradicts the long-held idea that lactic acid causes muscle fatigue.
Researchers identified an enzyme called SIK1 that regulates a pathway involving exercise-induced hormones and controls muscle-specific gene expression. Boosting SIK1 levels or inhibiting HDAC activity restored normal muscle function in genetically engineered mice with weak muscles. The discovery may provide clues for improving cellular...
Researchers identify protein WIP as crucial for cell fusion, shedding light on muscle development; potential applications include regenerating muscle tissue with stem cells. The study's findings have implications for understanding various cellular processes and may lead to new treatments or therapies.
Researchers at Johns Hopkins have identified a protein required for neighboring cells to fuse and become one super cell. The Solitary protein coordinates the movement of molecular delivery trucks and marks where the cell barrier needs to be broken, directing the building of a delivery road.
A study by Pittsburgh scientists found that female stem cells have a greater ability to regenerate skeletal muscle tissue than male cells. The researchers isolated female and male muscle-derived stem cells and tested their regenerative capabilities in dystrophic mice. Female stem cells were more efficient at regenerating skeletal muscl...
Researchers from Baylor College of Medicine identify Sox17 as critical for transforming embryonic stem cells into cardiac mesoderm, the precursor to heart muscle. The discovery provides insight into generating cardiac muscle more effectively from embryonic stem cells.
Researchers at the University of Minnesota successfully used adult stem cells to replace the immune system and bone marrow of mice, offering a promising new therapy for people in the future. The study replicated previous findings and demonstrated that multipotent adult progenitor cells (MAPCs) can give rise to blood cells.
A genetic 'switch' drives the formation of a poorly understood type of muscle in mice. These mice exhibit increased endurance and can sustain longer periods of physical activity.
Massachusetts General Hospital researchers have discovered a master cardiac stem cell capable of differentiating into three types of heart cells. This finding offers new prospects for drug discovery and genetically based models of human disease, as well as a novel strategy for the regeneration of cardiac muscle and associated structures.
Researchers found CaMKII alters Na+ channel function, leading to VTs in mice with heart failure. Overexpression of CaMKII increased susceptibility to life-threatening arrhythmias.
Researchers at Baylor College of Medicine found that immune system cells recruited from the body can cause muscle dysfunction leading to certain forms of heart failure. Treatment with serum amyloid P prevented the production of these fibroblasts and resulting fibrosis.
Scientists have found a way to create smooth muscle cells from adult stem cells using the soluble factors TGF-beta and PDGFB. This breakthrough could lead to new treatments for heart disease by allowing for the creation of healthy tissue. Additionally, researchers have discovered that regulatory T cell populations are impaired in indiv...
A team from Rice University and UT-Houston report a unique grip of the protein calmodulin, which operates independently like a batter in a bunt. This new grip plays a key role in allowing muscles to contract and relax quickly.
Researchers discovered that Ets1/2 transcription factor controls early heart formation in the sea squirt Ciona intestinalis. The signaling molecule FGF also plays a crucial role in this process.
Researchers at Beth Israel Deaconess Medical Center have discovered that carbon monoxide can reverse symptoms of pulmonary arterial hypertension by arresting smooth muscle cell growth and inducing apoptosis. The gas works with nitric oxide to target problematic cells, offering a potential new therapy for the debilitating condition.
U of MN researchers developed a mouse model for centronuclear myopathy, a poorly understood muscle disease. They found that knocking out the gamma actin gene impaired muscle cell function, leading to muscle cell death, and identified this protein as a key player in muscle structure.
A study by UT Southwestern Medical Center reveals that mature muscle fibers, rather than their less-developed neighbors, are the tissues that turn malignant in alveolar rhabdomyosarcoma. This breakthrough provides insight into how the cancer arises and offers a new model for analyzing its genetic causes.
Researchers found that muscle cells degenerate when BAG3 is absent, highlighting its importance in maintaining mature skeletal muscle. This discovery may lead to prevention of muscle atrophy associated with diseases like muscular dystrophy and myofibril myopathy.
Researchers successfully delivered a gene encoding a bioengineered cell-surface protein to heart muscle cells of pigs, mimicking the combined action of several proteins involved in maintaining a normal heartbeat. The study shows promise for replacing electronic pacemakers with a more permanent and reliable biological alternative.
Researchers at UCLA have successfully transformed adult stem cells from human adipose tissue into functional smooth muscle cells, which can help regenerate damaged organs like the intestine, bladder, and arteries. The study's findings offer a promising alternative to using patient's own tissue for organ regeneration without anti-reject...
Queen's University researchers found that two genes cooperate to protect aortic smooth muscle cells from death, pointing to new therapies for preventing heart attacks and strokes. The study's findings suggest that delivering the HO-1 gene using gene therapy may help stabilize plaques and prevent clogging in arteries.
Researchers developed engineered tissue that can conduct electricity, potentially replacing pacemakers in children with heart block. The tissue was tested in rats and shown to integrate with surrounding heart tissue, establishing an electrical conduction pathway.
A team of researchers has achieved a significant breakthrough in treating Duchenne muscular dystrophy by successfully transplanting healthy muscle cells into patients, showing promise for increasing the production of the missing protein dystrophin. The new clinical trials aim to further assess the treatment's effectiveness and measure ...
Researchers used RNA interference to silence genes regulating muscle cell formation and osteogenic signals. The study found that turning off these inhibitors increased the cells' bone-forming potential, with 60% of mice developing radiologically detectable bone after implantation.
Researchers discovered that prostaglandin E2 activates the pairing of EP1R with beta2AR receptors, reducing their ability to cause muscle relaxation. This may explain why some asthma treatments fail for individuals with elevated PGE2 levels.
Researchers have found that lactic acid is not a waste product, but rather a link between anaerobic and aerobic metabolism. Efficient use of lactic acid enables athletes to generate more energy from their body's fuel sources, reducing fatigue and improving performance.
A study by University of California - San Francisco researchers found that the prostate drug doxazosin blocks alpha 1-adrenergic receptors in heart muscle cells, increasing risk of heart failure. The study suggests blocking these receptors may be a direct cause of heart failure.