Articles tagged with Muscle Cells
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Researchers found that a small dose of ractopamine increased muscle mass and feed efficiency in pigs without compromising meat quality. The study confirmed previous findings that 5 mg/kg is an appropriate dose for Brazilian commercial pork production.
Researchers identified significant sections of the dystrophin gene that could provide hope to young patients and families with Duchenne muscular dystrophy. The discovery found a 'claw' in the gene that brings nNOS to the muscle cell membrane, preventing damage and potentially leading to treatments.
Researchers at Ruhr-University Bochum found an overactive CaM kinase II enzyme in failing hearts, which relaxes muscle cells by phosphorylating the giant protein titin. This may lead to a new starting point for treating heart failure.
Stem-cell therapy has been shown to prevent the decline in heart function associated with Duchenne muscular dystrophy. The treatment involves transplanting stem cells derived from normal mouse blood vessels into the hearts of mice with DMD, where it prevents dilated cardiomyopathy and promotes angiogenesis.
Researchers at Johns Hopkins University have developed a method to control the fate of human stem cells, producing two types of smooth muscle cells necessary for building tiny networks of veins and arteries. This breakthrough could lead to new treatments for heart disease, diabetes, and cancer.
Researchers found that two sections of the dystrophin gene contain a 'claw' that grabs nNOS and brings it to muscle cells for repair. The discovery could lead to a therapy for Duchenne muscular dystrophy, which affects males predominantly.
Researchers at the Max Planck Institute have discovered how external signals regulate vascular remodelling through G protein-mediated signalling pathways. These pathways work together in other contexts but act as antagonists in blood vessel remodelling, balancing cell growth and regression.
Researchers identified a new mechanism allowing the toxic DUX4 protein to be produced in skeletal muscle, causing progressive muscle weakness. Mutations in the SMCHD1 gene cause chromatin relaxation, leading to DUX4 production.
Researchers at NHCS have developed a novel human heart cell model of ARVC, allowing for safer study of genetic cardiovascular diseases and risk stratification. The model replicates key characteristics of the disease, including abnormal fatty changes and altered desmosomal proteins.
Researchers have identified a novel signalling pathway controlling cellular energy metabolism, independent of the known hedgehog pathway. This discovery suggests that substances targeting this pathway could provide an easy and safe adjunct therapy for diabetes and obesity, resolving complications induced by cancer treatments.
Researchers discovered regenerated lizard tails have distinct features, including a single cartilaginous rod and elongated muscle fibers. The new tail lacks vertebrae and interlocking joints, reducing flexibility compared to the original.
Researchers at Johns Hopkins University have made a breakthrough in understanding how muscles regenerate and grow. By blocking the action of myostatin, a protein that suppresses muscle growth, they found that muscle mass can be increased significantly without the need for fully functional satellite cells.
A new regulator for heart formation has been discovered by studying DNA packaging in embryonic stem cells. The researchers found that specific genetic regulators are activated at distinct times during the process of transforming stem cells into heart muscle cells, revealing potential insights into human development and organ repair.
Researchers have elucidated how muscle stem cells colonize niches for efficient growth and repair. They found that these stem cells weaken when located outside their muscle fiber niches, leading to weakened muscles. The Notch signaling pathway plays a crucial role in preventing differentiation of stem cells into muscle cells.
A new study found that inhibiting myostatin promotes muscle growth without incorporating satellite cells into myofibers, raising hopes for treating muscular diseases. The research team identified a specific type of cell targeted by myostatin, paving the way for potential drug development.
Researchers have made a major advance in efforts to regenerate damaged hearts by transplanting human cardiac muscle cells that electrically couple and beat in sync with the heart's own muscle. These grafts reduced the incidence of arrhythmias in a guinea pig model of myocardial infarction.
Harvard University researchers have successfully created an artificial jellyfish using a silicone polymer and heart muscle cells. The Medusoid, as it's called, is capable of swimming and reproducing complex behaviors seen in biological jellyfish.
Researchers discovered a crucial switch controlling cardiac stem cell activity, enabling the growth of healthy hearts and potentially treating congenital defects. By silencing this switch, scientists hope to regenerate damaged adult hearts using lab-cultured replacement cells.
Research finds that both brain and muscle cells require the protein LRP4 to ensure robust communication. Without it, communication is inefficient and short-lived, contributing to disabling disorders like myasthenia gravis. The study suggests that delivering LRP4 through gene therapy may help bolster insufficient levels in patients.
Researchers have developed a technique to reprogram adult cells from patients with limb-girdle muscular dystrophy into stem cells, which can then be genetically modified and transplanted into mice. The study shows promise for treating this rare form of muscular dystrophy.
Researchers at Michigan Medicine developed a new method to generate cardiac muscle patches from stem cells, which can mimic the heart's crucial squeezing action. The engineered cells displayed activity similar to most people's resting heart rate and could potentially be used to help 2.5 million people with arrhythmia.
Researchers at Harvard University found that mice brains undergo an explosion of neuromuscular branching before birth, with some muscle fibers contacted by up to 10 nerve cells. However, within days, most connections are pruned away, suggesting experience selects which connections to keep.
Researchers at the University of California, Berkeley, used genetic tracing to identify a previously unknown type of stem cell as the real culprit behind vascular diseases. This multipotent vascular stem cell is capable of differentiating into various specialized cell types and plays a key role in the calcification of blood vessels.
Scientists at University College London have discovered a potential new method to regenerate damaged skeletal muscle tissue using stem cells derived from amniotic fluid. The treatment resulted in improved survival rates and muscle activity in mice with spinal muscular atrophy, a genetic disease affecting one in six thousand births.
Researchers at McGill University discovered that heart muscle fibers are arranged in a special 'minimal surface' called the generalized helicoid. This finding offers significant new understanding of heart-wall muscle fiber geometry and could be used to guide tissue repair after heart attacks.
Researchers at Massachusetts General Hospital identified a tumor-propagating cell required for growth in a pediatric muscle tumor model. Another type of differentiated tumor cell must first colonize new areas to prime an environment for metastatic growth.
Researchers create functional motor circuits outside the body using stem cell-derived neurons and muscle cells, enabling accurate measurement of synaptic activity. The study provides a proof-of-principle for understanding neurological disorders that impair motor functions.
Researchers from the University of Minnesota have effectively treated muscular dystrophy in mice using human stem cells derived from a new process that makes the production of human muscle cells efficient and effective. The study outlines a strategy for developing a rapidly dividing population of skeletal myogenic progenitor cells, set...
Researchers at Imperial College London found that allowing heart muscle cells to rest can reverse structural changes caused by heart failure. This discovery could lead to new treatment strategies without the need for serious procedures like LVAD implants.
Researchers have discovered two proteins, Kif5B and MAP7, that play a vital role in positioning muscular nuclei on the edge of muscle fibers. The study, published in Nature, sheds light on the mechanism behind this process, which is essential for skeletal muscle function.
Muscle cells have efficient systems to seal holes in their plasma membranes. Researchers at KIT and Heidelberg University observed membrane repair in real-time using a novel imaging method. They found that membrane vesicles form a repair patch, which is sealed off from the extracellular environment.
Weizmann Institute scientists have disproved a claim about the origin of eggs in female mammals and created a new method for reconstructing lineage trees for cells. The study found that ova cannot be descended from bone-marrow stem cells, but older mice eggs undergo more cell divisions than younger ones.
Researchers found that hibernating woodchucks have a higher resistance to cardiac arrhythmias due to their unique calcium handling properties. This insight may suggest new strategies for protecting non-hibernating animals from fatal cardiac arrhythmias induced by hypothermic stresses and myocardial ischemia.
A study published in Nature found a link between the circadian clock and sudden cardiac death, revealing that the controller of the circadian clock, Klf15, affects potassium flow out of heart muscle cells. This can lead to abnormal heart rhythms and increased risk of deadly arrhythmias.
Scientists at the University of Nottingham developed a mathematical model of calcium activity in atrial heart cells, improving our understanding of heart disease and stroke. The model provides clinically relevant insights into sub-cellular calcium signals, allowing for new treatments for conditions like atrial fibrillation.
Researchers found amylin accumulation in failing hearts of obese and diabetic patients, leading to heart muscle destruction and failure. Controlling amylin circulation might prevent disabilities and deaths from heart disease.
Researchers at the University of Illinois discovered that exercise can trigger adult stem cells in muscle, releasing growth factors that promote muscle regeneration. The findings may provide a link between exercise and muscle health, with potential applications for rehabilitation and preventing age-related muscle loss.
Researchers found that enhancers, which are meant to be active only in certain muscle types, were occupied by transcription factors from other tissues. This discovery reveals a new model for how enhancers function and provides insights into the developmental history of cells.
Researchers at McMaster University found a 10-minute massage significantly reduces inflammation in muscle, triggering biochemical signals that can aid healing. The study suggests massage may be an effective alternative to pain medications for recovery from injury.
New research reveals that insulin stimulates the formation of new elastic fibers in human aortic smooth muscle cells, advancing understanding of diabetic vascular disease. Insulin therapy may help prevent arterial occlusions and improve healing processes in diabetic patients.
A study in Cell Metabolism identifies serum response factor (Srf) as a crucial signal that tells surrounding muscle stem cells to multiply and join muscle fibers, controlling muscle growth. SRF's role in regulating muscle atrophy is also confirmed, with potential applications for therapies targeting its targets.
Researchers identified a family of molecules that can stimulate stem cells to develop into beating heart muscle cells, paving the way for new therapies for cardiac regeneration and repair. The discoveries were made using a zebrafish model system and showed promise in enhancing the inherent regenerative capacities of the heart.
Researchers at the Wellcome Trust Sanger Institute have identified two cell surface proteins, Jamb and Jamc, crucial for muscle cell fusion. The discovery sheds light on cellular fusion and its importance in muscle development, potentially leading to new treatments for muscle-wasting disorders.
Researchers have identified a new pool of stem cells in the heart with long-term expansion capacity and ability to form various cell types, including muscle, bone, and neural cells. This discovery may lay the foundation for regenerative therapies to enhance tissue repair in the heart.
Researchers found that ephrin proteins help satellite cells navigate and differentiate into muscle fibers. By understanding this process, they hope to develop more effective treatments for muscular dystrophy, a condition where muscles are easily damaged and patients' satellite cells lose their ability to repair.
A team of scientists from Worcester Polytechnic Institute and CellThera regenerated functional muscle tissue in mice using a novel protocol that combined reprogramming human cells and biopolymer microthreads. The study showed promising results, with most new muscle fibers composed of mouse cells, suggesting that fibrin microthreads alo...
Researchers at UCF have successfully grown neuromuscular junctions between human muscle and spinal cord cells using stem cells. This breakthrough is a critical step towards developing human-on-a-chip models for medical research and drug testing.
Researchers have discovered a new muscle repair gene, MEGF10, which plays a crucial role in the fusion process of satellite cells. The findings provide accurate genetic testing and diagnosis for devastating conditions affecting muscle function, enabling hope for families affected by progressive muscle disease.
Researchers at the University at Buffalo have developed a new approach to regenerating heart muscle cells. By infusing cardiosphere-derived cells into coronary arteries, they were able to increase healthy heart muscle cells by 30% within a month.
Two studies found that reducing NCoR in muscles increases exercise capacity and fat-burning, while reducing it in fat cells improves insulin sensitivity. The findings imply that limiting NCoR activity could be a potential treatment strategy for metabolic disorders.
Researchers have developed a method to grow cardiac muscle cells from human cord blood stem cells, which could lead to new treatment options for patients with damaged hearts. The study found that these cells can be expanded and differentiated into cardiomyocyte-like cells, overcoming the technical hurdle of deriving cardiac muscle-type...
Researchers have identified a new strategy for preventing the migration of muscle cells that can lead to coronary artery reclogging after angioplasty. Introducing FRNK, a protein that inhibits muscle cell migration while allowing endothelial cell movement, could help prevent clots and reduce the need for repeat procedures.
Bioengineers at UC Berkeley have successfully reprogrammed mature muscle tissue, a major breakthrough in combating muscle degeneration. The researchers used small molecule inhibitors to de-differentiate mature muscle cells, allowing them to revert back to an earlier stem cell stage.
Researchers at UCLA have found that adult human cardiac myocytes lose their ability to proliferate due to their primitive state being incompatible with proper heart function. This knowledge could lead to reprogramming a patient's own cardiac myocytes to replace damaged heart muscle, potentially revolutionizing treatments for heart cond...
Research ties aging muscle weakness to leaky calcium channels in muscle cells. A drug already in Phase II clinical trials for heart failure may help repair these channels, restoring muscle function. The study's findings suggest a new approach to addressing age-related muscle wasting by focusing on muscle function rather than mass.
Researchers found that adult stem cells from the human nose can repair damaged brain tissue, while a cancer probe made of silica nanoparticles is effective at targeting tumors. Additionally, inhibiting a protein MRP4 could provide a new way to treat pulmonary hypertension.
Muscle cell fusion is crucial for understanding normal muscle growth and regeneration after injury or disease. Johns Hopkins researchers discovered the role of a regulatory protein called Blown Fuse in facilitating muscle cell merging by disrupting the WASP-WIP protein duo, which regulates cytoskeleton dynamics.
Researchers have discovered a new protein that links nerve cell motors to their cargo, providing insights into neurotransmitter transport. This discovery could lead to new drug therapies for illnesses like Parkinson's disease and depression.
A recent study suggests that successful genetic blueprints for mesodermal development are recycled by evolution, rather than being invented anew in different species. The researchers found highly conserved transcription factor binding sites across six fruit fly species, indicating a shared regulatory program.
Researchers found that blocking the action of a signaling protein in cardiac muscle cells halted serious ill effects of high blood pressure on the heart, including enlargement and scar tissue formation. Further tests revealed potential new treatments for heart failure by targeting specific proteins involved in disease progression.