Articles tagged with Pluripotent Stem Cells
Researchers at McMaster University have discovered a unique subset of cells, called human pluripotent founder cells, that appear to signal how surrounding cells will develop and grow. These 'kingpin' cells are found in primates but not in mice, suggesting they may play a key role in understanding cancerous tumours.
Researchers have discovered that human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation-associated 50-gene signature, which is also expressed in pluripotent stem cells. This finding highlights the potential of iMSCs to act via paracrine signalling and circumvent drawbacks associated with adult MSCs.
A new microscopy technique, PD imaging, helps isolate highly potent stem cells by measuring mitochondrial activity, potentially improving regenerative medicine outcomes. The method is non-invasive and cost-effective, offering a reliable tool for early-stage stem cell selection.
Researchers have engineered a human pluripotent stem cell line containing two 'suicide genes' that induce cell death in all but the desired insulin-producing cells. This approach addresses the limitations of PSC-derived beta cells and opens the door to creating safe cell-replacement therapies for people living with type 1 diabetes.
Researchers at UCLA create mature T cells capable of killing tumor cells from pluripotent stem cells using artificial thymic organoids. This breakthrough technique has the potential to lead to new approaches to cancer immunotherapy and create a virtually unlimited supply of T cells.
Researchers at Michigan State University have identified YAP1 and WWTR1 as crucial proteins in regulating the balance between pluripotent cells and placenta formation. This discovery sheds light on the natural process of creating embryonic stem cells, which could lead to advances in regenerative medicine and organoid technologies.
Scientists from the Salk Institute discovered a new protein complex that keeps embryonic stem cells at their fullest potential, allowing them to maintain their indefinite potential. This discovery could provide a future target for regenerative therapies.
A new virus- and oncogene-free induced pluripotent stem cell (iPSC) technology has been developed to produce safer pluripotent stem cells from cord blood and peripheral blood. This approach aims to address safety challenges inherent with pluripotent stem cell therapies.
Researchers at Cincinnati Children's Hospital Medical Center successfully grew human esophageal organoids using pluripotent stem cells, enabling the study of diseases like esophageal cancer and gastroesophageal reflux disease. The bioengineered tissues were compared to patient biopsies and showed striking similarities in composition.
Researchers at NUS have successfully reprogrammed mature cells into pluripotent stem cells by confining them in a defined geometric space for an extended period. By the 10th day, the cells expressed genes associated with embryonic stem cells and iPSCs, indicating complete transition into re-deployable stem cells.
Researchers at the University of Helsinki have developed a new method for turning skin cells into pluripotent stem cells by activating the cell's own genes, eliminating the need for artificial gene introduction. This breakthrough enables efficient and physiological cellular reprogramming using CRISPRa technology.
Researchers have identified oocyte-specific factors that can drive somatic cell reprogramming by modulating the epigenetic landscape. These factors include histones and their chaperones, histone deacetylases and acetyltransferases, and transcription factors.
A new grant will explore the use of genome editing to modify human pluripotent stem cells for cardiac treatment. This approach could lead to unlimited production of cardiac cells in the lab for therapy, reducing the need for heart donors.
Researchers at Stowers Institute for Medical Research have isolated a regenerative cell capable of regrowing entire organisms. By combining genomics, single-cell analysis, flow cytometry, and imaging techniques, they targeted the elusive cell, which is a subtype of adult pluripotent stem cells, to discover its secrets.
Researchers at University of Illinois Chicago have created atrial cells from pluripotent stem cells using vitamin A. This breakthrough enables better study of atrial fibrillation and potential personalized treatments.
A new study has identified a critical stage in human embryonic development that may contribute to infertility and miscarriage. The research, led by UCLA biologist Amander Clark, reveals that epigenomic changes in early embryonic stem cells play a crucial role in determining embryo viability.
CReM researchers engineered two new categories of lung epithelial cells in vitro using pluripotent stem cells. The study used single-cell RNA sequencing to generate comprehensive profiles of air sack-like and airway-like cells, which can be used to create lung tissue in vitro.
Kyoto University scientists have created a more cost-effective culture system for human pluripotent stem cells (hPSCs), which can support their long-term renewal without expensive growth factors. The new 'AKIT' culture, using three chemical compounds, is five to ten times cheaper than existing methods.
Arizona State University is developing a biomanufacturing platform to generate human neurons for testing treatments of neurodegenerative diseases. The project aims to engineer neural cell types needed for drug screening, potentially leading to innovative solutions for Alzheimer's, Parkinson's and Amyotrophic lateral sclerosis.
Duke researchers successfully grew functioning human skeletal muscle from induced pluripotent stem cells, offering a promising path for cellular therapies, drug discovery, and studying rare diseases. The technique allows for the growth of far more muscle cells and provides an easier route to genome editing and individualized models.
Researchers at UCLA have successfully created skeletal muscle from human pluripotent stem cells, a major step towards developing a cell replacement therapy for Duchenne Muscular Dystrophy. The study uses natural human development as a guide to mature muscle cells in the lab and restore dystrophin-producing muscle fibers.
A series of studies by Monash University researcher Jose Polo have unveiled new evidence in the decade-long mystery of cell reprogramming. The researchers found that the route to pluripotency depended on the original cell type, with different cell types requiring different approaches. This breakthrough has important implications for re...
Researchers discovered that inhibiting two forms of GSK3 can promote stem cell self-renewal or trigger differentiation into neural cells. The findings have implications for developing targeted therapies for diseases such as diabetes and Alzheimer's, and could lead to the production of human stem cells with specific properties.
A new study using pluripotent stem cell technology reveals that having too much or too little of the CHRNA7 gene can lead to similar biological effects in brain cells. This discovery sheds light on the mechanisms underlying neuropsychiatric disorders and offers a potential avenue for treatment.
Scientists have found a key to unlock blocked differentiation in microRNA-deficient embryonic stem cells, enabling neural cell differentiation without p53 expression. This breakthrough supports the goal of using stem cells in therapy and could lead to innovative treatments for various diseases.
A team of researchers has found an efficient way to produce neurons from pluripotent stem cells by knocking down a single gene. This approach enables 100% efficient neuron production and could facilitate the study of neurodegenerative diseases.
Scientists have developed a way to generate and correct specific lung cells using pluripotent stem cells, which could lead to new therapies for conditions like neonatal respiratory distress and COPD. The corrected cells were able to produce essential surfactant, previously an elusive milestone.
A new study reveals that insulin is essential for preserving pluripotent stem cells' ability to become any cell type. Insufficient insulin leads to a specialized endoderm cell type, similar to early embryonic cells, suggesting potential importance in human development and pregnancy.
A novel image analysis tool allowed researchers to observe which cells become 'losers' in cell competition and die, while others survive with higher Myc levels. This discovery reveals the importance of Myc levels in maintaining pluripotency during mammalian embryonic development.
The University of Texas at San Antonio has assembled a world-class research enterprise to develop groundbreaking approaches for treating brain diseases and injuries. Researchers will collaborate on complex projects using expertise in neurodegenerative disease, regenerative medicine, and stem cell therapies.
Scientists have successfully grown a structure similar to an early stage of human development using pluripotent stem cells. The lab-grown amniotic sac embryoid, or PASE, exhibits key features such as two distinct halves and a hollow center, making it a potential tool for exploring infertility research.
Scientists have successfully grown human embryonic colons in a laboratory using pluripotent stem cells, providing unprecedented detail for studying GI diseases. The technology also holds potential for generating human gastrointestinal tract tissues for transplantation into patients.
Researchers at Stowers Institute for Medical Research discovered direct cross-regulatory feedback between Nanog and Hox genes, which regulate pluripotency and differentiation. This study provides important insight into tissue formation processes and holds relevance for regenerative medicine and cancer therapy.
A new two-part system turns embryonic or adult stem cells into the desired target cell type, reproducing flawlessly. The system uses a DNA plasmid that makes cells glow green when exposed to blue light, allowing researchers to track its removal and control gene expression.
Scientists have successfully generated blood-forming stem cells in the lab using pluripotent stem cells from patients' own cells. The advance opens up new opportunities to create immune-matched blood cells and potentially treat genetic blood disorders.
Salk scientists have discovered a chemical cocktail that enables cultured mouse and human stem cells to generate both embryonic and extra-embryonic tissues. This breakthrough could lead to better disease modeling, drug discovery, and tissue regeneration, particularly in the field of organ regeneration.
A new platform for culturing human pluripotent stem cells has been developed at Kyoto University, combining micro and nanotechnologies to precisely control the culture environment. The Multiplexed Artificial Cellular Microenvironment (MACME) array mimics extracellular environments with nanofibres in fluid-filled micro-chambers of preci...
A recent study conducted at The Mount Sinai Hospital found that certain genetic mutations are challenging to recreate in laboratory-produced stem cells. This limitation may hinder neuropsychiatric research, highlighting the need for researchers to carefully check for retained genetic elements in newly created stem cells.
Researchers at UCL and Heinrich Heine University have discovered the OCT4 gene essential for chemically reprogramming human amniotic stem cells. The process allows these cells to be rejuvenated and function like embryonic stem cells, providing a promising alternative for therapies and research.
Researchers successfully grew functional human stomach and intestinal tissues using pluripotent stem cells, enabling the study of diseases such as gastric cancer. The discovery allows for the modeling of new treatments and understanding of human development and health.
Researchers at the McEwen Centre developed functional pacemaker cells from human stem cells, which regulate heart beats with electrical impulses. The cells were tested in rat hearts and shown to function as a biological pacemaker.
Scientists discovered that expressing a single subunit of a chaperone complex can improve protein folding and extend lifespan. The study found that this approach mimics the proteostasis of human pluripotent stem cells and delays age-related diseases in a model organism.
Researchers successfully engineered human intestines with functioning nerves using pluripotent stem cells, enabling the study of severe intestinal nerve disorder Hirschsprung's disease. The technology also allows for testing new therapeutics in lab-engineered human intestine before clinical trials.
Scientists have developed a method to create functional kidney units from patient cells, allowing for the study of human kidney diseases and potential therapeutic agents. The research enables in vitro studies of kidney pathophysiology and nephrotoxicity, with the ultimate goal of developing bioengineered kidneys for regenerative medicine.
A Lund University research team identified high levels of reactive oxygen species in newly generated blood stem cells from pluripotent stem cells, damaging their function. The researchers developed a cocktail to reduce oxidative damage, resulting in over twenty times more blood stem cells that could grow.
A team of researchers has created a microfluidic device that allows for the growth of human pluripotent stem cells in optimal, three-dimensional conditions. This technology enables fine-tuning of the culture environment and creates an ideal artificial microenvironment for hPSC analysis.
Researchers presented advancements in Droplet Digital PCR for detecting somatic cancer mutations, including novel methods for differentiating between mutant alleles and quantifying biomarker copy numbers. Single-cell sequencing was also showcased for understanding human pluripotent stem cell population heterogeneity.
Researchers have created a new library of human stem cells with different levels of admixed European, African and Native American genomic ancestry. The cell lines can be used to test drug toxicity and study differential drug response.
UAB researchers found that removing transcriptional bookmarks can improve reprogramming of human fibroblasts to create induced pluripotent stem cells. This process may increase the yield and quality of iPS cells, essential for patient-specific cell-replacement therapies.
Human pluripotent stem cells can be directed into functional osteoblasts by adding the molecule adenosine, enabling efficient regeneration of bone tissue. The breakthrough could lead to regenerative treatments for patients with critical bone defects and soldiers with traumatic bone injuries.
A new study reveals that human stem cells have pluripotency superior to some types of mouse-derived cells. Researchers mapped gene expression patterns in crab-eating monkeys to understand the developmental counterparts of primate stem cells.
Researchers developed a method to revert and maintain human ESCs in a naive state, closely resembling that of mouse ESCs. The team assembled a checklist of characteristics human ESCs must have to be considered naive, including gene expression, DNA methylation, and X chromosome inactivation.
Scientists have created a four-step process to determine accurate signatures of human embryonic stem cells, relating them to precise developmental stages. The key steps involve analyzing transposable elements and DNA methylation state to assess pluripotency.
Researchers at the University of Nottingham have developed a novel method for culturing human stem cells using a protein derived from human blood, which could lead to faster and more cost-effective large-scale production. This breakthrough has the potential to revolutionize the field of regenerative medicine and disease research.
A team of researchers has successfully grown functional pituitary tissue from human stem cells that can release hormones important for growth, reproductive functions, and stress response. The study's findings hold promise for a more permanent therapeutic option for patients with hypopituitarism.
Researchers have concluded that reprogramming does not create differences between reprogrammed and embryonic stem cells. A thorough study showed that reprogrammed and embryonic stem cells are similar, with a list of 275 key genes that can present reprogramming results.
Researchers at the University of Pennsylvania have discovered that lab-made stem cells often retain errors in DNA folding, leading to incomplete differentiation into adult cells. The team suggests ways to minimize these errors and has developed high-resolution maps of genome folding in iPS cells.
Researchers have developed a drug that can erase epigenetic markers on chromatin to restore the original state of stem cells in mice. The study shows that over half of mouse epiblast stem cells treated with the drug regained embryonic pluripotency, opening up new possibilities for regenerative medicine.
Scientists discovered that Zscan4 is a repair mechanism triggered by telomere shortening, allowing cells to recover from cell division stress. The protein expression is linked to longer cell cycles, enabling the cells to lengthen their telomeres before speeding up the cycle again.
Researchers at the University of Cambridge have successfully derived naïve pluripotent stem cells from human embryos, which can develop into all human tissue types. This breakthrough has significant implications for regenerative medicine and modeling human disorders, including Down's syndrome.