Articles tagged with Pluripotent Stem Cells
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Researchers generated simple kidney-like structures called organoids and used them to identify potential drugs for adult-onset polycystic kidney disease. They found nine compounds that inhibited cyst growth without stunting overall growth.
Researchers have discovered an alternative route that pluripotent and endoderm extra-embryonic stem cells can use to form intestinal organs in the lab. This finding could lead to improved cell development and potentially treat diseases, but further function testing is needed.
Researchers have developed a new protocol for differentiating human embryonic stem cells into retinal pigment epithelial (RPE) cells, which can be used to treat age-related macular degeneration. The study shows that the protocol produces a pure population of RPE cells that can continue maturing after transplantation, paving the way for...
A study reveals an epigenetic switch that restricts early embryo cells from differentiating into certain tissue lineages. The research identifies PRC2 as a key regulator of gene expression in embryonic development, allowing for better control of stem cell specialization and blastoid formation.
Biologists at the University of Rochester have identified two key systems controlling gene expression related to longevity: circadian networks regulating negative lifespan genes and the pluripotency network controlling positive lifespan genes. This research provides new insights into understanding how longevity evolves and may lead to ...
Researchers created human mini-kidneys that mimic diabetic kidneys, finding increased susceptibility to SARS-CoV-2 infection and a critical role for the ACE2 receptor. The study provides new insights into the link between diabetes and COVID-19 disease.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
Researchers have developed a process to convert non-neuronal cells into functioning neurons that can take up residence in the brain and restore capacities undermined by Parkinson's destruction of dopaminergic cells. In a proof-of-concept study, one group of experimentally engineered cells performs optimally in terms of survival, growth...
Scientists have created cilia-free human pluripotent stem cells that exhibit symptoms of ciliopathy, such as polycystic kidney disease. These cells can be used to study the cause of these diseases and guide therapy development.
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
A team at Baylor College of Medicine found that human NANOG's 'super stickiness' enables it to form large aggregates at low concentrations, which interact with chromatin to activate a pluripotent state. This process involves reshaping the genomic landscape and turning on genes involved in pluripotency.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Researchers at Mount Sinai have developed a reproducible method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes, which support heart muscle contraction. The new protocol enables efficient energy generation from both carbohydrates and fatty acids, improving disease modeling and regenerative therapies.
A genome-wide functional screen identified critical regulators of naïve stem cell reprogramming, enabling the creation of high-quality, stable stem cell populations. The study also uncovered epigenetic factors that hinder or help reprogramming, including the essential PRC1.3 complex and inhibitory HDAC2 protein.
Researchers created cortical organoids from patients' skin cells, mimicking focal cortical dysplasia and identifying mechanisms involved in its emergence. The model can be used to screen existing medications for patients with severe epilepsy.
Researchers developed a transgene-free method to convert human pluripotent stem cells into 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology. These cells can be used to regenerate human organs, study human embryonic development, and prevent pregnancy loss.
Researchers have successfully created artificial egg cells from northern white rhino stem cells using induced pluripotent stem (iPS) cells. This breakthrough brings the team closer to achieving their goal of creating artificially generated rhino oocytes, a crucial step towards saving the subspecies from extinction.
A Penn State-led team of researchers developed a new delivery system that improves the efficiency and lifespan of CRISPR gene-editing tools after delivery into stem cells. The method uses an enzyme called PiggyBac, which enables permanent integration of the editing tools into the cell's genetic code, resulting in 99% of mutated cells b...
A new test procedure using human stem cells identifies chemicals that may cause birth defects in humans. The method assesses the likelihood of toxicity by monitoring disturbances in precisely programmed signaling pathways.
Researchers at the University of Illinois have identified BEND3 as a critical regulator of cell differentiation, discovering that it represses genes associated with cell fate. This finding has implications for understanding normal development and potentially improving cancer treatment.
Scientists at Michigan Medicine have developed a new way to grow tiny models of organs, called organoids, using a simple suspension culture. This breakthrough improves the understanding of human development and could lead to new insights into disease.
Researchers studying acorn worms' regenerative abilities may have uncovered a key to understanding why vertebrates can't regenerate their bodies. The team found that the worms use reprogramming-based mechanisms to create complete body parts, which could lead to advances in reparative medicine for humans.
Neuroscientists have designed neural organoids with both mature neurons and astrocytic glial cells to study interactions between brain cells. The new technology enables the emulation of brain activity during healthy and disease states, opening doors to rapid drug screening for neurological diseases.
Researchers at RIKEN have developed a new retinal transplant technique by engineering human-derived retina sheets to lose bipolar cells, allowing better connections to host retinas and improved responses to light. The technique has shown substantial functional improvement in animal studies and is now poised for human clinical trials.
Researchers at University of Helsinki have developed a faster and more reliable method for converting adult skin cells into pluripotent stem cells, known as induced pluripotent stem cells (iPS). The new technique uses CRISPRa gene-editing and produces high-quality iPS cells with improved accuracy and reliability.
Researchers have discovered molecules that could be candidates for contraceptives or fertility enhancers using human blastoid models. These models also show promise in improving the self-organization of stem cells during IVF procedures.
A multicenter clinical trial demonstrates insulin secretion from engrafted stem cells in patients with type 1 diabetes. The study shows 20% reduced insulin requirements and 13% more time spent in target blood glucose range over a one-year follow-up period.
Scientists at Kobe University have successfully generated testosterone-producing Leydig cells from human iPS cells, a significant step towards developing a regenerative medicine treatment for late-onset hypogonadism. The induced cells expressed genes specific to Leydig cells and produced functional testosterone.
Researchers use transgenic worms to study whole-body regeneration and identify critical genes involved. They also gain insights into muscle cell connections and communication during regeneration.
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
Researchers have created a human disease model of FCMD using stem cells from a patient, which successfully mimicked the disorder's brain defects. The study found that a small compound called Mannan-007 can restore αDG glycosylation and reduce FCMD-related defects.
Researchers have discovered that the TRPV4 gene plays a crucial role in regulating cartilage growth, which could lead to more effective treatments for osteoarthritis and other cartilage diseases. The study also suggests that TRPV4 may be used to accelerate stem cell differentiation for bioengineering cartilage.
Researchers generated brain organoids containing functional optic cups from human induced pluripotent stem cells (iPSCs), demonstrating intrinsic self-patterning ability. The optic cups exhibited light sensitivity, diverse retinal cell types, and connectivity to brain regions.
Researchers at CNIO describe how embryonic stem cells are maintained in optimal conditions for use in regenerative medicine. The study reveals the molecular events that help stabilize these valuable cells, which can differentiate into any cell type.
Researchers at UC San Diego discover epigenetic mechanisms to accelerate muscle cell growth using pluripotent stem cells. Triggering specific factors can prime these cells for rapid regeneration.
Researchers at Duke University have discovered a mechanism by which mesenchymal stem cells (MSCs) modulate the inflammatory response, extending their beneficial effects even after being cleared from the system. The study sheds light on how MSCs suppress T cell activation and reprogram disease-fighting cells to promote healing.
Researchers have developed a method to genetically edit out proteins on human pluripotent stem cells that trigger immune rejection. This approach could generate universally compatible 'off-the-shelf' cell grafts without the need for immune suppression, offering a promising solution for regenerative medicine.
Researchers at Kyoto University found that gene regulatory networks for pluripotent stem cells are highly conserved across mammals, but also exhibit unique variations. These differences may explain why certain features of mammalian pluripotent stem cells have evolved differently in various species.
Researchers at University of Sheffield and UCL identified a key stage in forming the enteric nervous system using pluripotent stem cells. This breakthrough could pave the way for new treatments for neurodegenerative diseases such as Parkinson's, which is initiated in the enteric nervous system before reaching the brain.
Researchers at A*STAR in Singapore have identified a potential biomarker, GSTT1, to screen the quality of donor's stem cells before harvesting. This biomarker can help determine the growth capacity and potency of MSCs, which is crucial for effective stem cell therapies.
A new lab-grown human skin cell model has been developed at Stanford University, allowing researchers to study hair growth and development in greater detail. This breakthrough could potentially provide insights into reversing hair loss and developing new treatments.
Researchers found that p53 plays a crucial role in regulating cell division and apoptosis only during pluripotent stem cell differentiation, resolving years of conflicting results. The study used various chemotherapy drugs to induce apoptosis in ESCs and showed that p53 is not essential for cell cycle arrest or apoptosis prior to diffe...
Researchers at the University of Sheffield have discovered ways to reduce DNA damage and mutations in pluripotent stem cells, a crucial step for regenerative medicine. The findings may allow for safer use of these cells in patients and significantly reduce the risk of genetic mutations.
Researchers found that immune cells from early development, called natural killer cells, are more effective in treating cancer. These cells can be developed from human pluripotent stem cells, providing a new supply of immune cells for immunotherapy.
Using a combination of pluripotent stem cells and machine learning, researchers have improved how they generate lung cells. This technique enables the growth of lung cells in a laboratory for over a year, allowing for better modeling of lung diseases and potential personalized treatments.
Researchers at NUS Medicine have discovered a way to induce totipotency in pluripotent embryonic stem cells, allowing for maximum cell engineering and therapeutic potential. This breakthrough provides new avenues for regenerative medicine, particularly in cell replacement therapies for debilitating diseases.
Scientists identified 3 metabolites that can re-program pluripotent cells into totipotent-like cells, opening up possibilities for studying early developmental events and cell replacement therapies.
Scientists in China successfully induced granulosa cells to transform into functional oocytes in mice, which were then fertilized to produce healthy offspring. The chemical reprogramming method appears to offer a promising approach for preserving fertility and endocrine function.
A research team has developed biotransistors that can record small beats of live cells and micro-tissues, paving the way for drug development and screening. The transistors, made of organic material on a flexible substrate, are biocompatible and offer intrinsic signal amplification, reducing the need for external amplifiers.
Researchers at the University of Turku have used super-resolution microscopy to study focal adhesions in human pluripotent stem cells. The study reveals novel features in the ultrastructure of these adhesions, which may be important for maintaining pluripotency. Abrogation of focal adhesion structure leads to a speeded-up exit from the...
Researchers at the Center for Cell-Based Therapy identified microRNAs involved in pluripotency maintenance and cell differentiation. The study found that these molecules play a crucial role in regulating ESC behavior, with some miRNAs contributing to both pluripotency and differentiation.
Osaka University researchers discovered a key regulatory mechanism in the development of normal pluripotent embryonic cells using the Hippo pathway. They found that TEAD and YAP proteins support pluripotency in blastocysts by activating cell competition, leading to elimination of low-potential cells.
Researchers propose a possible cell-based therapy to stimulate lung development in fragile premature infants with Bronchopulmonary Dysplasia (BPD). The study suggests using c-KIT-positive endothelial cells from donors or generating them with pluripotent stem cells as a potential treatment.
Researchers at UW-Madison have developed a new approach to induce pluripotent stem cell generation, increasing efficiency from 5% to 40% and shortening the process. This breakthrough could lead to significant advancements in regenerative therapies and precision medicine.
Researchers at McMaster University have discovered a unique subset of cells, called human pluripotent founder cells, that appear to signal how surrounding cells will develop and grow. These 'kingpin' cells are found in primates but not in mice, suggesting they may play a key role in understanding cancerous tumours.
Researchers have discovered that human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation-associated 50-gene signature, which is also expressed in pluripotent stem cells. This finding highlights the potential of iMSCs to act via paracrine signalling and circumvent drawbacks associated with adult MSCs.
A new microscopy technique, PD imaging, helps isolate highly potent stem cells by measuring mitochondrial activity, potentially improving regenerative medicine outcomes. The method is non-invasive and cost-effective, offering a reliable tool for early-stage stem cell selection.
Researchers have engineered a human pluripotent stem cell line containing two 'suicide genes' that induce cell death in all but the desired insulin-producing cells. This approach addresses the limitations of PSC-derived beta cells and opens the door to creating safe cell-replacement therapies for people living with type 1 diabetes.
Researchers at UCLA create mature T cells capable of killing tumor cells from pluripotent stem cells using artificial thymic organoids. This breakthrough technique has the potential to lead to new approaches to cancer immunotherapy and create a virtually unlimited supply of T cells.
Researchers at Michigan State University have identified YAP1 and WWTR1 as crucial proteins in regulating the balance between pluripotent cells and placenta formation. This discovery sheds light on the natural process of creating embryonic stem cells, which could lead to advances in regenerative medicine and organoid technologies.