Articles tagged with Pluripotent Stem Cells
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Organoids are transforming biomedical research with their ability to model complex diseases like cancer, Zika virus infection, and cystic fibrosis. They enable high-throughput drug testing, personalized treatment prediction, and safety assessment.
Scientists successfully derive and maintain self-renewing and pluripotent ESCs from chickens and seven other bird species using a growing medium of egg yolk. The study holds promise for applications in studying embryonic development, producing lab-grown poultry, and reviving endangered birds.
Researchers have uncovered how mosquito-borne viruses invade the brain by exploiting specific proteins on blood-brain barrier cells. The study highlights promising molecular targets for future vaccines and antiviral drugs to prevent severe neurological complications.
Researchers successfully created functional ureter tissue from pluripotent stem cells, bringing them closer to developing transplantable kidneys that can produce and expel urine. The achievement is a significant step toward next-generation regenerative therapies.
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
Researchers will gather in Italy to review a decade of work on promoting healthy aging and extreme longevity. The study aims to identify key factors that contribute to the remarkable health of residents over 100 years old.
Researchers found that inhibiting WNT signaling after the hemogenic endothelium stage enhances blood progenitor formation from pluripotent stem cells. This strategy corrects intrinsic deficiencies and brings in vitro-derived HSPCs closer to their in vivo counterparts.
Researchers have identified a novel mechanism of intercellular communication involving mRNA transfer between different types of stem cells. This phenomenon enables cell fate conversion and reverts human pluripotent stem cells to an earlier embryonic stage.
Researchers at Wisconsin National Primate Research Center and Morgridge Institute for Research have developed a universal, small-diameter vascular graft using stem cell-derived arterial endothelial cells. The graft overcomes limitations of current clinical options, which include invasive procedures and limited donor availability.
Researchers at Osaka Metropolitan University have successfully generated feline embryonic stem cells, a major breakthrough for veterinary regenerative medicine. The high-quality stem cells can differentiate into various cell types and be transplanted to restore internal damage.
Dr. Gordon Keller's groundbreaking research on directed differentiation of human pluripotent stem cells has illuminated the path to transforming human health. His lab's world-first discovery and pioneering efforts have pushed the boundaries of what is possible, offering hope for regenerating heart, liver, and blood cells.
Researchers discovered a novel mechanism of intercellular communication through mRNA transfer between stem cells, allowing for biologically significant effects such as cell fate conversion and pluripotent state maintenance.
Scientists discovered a novel method to activate extraembryonic trophoblast potentials in conventional human pluripotent stem cells through transient treatment of epigenetic regulators. This approach holds promise for advancing understanding and treatment of diseases related to placental development.
Researchers successfully created a bi-paternal mouse by modifying genes involved in reproduction. The mice that reached adulthood exhibited altered growth and shortened lifespan, but could potentially lead to new therapeutic strategies for imprinting-related diseases.
Dr. Christopher Seet has received a $2.9 million R37 MERIT Award from the National Cancer Institute to develop innovative T cell therapies for cancer. The grant will support research into iPSC-derived T cells, which can be engineered for enhanced tumor-fighting capabilities.
Researchers have discovered a critical component in the development of neural cells, revealing its role in maintaining cellular identity and early neural fate commitment. This finding provides valuable insights into neurodevelopmental syndromes and suggests new potential solutions.
An international team of researchers successfully created a mouse using genetic tools from a unicellular organism, challenging the notion that these genes evolved exclusively within animals. The study uses ancient genetic tools to reprogram mouse cells into pluripotent stem cells.
New research from Sharon Torigoe at Lewis & Clark College confirms the importance of low-affinity binding sites for Klf4 gene enhancers in naive-state pluripotent stem cells. This discovery advances scientists' knowledge of gene expression mechanisms and has implications for regenerative medicine and understanding human disease.
Researchers found a strikingly similar pluripotency gene network across jawless and jawed vertebrates, suggesting a common evolutionary origin. The study reveals that the loss of the pou5 gene in lampreys' neural crest cells may have limited their ability to form cell types found in jawed vertebrates.
A breakthrough discovery by Nara Institute of Science and Technology researchers identifies EPHA2 as a critical surface protein for preserving stem cell potency. This finding holds promise for safer regenerative medicine by reducing the risk of tumorigenesis, paving the way for organ repair and treatment of degenerative conditions.
Researchers have created the world's first human mini-brain that incorporates a fully functional blood-brain barrier, mimicking human neurovascular development. This breakthrough model promises to accelerate understanding and treatment of brain disorders like stroke, cerebral vascular disorders, and Parkinson's disease.
Researchers at Rice University have made significant strides in understanding the processes guiding human embryonic development. The study reveals that the duration of BMP signal exposure, rather than its strength, plays a crucial role in determining cell fate.
Researchers developed a method to quantify mRNA transcription and degradation rates within individual cell types, uncovering varied regulatory rates across genes. The study provides novel insights into how pluripotent cells adopt specialized identities through gene expression.
Researchers have developed a method to differentiate human pluripotent stem cells into cell populations that form patterns resembling the facial primordium. This allows for the creation of an in vitro model to study early facial development and potential treatments for craniofacial disorders.
A recent study reveals that a significant proportion of human pluripotent stem cell samples possess cancer-related mutations acquired during culture propagation. These mutations impact cell growth and differentiation, emphasizing the importance of regular evaluations in research and clinical applications.
Researchers have successfully genetically modified pluripotent stem cells to evade immune recognition, offering a viable path forward for pluripotent stem cell-based therapies. The study's findings suggest that these engineered stem cells could pave the way for new treatments for diseases such as Type 1 diabetes and macular degeneration.
Researchers successfully created a rat-derived lung in mouse model using reverse-blastocyst complementation and tetraploid-based organ complementation. The study identified crucial factors required for functional lung formation, including fibroblast growth factor 10 (Fgf10) and its interaction with Fgfr2b.
Scientists have successfully grown neurons from stem cells that can repair damaged brain tissue after stroke, offering new hope for treatments. The technology also holds promise for studying neurodegenerative diseases like Alzheimer's, Parkinson's, and spinal cord injury.
Researchers have identified the genetic defect causing infantile cystinosis, a rare disease that shortens lifespan, and developed a protocol to differentiate stem cells into healthy kidney cells. The study suggests using CRISPR genome editing to repair the defective gene and potentially cure the disease.
Researchers at the University of Wisconsin-Madison have successfully generated human norepinephrine neurons from stem cells using a key protein called ACTIVIN-A. These LC-NE neurons may serve as models for disease in humans, enabling scientists to screen drugs and answer questions about neurodegeneration.
Researchers in China have reported the groundbreaking achievement of creating a live birth of a chimeric monkey using embryonic stem cell lines. The study demonstrates the ability of these cells to differentiate into various tissues in vivo, opening up new possibilities for genetic engineering and species conservation. Analysis reveale...
Researchers discovered an anti-nucleolin DNA aptamer that modulates gene expression and nucleolin localization to determine a cell's lineage during differentiation. The study shows promise as a regenerative therapy for cardiovascular diseases.
Researchers have discovered that midbody remnants, thought to be cellular trash, contain working genetic material that can change the fate of other cells, including turning them into cancer. The study suggests that these remnants may play a key role in spreading cancer throughout the body.
Researchers at the University of Helsinki and NIH found that the ectoderm retains its pluripotency during gastrulation, challenging previous understanding. This discovery sheds light on the chain of events in early embryonic development and has implications for neural crest stem cell potential.
The International Society for Stem Cell Research (ISSCR) has introduced a 'checklist' to promote global best practices for human stem cell research. The checklist aims to increase transparency and clarity in the reporting of key quality control measures, enabling authors to disclose critical experimental details.
A study published in Nature Cell Biology found that blood stem cell diversity arises during embryonic development and can be manipulated in childhood to improve overall health. The researchers used zebrafish and human pluripotent stem cells to demonstrate the potential of enhancing blood stem cell production.
Scientists have created human brain organoids free of animal cells, which could greatly improve the study and treatment of neurodegenerative conditions. The novel method uses an engineered extracellular matrix to support stem cell growth, resulting in more accurate models of brain development.
A collaborative study by researchers at the University of Ottawa and McMaster University has made a groundbreaking discovery linking different types of cancers to their embryonic origins. The team found that drugs targeting specific embryonic pathways can effectively treat various tumors, including brain, colon, and leukemia cancers.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Researchers at the University of Washington School Medicine have engineered stem cells that do not generate dangerous arrhythmias. These 'MEDUSA' cardiomyocytes can engraft in the heart, mature into adult cells and beat in sync with natural pacemaking without generating dangerous heart rates.
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.
The study successfully generated functional patient-specific T-cells and thymic epithelial cells from human pluripotent stem cells using thymus organoids. This breakthrough provides a new experimental model system to investigate thymic insufficiency and function, potentially leading to cell-based treatments for thymic defects.
Researchers have successfully converted pluripotent stem cells into hematopoietic stem and progenitor cells using optimized transcription factors. The resulting PSC-derived cells generated all types of white blood cells in mice without giving rise to tumors or leukemias, suggesting a promising future for PSC-based transplant therapies.
Researchers have identified a master gene that controls stem cell behavior, found in an ancient fish species, which can be used to improve human stem cell growth. The study sheds light on the evolutionary origins of pluripotent stem cells, a crucial step towards creating artificial organs.
Researchers discovered the cellular mechanism and molecular trajectory for formation of adult pluripotent stem cells in the acoel worm Hofstenia miamia. This study provides insight into regenerative abilities of certain animals and may lead to new understanding of how stem cells are made.
A new bioreactor system developed by KAUST scientists delivers gases to maintain physiological environments, reducing unpredictable shifts in cell growth. The system allows for more accurate and reproducible experiments in biomedical research.
A team of Berlin scientists has successfully grown stem cells and mini-brains from Sumatran rhino skin cells, paving the way for potential use in assisted reproduction. The next step is to create sperm cells that may help save the critically endangered species from extinction.
A team of scientists has made a breakthrough in growing stem cells and mini-brains from Sumatran rhino skin cells, which may help save the endangered species from extinction. The goal is to create sperm cells that can be used in artificial insemination, increasing the chances of successful breeding.
Researchers generated induced pluripotent stem cells and cerebral organoids from the last male Malaysian Sumatran rhino, enabling study of brain development and potentially aiding in breeding program. The technology holds promise for fighting extinction of critically endangered species.
Researchers produced human and chimpanzee brain organoids to investigate the role of ARHGAP11B in brain evolution. The study found that the gene is essential for neocortex development, with its absence or inhibition leading to decreased levels of critical brain stem cells.
Researchers have created a stem cell-based model of the human liver, allowing for the study of how Ebola virus infects liver cells. The infected cultures showed that viral infection directly disrupts liver function, while immune cells can transfer the virus to other cells.
Researchers have developed a mouse embryo model using only embryonic stem cells, achieving a high level of developmental stages including beating hearts and brain formation. This advancement opens up new avenues for understanding human pregnancy loss and developing organs in culture.
Researchers at KU Leuven have developed a new model of human extraembryonic mesoderm cells, which closely resemble their natural counterparts in early embryos. This breakthrough enables scientists to study processes previously inaccessible during development.
Researchers have successfully engineered human immune cells to model an infection common among immunocompromised people, paving the way for new drug testing and treatments. The immune cell type created played a key role in infection, inflammation, and regeneration, but also served as a natural host for germs.
A study published in Stem Cell Reports found that manipulating two signaling pathways, MAPK and PI3K-AKT, enhances the maturation of human-induced pluripotent stem cell-derived cardiomyocytes. This breakthrough discovery has significant implications for the development of cell therapy for heart disease.
Researchers generated rat sperm cells inside sterile mice using blastocyst complementation, achieving a proof-of-principle for producing gametes from one animal species in another. This breakthrough may speed up the production of transgenic rats for biomedical research and potentially support animal species conservation efforts.
A Purdue University chemical engineer has improved upon traditional methods to produce off-the-shelf human immune cells that show strong antitumor activity. The new method, developed by Xiaoping Bao, mass-produces CAR-neutrophils from human pluripotent stem cells with superior and specific antitumor activities against glioblastoma.
Researchers at Tokyo Institute of Technology have revealed that zinc (Zn) content is essential for the methionine-mediated regulation of pluripotent stem cells (PSCs). The team developed a protocol to convert PSCs into insulin-producing β cells, overcoming diabetes treatment challenges.
Researchers used human heart muscle cells and machine learning to predict arrhythmias in patients, achieving over 90% accuracy. The study lays the foundation for safer and more effective medicines by generating patient risk profiles and drug toxicity testing.