Articles tagged with Progenitor Cells
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Scientists at JDRF have identified a new pancreatic progenitor cell capable of generating insulin-producing beta cells. These cells, similar to embryonic progenitors, show promise for regenerating lost beta cells in people with type 1 diabetes.
A new study by Atsushi Mizoguchi and colleagues established that IL-22 ameliorates disease in a mouse model of ulcerative colitis. The authors suggested that individuals with UC might benefit from local delivery of the IL-22 gene to their intestines.
Engineered blood vessels could be transplanted into tissues such as the kidneys, liver, heart or any other organs that require large amounts of vascular tissue. The researchers created a surface template to grow capillary tubes aligned in a specific direction using nano-scale patterning.
Researchers at Stanford University School of Medicine have isolated a human blood cell called the multipotent progenitor, which is thought to be the great-grandparent of all cells in the blood. This finding could lead to new treatments for blood cancers and other blood diseases.
Researchers are using patients' own bone marrow stem cells to treat cardiac muscle damage after a heart attack. The study, funded by biotech company Amorcyte, has progressed halfway through its four planned groups of patients and aims to assess the safety and feasibility of harvesting bone marrow cells.
Scientists have discovered a method to track neural progenitor cells in the adult human brain, opening new avenues for diagnosis and treatment of neurological disorders. The breakthrough uses magnetic resonance spectroscopy (MRS) to detect proteins produced by these cells.
Scientists have developed a non-invasive method to track neural stem and progenitor cells in the live human brain using MRI technology. This breakthrough could lead to better diagnosis and monitoring of brain tumors and serious neurological disorders.
Two studies found that exercise training increases the growth of new muscle cells and blood vessels in weakened muscles of people with heart failure. The studies showed significant improvements in muscle cell regeneration and vasculogenesis, leading to better health status and increased exercise capacity.
Researchers have discovered gastric progenitor cells in mouse stomachs, which can give rise to all functional stomach glands. This discovery may aid understanding of normal cell turnover and potentially open doors for investigating gastric cancer origins.
The study found that the lymphatic vasculature arises directly and solely from the embryonic veins in mammals, contradicting a competing theory. This discovery holds promise for developing new therapies for lymphatic system disorders and promoting the growth of new lymphatic vessels.
Children’s Hospital Boston researchers have developed a solution to the repeat operations faced by infants and children receiving artificial heart-valve replacements. They created living, growing valves using tissue engineering techniques, which provide one-way blood flow from the heart’s right ventricle into the pulmonary artery.
A new study found that lung-derived mesenchymal stem cells reside in transplanted lungs, challenging the assumption that they originate from bone marrow. These cells have been shown to differentiate into multiple connective tissue cell types and may hold the key to understanding therapeutic options using MSCs that reside in adult organs.
Researchers at St. Jude Children's Research Hospital discovered previously unsuspected mutations in genes that control B-cell differentiation, contributing to pediatric acute lymphoblastic leukemia. The study suggests novel methods for treating pediatric ALL and provides a roadmap for identifying unsuspected mutations in adult cancers.
Researchers propose a novel treatment strategy for retinopathy by repairing abnormal blood vessels instead of destroying them. The study shows that transplanted bone marrow-derived cells can convert leaky blood vessels into normal ones, suggesting a potential therapy for human diseases like ROP.
Researchers successfully generated smooth muscle cells from multipotent adult progenitor cells using TGF-beta and PDGFB, offering a potential source for tissue engineering. This study identifies a model system for studying the effects of therapeutics on SMC development.
Researchers at Duke University Medical Center discovered that zebrafish regenerate heart tissue through a mass of stem cells and protective cell layer interaction. Biochemical signaling between the cell mass and epicardial cells controls the regeneration process, involving growth factors such as fibroblast growth factors.
Researchers found that zebrafish have progenitor cells and an epicardium that can restore wounded heart muscle. The study's findings suggest that these mechanisms could be utilized for therapies, potentially improving the regenerative capacity of mammalian hearts.
Researchers at Mayo Clinic have devised a novel approach to improving the effectiveness and safety of heart stents by magnetizing healing cells from a patient's blood. The cells are quickly drawn to magnetically coated stents, reducing blood clot formation by lining the site fully and quickly.
Researchers found that GM-CSF treatment increased circulating endothelial progenitor cells, improving walking ability without pain. The therapy also showed promise for reducing vascular function risk and atherosclerosis.
Researchers at UT Southwestern Medical Center are exploring the potential of reparative cells to repair damage in multiple sclerosis. The study identifies specific injury cascades and molecular mechanisms that could be targeted for treatment, offering a new avenue for fighting this debilitating disease.
Researchers developed a model system for studying neuro-vascular interactions, enabling the creation of stable vascular networks that can connect with larger blood vessel structures. The approach uses a macroporous hydrogel polymer scaffold and co-seeds it with endothelial cells and nerve progenitor cells.
Researchers found that a protein called alpha4-beta1 integrin promotes the homing of bone marrow-derived progenitor cells to tumor-associated blood vessels. Inhibiting this process could be useful in suppressing new blood vessel formation in tumors.
Research reveals a homing mechanism for bone marrow-derived progenitor cell recruitment to neovasculature. This process is crucial in cancer progression as it enables tumors to acquire new blood vessels.
Researchers discovered that paclitaxel can suppress TGF-beta activity and reduce fibrotic tissue formation in scleroderma. The study also found enhanced angiogenesis in scleroderma skin samples, suggesting a potential treatment pathway.
A new BCG vaccine strain protects against tuberculosis with high efficacy, while a novel TWEAK pathway induces liver cell proliferation in response to injury. These findings may lead to specific therapies for liver diseases and improved TB protection.
Researchers discovered that hyaluronic acid inhibits oligodendrocyte progenitor maturation, leading to brain damage. The findings offer clues on reversing some forms of brain damage and improving lives of thousands of infants.
Researchers found that heterotrimeric G proteins regulate cell division orientation, influencing brain size. Impairing Gβγ signaling leads to overproduction of neurons, potentially contributing to inherited disorders like microcephaly or macrocephaly.
Researchers at the University of Wisconsin-Madison successfully infused rat spinal cords with brain-derived human stem cells that secrete neuron-protecting protein GDNF. This approach has shown promise in protecting healthy neurons and prolonging life in ALS-ridden rats, paving the way for potential treatment of other diseases.
Researchers at Ohio State University discovered that precursors to natural killer cells are found in lymph nodes, not bone marrow. This finding may offer new insights into manipulating NK cells to enhance immune responses to cancer.
A new study reveals that Mcl-1 protein is essential for the survival of hematopoietic stem cells (HSCs), which can contribute to poor leukemia outcomes. The research suggests that interfering with this protein may improve leukemia treatment options.
The UCSD team identified isl1+ cardiac progenitor cells in newborn rats and mice, as well as in human heart tissue, which can spontaneously form heart muscle tissue. The discovery raises the possibility of using these cells to correct a wide spectrum of pediatric cardiac diseases.
A Stanford study found that infusing bone marrow cells from a donor mouse into laboratory mice before chemotherapy can significantly improve their ability to fight infections and survive. This new approach boosts neutrophil production, reducing the risk of neutropenia-related complications.
A team of European researchers, led by Prof. Rosenthal, will collaborate with American scientists to develop and study human cells with an enhanced potential for cardiac regeneration. They aim to apply their collective understanding of adult progenitor cell biology to effective human cardiac repair.
Researchers found that embryonic endothelial progenitor cells could reduce infarct size and improve regional myocardial function when delivered regionally, but not systemically. This study uses a large animal model to test the cardioprotective potential of these cells, paving the way for future human trials.
Researchers found that administering CD34+ cells after a mouse stroke increased new blood vessel growth and neural regeneration. The study suggests that angiogenesis is essential for repairing stroke damage, providing new hope for treating this deadly condition. Additionally, a separate study on leptin regulation revealed an additional...
Researchers found that administering CD34+ cells to mice with stroke damage led to increased new blood vessel growth and improved neural regeneration through the production of growth factors. The findings provide direct evidence for the importance of angiogenesis in repairing stroke damage.
Researchers from Indiana University have identified adult type stem cells that can be grown in large quantities and easily modified with genes. These endothelial progenitor cells show promise as a new gene therapy tool for treating circulatory problems, such as diabetes-related amputations and heart attack repair.
Duke University Medical Center researchers discovered a link between the level of endothelial progenitor cells (EPCs) and coronary artery disease severity. Patients with multi-vessel disease had significantly lower EPC counts, indicating that these cells play an important role in protecting blood vessels from damage.
Researchers have identified a critical gene called Lgl1, which plays a vital role in shaping cell behavior during embryonic brain development. The study found that mice lacking this gene exhibit dramatic abnormalities and resemble human patients with medulloblastoma, a type of brain tumor.
Researchers created immortal human nerve cells by introducing a telomerase gene into progenitor cells, allowing them to continuously divide and produce specific types of neurons. The cells were used to partially repair damaged spinal cords in laboratory animals without forming tumors.
Researchers at Northwestern University have successfully grown nerve cells using an artificial three-dimensional network of nanofibers, a technique important in regenerative medicine. The innovative scaffold directs cell differentiation, driving neural progenitor cells to become neurons and not astrocytes.
The study found that intracoronary infusion of progenitor cells after acute myocardial infarction (AMI) significantly increased mean signal intensity (MSI) in areas with AMI damage, regardless of the type of progenitor cells used. The treatment showed a positive effect on myocardial viability.
Researchers found that progenitor cells from the bone marrow contribute to atherosclerosis by seeding into plaque formations, and that these cells can also help stabilize vulnerable plaques. The study opens up new possibilities for preventing heart attacks.
Researchers have identified 'transcription factors' that control the time of neural cell generation, surprising discovery given earlier spatial control roles. The findings suggest a link between temporal and spatial control mechanisms in neuronal differentiation.
A recent NHLBI study found a link between low levels of endothelial progenitor cells and increased cardiovascular disease risk. The study suggests that these cells play a crucial role in repairing damaged blood vessels, and their depletion may contribute to the progression of heart disease.
Researchers found a significant inverse correlation between circulating endothelial progenitor cells and cardiovascular risk factors. They also discovered that individuals with higher cardiovascular risk factors experience premature aging of these cells.
Researchers have made significant progress in understanding the effects of HIV protease inhibitors on atherosclerosis, as well as exploring novel gene therapies for epidermolysis bullosa. Additionally, studies on CXCR4/CXCL12 interaction reveal new insights into hematopoietic stem cell mobilization.
Researchers found that bone marrow cell transplantation significantly increased new capillary formation and improved blood flow in patients with PAD. The study's findings suggest that this therapy may help alleviate symptoms of PAD, including pain, fatigue, and ischemic ulcers, by promoting angiogenesis.
Researchers have developed a potential treatment for limb ischemia by injecting bone marrow cells into the affected area, stimulating the growth of new blood vessels. This process can reduce pain and improve ulcer healing rates, offering a promising alternative to surgical interventions.
Researchers at Emory University found that growth factor BDNF stimulates the production of new neurons in several areas of the adult brain, including the striatum and hypothalamus. This discovery suggests a more profound capacity for neurogenesis in the adult forebrain than previously thought.