Articles tagged with Progenitor Cells
Changes in progenitor cell populations in breast tissue may contribute to breast cancer development, according to new research. The study found that aging leads to a decrease in myoepithelial cells and an increase in multipotent progenitors, which can fuel malignant growth.
Scientists at Albert Einstein College of Medicine have discovered that coronary arteries form from cells in the ventricles, which can potentially be used to regenerate healthy vessels. This breakthrough could lead to more effective cardiac care and treatments for heart disease.
New research from UTHealth suggests that fat progenitor cells in obese individuals can fuel tumor growth by supporting blood vessel formation. This discovery has the potential to help prevent or slow down cancer progression.
Researchers at the University of Utah discovered that Wnt signaling is essential for the production and specialization of nerve cell precursors in the hypothalamus. The study found that Wnt signaling continues to be required for adult neurogenesis, suggesting a key role in brain plasticity.
A recent study published in Nature Neuroscience has found that external stimulation can impact the development of white matter in the postnatal brain. Researchers used sensory deprivation to examine the growth and collection of NG2-expressing oligodendrocyte progenitor cells, which generate myelin around neurons.
Scientists have identified proteins as the key to maintaining self-renewal in human epidermal progenitor cells and stem cells. The discovery highlights the importance of exosomes in regulating transcription factors, enabling cells to produce new skin cells throughout life.
Scientists develop technique to monitor protein phosphorylation in single living cells, revealing chemical changes over time. The method uses Fourier-transform infrared spectromicroscopy to analyze infrared radiation from a synchrotron light source without damaging cells.
Researchers discovered that TopBP1 is crucial for preventing DNA damage early in brain formation and may act as a tumor suppressor. The study found that cells in the developing brain require TopBP1 to prevent DNA strands from breaking during cell division.
Researchers at Max Planck Institute successfully generated artificial thymus tissue in mouse embryo, discovering key signalling molecules controlling T cell maturation. The discovery represents a crucial step towards producing artificial thymus glands that could be used to replace or augment damaged organs.
Scientists have discovered a way to increase motor neurone production in adult zebrafish using a drug that inhibits the notch-signalling pathway. This breakthrough could potentially help research find ways to turn progenitor cells into motor neurons following damage caused by these diseases.
A study by researchers from Walter and Eliza Hall Institute reveals that progenitor cells can develop into both megakaryocytes and red blood cells, rewriting the 'map' of blood cell production. The discovery has wide-ranging implications for understanding blood diseases and developing new treatments.
Researchers identify CCL5/CCR5 interaction as key to recruiting endothelial progenitor cells for wound healing. Mice with faulty CCR5 show delayed healing, suggesting similar issues in humans with CCR5 mutations.
Researchers at UCLA have discovered that two-way signaling between niche cells, the progenitor cells themselves, and their daughter blood cells is necessary for maintaining a balanced population of blood cells. This balance ensures the creation and maintenance of the blood supply in Drosophila fruit flies.
Scientists at Nationwide Children's Hospital have developed a human-cell-derived model of ALS that accurately mimics the majority of cases. The new model reveals that astrocytes may be releasing toxins that contribute to motor neuron degeneration, highlighting the importance of replacing these cells as a potential therapy target.
A research team led by Bradley Davidson discovered that specialized structures in sea squirt cells, called invadopodia, may help cancer cells evade elimination processes. In contrast to cancer cells, sea squirt cells use these structures to pick up chemical signals for development, not invasion.
New research reveals adult stem cells have distinct epigenetic marks that prevent them from differentiating, which are lost over time. This study provides insights into the mechanisms of epigenetics and its role in regulating stem cell behavior, with potential applications in tissue degenerative disorders.
A study published in Cell Transplantation found that cryopreserved endothelial progenitor cells have the same phenotypic, structural, and functional properties as non-frozen cells. This discovery eliminates the need for cell isolation procedures before using these cells in clinical transplantation.
Researchers have discovered a molecule, Wnt1, that improves the function of endothelial progenitor cells, increasing blood flow to organs with previously blocked circulation. The finding could enhance clinical trials testing these powerful cells in patients hospitalized with cardiac arrest.
Researchers found that transplanted EPCs from human umbilical cord blood significantly accelerated wound closure in diabetic mouse models. The study showed that growth factors and cytokines produced at the wounded skin sites contributed to healing. This experimental study opens the possibility of using endothelial progenitor cells deri...
Researchers found that transplanting autologous renal progenitor cells into rats with kidney damage from pyelonephritis improved kidney structure and function. The study demonstrated benefits for a disease characterized by severe inflammation, renal function impairment, and scarring.
Scientists have pinpointed the type of cell responsible for brain tumors known as oligodendrogliomas, a category of malignant brain tumors. The tumor originates in and spreads through glial progenitor cells, which are often referred to as 'daughter' cells of stem cells.
Researchers found that male pattern balding may arise from a problem with stem-cell activation rather than the numbers of stem cells in follicles. The team discovered that bald areas had the same number of stem cells as normal scalp, but were depleted in progenitor cells.
Scientists at Joslin Diabetes Center have identified progenitor cells in mouse white fat tissue and skeletal muscle that can be transformed into brown fat cells. The study found that exposure to the protein BMP-7 and the diabetes drug rosiglitazone increased conversion rates, suggesting a potential for cell-based brown fat therapies.
Scientists have identified a new area of the brain that generates excitatory neurons in adults, which arise from non-neuronal support cells. This finding has significant implications for regenerative medicine and may lead to new treatments for brain injuries or disorders.
The 'life between the sheets' hypothesis proposes that structured compartments formed between layers of mica could have sheltered and evolved pre-life molecules. Mica's unique properties make it an ideal environment for life to emerge, with its ability to withstand wet/dry cycles and provide a stable surface for cells to develop.
Researchers discover a commercially available supplement stimulates production of hematopoietic stem cells, repairing the body. The supplement increases levels of these cells in the blood over a two-week period, showing potential for treating conditions associated with low cell counts.
Researchers at Penn identified a previously unidentified cell population, termed multipotent progenitor cells, which may be the body's double-edged sword, fighting off parasitic infections but also causing harmful immune responses. This discovery may lead to new targets for treatment of infection and allergic inflammation.
Researchers have developed a micro-implant that clears scar tissue and delivers progenitor cells to the eye, increasing cell survival by 9-fold. The implant's scaffolding uses electrospinning to produce biodegradable fibers with pockets containing enzymes that degrade local scar tissue.
A new study published in the FASEB Journal shows that choline plays a critical role in fetal brain development, particularly in regions associated with memory. Choline is found in meats like bacon and eggs.
The University of Maryland School of Medicine will coordinate a consortium of national experts in stem cell research, with a focus on regenerative therapy and new clinical therapies. The seven-year grant aims to advance the field at a faster pace and realize potential for new treatments sooner.
Researchers found that bone marrow cells can significantly reduce the risk of death or another heart attack in patients who have had a heart attack. The treatment, known as progenitor-cell therapy, showed benefits for at least two years after the initial heart attack.
Researchers at Helmholtz Munich have discovered a new source of nerve cell generation in the adult brain, specifically in the olfactory bulb. This discovery may lead to new therapeutic approaches for Alzheimer's disease, where nerve cell degeneration plays a crucial role.
Researchers at Salk Institute discover critical period during which Lhx2 decides progenitors' regional identity, determining the development of distinct cortical regions. This knowledge may help understand neurodegenerative disorders and specify stem cells to repair brain damage.
A study led by Beth Israel Deaconess Medical Center found that mice on low-carb diets developed significantly more atherosclerosis and had impaired ability to form new blood vessels compared to those on Western or standard diets. Standard markers of cardiovascular risk, including cholesterol, were not affected.
Scientists have discovered a way to regenerate insulin-producing beta cells from non-insulin-producing alpha cells, offering new hope for treating type 1 diabetes. The research found that modifying the expression of a specific gene in alpha cells can drive their conversion into functional beta cells.
A study by Walter and Eliza Hall Institute scientists suggests that luminal progenitor cells, the 'daughters' of breast stem cells, are likely responsible for basal-like breast tumours in women with BRCA1 mutations. The research, published in Nature Medicine, represents a major shift in understanding how breast cancer develops.
Research led by St. Jude Children's Research Hospital scientists shows that switching off a key DNA repair system in the developing nervous system is linked to smaller brain size and problems with movement, memory, and emotion. The study provides new insights into the role of DNA damage response in preventing neurological disease.
Researchers found higher levels of endothelial progenitor cells in pediatric patients with metastatic disease compared to healthy participants. This study provides new insights into the role of circulating endothelial cells and progenitor cells in cancer progression in children.
Research from Boston University School of Medicine sheds light on how airways form and provide insights into lung diseases like asthma and COPD. The study reveals that Notch signaling controls the balance between ciliated and secretory cells in developing airways.
Researchers have developed a credit card-sized device that can detect heart disease using just 200 microliters of blood, a significant improvement over current techniques. The device collects endothelial progenitor cells, which can be used to grow new vascular tissue for transplants and bypass surgeries.
Researchers found that cells use controlled dissolution and condensation to localize subcellular structures called P granules. These liquid droplets transition between dissolved and condensed states, eventually forming germ cells in newly fertilized embryos.
Researchers found that minor differences in cell proliferation timing can explain large differences in eyes of owl monkeys and capuchin monkeys. This discovery reveals an evolutionary mechanism for changes in brain structure, enabling flexibility in eye specialization.
Researchers discovered that only minor differences in cell proliferation timing explain the anatomical differences between owl and capuchin monkey eyes. This finding sheds light on how complex structures like the eye evolve gradually through evolution without compromising function.
A new study identifies chondrogenic progenitor cells (CPCs) in late-stage osteoarthritis cartilage with migratory capabilities and tissue-specific stem cell characteristics. The CPCs may be recruited to degenerating cartilage, offering a potential regenerative therapy for arthritis.
A recent study published in the Journal of Cell Biology found that Vangl2, a protein involved in planar cell polarity, controls asymmetrical cell division and developmental fate of progenitor neurons. In Vangl2-lacking mouse embryos, large numbers of early-born neurons were observed, suggesting premature differentiation.
Scientists have created unique microenvironment microarrays that reveal how adult stem and progenitor cells develop in a woman's breast. They found that the ultimate fate of these cells depends on signals from multiple microenvironments, suggesting a promising pathway for beneficial therapies.
Researchers developed an organic substance that attracts and supports cells necessary for tissue repair and can be directly injected into problem areas. The 'smart scaffolds' work by containing a protein that allows progenitor cells to adhere to damaged tissue and survive long enough to promote healing.
Researchers found that oxidantive stress impairs EPC function, a critical determinant in maintaining a healthy cardiovascular system. High cholesterol and oxidative stress are linked to cardiovascular diseases and diabetes.
Researchers at the University of Washington have reported that mammals can be stimulated to regrow inner nerve cells in their damaged retinas. The study used a specific type of cell called Müller glia and found that it could be encouraged to regenerate in living mice by injecting growth factors.
Researchers at Joslin Diabetes Center have identified pancreatic progenitors that can form into insulin-producing cells after birth or injury, contradicting earlier studies. This finding offers new hope for treating and potentially curing diabetes through replacement therapy.
Researchers discovered that the Hippo signaling pathway regulates vertebrate neural development by controlling cell growth and differentiation. The study identified a new transcription factor protein, TEA domain (TEAD), as the cognate partner of YAP in the nucleus.
Researchers identified two genes that sensitize lymphoid progenitor cells to the effects of aging and confer resistance to leukemogenesis. These genes regulate cell cycle progression and mediate senescence and tumor suppression in aged cells.
The journal features two articles with detailed instructions for setting up experimental culture systems. These methods allow researchers to study and manipulate developing cells and tissues in the laboratory, enabling the identification of neural progenitor cells and the analysis of cell migration between organs during development.
Researchers at UT Southwestern Medical Center have found immature fat cells embedded in blood vessel walls that can grow into adult monsters with excess calories. These cells, called progenitor cells, could be used to treat obesity, diabetes and other metabolic conditions by isolating them from unwanted fat.
Researchers at MIT have developed an imaging system that allows them to pinpoint the number and location of mutant cells in intact tissue. The study found that over 90% of cells with mutations were within clusters, suggesting that most mutations are inherited from another cell.
Researchers successfully grew functional human blood vessels in mice using adult human donor cells, creating a new model for tissue engineering. The study used a combination of two types of progenitor cells to form a small ball of healthy blood vessels, with the ability to rapidly grow two-layered vessels without embryonic stem cells.
Researchers discovered that statins increase the development of oligodendrocytes from glial progenitor cells, a crucial reservoir for brain cell customization. The findings suggest potential benefits and risks associated with statin use in brain health and dementia prevention.
A new non-invasive method to determine tumor oxygen levels and image surrounding tissues has been developed, offering promising insights into tumor development. Researchers suggest that this approach could lead to improved diagnosis and treatment strategies for tumors and other diseases.
Researchers used PET and SPECT imaging to monitor the effectiveness of a new therapy, which successfully preserved healthy heart tissue and corrected blood flow imbalance. Nearly 50% of repaired artery segments showed normalization of glucose metabolism and coronary blood flow.
A study published in AIDS found that neural progenitor cells can form HIV reservoirs in the brain, similar to astrocytes. These cells have the potential to replicate the virus and transmit it outside the brain. Researchers hope to investigate how to protect these cells from the virus and develop new treatments.