Articles tagged with Progenitor Cells
Researchers have found that using a small molecule called givinostat can coax induced pluripotent stem cells to become muscle progenitor cells, increasing muscle stem cells and decreasing destructive inflammation. The strategy also restores levels of dystrophin, a key protein for the muscle, in animal models of muscular dystrophy.
The Drosophila headcase gene regulates adult progenitor cell development, including metamorphosis, by controlling growth, proliferation, survival and resistance to stress. It maintains an equilibrium between hormone-stimulated growth control and the stress response.
Researchers developed a CD45-directed antibody radioconjugate to target and deplete specific immune cells. The treatment safely depleted T cells, B cells, NK cells, and Tregs in mice while sparing red blood cells and platelets.
Researchers have mapped the origins of the embryonic mouse heart at single-cell resolution, identifying a pool of progenitor cells that form heart muscle cells and the early epicardium. This understanding could improve regenerative heart therapies and inform congenital heart defect research.
The SCOUT pipeline enables quantitative comparisons among unique organoids by extracting comparable features. Researchers use it to identify patterns in cell configurations, highlighting similarities and differences across organs
Researchers at Eindhoven University of Technology developed a 'nanobiologic' immunotherapy that trains the innate immune system to eliminate tumorous cells. The approach has shown promising results in mouse melanoma models and non-human primates, offering a new anti-cancer therapy.
Reelin signaling suppresses OPC proliferation both in vitro and in vivo, regulating their radial distribution in the late embryonic mouse neocortex. The regulation of Reelin function by proteolysis is crucial for normal OPC development.
Researchers have generated a single-cell atlas of mouse innate lymphoid cells in the lung, discovering a pool of local progenitors that can generate mature ILC2s. The study reveals the complexity of ILC2 functions and their developmental relationships, shedding light on how they contribute to immune defense and inflammatory diseases.
Scientists at Joslin Diabetes Center have developed a novel cell-based therapy using 'HUMBLE' cells, genetically modified human white fat cells that mimic heat-generating brown fat cells. Transplanted into mice with type 2 diabetes, these cells improved insulin sensitivity and glucose clearance, reducing weight gain and related chronic...
Scientists at La Jolla Institute for Immunology have tracked down the rare stem cells that generate neutrophils in human bone marrow, offering a potential path for intervening in diseases where neutrophil development goes awry. This research may also provide clues to COVID-19 and cancer drug targets.
A six-week blueberry-enriched diet was found to increase human muscle progenitor cell numbers and reduce dead cells, while also lowering oxidative stress and increasing oxygen consumption rate. The study paves the way for future clinical interventions to support skeletal muscle regeneration in humans.
Scientists have discovered that the novel coronavirus SARS-CoV-2 primarily infects progenitor cells in the lungs and bronchi, which are responsible for producing cilia that sweep mucus and bacteria out of the lungs. The virus acts in a highly selective manner, dependent on certain human cells to spread and replicate.
A new study by KU Leuven and Harvard University found that specific nutrients can inform stem cells which type of cell they should become. Fatty acids signal to stem cells to develop into bone-forming cells when blood vessels are present, while cartilage is formed without them.
Researchers found that treating spinal cord injuries with conditioned stem cells boosted neural growth and improved motor function in rat models. After four months, the treated rats showed a three-fold increase in motor activity and significant improvements in cell survival, offering new hope for human treatment.
Researchers have developed biologic pacemaker-like cells using stem cells from fat, offering an alternative treatment for conduction system disorders and cardiac repair after a heart attack. The new cell type can adapt to the body and respond to physiological changes, eliminating the need for regular maintenance by a physician.
Researchers at Scripps Research identified cellular workings that stop and restart early brain development in tadpoles. When food is reintroduced after a period of starvation, neural progenitor cells resume dividing and the brain catches up on its growth.
Researchers at UVA School of Medicine found that oligodendrocyte progenitor cells, previously thought to be harmless, actively participate in the immune system's attacks on myelin in multiple sclerosis. This discovery offers new hope for finding a cure by promoting brain repair and targeting both aspects of the pathology.
Researchers have discovered a new drug target for Myelodysplastic Syndrome (MDS) by targeting an earlier stage of progenitor cells. Blocking the CHRM4 protein receptor significantly improves blood cell production in MDS patients. Preclinical tests in mice show sustained therapeutic efficacy.
Researchers discovered that bone marrow-derived cells contribute to embryo implantation and pregnancy by differentiating into decidual cells in the uterine environment. The study suggests a potential role of these cells in human implantation and pregnancy, potentially leading to new treatments for recurrent implantation failure and pre...
Researchers at UNIGE identified key genes regulating retinal cell differentiation and axon guidance, offering insights into the construction of vision and potential treatments for neurodegenerative diseases. The study's findings have significant implications for regenerative medicine and could lead to new therapies for optic nerve damage.
Researchers at UNIGE have discovered that brain progenitor cells can recover their past skills and rejuvenate when transplanted into a young mouse embryo. This finding sheds light on how the brain constructs itself and opens up new possibilities for cortical neuroregeneration.
Researchers have identified seven types of germ cell tumors, which are caused by failure of mechanisms that prevent spontaneous embryonal development. The new classification is valuable for future research, epidemiology, and clinical care, as it enables more reliable mapping of treatment sensitivity and resistances.
Researchers at Emory University School of Medicine have developed an 'optochemogenetics' approach that modifies a widely used neuroscience tool to stimulate brain cells. The approach uses light to promote functional recovery in mouse models of stroke, with promising results for treating stroke patients.
Researchers have identified the key challenges and breakthrough technologies for applying skeletal muscle progenitor cells in cell therapy. The study highlights the importance of suitable scaffolds and extracellular matrices in regulating progenitor cell behavior, which is crucial for successful tissue regeneration.
Researchers propose a possible cell-based therapy to stimulate lung development in fragile premature infants with Bronchopulmonary Dysplasia (BPD). The study suggests using c-KIT-positive endothelial cells from donors or generating them with pluripotent stem cells as a potential treatment.
The NINDS R35 grant will fund the Casaccia lab's work to elucidate signals regulating oligodendrocyte progenitor cells in healthy brains, addressing normal and dysfunctional cell behavior. This award supports long-term research on regenerative properties of progenitor cells and their role in neurological diseases.
A new study using FlashTag technology and single-cell RNA sequencing identified a core set of temporally patterned genes driving the shift in fate of neural progenitor cells. These molecular 'birthmarks' are transmitted from mother to daughter cells, influencing the types of neurons they will become.
Researchers at Stanford University School of Medicine have identified a specific set of brain cells that are particularly susceptible to harm from low oxygen exposure in early development. The discovery has implications for preventing brain injuries in premature babies, who often suffer from poor neurodevelopmental outcomes.
A study found that eliminating senescent oligodendrocyte progenitor cells can reduce brain damage and inflammation, slowing cognitive decline in mice with Alzheimer's-like symptoms. The treatment, which combines two FDA-approved drugs, was shown to effectively eliminate these cells and protect against cognitive decline.
Scientists have identified three specific subtypes of precursor cells that go on to become fat cells, which may help determine an individual's health risk. The discovery could lead to the development of new treatments that target 'fast burning' fat cells to prevent weight gain and metabolic disease.
Researchers have identified several classes of adipocyte progenitor cells that give rise to fat tissue in mice and humans. The discovery provides insight into the complex mechanisms underlying fat tissue formation and highlights the importance of targeted approaches to prevent metabolic diseases.
Researchers found that severe flu cases reshape the lungs by triggering the growth of 'tuft cells', which may help protect lung function. The discovery may provide insight into preventing long-term respiratory damage after a severe flu infection.
Researchers tracked and quantified blood cell production from hematopoietic stem cells, revealing that red blood cells are the default pathway for all myeloid progenitors. This finding has important implications for understanding disorders such as anemia and blood cancers.
Researchers found that a stem niche in the growth plate produces infinite numbers of cells, changing the concept of growth and potential treatment methods. The discovery may explain cases of unconstrained growth and provide new approaches to treating children with growth disorders.
A new study reveals that the development of progenitor cells depends on protein quantity and interaction with other cells. Cells with high P120ctn expression remain in the central part of the pancreas, while those with low expression migrate to the peripheral area, where they acquire their final fate.
Researchers discovered that exosomes carry heart-specific microRNAs from the bloodstream to progenitor cells in the bone marrow, triggering a repair response. This signals can improve cell-based cardiovascular repair after heart attacks.
A study published in Nature reveals that bone growth in mice follows the same principles as cell production in blood and other tissues. The discovery suggests that bone growth may be more dynamic than previously thought, with cells generated from a stem-cell like progenitor cell.
Researchers identified a new type of immune cell called macrophages that play a critical role in heart valve formation and maintenance. These heart-derived macrophages are particularly adept at consuming excess tissue, making them indispensable to the formation and maintenance of healthy valves.
Researchers at Children's Hospital of Philadelphia have discovered that specialized lung cells emerge early in fetal development, contributing to prematurity-related lung injuries. The study reveals the role of signaling pathways in shaping these cells and paves the way for future therapeutic interventions.
Researchers at Max Delbrück Center found that B1-typical B-cell receptor can reprogram B2 cells into B1 cells, suggesting a new origin for B1 cells. This discovery provides clear evidence for the validity of the second hypothesis on the origin of B cells.
Researchers are exploring ways to speed up and enhance the recovery of the sense of taste after a significant injury. By understanding how IL-1 signaling works in the body, they hope to develop novel treatments to aid regeneration and recovery. In mice, studies have shown that IL-1 plays a crucial role in repairing the taste system.
A team of researchers at La Jolla Institute for Immunology has identified a previously unknown progenitor population with neutrophil characteristics, which promotes tumor growth. The discovery could serve as an early warning sign for cancer and drive new therapeutic approaches for treating neutropenia, chronic inflammation, and cancer.
Investigators from Brigham and Women's Hospital used massively-parallel, single-cell RNA sequencing to analyze nasal polyp samples and identify dramatically altered cells. The team found that epithelial progenitor cells had been permanently altered and expressed an aberrant program, pointing to many pathways that have been altered in t...
Researchers created a mathematical model that captures cellular intent by analyzing mRNA changes over time. This approach helps analyze cell function, disease, and organ development, providing insights into treatment efficacy.
Researchers at ASRC uncover the role of PRMT5 in myelin production, finding it essential for oligodendrocyte differentiation and cell survival. The study provides new insights into myelin formation mechanisms and potential therapeutic strategies for treating CNS diseases.
Bioengineering professor TK Kozai is developing in vivo imaging technology to investigate the role of oligodendrocytes and oligodendrocyte progenitor cells in chronic brain implant degradation. This research aims to identify targets for intervention strategies to improve device performance.
Researchers at ETH Zurich discovered a new type of regulatory fat cell called Aregs that inhibits the formation of new fat cells. This discovery opens up promising avenues for future therapies to protect obese people from diabetes and other secondary illnesses.
Researchers at Princess Margaret Cancer Centre discovered that epigenetic proteins promote mammary gland stem cell proliferation in response to progesterone. Inhibiting these proteins with drugs could potentially prevent breast cancer development in women at high risk of the disease.
USC researchers have discovered that the precise arrival of progenitor cells determines their form and function in the kidney. The study advances understanding of how to assemble building blocks to fashion kidney tissue, which can lead to breakthroughs in drug development and organ transplantation.
Researchers used mathematical models to re-enact brain development in humans, monkeys, and mice, finding that the human brain requires fewer initial cells to grow. The study suggests that humans may have adopted a different developmental program to produce neurons efficiently within a longer gestational period.
Researchers discovered the Hippo pathway is essential for normal heart and blood vessel development. The study used single cell transcriptomics to analyze thousands of cells from developing heart tissue, revealing new insights into cellular and molecular processes leading to an adult heart.
The study found that sensory experiences impact the production of new brain cells and brain growth in zebrafish larvae. Researchers suggest that simulated physical movement could be used to combat abnormal neurogenesis and improve learning and cognition.
Researchers successfully deciphered the origin of repopulated microglia in the brain and retina, revealing that they are solely derived from residual microglia after acute depletion. This study provides insights for regenerative medicine and sheds new light on the origins and maintenance of microglia in the retina.
A Japanese research group develops a method to induce ureteric buds from pluripotent stem cells and successfully reproduces the higher-order structure of the kidney. This achievement is a significant step towards regenerating functional kidneys, which could potentially treat millions of patients with chronic kidney disease.
A Phase I/II clinical trial found that cardiac progenitor cell infusions improved heart function and arm strength in patients with Duchenne muscular dystrophy. The study showed a 7% reduction in heart scar tissue and improved skeletal muscle function in the hands and forearms of patients who received the treatment.
A new study reveals that a population of progenitor cells, marked by high expression of matrix metalloproteinase 9, provides osteoblasts during bone regeneration. These cells are derived from embryonic somites and reserved in niches of bone-forming tissues in adult animals.
A single infusion of wildtype hematopoietic stem and progenitor cells into a mouse model of Friedreich's ataxia restored normal cellular functions, halted cellular damage, and improved mitochondrial function. This breakthrough suggests a potential therapeutic approach for the currently incurable disease.
Researchers at IST Austria have identified a positive feedback loop between cell-cell contact formation and cell fate specification in zebrafish embryos. This loop, triggered by long-lasting contacts, leads to the specification of head mesoderm cells, while short-lasting contacts result in endoderm cells.
UNC School of Medicine researchers found that faulty cell signaling in progenitor cells can derail cerebral cortex development, potentially leading to autism. The study suggests that disruptions in the Wnt protein pathway may play a crucial role in brain development and autism symptoms.
A study published by researchers from the University of Pennsylvania School of Medicine has identified two distinct cell types in the lungs, one promoting regeneration and the other forming scar tissue. This discovery could lead to targeted therapies for conditions such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary...