Researchers used single-cell analyses to track the molecular biology of neutrophil and endothelial cell interactions in moderate and severe COVID-19 cases. They found that neutrophils remain permanently activated in severe cases, leading to a storm of pro-inflammatory signals and massive inflammatory responses.
Scientists from BIH and Open Targets mapped MASLD progression in humans, discovering a regenerative process driven by transdifferentiation. They identified key factors controlling this process, including insulin signalling, which could provide a therapeutic avenue for future development.
Researchers at BIH developed a theory on traveling waves of activity in the human brain, which influences cognitive processes such as learning and remembering. Understanding these waves can support treatment of patients with cognitive disorders, including schizophrenia, epilepsy, and Parkinson's disease.
Scientists identified two genes, ADRA2A and IRX1, that predispose individuals to Raynaud's phenomenon. The genes affect the body's ability to regulate blood vessel constriction, leading to white fingers and toes in response to cold or stress. The study provides new insights into the disease and potential treatment options, including th...
Researchers developed a novel vaccine against SARS-CoV-2 by selecting antigen variants with low binding affinity, resulting in higher neutralizing antibody concentrations. This design strategy may also improve vaccine efficacy for other coronaviruses and herpes viruses.
The research discovered that T cells are especially sensitive to genetic disturbances in their mitochondrial power plants. Different types of T cells show varying degrees of tolerance to defects in the mitochondrial genome, with memory CD8+ T cells rarely affected.
Researchers identified 10 genomic regions associated with insulin resistance after a meal, including a gene that affects glucose transport into cells. The study suggests targeted interventions may be possible in preventing type 2 diabetes.
Researchers found that higher intelligence scores are only associated with quicker performance on simple tasks, while more difficult problems require more time and lead to better results. The brain models also showed that slower brains make fewer errors due to reduced synchrony between brain areas.
Researchers have identified over 300 genome regions that contribute to an individual's chemical fingerprint, influencing susceptibility to diseases and response to drugs. The study's findings can help tailor treatment decisions and improve disease outcomes.
Researchers at the Berlin Institute of Health have found genes and proteins associated with a higher risk of severe COVID-19. The study identified a protein called ELF5, which is present in lung cells and may contribute to the severity of the disease.
Scientists at BIH have found a new metabolite, S-2-hydroxyglutarate, that regulates endothelial cell quiescence and prevents excessive vessel growth. This discovery brings the researchers closer to developing targeted therapies for vascular diseases.
A study of over 11,000 participants found that certain metabolic processes are associated with up to 14 diseases. The researchers identified key factors influencing human metabolism and developed a web application to make their results publicly available.
A team of researchers led by Professor Alexander Meyer has created an early warning system for intensive care units (ICUs) using big data and artificial intelligence. The system predicts postoperative bleeding and acute kidney injury with high accuracy, allowing timely interventions to save lives.
Researchers developed PopDel, a program that reliably identifies large deletions in thousands of genomes simultaneously. The software outperformed existing methods, detecting rare gene variants associated with healthy lipid metabolism.
Researchers discovered hundreds of previously unknown genetic variations affecting small molecule concentrations in the blood, which can impact diseases such as diabetes and eye disorders. The findings provide valuable biomarkers for clinical diagnosis and therapy.
Scientists have discovered that the novel coronavirus SARS-CoV-2 primarily infects progenitor cells in the lungs and bronchi, which are responsible for producing cilia that sweep mucus and bacteria out of the lungs. The virus acts in a highly selective manner, dependent on certain human cells to spread and replicate.
A new algorithm called DeeProtein uses sensitivity analysis to unravel the secret of its predictions, providing valuable insights into protein functions. This technique enables researchers to identify critical regions in proteins that tolerate changes well or poorly, paving the way for targeted modifications.
A recent study published in BMC Public Health found that stressed mothers are more likely to have overweight children, with girls being particularly vulnerable. The research, which analyzed data from over 498 mother-child pairs, suggests that maternal stress during the first year of life can lead to long-term weight development issues ...
A new hypertension disease gene has been identified by Ute Scholl's team, which alters blood pressure regulation. The study focused on familial hyperaldosteronism type II, an inherited condition causing high blood pressure due to overproduction of aldosterone.
The Berlin Institute of Health (BIH) recognizes Professors Louise Pilote and Rhonda Voskuhl for their pioneering work on sex and gender differences in cardiovascular diseases and multiple sclerosis. Their research focuses on incorporating gender aspects into medical practice.