The study highlights the low awareness of foreigners about Russian medical services, lack of language-skilled staff, and limited resources as major obstacles. Experts recommend improving personnel and equipment, informing potential patients, and promoting clinics through word-of-mouth and online platforms to boost medical tourism in Ru...
Researchers at Sechenov University study immune reactions to develop an effective vaccine against SARS-CoV-2. The key finding is that vaccines should induce high-affinity neutralizing antibodies targeting ACE2, while avoiding eosinophilic complications.
Researchers describe various approaches to treating SARS-CoV-2 infection, including immunotherapy and suppression of excessive immune system reaction. Several drugs have shown promise in slowing down the spread of the virus, but no single optimal algorithm has been found yet.
Researchers have discovered genes that facilitate the penetration of cancer cells into the brain, a process that complicates cancer treatment. The study highlights potential targets for therapy, including enzymes and microRNAs involved in disrupting blood-brain barrier integrity.
Current research suggests that adequate zinc status can lower the risk of infectious respiratory diseases, pneumonia, and its complications. Zinc intake has also shown promise in modulating inflammation and suppressing viral replication, including coronaviruses that cause COVID-19.
A recent study published in Sports Medicine - Open reveals that professional soccer players experience asymptomatic cartilage and meniscus damages in their knee joints, regardless of age or career duration. The dominant leg's condition is identical to the non-dominant one, with certain tissue changes more common in experienced athletes.
The study reveals that matrix-bound vesicles (MBVs) have a similar size to liquid-phase EVs but contain different proteins, lipids, and microRNAs. MBVs also share common characteristics with parent cells, suggesting a possible origin from mitochondria.
Researchers analyzed RNA structure data to estimate virus subtypes' age and track spread in Eurasia. The study found that most viruses originated within the last three centuries, with significant expansion in the past 50-100 years.
Researchers discovered that M2-type macrophages are more susceptible to ferroptosis and may exacerbate chronic inflammation. A mathematical model was developed to describe the stability of macrophages under different conditions.
Researchers discovered significant antioxidant activity and enzyme inhibition in various culinary herbs, including rosemary, oregano, and lemon myrtle. These findings suggest that these herbs may have preventive effects on cardiovascular diseases and type 2 diabetes, as well as cognitive decline.
Researchers developed a microfluidics device that isolates cancer cells from urine, achieving high detection rates of up to 85% and 86% for localized cancer cases. The new method provides an alternative to invasive tissue biopsies and blood tests with false positive results.
Scientists investigated allolysis, a phenomenon where bacteria kill genetically identical neighbors under certain conditions. This process may help develop new antibacterial medicines by targeting community dynamics rather than individual cell killing.
Scientists developed a new method to evaluate meat quality using fluorescence spectroscopy, which is precise in classifying meat into standard quality categories. The method detects specific compounds that emit light of a specific frequency range, agreeing with the assumption that connective and adipose tissue make meat more tender.
Scientists are searching for the source of group E antibodies, which trigger most allergic reactions. They aim to deepen understanding of these molecules and develop effective treatments, as class E immunoglobulin is involved in one-third of all diseases.
The study aimed to understand how the properties of tubulin dimers and protofilaments depend on GTP hydrolysis. Scientists verified the first hypothesis that GTP affects flexibility in bonds between dimers, enabling easier straightening of microtubules.
Parkinson's disease is a neurodegenerative disorder characterized by motor and cognitive impairments. Scientists listed ways of applying genetic engineering to study and treat the disease, including manipulating mitochondria and iron homeostasis. CRISPR technology holds promise for finding new effective treatments.
Researchers analyzed 33 studies on laser-induced forward transfer (LIFT) bioprinting to optimize techniques and materials. They found that LIFT technology provides precise cell transfer and precise 3D printing capabilities, with potential applications in tissue transplantation.
Researchers have identified the key challenges and breakthrough technologies for applying skeletal muscle progenitor cells in cell therapy. The study highlights the importance of suitable scaffolds and extracellular matrices in regulating progenitor cell behavior, which is crucial for successful tissue regeneration.
Researchers found a protein called FATP2 that causes neutrophils to weaken the body's reaction against tumors and decrease cancer treatment efficiency. Suppressing its activity delays cancer development.
The study evaluated four chemical fixatives, including diisocyanate, carbodiimide, epoxy compound, and genipin, on bovine pericardium biomeshes. The results showed that three of the four tested agents significantly increased the resistance of biomeshes to collagenase.
Shambhala helps process and compare RNA-Seq data from different equipment, allowing for better study of gene expression and its relation to diseases. The tool facilitates harmonization of large datasets, enabling comparisons across various samples and biological organs.
Researchers analyzed methods of targeted drug delivery to malignant tumors, exploring passive targeting, active targeting, and cell-mediated targeting. By understanding tumor structure and metabolism, scientists can develop personalized treatment approaches to increase efficiency and reduce side effects.
Researchers created biocompatible structures on the basis of chitin obtained from crab shells through mechanochemical synthesis. The resulting structures can be used to replace damaged soft tissues in the human body, and have been shown to be biodegradable and non-toxic.
Researchers found that a stem niche in the growth plate produces infinite numbers of cells, changing the concept of growth and potential treatment methods. The discovery may explain cases of unconstrained growth and provide new approaches to treating children with growth disorders.
Researchers identified 1,544 enzymes that play a key role in wheat's defense against fungal infections. The study found that proteases are involved in cell death induced by infection, but contradicting the current understanding that caspase-like enzymes initiate this process.
Scientists discovered that earthworms efficiently process rice straw, increasing its fertility and preventing the burning of crop residues. This method reduces greenhouse gas emissions and improves soil health, making it a more sustainable alternative to current practices.
Scientists at Sechenov First Moscow State Medical University have discovered new genetic mutations associated with Usher syndrome, an inherited disorder that affects deaf-blindness. The study found unique mutations in DNA regions and confirmed diagnoses of type II USH in Russian patients.
A team of researchers isolated a peptide named emericellipsin A from soil fungi, which possesses antitumor and antibacterial properties. The substance was proved to be effective against various types of bacteria and fungi, including those resistant to other antibiotics.
Scientists at Sechenov University have discovered a new highly sensitive and quick method for diagnosing kidney cancer using antibodies to a retina protein. The method measures the immune response to arrestin-1, which is synthesized in cancerous cells of kidneys, and has been shown to detect benign growths at early stages.
An international team of scientists developed a hybrid micro mixer that increases mixing efficiency by up to 90%, making it suitable for various biological studies. The device combines different geometry elements, offering high process efficiency and replacing existing passive micro mixers.
Scientists developed a hybrid biosensor scaffold material based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. This allows visualization of cell growth and metabolism in engineered tissues by microscopy. The study was published in Acta Biomaterialia and has promising prospects for regenerative medicine.
Iron plays a significant role in ferroptosis, a type of programmed cell death, by inducing lipid oxidation and ROS formation. A recent review by MSMU scientists reveals that glutathione peroxidase 4 reduction is the primary mechanism driving this process.
A new combined action drug was developed by Russian scientists using ionizing radiation and bacterial toxin, showing a 2,200 times stronger effect than separate use. The drug selectively targets tumor cells and facilitates visualization of tumors, making it a diagnostic tool for cancer treatment.
Researchers from Sechenov University found that the absence of cadherin 13 protein affects mice's response to early stress differently than its activation. This discovery sheds light on the genetic basis of neuropsychiatric disorders.
Researchers discovered rare functional variants in genes AAED1 and ATAD2 associated with ADHD risk. These findings may lead to the development of genetic diagnostic methods and a better understanding of the disorder's underlying mechanisms.
Scientists at Sechenov University developed an eco-friendly way to obtain highly active catalysts using supercritical CO2. The new method produced metal-polymeric catalysts with high activity in hydrogenation reactions, offering a safer and cheaper alternative to traditional organic solvents.