Articles tagged with Stem Cell Lines
Researchers at JAX-NYSCF will create and share human stem cell models to better understand Parkinson's disease development. The team aims to create a shared platform of rigorously validated models, data, and protocols to accelerate therapeutic discovery.
A recent study reveals that MLKL activation causes direct damage to mitochondria, impairing energy production and leading to functional decline in hematopoietic stem cells. In contrast, deletion or inhibition of MLKL significantly alleviates these defects, suggesting a post-transcriptional mechanism driving HSC aging.
Researchers have compiled a comprehensive list of 166 human pluripotent stem cell lines available for clinical applications, guiding researchers and developers in selecting optimal cell lines. The study aims to drive hPSC-derived products towards the clinic, addressing a knowledge gap in off-the-shelf product development.
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
The Arc Institute has launched its inaugural Virtual Cell Challenge, a public competition using AI to solve one of biology's biggest challenges. Competitors will train models on gene expression data from over half a billion cells and predict changes in gene activity when individual genes are silenced.
Researchers in China have reported the groundbreaking achievement of creating a live birth of a chimeric monkey using embryonic stem cell lines. The study demonstrates the ability of these cells to differentiate into various tissues in vivo, opening up new possibilities for genetic engineering and species conservation. Analysis reveale...
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Researchers have generated large-scale muscle-controlling nerve cells from ALS patients, revealing striking differences in gene expression between males and females. The study, published in Neuron, used over 450 lines of stem cells to create motor neurons that can potentially lead to the development of new therapeutics.
Researchers at the University of Cambridge discovered that nearly three-quarters of stem cell lines carry substantial DNA damage, which could compromise their use in research and cell-based therapies. The study found that whole genome sequencing is essential for confirming if cell lines are usable.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers have created stem cell models that mimic the genetic disorder, revealing the role of WASP protein in regulating RNA splicing and finding potential therapeutic targets. These findings could lead to new treatments for Wiskott-Aldrich syndrome, a devastating immune deficiency disorder.
Researchers have discovered an alternative route that pluripotent and endoderm extra-embryonic stem cells can use to form intestinal organs in the lab. This finding could lead to improved cell development and potentially treat diseases, but further function testing is needed.
Researchers monitored cell environments for three days, finding significant differences from native conditions. The team aims to develop recommendations on improving culture conditions and reduce environmental instability.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
Researchers at ETH Zurich developed a new chip-based test that incorporates the placenta into embryotoxicity assessments. The test detects indirect damage to embryos by analyzing stress responses of human placental cells to toxic substances.
Researchers at the University of Bath have developed a bioengineering process that uses grass blades to create scaffolds for animal cells to grow on, resulting in cultured meat. The study successfully demonstrates significant cell adhesion and tissue formation, paving the way for a more sustainable meat production method.
Researchers at Skoltech have designed a labeling system for individual cells using polymer multilayer microcapsules that can be easily reproducible and non-toxic. The system allows for the tracking of single-cell behavior and migration with extreme precision, facilitating studies on cell movement and communication in populations.
Researchers from Utrecht University publish a consensus on what constitutes an organoid, highlighting the importance of using primary cells for personalized therapies. The new system categorizes organoids into three types based on defining characteristics, providing clarity for future research and clinical applications.
Osaka University researchers have generated immortalized human eccrine sweat gland myoepithelial cells (iEM cells), which can be cultured for over ten generations. This achievement has the potential to develop next-generation antiperspirants and promote research on sweat dysfunction and regeneration.
Researchers at Arizona State University have developed a new method called TREE to edit genes implicated in Alzheimer's disease, achieving 90% efficiency in human stem cells. The breakthrough uses base editors to make single DNA edits with high accuracy, paving the way for personalized medicine and disease modeling.
Researchers have engineered a human pluripotent stem cell line containing two 'suicide genes' that induce cell death in all but the desired insulin-producing cells. This approach addresses the limitations of PSC-derived beta cells and opens the door to creating safe cell-replacement therapies for people living with type 1 diabetes.
Researchers have developed a new method to analyze cardiac muscle cells derived from human pluripotent stem cells, using a non-invasive fluorescence technique that enables faster and more accurate analysis. This breakthrough method uses CRISPR-Cas9 to generate a calcium-indicating reporter stem cell line, which allows for the examinati...
The discovery of human embryonic stem cells in 1998 revolutionized regenerative medicine, with 29 clinical trials underway globally. The field has grown exponentially, enabling large-scale production of pure cells for research, and nearly $1.43 billion spent on NIH stem cell research over the past 20 years.
Researchers at Tohoku University have successfully cultured human placenta stem cells for the first time, opening up new avenues for studying fetal development and maternal health. The study, led by Takahiro Arima, has shed light on the crucial role of trophoblast cells in supporting fetal growth and development.
Researchers at The Scripps Research Institute identified the p53 gene as a master regulator of mesenchymal stem cells' ability to differentiate. The study found that a basal level of p53 is required for MSCs to act accurately in the body, and its deletion can lead to unexpected differentiation outcomes.
Researchers created Expanded Potential Stem Cells (EPSCs) with greater development potential than current stem cell lines, shedding light on miscarriage and developmental disorders. The EPSCs can develop into any type of cell, offering a platform to study early embryo cells in detail.
Researchers have successfully produced functional arterial cells using new techniques, exhibiting key functions required by the body. Mice treated with these cells showed an 83% survival rate, compared to 33% for controls, and demonstrated improved artery formation and survival.
Scientists have created a comprehensive, high-quality reference set of human induced pluripotent stem cell lines from 301 healthy volunteers. The resource is available for independent research and will help researchers study common genetic variation to put disease variations in context with healthy people.
Researchers at Boston University School of Medicine are creating an induced pluripotent stem cell-based library for sickle cell disease, offering a valuable resource for disease modeling and treatment development. The library comprises diverse patient samples, enabling the study of genetic backgrounds and potential therapies.
A complex of genes regulating epigenetic mechanisms is linked to premenstrual dysphoric disorder (PMDD), a condition affecting 2-5% of women of reproductive age. Dysregulated expression of these genes suggests abnormal cellular response to sex hormones, which may hold hope for improved treatment.
Scientists at Tomsk Polytechnic University have developed magnetic stem cells that can target cancer cells with precision and deliver medication directly to the tumor site. The technology uses patient's own magnet-controlled cells, which are not rejected by the immune system and cause less harm.
Researchers at ETH Zurich have created artificial beta cells that can effectively regulate blood sugar levels. These cells work by measuring glucose concentrations in the blood and producing insulin when necessary, making them a promising solution for diabetes treatment.
The GeroScope algorithm identified 10 substances with potential geroprotector properties, including PD-98059 and NAC. The study suggests that computer modeling can significantly reduce the time and cost of developing new drugs.
A recent study has found that induced pluripotent stem (iPS) cells derived from patient skin cells may contain faulty mitochondrial DNA mutations, which could undermine their therapeutic value. Screening and checking for mitochondrial DNA mutations is crucial to ensure the quality of iPS cell lines intended for therapeutic use.
Researchers have discovered significant differences in cells derived from dura mater and skin samples across the lifespan, highlighting the importance of considering the cell's original location and donor age. These findings necessitate further exploration into epigenetic patterns in stem cells used for new tissue and organ generation.
Researchers designed a revolutionary high-throughput robotic platform to automate the process of generating patient-specific stem cells, reducing variability and increasing scale. This technology allows for 'clinical trials in a dish' and can identify potential drug metabolism and toxicity issues in human cells before clinical trials.
Scientists at University of Michigan and University of Texas Southwestern Medical Center discovered microscopic nanotubes facilitating cell-to-cell communication in stem cells. The findings suggest that these structures may play a crucial role in retaining stem cell identities during division.
The New York Stem Cell Foundation has launched the largest-ever stem cell repository, offering over 600 induced pluripotent stem (iPS) cell lines from diverse human subjects. The repository provides a vast resource for scientists to study various diseases, including type 1 diabetes, Parkinson's disease, and multiple sclerosis.
Researchers have developed a new reprogramming factor cocktail that produces high-quality induced pluripotent stem cells with fewer genetic abnormalities. The SNEL combination outperforms existing methods, such as OSKM, in terms of cell quality and efficiency.
Researchers have developed a method to grow human GI cells from patient tissue in as little as two weeks, creating over 65 cell lines. This breakthrough enables the study of individual patients' underlying problems and can be used to test new treatments.
Scientists suggest that every town could have a small-scale cultured meat factory, producing sustainable and cruelty-free meat alternatives. The production process involves taking stem cells from cell banks and using them to create minced meat cakes.
Scientists at the University of Washington have successfully created a line of human embryonic stem cells that can develop into various tissues. The new 'naive' cells retain their natural ability to differentiate into all types of human cells without artificial genes, opening up possibilities for regenerative medicine and transplantation.
Researchers have developed a device that can sort human cells based on their stiffness, which may help doctors diagnose diseases more accurately. The technology uses microfluidic channels and ridges to separate cells into two streams depending on their mechanical properties.
NYSCF and PPMI collaborate to develop stem cell lines from patients, enabling researchers to study Parkinson's disease progression. The partnership aims to identify biomarkers and accelerate treatment development.
Experts recommend approaches to standardize quality control, develop cost-effective sharing models, and create large-scale libraries of iPSC lines. These efforts aim to tap into the potential of iPSCs for drug screening, disease modeling, and medical treatments.
Researchers at the University of Pennsylvania School of Medicine have created a human-cell model of early-disease progression in pancreatic cancer using induced pluripotent stem cells. The study identified biomarkers that could be used for early detection, treatment, and prognosis.
Researchers at Boston Children's Hospital discovered a biomarker, WNT3, that helps pinpoint stem cell lines primed to develop into cells and tissues including pancreas, liver and bladder. This finding could simplify the process of selecting the right cell line for generating specific tissues for study.
Scientists have developed a safety test for human induced pluripotent stem cells (iPS) that can identify unwanted cells forming tumours and assess cell stability. The breakthrough could improve the quality of iPS cells and lead to safer cell therapies.
A collaborative study reveals how modifications in key epigenetic markers influence human embryonic stem cells as they differentiate into specialized cells. The findings provide insights into processes during early human development and tissue formation.
New York Stem Cell Foundation researchers have developed a quantitative protocol to consistently harvest early-reprogrammed cells, resulting in standardized iPS cell lines. This method enables the derivation of 228 individual iPS cell lines, which can be compared to one another for use in drug screens and cell therapies.
Researchers at Baylor College of Medicine discovered a positive feedback loop between Notch and TGF beta proteins that maintains basal cell population in the prostate. Disrupting this loop may contribute to prostate cancer initiation.
A new human embryonic stem cell line has been developed to aid research on Charcot-Marie-Tooth disease, a common inherited neurological disorder. The line, derived from a donated embryo carrying the gene defect responsible for CMT, is now available for federally-funded research.
A small number of cells in the embryo are enough to form the outer layer of pumping heart muscle in an adult zebrafish. The researchers discovered that only eight single cells contributed to forming a major type of heart muscle, and just one or two cells could create up to 70% of the entire ventricular surface.
Researchers at King's College London have made a breakthrough in developing xeno-free human embryonic stem cell lines that are suitable for public benefit. The lines will be grown and processed by the UKSCB to provide stem cell stocks for clinical research and treatment.
A study published in Cell Stem Cell reveals that adjusting the levels of reprogramming factors can significantly impact the quality and fidelity of induced pluripotent stem (iPS) cells. This finding explains the variability in iPS cell quality reported in recent studies, which has sparked debate about their therapeutic potential.
Researchers found that newly derived human embryonic stem cell lines have a better molecular signature than established lines, indicating higher quality and potentially better performance in disease modeling. The study suggests that maintaining the original state of X chromosome inactivation could be crucial for achieving optimal results.
A Scripps Research team has overcome a major purification problem for stem cells, enabling more reliable and safe treatments. The new method uses lectin arrays to separate stem cells from other cell types, promising significant cost savings and reliability improvements.
Researchers have successfully manipulated targeted genes in human embryonic and induced pluripotent stem cells using zinc finger nucleases and transcription activator like effector nucleases. This precision enables the study of genetic diseases and the development of disease-modifying drugs.
A new study by University of Michigan researchers suggests that banning federal funding for human embryonic stem cell research would have disastrous consequences on the use of induced pluripotent stem cells (iPS cells). The two cell types are complementary and interdependent research tools, and their use has become intertwined. As a re...