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Turning off stress

The study found that three urocortin proteins play a central role in regulating stress responses and shutting down the stress response. Genetically engineered mice lacking these proteins showed impaired recovery from stress, highlighting their importance in returning to normal behavior.

SourceWeizmann Institute of Science·JournalProceedings of the National Academy of Sciences·DateFeb 8, 2011

JCI table of contents: Nov. 22, 2010

High-throughput DNA sequencing of gut bacteria confirmed that antibiotic treatment disrupts bacterial patterns, which precedes VRE colonization and bloodstream invasion. Monitoring fecal bacteria content could identify patients at high risk of life-threatening infections.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 22, 2010

Walnuts, walnut oil, improve reaction to stress

A diet rich in walnuts and walnut oil may improve blood pressure responses to stress by lowering resting blood pressure and inflammation. The study found that adding flaxseed oil did not further lower blood pressure.

SourcePenn State·JournalJournal of the American College of Nutrition·DateOct 4, 2010

New research shows cardiologists can quickly detect significant coronary artery disease using a noninvasive simple, short respiratory stress test

Researchers have developed a non-invasive Respiratory Stress Response (RSR) test that can accurately measure the presence of significant coronary artery disease, with a sensitivity and specificity of 83% and 70%, respectively. The test uses a Pulse Oximeter to measure blood flow in response to paced breathing.

Men and women respond differently to stress

A University of Montreal study found that men and women respond differently to stress, with high blood pressure and heart rate in women who are more defensive. Older men with low defensive reactions have higher cardiovascular rates. The study suggests that socialization and maintaining self-esteem contribute to these responses.

SourceUniversity of Montreal·JournalPsychophysiology·DateMar 23, 2010

New data show cardiac respiratory stress test can quickly detect significant coronary artery disease

Researchers found patients with significant coronary artery disease had a significantly lower cardiac respiratory stress response compared to those without the condition. The test uses a Pulse Oximeter to measure blood flow in response to paced breathing, with high accuracy and sensitivity.

SourceEdelman Public Relations, New York·JournalCardiovascular Revascularization Medicine·DateJan 19, 2010

Severe stress can cause stroke

A study published in BMC Medicine found a correlation between severe stress and an increased risk of stroke, particularly among patients with cerebral infarction due to atherosclerosis or blood clots. The study suggests that further research is needed to understand the role of stress in developing certain types of strokes.

SourceUniversity of Gothenburg·JournalBMC Medicine·DateOct 1, 2009

Taking the stress off yeast produces better wine

Researchers have identified genes in yeast that enable it to respond to stress and are investigating ways to improve its performance by modifying its stress response mechanism. By manipulating these genes, they found a family of enzymes called sirtuins plays an important role in controlling wine yeast lifespan.

New insights on heart's 'fight or flight' response to stress

Researchers at University of Iowa discovered that calcium/calmodulin-dependent protein kinase II (CaM kinase II) activation can increase heart rates, contrary to traditional beta-adrenergic receptor stimulation understanding. This finding suggests inhibiting CaM kinase II function could help control heart rate problems in people with a...

SourceUniversity of Iowa·JournalProceedings of the National Academy of Sciences·DateMar 9, 2009

Enzyme weakens the heart

Researchers from Heidelberg University Hospital found that CaMKII delta enzyme activates stress response and hypertrophy of the heart. Genetic suppression of this enzyme protects mice from chronic cardiac insufficiency, offering a promising approach for systematic prevention.

SourceHeidelberg University Hospital·JournalProceedings of the National Academy of Sciences·DateFeb 17, 2009

Rutgers research reveals how deadly food poisoning and bioterrorism toxins could be tamed

Scientists at Rutgers University have made a breakthrough in understanding the mechanism of ricin-induced cell death. By inhibiting a natural defense mechanism called unfolded protein response (UPR), researchers may develop new therapeutic agents to counteract ricin poisonings, which can also be triggered by certain bacteria.

SourceRutgers University·JournalJournal of Biological Chemistry·DateMar 6, 2008

Penn researchers use brain imaging to demonstrate how men and women cope differently under stress

A study using functional Magnetic Resonance Imaging (fMRI) scans found that men and women's brains respond differently to stress, with women exhibiting stronger lasting responses in the limbic system involved in emotion. The findings suggest a fundamental difference in stress response between genders.

SourceUniversity of Pennsylvania School of Medicine·JournalSocial Cognitive and Affective Neuroscience·DateNov 19, 2007

Mice offer clues to the roots of human resilience

A new mouse study found that mice who are more susceptible to social defeat show increased levels of a growth factor known as BDNF in their brains' reward circuits, which promotes plasticity and learning. Resilient mice, on the other hand, did not exhibit this chemical rise, suggesting a potential link between BDNF and human resilience.

SourceCell Press·JournalCell·DateOct 18, 2007

Early family intervention alters preschoolers' biological response to stress

A new study found that early family intervention can alter children's biological response to stress, leading to improved behavior and reduced risk of delinquency. The intervention, which includes parenting strategies and social skills training, resulted in increased cortisol levels in anticipation of a socially stressful situation.

SourceNYU Langone Health / NYU Grossman School of Medicine·JournalArchives of General Psychiatry·DateOct 1, 2007

JCI table of contents: May 10, 2007

Researchers found that a gene deficiency in CalDAG-GEFI may explain the loss of platelet function leading to recurrent bleeding in patients with leukocyte adhesion deficiency III. Additionally, IL-33 and ST2 signaling was identified as a critical mechanism for protecting the heart from stress, suggesting potential new therapeutic targets.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateMay 10, 2007

JCI table of contents: Feb. 1, 2007

Researchers found that an inhaled drug may provide a new therapeutic for asthma by inhibiting Th2 cell inflammatory responses. Additionally, hematopoietic stem cell transplantation enabled infused tumor-reactive T cells to expand and increase tumor regression in mice.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateFeb 1, 2007