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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Gene network illuminates stress, mutation and adaptation responses

A recent study from Baylor College of Medicine describes an elaborate gene network that functions in causing mutations during DNA repair in stressed cells. The network, composed of 93 genes, regulates the production of mutations in response to environmental challenges such as starvation or antibiotics.

Listen up, doc: Empathy raises patients' pain tolerance

A Michigan State University research team discovered that doctors who listen carefully to their patients have happier patients with better health outcomes. The study found that patient-centered relationships reduce brain activity in the anterior insula, a region responsible for pain perception, and lead to lower self-reported pain levels.

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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.

New paper examines shifting gears in the circadian clock of the heart

A new study reveals that time-of-day specific treatment with a synthetic glucocorticoid can shift the circadian rhythms of atria samples, but with different effects on the direction of shifts compared to the liver. The study highlights the sensitivity of the heart's circadian clock to glucocorticoid signaling.

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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

Women react to and recollect negative news more than men do

Researchers found that women who read negative news had higher cortisol levels after a psychological stress test compared to men. Women also showed stronger emotional responses to the negative news they had viewed previously, suggesting a gender difference in how we react to negative news in the media.

Organisms cope with environmental uncertainty by guessing the future

In uncertain environments, organisms use molecular processes to make guesses about the future, according to a study. Genetic identical individuals exhibit variation in stress responses due to random decisions, which is beneficial as it reduces metabolic costs without compromising overall benefits.

Exposure to violence has long-term stress effects among adolescents

A study by Penn State researchers has found that exposure to violence among adolescents can have lasting physical stress response effects up to a year after the exposure. Cortisol levels were found to be lower in males with higher exposure to violence, suggesting an evolutionary adaptation to suppress cortisol levels.

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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

Sleep deprivation effect on the immune system mirrors physical stress

Researchers found that severe sleep loss affects white blood cell counts, particularly granulocytes, which react immediately to physical stress and mirror the body's stress response. The study suggests implications for clinical practice and professions associated with long-term sleep loss.

Today's environment influences behavior generations later

Researchers found that rats exposed to vinclozolin as fetuses showed increased anxiety, sensitivity to stress, and altered brain activity in their third-generation offspring. This study suggests epigenetic transgenerational inheritance may play a role in the development of post-traumatic stress syndrome and other mental disorders.

Pioneering study shows prenatal choline may 'program' healthier babies

A pioneering study found that increased maternal choline intake during pregnancy can decrease children's chances of developing hypertension and diabetes. The researchers believe choline alters gene expression patterns involved in cortisol production, potentially reducing stress-related diseases.

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Why getting healthy can seem worse than getting sick

A new study offers a fresh perspective on the immune system's acute-phase response, which creates systemic stress that can harm both healthy cells and pathogens. By viewing this response as 'immune brinksmanship,' researchers argue that it may be beneficial for natural selection.

Researcher watches the start of his own disease with unprecedented detail

A study using integrative Personal Omics Profiling (iPOP) combines genome sequencing, disease risk analysis, and molecular measures to capture changes in human biology. The researchers observe tens of thousands of components over two years, revealing dynamic molecular-level changes that provide meaningful physiological information.

Green spaces reduce stress levels of jobless, study shows

A study shows that unemployment stress is more closely tied to local green space than age, income, or deprivation. The presence of parks and woodland in economically deprived areas can help people cope with job losses and reduce cortisol levels.

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Expensive egos

Researchers found that unhealthy narcissism is more than twice as large a predictor of cortisol in males as in females, indicating chronic HPA axis activation. The study suggests that societal definitions of masculinity may contribute to the physiological effects of narcissism on men.

A major step forward towards drought tolerance in crops

Researchers develop novel approach to enhance plant stress response, increasing crop yield under drought conditions. By modifying abscisic acid receptors, the team achieves prolonged activation of stress response pathways, paving the way for breeding more resilient crops.

A novel mechanism regulating stress is identified

Researchers at Tufts University have discovered a novel mechanism regulating stress response in the brain, involving neurosteroids and specific receptors. Blocking these receptors may lead to new approaches for managing stress-related disorders such as depression, epilepsy, and obesity.

Apple iPad Pro 11-inch (M4)

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Caltech researchers find pulsating response to stress in bacteria

Researchers at Caltech found that bacterial cells respond to stress by continuously flipping genes on and off, similar to a heater switching on and off. This pulsating mechanism, triggered by molecular fluctuations, could drive other cellular processes and reveal more about how life works.

How chronic stress short-circuits parenting

A study from the University of Rochester found that chronic stress disrupts a mother's natural stress response, leading to problematic parenting behaviors. Mothers with higher depressive symptoms exhibited hyperactive stress responses, resulting in harsh and reactive parenting.

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Scientists highlight link between stress and appetite

Researchers discovered that stress induces a re-wiring in the brain, impairing endocannabinoids' ability to regulate food intake and contributing to enhanced food drive. Blocking stress hormones prevented this effect, suggesting a potential therapeutic target for manipulating food intake.

Stress and alcohol 'feed' each other

A new study found that acute stress can increase alcohol consumption by altering its effects, while chronic stress may prolong recovery from a stressful event. The study's results suggest that using alcohol to cope with stress may actually make a person's response to stress worse.

Researchers flip the switch between development and aging in C. elegans

Scientists at Buck Institute discover that inhibiting an mRNA translation factor increases stress response genes and extends lifespan in C. elegans. The study highlights the importance of mRNA translation in aging and may lead to the development of therapeutics to slow age-related diseases.

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Plant biology meets up with computational wizardry

Researchers are using computational approaches to analyze and unify data on plant responses to environmental stresses, aiming to improve crop stress adaptation abilities. The Beacon database will facilitate the curation and archiving of signaling pathways for abiotic stress responses.

Elevated levels of sodium blunt response to stress, study shows

New research from the University of Cincinnati shows that elevated levels of sodium can suppress social anxiety by inhibiting stress hormones in the body. The study found that rats exposed to high sodium levels responded less to stress and displayed reduced cardiovascular responses.

Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)

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Behavioral problems linked to cortisol levels

Researchers found cortisol levels increase when behavior problems first appear, then decrease if issues persist. Interventions should start as soon as behavioral problems emerge to address mental and physical health concerns.

Turning off stress

The study found that three urocortin proteins play a central role in regulating stress responses and shutting down the stress response. Genetically engineered mice lacking these proteins showed impaired recovery from stress, highlighting their importance in returning to normal behavior.

JCI table of contents: Nov. 22, 2010

High-throughput DNA sequencing of gut bacteria confirmed that antibiotic treatment disrupts bacterial patterns, which precedes VRE colonization and bloodstream invasion. Monitoring fecal bacteria content could identify patients at high risk of life-threatening infections.

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Childhood adversity may lead to unhealthy stress response in adult life

Healthy adults who experienced childhood abuse or neglect may have an elevated inflammatory response to stress, increasing their risk of depression and anxiety disorders. A study found that adults with adverse childhood experiences had higher levels of inflammatory markers, such as interleukin-6, in their blood.

Walnuts, walnut oil, improve reaction to stress

A diet rich in walnuts and walnut oil may improve blood pressure responses to stress by lowering resting blood pressure and inflammation. The study found that adding flaxseed oil did not further lower blood pressure.

Why we fight: Men check out in stressful situations

A new study by USC researchers found that stressed men have diminished brain activity in regions responsible for understanding others' feelings, whereas stressed women show increased coordination. This sex difference is linked to the effects of stress on social behavior and empathy.

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New understanding of the 'flight-or-fight' response

A new study published in The Journal of General Physiology reveals that HCN channels play a crucial role in regulating heart rate during stress. The research provides insight into the mechanisms behind the 'flight-or-fight' response, offering new understanding of this complex physiological process.

Stress hormones help lizards escape from fire ants

Research by Tracy Langkilde reveals that stress hormones increase energy mobilization in lizards, enabling them to flee from fire ants. Elevated glucocorticoid levels in affected species facilitate adaptive responses, improving survival rates and reproductive success.

Kestrel 3000 Pocket Weather Meter

Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.

Study sheds light on how marine animals survive stress

A Tufts University study sheds light on how marine animals like Galapagos iguanas survive stress, revealing the crucial role of negative feedback in coping with 'fight or flight' responses. The research also has implications for understanding wildlife responses to environmental disasters and oil spills.

Depression affects how women with PMDD respond to stress, pain

A recent study reveals that women with premenstrual dysphoric disorder (PMDD) have distinct biological responses to stress and pain, differing from those with major depression. The findings suggest that PMDD is a separate entity from depression, warranting more precise treatments.

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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.

Men and women respond differently to stress

A University of Montreal study found that men and women respond differently to stress, with high blood pressure and heart rate in women who are more defensive. Older men with low defensive reactions have higher cardiovascular rates. The study suggests that socialization and maintaining self-esteem contribute to these responses.

Severe stress can cause stroke

A study published in BMC Medicine found a correlation between severe stress and an increased risk of stroke, particularly among patients with cerebral infarction due to atherosclerosis or blood clots. The study suggests that further research is needed to understand the role of stress in developing certain types of strokes.

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Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.

Taking the stress off yeast produces better wine

Researchers have identified genes in yeast that enable it to respond to stress and are investigating ways to improve its performance by modifying its stress response mechanism. By manipulating these genes, they found a family of enzymes called sirtuins plays an important role in controlling wine yeast lifespan.

UTSA plant biologists publish where their peers are -- on the Web

Researchers at the University of Texas at San Antonio have published an 11-minute video in JoVE to demonstrate their novel hormone extraction technique. The video provides a clear format for communicating complex scientific experiments and has received nearly 3,000 views since its publication.

Low lead levels in children can affect cardiovascular responses to stress

A study found that even low levels of lead in children's blood can increase vascular resistance and decrease aldosterone levels, which may predispose them to hypertension. The researchers also discovered increased sympathetic nervous system activity during rest and a paradoxical depression of this response during stressful tasks.

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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.

New insights on heart's 'fight or flight' response to stress

Researchers at University of Iowa discovered that calcium/calmodulin-dependent protein kinase II (CaM kinase II) activation can increase heart rates, contrary to traditional beta-adrenergic receptor stimulation understanding. This finding suggests inhibiting CaM kinase II function could help control heart rate problems in people with a...