Tumor Cells
Articles tagged with Tumor Cells
Molecular grappling hooks improve cancer drug targeting and effectiveness
New AI tool developed by Stowers Institute and Helmholtz Munich scientists predicts how cells choose their future — helping uncover hidden drivers of development
Researchers developed RegVelo, an AI framework that models cellular dynamics and gene regulation to predict cellular fate decisions. The model traces developmental trajectories and simulates regulatory interactions, providing insights into hidden drivers of development and potential therapeutic targets.
A blood test reveals ‘neighborhoods’ of cells in tumors, predicts immunotherapy responses
Researchers developed a blood test that identifies nine cellular neighborhoods surrounding tumors, correlating with tumor response to immunotherapy and patient prognosis. The test provides real-time access to information about successful therapies.
Researchers uncover strategy to help exhausted immune cells fight tumors
A new study reveals that impaired protein recycling is the key factor in T cell exhaustion, allowing researchers to develop a 'tag and sort' fix to restore normal proteostasis. This approach boosts the potency of cell therapy against cancer.
Tumor-on-a-chip brings new insight to pancreatic cancer
A team of researchers has developed a 'tumor-on-a-chip' system designed to recreate the complex environment surrounding pancreatic tumors. The system, which combines patient-derived organoids with microfluidic technology, closely mimics the behavior of human pancreatic tumors and demonstrates potential for studying immune responses.
NIH-funded AI model predicts cancer survival from single-cell tumor data
Researchers developed a cancer assessment tool that can identify high-risk patients and specific cell populations linked to their risk. The tool, called scSurvival, predicts survival outcomes more accurately than traditional methods by analyzing single-cell data at cellular resolution.
Primary breast tumors already harbor cells with metastatic potential
Researchers have identified the Prrx1 gene as a key regulator of metastatic potential in breast cancer tumors. This discovery helps explain why highly invasive cells do not always give rise to metastases, and how cells combine invasiveness and proliferation to become the most dangerous from a clinical perspective.
Single nutrient fuels cancer-fighting power of T cells
A Johns Hopkins study reveals that cysteine metabolism shapes CD8+ T-cell function, with implications for boosting cancer-killing immune responses. Limiting cysteine in laboratory models enhanced anti-tumor immunity but impaired T-cell expansion and weakened anti-tumor activity.
New insights into rare pancreatic tumors that cause low blood sugar
A study by researchers at Institute of Science Tokyo has identified a key gene, DOCK10, involved in abnormal insulin secretion in insulinomas. The findings pave the way for novel diagnostic biomarkers and treatment options.
Boron agents termed GluBs reach previously untreatable tumors
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
Researchers uncover distinct tumor “neighborhoods”, with each cell subtype playing a specific role, in aggressive childhood brain cancer
New research reveals that tumor cells in supratentorial ependymomas cluster into distinct neighborhoods, each with a specific role, such as proliferating or invading. Understanding these cell subtypes could help predict treatment response and inform targeted therapies for this aggressive childhood brain cancer.
Unusual tumor cells may be overlooked factors in advanced breast cancer
Researchers found that dual-positive cells, a type of circulating tumor cell, are associated with shorter survival times and increased risk of metastasis in patients with advanced breast cancer. The study highlights the potential importance of these under-studied cells in breast cancer progression.
Senescence behind the aggressive nature of postpartum breast cancer
A study reveals that senescence plays a paradoxical role in postpartum breast cancer, promoting tumor formation while also aiding tissue repair. Targeting senescent cells during mammary gland involution could potentially reduce the risk of this form of cancer.
Cancer treatment: Optimization of CAR T-cell therapy
Unraveling the mystery of why some cancer treatments stop working
SLAMF6 is a molecule on the surface of immune cells that prevents T cells from effectively attacking tumours. Researchers have developed new monoclonal antibodies that prevent SLAMF6 from interacting with itself, potentially offering an option for patients who no longer respond to PD1 or PDL1 treatments.
Decoding a new "engine" of prostate cancer—team led by professor Jun Pang from Department of Urology at the Seventh Affiliated Hospital of Sun Yat-Sen University unveils novel mechanism of CDK12-FOXA1 pathway driving progression
A new study reveals the CDK12-FOXA1-MDM2-p53 signaling axis promotes prostate cancer development through FOXA1 modification. The study identifies S234 phosphorylation as a critical site, and a CDK12 inhibitor THZ531 effectively blocks this pathway, reducing tumor growth.
Discovery illuminates how inflammatory bowel disease promotes colorectal cancer
Researchers found that TL1A, a key immune signaling protein, stimulates the growth of new white blood cells in the bone marrow, which then promote tumor formation in the gut. The study suggests that blocking TL1A activity could be an effective strategy to treat IBD and prevent associated colorectal tumors.
Decoded: How cancer cells protect themselves from the immune system
Cancer researchers have identified a key mechanism by which cancer cells protect themselves from the immune system. The study found that MYC protein can bind to RNA molecules, eliminating alarm signals that would activate the immune defense.
An AI to predict the risk of cancer metastases
Scientists at UNIGE created an AI tool called MangroveGS that can accurately predict the risk of cancer metastasis and recurrence. The algorithm uses gene expression signatures from colon cancer cells to identify key factors influencing metastatic potential, paving the way for more precise care and discovery of new therapeutic targets.
Why do T cells attacking tumors become fatigued?
Active aldehydes promote toxic lipid peroxidation, impairing FAO and activating glycolysis in killer T cells, accelerating exhaustion. This vicious cycle exacerbates T cell differentiation and dysfunction.
A new consensus classifyer for pancreatic cancer available online and as an app
A new consensus classifier for pancreatic cancer has been developed, enabling accurate determination of tumor subtypes and informing treatment choices. The tool also identifies risk factors for the disease, including smoking, which may be more significant in certain subtypes.
World-first discovery uncovers how glioblastoma tumours dodge chemotherapy, potentially opening the door to new treatments
Researchers discovered glioblastoma cells use PRDM9 to survive chemotherapy and regrow tumors. By blocking PRDM9 or cutting off cholesterol supply, persister cells can be wiped out, improving survival in mice. This breakthrough offers new strategies for treating the deadliest brain cancer.
Study captures how cancer cells hide from brain immune cells, shows that removing their “don’t eat me” signals stops their escape
Researchers have identified two proteins that allow cancer cells to evade destruction by brain immune cells, known as microglia. By removing these proteins, microglia play a key role in eliminating cancer cells during the early stage of their arrival in the brain.
Identifying genes that keep cancer from spreading
Scientists at Penn Vet have identified two genes, Ctnna1 and Bcl2l13, that suppress metastasis in preclinical models of colorectal cancer. These findings could lead to better treatments and therapies for patients with metastatic disease.
Customized cells to fight brain cancer
Researchers at UNIGE and HUG have developed CAR-T cells capable of destroying glioblastoma cells by targeting specific proteins present in the tumour environment. The new approach has shown promising results in animal models, paving the way for clinical trials in humans.
Chinese Neurosurgical Journal study decodes clinical features of tumor in brain ventricles
Researchers analyzed 29 new and 22 previously reported cases of PCNSL involving the ventricles, finding different clinical symptoms such as headache, dizziness, and vision impairment. The study suggests that despite its unusual location, ventricular PCNSL behaves like other forms of brain lymphoma, with a recommended treatment strategy...
Decoding the mechanics of cancer invasion
Biomechanical forces play a crucial role in regulating cancer invasion and metastasis by modulating cell membrane topology, actin cytoskeletal remodeling, and mechanical stress adaptation. The review highlights the importance of three-dimensional tumor models and novel therapies targeting mechanical signaling pathways to inhibit invasion.
Chinese Medical Journal Study reveals circulating tumor cells' immune evasion strategies
A recent review in the Chinese Medical Journal uncovers how circulating tumor cells evade immune elimination, highlighting their interactions with immune cells and blood components. The study suggests new therapeutic targets, including anti-platelet therapy and immune checkpoint inhibitors, to combat cancer metastasis.
Lighting up life: Rice scientists develop glowing sensors to track cellular changes as they happen
Researchers at Rice University have engineered living cells to use a 21st amino acid that illuminates protein changes in real time, providing a new perspective on the inner workings of life. This breakthrough addresses a long-standing challenge in biology by allowing scientists to track subtle protein changes within living systems.
Study finds protein target that predicts drug resistance in colon cancer
A team of researchers identified a unique protein signature that can predict which patients are likely to resist standard therapies, paving the way for personalized treatments. By blocking a specific transporter system, they made tumors more sensitive to treatment, suggesting a promising new avenue for treating colorectal cancer.
Tagging ‘fake targets’ for antigen-independent immunotherapy
Researchers developed a novel technology to attach 'fake targets' to tumor cells, enabling immune cells to attack regardless of antigen presence. The Univody platform showed promising results in animal models, suppressing tumor growth and triggering broader immune activation.
New clinical trial to target cancer’s elusive growth switch
The study identified chemical compounds that precisely block the interaction between RAS and a key pathway for tumour growth. The treatment has entered its first clinical trial in humans and has shown promising results, with potential to treat many different types of cancers while avoiding effects on healthy cells.
New mechanism revealed: How leukemia cells trick the immune system
A team at Lund University has discovered a surface protein, SLAMF6, that helps leukemia cells evade the immune system. The researchers developed an antibody to block this mechanism, restoring the immune system's ability to kill cancer cells in laboratory trials and mice.
Myeloid immune cells may offer a new target for immunotherapy in liver cancer
Researchers have discovered myeloid cells in children's liver tumors that could be activated for treatment. This discovery provides new avenues for immunotherapy in childhood liver cancer.
Targeting "aged" immune cells: New strategy to boost immunotherapy in solid tumors
Researchers developed a new strategy to boost immunotherapy in solid tumors by targeting senescent immune cells, which contribute to treatment resistance. The approach showed improved efficacy and lower toxicity compared to existing treatments.
Engineered gut bacteria improves survival outcomes in colorectal cancer tumors
Researchers developed an engineered strain of gut-homing bacteria that induces mature tertiary lymphoid structures, associated with improved survival and stronger treatment responses. The therapy also restored healthy gut microbiota and showed excellent biocompatibility.
“Click-to-glue” turns γδ T cells into cancer-killing ninjas
Researchers develop antibody-γδ T cell conjugates to target PD-L1-positive cancers, inducing pyroptosis and remodeling tumor microenvironment. This dual action promotes direct killing of cancer cells and sustained anti-tumor immunity.
Graz University of Technology opens up new avenues in lung cancer research with digital cell twin
Researchers at Graz University of Technology created a highly detailed digital twin of the A549 lung cancer cell line, paving the way for individualized cancer treatment. The model simulates calcium dynamics and electrical voltages, allowing for testing of drugs and personalized treatment strategies.
‘Internal alarm system’ harnesses immune system against cancer
Scientists at the University of Cambridge created a smarter way to activate the immune system against cancer by harnessing the STING pathway. The new two-part prodrug system triggers the immune response only in tumour tissues, reducing harm to healthy cells.
MD Anderson and Nature to co-host conference on the tumor ecosystem
The University of Texas MD Anderson Cancer Center and Springer Nature will host a free conference on the tumor ecosystem, featuring presentations on cancer immunology, microbiome, disease evolution, and metastasis. Researchers can register for the event and submit abstracts to share their findings.
DGIST successfully demonstrated clinical feasibility of “simultaneous cell isolation technology” to increase accuracy in cancer diagnostics
The study demonstrates the clinical feasibility of simultaneous cell isolation technology, capturing tumor cells and microenvironment cells with high efficiency. The technology improves sensitivity and precision of liquid biopsy, increasing accuracy of early diagnosis and treatment response monitoring.
Study sheds light on how pediatric brain tumors grow
Research uncovers how glutamate regulates pediatric brain tumor growth, suggesting novel approaches to treating these cancers. Inhibiting glutamate receptors has been shown to reduce human pediatric brain tumor growth in mice.
Breast tumors tunnel into fat cells to fuel up. Can we stop them?
Breast cancer cells build molecular tunnels into nearby fat cells to release energy, blocking gap junctions stops tumor growth. The discovery provides a golden opportunity for developing effective strategies to treat the most aggressive forms of breast cancer.
Powering up T cells: a new path in cancer immunotherapy
Researchers discovered a way to boost T cells' ability to fight cancer by rewiring their energy metabolism. By blocking Ant2 protein, they created a state of heightened readiness and potency in T cells, leading to greater stamina, faster replication, and sharper targeting of cancerous threats.
What makes cells migrate – and what can stop them
A team of scientists from the University of Konstanz has identified the PPM1F enzyme as essential for cell migration in both embryonic development and tumor cell invasion. The study found that increased levels of PPM1F enhance the invasive potential of cancer cells, while its absence impairs cell adhesion and migration.
Microrobotic swarms for cancer therapy
Researchers explore the design of microrobots for targeted cancer therapy, including tumor cell eradication, improved penetration, and immune system modulation. The review also discusses advanced delivery strategies and imaging technologies to enhance treatment efficiency and precision.
"Fluorescence ON in cancer cells only" – Diagnosing cancer with light
A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
New urine-based tumor DNA test may help personalize bladder cancer treatment
A new urine-based tumor DNA test can help personalize bladder cancer treatment by predicting which patients are at higher risk for recurrence after immunotherapy. The test, UroAmp, analyzes urine samples to identify bladder cancer-related mutations and generate a genomic profile for each patient.
AI tool set to transform characterisation and treatment of cancers
Researchers developed an AI tool called AAnet to characterize cancer cell diversity, identifying five distinct cell groups with different gene expression profiles. This could lead to more targeted therapies and improved patient outcomes.
Organ sculpting cells may hold clues to how cancer spreads
Researchers discovered dynamic cells coordinate movements to sculpt living tissue in developing fruit flies, highlighting a powerful role of migrating cells in organ formation. This finding suggests similar systems may shape different organs, including the brain and testis.
Magnetically-driven innovative solution developed for personalized intracranial tumor therapy
Researchers developed magnetically driven biohybrid blood hydrogel fibers that can deliver chemotherapy directly to brain tumors while evading the immune system. These fibers exhibit exceptional capability to navigate intricate environments and offer real-time tracking capabilities.
Pancreatic cancer spreads to liver or lung thanks to this protein
Scientists at UC San Francisco discovered how pancreatic cancer cells metastasize to the lungs or liver using the PCSK9 protein. PCSK9 controls cholesterol acquisition, with low levels favoring the liver and high levels supporting lung adaptation.
Study links a novel biomarker with potential to predict and treat skin cancer metastasis
Researchers identified C5aR1 as a novel prognostic biomarker and potential therapeutic target for treating metastatic skin cancer. Elevated C5aR1 presence suggests increased metastasis risk and poor survival in patients with cutaneous squamous cell carcinoma.
Live view: Stress-induced changes in generations of cancer cells
A study at the University of Zurich tracks live cellular development and epigenetic changes over multiple generations, showing how stress induces heterogeneity and increases genetic complexity. This research may lead to better understanding of cancer cell diversity and develop more effective therapies.
Blood type a identified as potential breast cancer risk factor
A systematic review and meta-analysis found that individuals with blood type A have a significantly higher risk of developing breast cancer compared to those with blood type O. The research, which pooled data from over 13,000 breast cancer patients and 717,000 controls, suggests an 18% increased risk associated with blood type A.
New nanoparticle could make cancer treatment safer, more effective
Researchers created a new nanoparticle that combines focused ultrasound and chemotherapy to destroy tumors more precisely and prevent recurrence. The treatment shows promising results in preclinical models, offering a potential breakthrough in cancer therapy.
AACR: New CAR T cell therapy benefits patients with advanced thyroid cancers
AIC100 demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer, including anaplastic thyroid cancer (ATC) and relapsed/refractory poorly differentiated thyroid cancer (PTDC). The therapy showed significant tumor shrinkage and disease control in 56% of patients.
Natural killer cells remember and effectively target ovarian cancer
Adaptive NK cells exhibit tumor-specific immune memory and cytotoxicity in ovarian cancer, making them promising for cancer treatment. The study challenges previous perceptions of NK cells, which have historically been considered only innate immune cells with no memory function against cancer.
Tumor microenvironment dynamics: the regulatory influence of long non-coding RNAs
Long non-coding RNAs (lncRNAs) play a crucial role in regulating the tumor microenvironment, influencing processes such as immune evasion, angiogenesis, and metastasis. They mediate interactions between tumor cells and their surrounding microenvironment, modulating stromal cell activities and promoting tumor growth and survival.