Articles tagged with Tumor Cells
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study found that increased LOXL2 protein levels in alveolar rhabdomyosarcoma cells promote metastasis. The protein's role in regulating metastatic function remains unclear, but it interacts with vimentin, a cytoskeletal protein involved in cell migration.
Researchers from Brazil, the UK, and Italy developed a novel palladium compound that acts selectively and powerfully against ovarian tumor cells without affecting healthy tissues. The compound has shown twice the potency of cisplatin against resistant tumor cells.
Immune cells facilitate glioblastoma growth by clearing necrotic areas while ignoring tumour cells. Researchers aim to train microglia and macrophages for tumour elimination through immunotherapy or other strategies.
Research reveals frequent RB1 intragenic rearrangements in non-smoking patients with EGFR mutations, indicating higher resistance to EGFR inhibitors. The alteration may favor growth and tumoural versatility of resistant clones.
Brazilian scientists led by Rodrigo Ramos Catharino found that Zika virus inhibits tumor cell proliferation in prostate cancer cells, even when inactivated. The study, supported by FAPESP, used a human prostate adenocarcinoma cell line and identified markers of metabolic changes caused by the virus.
Researchers discovered that reactivating the PPP2R2A gene can slow or stop prostate cancer progression. The study found that patients with only one functional copy of the gene have shorter survival rates, and that reconstituting PP2A protein ultimately kills prostate cancer cells.
Researchers have successfully used copper-based nanomaterials to eliminate tumour cells in mice, combining with immunotherapy for long-lasting immune effects. The breakthrough offers a novel approach to treating lung and colon cancers without the use of chemotherapy.
Researchers found that blocking androgen receptors can increase the density of prostate-specific membrane antigen (PSMA) sites on tumor surfaces, allowing for more targeted radiation therapy. This breakthrough could lead to more efficient treatment of advanced prostate cancer.
Researchers found that pancreatic tumor cells secrete interleukin-1β (IL-1β) to reduce anti-cancer immune responses, promoting PDA tumor growth. Blocking IL-1β with an antibody treatment doubled T cell infiltration and increased PD-1 blockade efficacy by 40%.
A Northwestern University study discovered an inverse relationship between patient survival and the plasticity of tumor cells. Cancer cells with disorderly chromatin packing are more likely to adapt to treatments, but researchers can now develop new therapies that target chromatin packing to make cancer cells more vulnerable.
Researchers have developed a low-intensity ultrasound approach that exploits the unique physical and structural properties of tumor cells to target them. By tuning the frequency to match the target cells, they were able to break apart several types of cancer cells without harming healthy blood cells.
Researchers have made a breakthrough in understanding cancer prediction by developing a new method to evaluate cell dynamics and tumor initiation. Their calculations reveal that fixation times are a more important metric than lifetime risks, and that some mutated cells may fix tumors faster than expected.
Pancreatic cancer cells use a process called macropinocytosis to engulf nutrients, which are then broken down into building blocks for cell growth. The study identified key molecular steps involved in boosting this process, including the activation of protein kinase A and v-ATPase.
A new method called scPred uses single cell analysis techniques with machine learning algorithms to identify specific types of cells. This can help diagnose cancer and autoimmune diseases earlier, and personalize treatments for individual patients.
The European Research Council has awarded €2 million to Ruben van Boxtel's research on late effects of childhood cancer treatment, focusing on developing second cancers. Van Boxtel aims to identify the components of treatment that cause DNA changes and predict patient risk for developing a second novel cancer.
A team of researchers identified a cell surface receptor, CXCR2, essential for hormone-resistant prostate cancer cells. They showed that targeting this receptor can halt tumor growth using a drug originally intended for lung diseases.
Researchers found that MALT1 levels correlate with patient survival in brain cancer, and blocking the gene with MALT1 inhibitors causes glioblastoma stem cells to undergo cellular suicide. This discovery points to the potential of further exploring MALT1 inhibitors as a treatment for glioblastoma.
A research team identified that several types of highly aggressive pediatric brain tumors originate from stalled development of progenitor cells in the pons and forebrain. The findings represent a significant advance in understanding these diseases, which are the leading cause of cancer-related deaths in children.
Researchers analyzed pleural effusion fluid from patients with non-small cell lung cancer and malignant mesothelioma, discovering unique cytokine profiles that may influence the tumor environment. The study suggests harnessing the local pleural immune environment could lead to improved treatment outcomes.
In a mouse model of liver cancer, researchers found that activating the Hippo molecular signaling pathway in tumor cells drives growth, while suppressing it in surrounding healthy cells inhibits tumor growth. Systemic inhibition of Yap and Taz could have unwanted consequences by blocking tumor-suppressing abilities of healthy cells.
Researchers found that circular extrachromosomal DNA in cancer cells dramatically amplifies mutant oncogenes, promoting aggressive behavior and resistance to therapy. This unique shape enables tumor cells to generate massive amounts of growth-promoting oncogenes and evolve quickly.
Researchers identify a hyperploid salvage survival pathway in high-grade serous carcinoma cell line models that bypasses apoptosis and emerges as viable large hyperploid cells. This pathway may contribute to acquired resistance and genomic diversity of recovering tumor cells.
Researchers found that CD95 activation triggers apoptosis in individual cells, but stimulates growth in clusters of cancer cells. The study suggests new ways to transform growth-stimulating signals into cell death signals for cancer cells.
Researchers at FEFU developed a method to synthesize biologically active derivatives of fascaplysin, a compound found in sea sponges. The new compounds, including 14-bromoreticulatine and 3,10-dibromofascaplysin, show selective effects on cancer cells, particularly Pseudomonas Aeruginosa bacteria and human prostate cancer cells.
Researchers have discovered a way in which leukemia cells can change their identity to become macrophages, a process known as transdifferentiation. This transformation occurs through epigenetic changes that alter the cell's genetic material, allowing it to acquire new functions and behaviors.
A study published in Nature Cell Biology has identified a protein called CD9 that drives growth of pancreatic cancer and could be a target for new treatments. The researchers found that CD9 is present on the surface of cancer stem cells, which are a driving force behind cancer growth.
Scientists at Shinshu University discovered a compound in grape stems that induces cell cycle arrest and suppresses the invasive activity of prostate cancer cells. The study found significant anti-cancer activity, with potential applications for metastasis prevention and cancer treatment.
Researchers have discovered that mitochondria undergo reprogramming under low oxygen conditions, a process that could provide new therapeutic targets for pancreatic cancer. This reprogramming enables cancer cells to adapt to energy scarcity by switching to glycolysis, allowing them to continue growing despite limited nutrients and oxygen.
A compound developed by Johns Hopkins researchers has been shown to slow tumor growth, alter the tumor microenvironment, and promote durable and highly active anti-tumor T cells. The drug, a prodrug version of glutamine antagonist DON, was designed to target cancer cells' high demand for glutamine.
Researchers found that oxygen-starved tumor cells have a four times greater probability of becoming viable circulating tumor cells than those under normal oxygen conditions. These cells also have six times the probability of forming lung metastases, suggesting that oxygen starvation enhances their metastatic capabilities.
A team of scientists has identified a specific gene, eIF2B5, that is essential for the survival of colon cancer cells with APC mutations. Inhibiting this gene causes programmed cell death in mutated cells but not in healthy cells, providing a promising new target for antitumor therapies.
Researchers analyzed pleural effusions from NSCLC patients, mesothelioma, and benign cases, identifying distinct cytokine levels that may influence tumor growth and immune response. The study suggests modifying the local pleural immune environment with antibody-based therapeutics could enhance anti-tumor effects.
The study found that tumor cells undergoing epithelial to mesenchymal transition (EMT) play a key role in metastasis. However, the reverse transition, MET, is occurring at the metastatic site, suggesting that EMT is not always required for metastasis.
Researchers at Linköping University have successfully captured the instantaneous image of the MYC protein bound to TBP, shedding light on its role in cancer. The study reveals that MYC's adaptability and dynamic structure enable it to interact with over 300 proteins, making it a promising target for new cancer therapies.
Gajewski's research found that a 'hot' or T cell inflamed tumour microenvironment is key to unlocking immunotherapy efficacy. STING agonists and targeted therapies are being developed to combat 'cold' tumours with limited immune response.
Weiqiang Chen, an assistant professor at NYU Tandon School of Engineering, has been awarded a $1.7 million NIH grant to develop personalized approaches to CAR-T cell therapy for cancer treatment. The grant will support the development of microfluidic systems to model disease environments and study cell interactions.
Researchers created a 3D-printed cell trap that captures white blood cells and filters out red blood cells, leaving behind tumor cells for diagnosis and research. The device can process large volumes of blood at low cost, making it suitable for clinics and hospitals.
Researchers at UNIGE have developed a new formula, C2, composed of four anti-cancer drugs that target and kill tumour cells while leaving healthy cells intact. The formula has shown promising results in reducing the risk of resistance and side effects associated with high-dose treatments.
A USC study reveals that circulating tumor cells have a unique molecular signature that predicts specific organ targets, such as the brain. The discovery provides potential treatment targets to prevent cancer spread and improves detection and monitoring methods.
Researchers found that cells on a tumor's periphery are softer and more likely to invade surrounding tissues. This softness enables the cells to spread through the body's vasculature, forming 'invasive tips' that break away from the tumor.
Researchers at Washington University and USF Health developed a peptide-based nanoparticle that delivers siRNA to suppress KRAS-driven cancer growth without adverse effects. The nanoparticles effectively target tumor cells, reducing tumor cell death and slowing cancer growth.
A compound has been identified as effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs), a major challenge in treating this devastating cancer. The research also showed that the compound is non-toxic to normal cells, raising hopes for developing drugs with low toxicity.
Researchers from CNIO developed stable long-term cultures of mouse urothelial cells, enabling the study of biological mechanisms underlying bladder cancer. They identified a small population of stem cells that gives rise to cancer, providing new insights into disease development and tissue regeneration.
Researchers developed a 3D in vitro system to examine dynamic interactions between brain tumors and the surrounding extracellular matrix. The study found that fetal ECM supported tumor growth better than adult ECM, and lipid droplets released by glioblastoma cells may contribute to lower drug sensitivity.
A team of researchers has developed a novel anti-cancer prodrug called phorbiplatin, which can be controllably activated by low-intensity red light. This unique property reduces collateral damage and kills cancer cells while minimizing harm to normal tissues.
Researchers at Tel Aviv University have discovered that engineered T cells can target and kill solid tumor cells coated in specific antibodies. This breakthrough in immunotherapy shows promise for treating various types of cancer, offering a more targeted approach than traditional chemotherapy.
Researchers at Washington University in St. Louis found that collagen fiber length can affect how cells move collectively, with longer fibers supporting streaming out of colonies and elongating cells. The study suggests that a balance between aggressiveness and cooperation is crucial for cell movement.
Researchers at UCLA developed a therapy that permanently boosts the body's ability to produce invariant natural killer T cells (iNKT cells), which attack human tumors. The treatment, engineered from hematopoietic stem cells, effectively suppressed tumor growth in mice with multiple myeloma and melanoma.
The study found that tumor heterogeneity, not mutational burden, is a key factor in determining the success of immunotherapy for melanoma patients. Researchers developed an experimental system to systematically generate tumors with intermediate levels of genetic heterogeneity, leading to a high correlation between this factor and treat...
Researchers found that neurons in the brain form direct cell-to-cell contacts with aggressive glioblastoma cells, transmitting activation signals that drive tumor growth and invasion. Blocking this signal transmission can slow down tumor spread, offering new avenues for treatment.
A team of researchers has identified a new circular RNA that promotes tumor activity, contradicting its role as a cancer suppressor. The discovery opens up new opportunities to understand the genetics of cancer and potentially develop targeted treatment protocols.
Researchers have created a targeted transport system using palladium-based exosomes to deliver chemotherapy drugs directly to cancer cells. This method has the potential to reduce side effects and increase treatment efficacy.
Researchers have developed a molecular shuttle system to deliver precious metal catalysts directly to cancer cells, potentially reducing side effects of chemotherapy. The new method uses artificial exosomes to transport palladium catalysts straight to primary tumours and metastatic cells.
Researchers have made a breakthrough in cancer treatment using nanoparticles that can be activated by radiation, resulting in statistically significant reductions in tumor size. This innovative approach builds on previous research and has the potential to effectively treat tumors throughout the body.
A non-coding region of the genome has been discovered to regulate the development of cancer in various types of tumors, including breast cancer and sarcomas. The RPSAP52 RNA molecule triggers cell proliferation and cancels differentiation, allowing tumor cells to multiply and spread.
Rhabdoid tumors are aggressive brain and kidney cancers with poor prognosis, requiring innovative treatments. The ERC grant aims to understand the disease's underlying mechanisms through unique models and lineage tracing techniques.
Researchers discovered that telomerase, which promotes unlimited cell division in cancer cells, also prevents tumors and slows a key stage in normal cell death. In healthy adult cells, telomerase activates just before cell death, buffering cells from aging stresses and reducing DNA damage.
The National Institutes of Health has granted $2.23 million in funding to develop statistical and computational methods for genome-wide CRISPR/Cas9 screening. The goal is to improve functional gene identification, analyze non-coding elements, and study genetic interactions, with potential applications in cancer research.
Researchers found that non-cancerous cells in tumor microenvironment regress into stem cell-like state, supporting cancer growth. This 'corruption' of neighboring cells enables cancer to thrive and spread.
Researchers at Mayo Clinic found that increasing PD-L1 expression in colorectal cancer cells can improve chemotherapy effectiveness. This discovery suggests a potential strategy to enhance treatment outcomes for patients with resistant colon cancer.