Researchers discovered that deleting the aryl hydrocarbon receptor from oral cancer cells results in a robust tumor-specific immune response, allowing mice to reject the cancer. This finding provides a new target for cancer immunotherapy treatment, potentially leading to more effective treatments.
SourceBoston University School of Medicine·JournalProceedings of the National Academy of Sciences·DateMay 4, 2021
Biomedical engineer Chase Cornelison is exploring ways to harness cancer cells to treat spinal cord injuries and restore function following brain damage. His research aims to retrain neural cells to suppress inflammation and promote repair, potentially reversing the damage caused by paralysis and diseases.
SourceUniversity of Massachusetts Amherst·DateMay 4, 2021
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Scientists from UNIGE and UZH used a statistical physics approach to study wound healing, identifying the scales of dominant cell interactions that govern tissue growth. The results allow for better analysis of cell front behavior in both healthy tissue and tumour development.
SourceUniversité de Genève·JournalScientific Reports·DateMay 3, 2021
A new strategy combines AIEgen-mediated photodynamic therapy with Poly(I:C)-based immunotherapy to enhance anti-tumor immune responses. The system induces tumor cell death and stimulates cytokine release, demonstrating potential for preventing tumor recurrence and metastasis.
SourceScience China Press·JournalNational Science Review·DateApr 30, 2021
Researchers at UCSF have engineered smart immune cells effective against solid tumors, overcoming hurdles for immunotherapies. The new approach may be ready for clinical trials in the near future, offering hope for patients with previously untouchable cancers.
SourceUniversity of California - San Francisco·JournalScience Translational Medicine·DateApr 28, 2021
A new method called XYZeq allows researchers to map variation across cells in a tissue or tumor, gaining insight into their spatial location and function. The technique enables the analysis of cellular patterns in complex environments like cancerous tumors and other organs.
SourceGladstone Institutes·JournalScience Advances·DateApr 22, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A recent study by Vanderbilt researchers reveals that non-cancer cells in a tumor, primarily immune cells called macrophages, have the highest glucose uptake, upending traditional models of cancer metabolism. This finding could lead to new therapies and imaging strategies.
SourceVanderbilt University Medical Center·JournalNature·DateApr 7, 2021
Researchers discovered two subsets of tumor cells that can be targeted using different methods, one inducing ferroptosis and the other inhibiting antioxidant production. The study found that combining these approaches could improve treatment outcomes for small cell lung cancer patients.
SourceUniversity of Cologne·JournalNature Communications·DateApr 6, 2021
Researchers discovered a cell-to-cell communication network that instructs tumor cells in tissues to regrow after genotoxic therapy. The study found that elevated p53 levels and release of interleukin-6 signal cells to activate growth signals, leading to tumor regrowth.
SourceUniversity of Missouri-Columbia·JournalCommunications Biology·DateApr 5, 2021
Researchers found that autophagy selectively degrades PKA inhibitory subunit RIa, promoting mitochondrial metabolism and tumor cell growth. Suppression of AKAP11 levels in tumor cells prevents degradation and blocks PKA activation, inhibiting tumor cell growth.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalProceedings of the National Academy of Sciences·DateMar 31, 2021
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers have identified a key protein, DAPK3, that plays a crucial role in the body's early immune response to cancer. The discovery highlights a new approach to cancer immunotherapy, where targeting the tumor's own innate immune system can help slow tumor growth and improve treatment outcomes.
SourceLa Jolla Institute for Immunology·JournalNature Immunology·DateMar 25, 2021
Scientists have identified new biomarkers in exosomes produced by cancer stem cells, which could help diagnose and predict malignant melanoma. These biomarkers were found to be present in the blood of patients with different stages of the disease, distinguishing them from healthy individuals.
SourceUniversity of Granada·JournalMolecular Oncology·DateMar 25, 2021
Researchers at the University of Chicago developed a new therapeutic vaccine that uses a patient's own tumor cells to train their immune system to find and kill cancer. The vaccine stopped melanoma tumor growth in mouse models and promoted a broad, robust immune response, preventing new tumor growth when tumor cells were re-introduced.
SourceUniversity of Chicago·JournalScience Advances·DateMar 24, 2021
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers developed a new vaccine that uses a patient's own tumor cells to train the immune system to find and kill cancer, promoting a broad and robust immune response. The therapy has shown long-term efficacy against metastasis and relapse in mouse models, offering potential for treatment of various cancers.
SourceUniversity of Chicago·JournalScience Advances·DateMar 24, 2021
Researchers have identified YAP as a key regulator in the development and spread of basal-like breast cancer. Inhibiting YAP activity with medication can significantly reduce tumour volume, offering new hope for patients' survival.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalCancer Research·DateMar 22, 2021
Researchers at Imperial College London have developed a new type of nanoprobe that uses second harmonic generation (SHG) to detect tumors more brightly and precisely than existing fluorescent nanoprobes. The biodegradable bioharmonophores attach specifically to tumor cells, reducing misrepresentation and improving detection sensitivity.
SourceImperial College London·JournalACS Nano·DateMar 11, 2021
Researchers discovered that metastatic cancer cells use adhesion and contractility to move away from stiffer tissue, defying the typical durotaxis process. By modulating cell contractility, they can change their ability to migrate in response to environmental stiffness.
SourceUniversity of California - San Diego·JournalCell Reports·DateMar 9, 2021
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers have developed a lower-dose radiopharmaceutical that improves treatment efficacy for neuroendocrine cancers while reducing side effects. The new medication uses reversible binding technology to extend its half-life in the blood, providing an extended therapeutic time window and improved treatment outcomes.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalJournal of Nuclear Medicine·DateMar 9, 2021
Researchers assessed tumor cell isolation and in vitro proliferation assays to predict chemotherapy response in ovarian cancer. In 12 of 14 cases, in vitro drug sensitivity correlated with clinical outcome.
SourceImpact Journals LLC·JournalOncotarget·DateMar 8, 2021
Researchers successfully developed bispecific antibodies that can target and deplete cancer cells without damaging healthy ones, including mutant tumor suppressor genes like p53. These antibodies could be used 'off-the-shelf' and are a promising alternative to engineered immune cell therapies.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateMar 1, 2021
Researchers found that tumor cells increase SLC6A14 expression levels in response to methionine deprivation, leading to increased AMPK activation. Targeting both SLC6A14 and AMPK may drive unbalanced metabolism in starved tumor cells, promoting apoptosis.
SourceImpact Journals LLC·JournalOncotarget·DateMar 1, 2021
Researchers at SCCL have found that CD4 T lymphocytes, which typically support immune responses, can also kill cancer cells directly. Up to a third of these cells were able to destroy tumor cells within five hours.
SourceUniversité de Genève·JournalScience Advances·DateFeb 26, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers at Max Delbréck Center for Molecular Medicine in the Helmholtz Association have made significant findings on the role of chromatin modulators in tumor cell identity changes. By using a combination of CRISPR and molecular reporter technology, they found that chromatin proteins significantly influence how tumor cells change t...
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalScience Advances·DateFeb 24, 2021
Scientists visualized anti-CD20 antibody effects in tumors using innovative imaging, finding macrophages play a crucial role in therapy efficacy. The study suggests increasing macrophage presence could boost therapeutic antibody effectiveness.
SourceInstitut Pasteur·JournalScience Advances·DateFeb 21, 2021
Researchers use zebrafish to study human cancer and discover that the innate immune system actively destroys cancer cells. However, tumor cells can adapt and evade immune detection through a process called 'Immunoediting', leading to immunotherapy resistance.
SourceChampalimaud Centre for the Unknown·JournalNature Communications·DateFeb 19, 2021
Researchers develop a new protein, 161519 TriKE, to target cold tumors and enhance the immune response. The study found that 161519 TriKE successfully reduced tumor growth and increased overall survival in tumor-bearing mice.
SourceCactus Communications·JournalCancer Biology and Medicine·DateFeb 18, 2021
Researchers discovered that human tumours contain solid and fluid cell clusters, enabling cancer cells to move and multiply. The study's findings could lead to improved cancer diagnosis and therapy, with potential applications in detecting metastatic cancer cells.
SourceUniversität Leipzig·JournalPhysical Review X·DateFeb 18, 2021
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers studied cell interactions in a microscopic 'cell collider' and found that normal cells repel each other's protrusions, while cancer cells try to squeeze past each other. The study suggests new approaches for understanding cancer cell behavior and identifying molecular bases for these differences.
SourceLudwig-Maximilians-Universität München·JournalProceedings of the National Academy of Sciences·DateFeb 16, 2021
Scientists have identified CD161 as a potential new target for immunotherapy of malignant brain tumors, including glioblastoma. The molecule suppresses the cancer-fighting activity of immune T cells, but blocking its pathway enhances the killing of tumor cells and improves survival rates in animal models.
SourceDana-Farber Cancer Institute·JournalCell·DateFeb 15, 2021
This review article highlights the complex crosstalk between cancer stem cells (CSCs) and tumor-associated macrophages (TAMs), two key players in cancer progression. CSCs have been identified as the drivers of cancer initiation and progression, while TAMs create a protective microenvironment for CSC development and dissemination.
SourceImpact Journals LLC·JournalOncotarget·DateFeb 15, 2021
Researchers discovered that immunomodulatory drugs like lenalidomide and pomalidomide starve cancer cells by destabilizing essential surface proteins, ultimately inhibiting tumor growth. This finding opens up new possibilities for targeted therapies in multiple myeloma.
SourceTechnical University of Munich (TUM)·JournalMolecular Cell·DateFeb 12, 2021
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers found that non-metastatic cells can spread to distant organs through a new mechanism involving the fibrotic niche induced by malignant cells. This discovery suggests targeting the fibrotic niche as a promising strategy to control solid tumor progression.
SourceKanazawa University·JournalNature Communications·DateFeb 12, 2021
Researchers at Technion-Israel Institute of Technology have discovered a new pathway that targets cancer cells specifically, minimizing damage to healthy cells. The folate cycle is essential for DNA and RNA production, and the team found that tumor cells relying on the cytosolic pathway are more susceptible to targeted treatments.
SourceTechnion-Israel Institute of Technology·JournalCell Metabolism·DateFeb 5, 2021
Researchers at Tokyo University of Science explore the structure of porphyrin derivatives to selectively target cancer cells and improve drug delivery. They found that meso-derivatives accumulate in cells at 3-fold higher amounts than β-derivatives, and that smaller functional groups allow better aggregation.
SourceTokyo University of Science·JournalScientific Reports·DateJan 28, 2021
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers have identified a little-known glycoprotein called stanniocalcin-1 that blocks the immune system's ability to fight cancer cells. By targeting this pathway, scientists hope to improve response rates to cancer immunotherapy treatments.
SourceMichigan Medicine - University of Michigan·JournalCancer Cell·DateJan 28, 2021
Researchers at MIT have devised a way to label and sequence individual RNA molecules within a tissue sample, allowing for a unique snapshot of which genes are being expressed in different parts of a cell. This technique offers new insights into how gene expression is influenced by a cell's location or its interactions with nearby cells.
SourceMassachusetts Institute of Technology·JournalScience·DateJan 28, 2021
Researchers at Boston University School of Medicine have identified genetic dependencies in tumors that have undergone whole genome doubling. The study found that WGD tumor cells possess unique vulnerabilities that can be targeted by new therapeutics.
SourceBoston University School of Medicine·JournalNature·DateJan 27, 2021
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers developed a BCL strategy to generate highly potent tumor-targeted drugs from non-toxic compounds within the tumor, avoiding decomposition and side effects. The targeting drug Ru-rhein exhibits high anti-cancer activity against lung cancer cells while being non-toxic to normal cells.
SourceScience China Press·JournalNational Science Review·DateJan 25, 2021
Researchers at Moffitt Cancer Center discovered that cancer cells can fuse and recombine their genetic material, leading to increased diversity and adaptability. This mechanism, similar to parasexual recombination in pathogenic microbes, enables cancer cells to rapidly evolve and acquire resistance to treatments.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalNature Ecology & Evolution·DateJan 20, 2021
Researchers at UT Southwestern Medical Center have discovered that removing a key gene called Cbl-b can revitalize exhausted CD8+ T cells to combat malignant tumors. This breakthrough could offer a new approach to harnessing the body's immune system to fight cancers.
SourceUT Southwestern Medical Center·JournalJournal for ImmunoTherapy of Cancer·DateJan 20, 2021
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Cancer cells can thrive in hostile environments through metabolic adaptation known as the Warburg Effect. Moffitt researchers found that activation of transcription factor KLF4 allows cells to select for this phenotype, enabling them to survive and thrive in poor conditions.
SourceH. Lee Moffitt Cancer Center & Research Institute·DateJan 19, 2021
Researchers developed CopyKAT, a new computational technique that accurately differentiates between cancer and normal cells in solid tumor samples. The tool uses gene expression data to identify aneuploidy and distinct subpopulations within cancer cells.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Biotechnology·DateJan 18, 2021
Researchers from UC3M and UCM developed a mathematical model to understand how cancer cells invade healthy tissue, using topological data analysis techniques. The model simulates the collective movement of cells in tissues and can be used to track the progression of tumor growth.
SourceUniversidad Carlos III de Madrid·JournalPLOS Biology·DateJan 18, 2021
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A new study published in Cell reveals that RNA splicing therapeutics can activate antiviral immune pathways in triple negative breast cancers, triggering tumor cell death and signaling the body's immune response. The discovery highlights a novel mechanism for turning on the immune system in aggressive cancers.
SourceBaylor College of Medicine·JournalCell·DateJan 14, 2021
Researchers developed a gene expression signature that robustly predicts patient survival in patients with peritoneal carcinomatosis, a form of metastatic gastric cancer. The signature is associated with tumor cell populations and lineage compositions, offering potential for tailored treatment strategies.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Medicine·DateJan 4, 2021
Researchers have developed molecular reporters that reveal how immune cells strengthen brain tumors, making them more aggressive. The technology has the potential to guide therapy development and is applicable to various biological systems.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalCancer Discovery·DateDec 23, 2020
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers have developed nanoparticles that can breach cell barriers and kill tumor cells, reducing tumor sizes by 40-70% in mice. The highly selective toxicity of the particles offers new hope for treating aggressive cancers.
SourceLudwig-Maximilians-Universität München·JournalChem·DateDec 18, 2020
Researchers found that targeting the fas protein can prevent cancer cells from escaping immunotherapies, leading to longer-lasting positive responses and improved survival rates. By combining immunotherapies with small molecule inhibitors, bystander tumor cell killing may be potentiated to eliminate antigen-loss variants.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalCancer Discovery·DateDec 17, 2020
Researchers developed inhibitors targeting mitochondrial DNA, affecting only rapidly dividing cells like cancer cells. Treatment stopped cell proliferation and reduced tumour growth without harming healthy cells.
Research suggests stress hormones and immune cells may contribute to tumor recurrence by reactivating dormant cancer cells. Targeting stress hormones with approved drugs like beta-blockers could potentially prevent tumors from returning.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Translational Medicine·DateDec 2, 2020
Researchers at Brigham and Women's Hospital developed a small-molecule inhibitor targeting SerpinB9 protein in cancer cells, weakening its defense mechanisms and triggering cell death. The approach shows promise for treating 'cold tumors' that evade immunotherapies.
SourceBrigham and Women's Hospital·JournalCell·DateDec 1, 2020
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
A study by Harvard Medical School scientists reveals a transient, cooperative interaction between ovarian cancer cells that allows nonmetastatic tumor cells to invade distant sites. The team identified amplified ERBB2 levels in a specific cell population, which was activated by amphiregulin, a signaling protein found in advanced ovaria...
SourceHarvard Medical School·JournalNature Communications·DateNov 18, 2020
The new WEHI-TV animation explains how the 'tumour suppressor' protein p53 prevents cancer-causing changes in cells. More than half of human cancers involve faulty p53, and researchers are still working to develop better therapies for these cancers.
Researchers have identified a gene, VSIG1, that prevents the development of metastatic tumour cells, enabling targeted therapies to be developed. The study validates the use of spiked-scRNAseq technology for testing drugs against metastases, including personalized approaches.
SourceUniversité de Genève·JournalCell Reports·DateNov 10, 2020
Researchers from Tokyo Medical and Dental University identify TruB1 as a regulator of the microRNA let-7, which has significant implications for cancer development and suppression. The study reveals that TruB1 promotes maturation of let-7 and suppresses cell growth and division.
SourceTokyo Medical and Dental University·JournalThe EMBO Journal·DateNov 9, 2020
Pancreatic cancer cells use nerve growth factor to signal nerves to grow into dense tumors and secrete nutrients like serine. This allows the cancer cells to multiply despite nutrient starvation, highlighting a unique adaptation that contributes to their deadliness.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalCell·DateNov 2, 2020
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
This study examines the effects of talc on mesothelial and neoplastic cells, revealing high levels of IL-6 and TNFRI. The results suggest that normal mesothelium is the main stimulus for the inflammatory process, with talc inducing higher rates of apoptosis in neoplastic cells.
SourceImpact Journals LLC·JournalOncotarget·DateOct 24, 2020
Researchers at Swiss Federal Institute of Technology and Philochem AG describe four novel formats for L19-IL2 fusion proteins, featuring different arrangements of antibody and IL2, which exhibit superior tumor-targeting properties in vivo. The new format also reduces activation of regulatory T cells.
SourceImpact Journals LLC·JournalOncotarget·DateOct 23, 2020
A new technique developed at Scripps Research isolates tumor-reactive immune cells in just one day, offering a platform for personalized cancer treatments. The method, called FucoID, detects and tags the surface of sought-after immune cells using an enzyme, enabling their detection with fluorescent probes.
SourceScripps Research Institute·JournalCell·DateOct 22, 2020
A new study by Brown University scientists has identified vimentin as a potential target for treating aggressive cancer cells known as polyploidal giant cancer cells (PGCCs). PGCCs have been found to rely on vimentin to migrate and invade surrounding tissues.
SourceBrown University·JournalProceedings of the National Academy of Sciences·DateOct 21, 2020
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.