New bowel cancer drug target discovered
Researchers at the Francis Crick Institute have identified a novel protein that exclusively targets Wnt signalling in tumour cells, reducing growth of colon cancer cells without harming healthy cells.
Tumor Cells
Articles tagged with Tumor Cells
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Scientists pinpoint surprising origin of melanoma
Researchers have identified melanocytes as the origin of cutaneous melanoma, a deadly form of skin cancer. These cells are reprogrammed to become invasive and migratory cancer cells, leading to tumor formation.
Lung cancer research gets a breath of fresh air
Researchers at the Wyss Institute for Biologically Inspired Engineering have developed a human lung-on-a-chip technology that models the growth and metastatic behaviors of non-small cell lung cancer. The study found that tumor cells grow rampantly in the alveolar microenvironment but remain quiescent in the airway chip, and that cyclic...
International experts describe a new way of cells behaving when submitted to chemotherapy
International experts have identified a new protein called ZATT that can directly clean DNA breaks without degradation, allowing for more efficient repair and potentially increasing chemotherapy sensitivity. This breakthrough has the potential to improve treatment outcomes and enable personalized therapies.
Computer program detects differences between human cells
A new computer program called SCENIC enables researchers to quickly and accurately identify different cell types in the human body. The method helps understand how cell fate is regulated and could lead to the discovery of master regulators and potential drug targets.
Molecular fingerprint of breast tumors linked to immune response in bloodstream
Researchers have developed a new software tool that reveals molecular connections between breast cancer tumor cells and immune system cells in the bloodstream. The study found that these connections vary depending on the type of breast cancer, potentially leading to new treatment and monitoring strategies.
New approaches in targeted cancer therapy
Researchers at Cologne University Hospital have discovered a novel inhibitor that specifically targets NMC tumours, a rare and lethal form of cancer. The study's findings provide valuable insights into the molecular mechanism responsible for the effectiveness of the inhibitor, paving the way for new and improved therapies.
UA Cancer Center team identifies a switch that may help target dormant cancer cells
The UA Cancer Center's research may lead to ways to target metastatic tumors by altering the depth of quiescence in cancer cells. This could make it easier for chemotherapy drugs to target and kill these cells.
When good immune cells turn bad
Researchers at Children's Hospital Los Angeles identified a molecular pathway in an immune cell called a tumor-associated macrophage that supports neuroblastoma, a pediatric cancer. Targeting the STAT3 pathway with a clinically available drug may be a promising approach to improve outcomes for children with high-risk neuroblastoma.
Cholesterol-like molecules switch off the engine in cancer-targeting Natural Killer cells
Scientists discovered how cancer-fighting Natural Killer cells power up and how cholesterol-like molecules cut them off. Activated NK cells use a unique energy production system that can be disrupted by oxysterols, which may explain poor performance in patients with high cholesterol levels.
Altitude training for cancer-fighting cells
Researchers at Weizmann Institute of Science find that oxygen-starved killer T cells are more effective at destroying cancerous tumors and outperform regular T cells in a mouse model. The study suggests an easy improvement to existing immunotherapy protocols.
Mitochondrial metastasis suppressor pathway controls tumor cell metabolic reprogramming
Researchers at The Wistar Institute have discovered a novel metastasis suppressor pathway orchestrated by the mitochondrial protein SNPH. This pathway promotes tumor cell proliferation in local growth but inhibits invasion and metastasis. By studying SNPH, scientists may uncover new therapeutic approaches to target metastatic cells.
A blood test can predict early lung cancer prognosis
A new blood test can predict how early-stage lung cancer patients will fare, identifying clusters of aggressive tumor cells that indicate shorter survival times. The test uses circulating tumor cells in the bloodstream to monitor cancer progression and resistance to treatments.
Study paves the way for cancer treatments that might prevent relapses after radiotherapy
Researchers suggest that combining drugs blocking PAF-R protein may increase radiotherapy's killing of tumor cells by one third and reduce tumor repopulation. Analysis with human oral cancer cells and murine cervical cancer cells showed promising results, supporting a new therapeutic strategy.
DNA sensor plays critical role in cancer immunotherapy via response to unexpected DNA form
Researchers at UT Southwestern Medical Center report that tumors stressed by cancer immunotherapy release mitochondrial DNA into nearby immune cells, triggering a host alert system. This discovery highlights the critical role of cGAS as an innate immune sensor for DNA and its importance in bridging the body's two immune systems.
Giving cancer-killing viruses a boost
A compound has been identified that enhances tumor-targeting viruses' ability to selectively kill liver cancer cells while sparing healthy ones. The oncolytic virus M1 was boosted by combining it with Eeyarestatin I, increasing its potency 3,600-fold against cancer cells in culture and animal models.
Blood test predicts prostate tumor resistance
A new blood test developed by TUM researchers can predict drug resistance in patients with advanced prostate cancer, analyzing AR-V7 RNA molecules for early detection. The test has shown high sensitivity and accuracy, identifying approximately one-fifth of patients with large amounts of resistant tumor cells.
Researchers map brain tumor cells' adaptation to oxygen deprivation
Researchers at Lund University identified a specific marker (CD44) that interacts with protein HIF-2a, allowing cancer stem cells in glioblastoma to adapt to oxygen deprivation. This interaction enables the growth of more aggressive tumor cells, which are resistant to treatment and contribute to recurrence.
Cancer detection with sugar molecules
Researchers have designed a complex sugar molecule that binds to galectin-1, enabling the immune system to recognize and attack tumor cells. This breakthrough could lead to the development of new drugs and rapid tests for early cancer detection.
Improved analysis of kidney cancer
A research team at Lund University has discovered that gene expression in normal tissue varies depending on the location within the kidney. This variation affects the accuracy of comparisons between tumour cells and healthy tissue, leading to a better understanding of kidney cancer subtypes.
Study identifies molecules that could help to prevent the development of brain tumors
Researchers at the University of Portsmouth have identified two molecules, CD15s and CD62E, that play a key role in brain tumor cells binding to blood vessels. By blocking these molecules, it may be possible to prevent brain tumors from developing in patients with non-small cell lung cancer.
Shooting the Achilles heel of nervous system cancers
Researchers at Dartmouth's Norris Cotton Cancer Center have discovered a novel synthetic lethality screen to discover molecules that target genetically modified yeast lacking NF1. The team identified one lead candidate called Y100, which disrupts tumor cell growth and induces oxidative stress causing death of NF1-deficient cancer cells.
Study reveals ways in which cells feel their surroundings
A new study led by Princeton University researchers finds that cells must move around and change shape to gain a meaningful understanding of their environment. The typical cell's environment is highly varied in stiffness or flexibility, making it difficult for the cell to determine its surroundings through mechanosensing.
Cannibal cells may limit cancer growth
New research reveals a mechanism driving cell cannibalism in tumors, suggesting it may resist cancer growth. Weakened cell attachments trigger entosis, where one cell kills and digests another, potentially slowing or preventing tumor growth.
Exploiting acidic tumor microenvironment for the development of novel cancer nano-theranostics
Researchers design multifunctional nano-theranostics targeting the unique acidic tumor microenvironment. These smart imaging nanoprobes enable sensitive and accurate tumor diagnosis through signal amplification under reduced pH conditions.
A new weapon for the war on cancer
Researchers developed an engineered opsonin protein to capture CTCs in the bloodstream, reducing detection time and increasing efficiency. The technology shows promise for improving cancer diagnostics by targeting specific carbohydrate molecules on CTCs.
Glycans as biomarkers for cancer?
Scientists have developed a bioorthogonal labeling approach to identify sialylated glycoproteins in prostate cancer tissue, which could serve as tumor markers. The method allows for direct assessment of tumor metabolism in its natural environment, providing insights into cancer biology.
A unique amino acid for brain cancer therapy
Researchers at OIST have discovered a new photosensitizer that targets brain cancer cells with improved efficiency, using the naturally occurring amino acid taurine to enhance its effectiveness. The study shows promise for developing more effective brain cancer treatments through photodynamic therapy.
When healthy cells stimulate the migration of tumor cells
Researchers at Université de Genève discovered that healthy fibroblasts surrounding breast cancer cells have a unique variant of the estrogen receptor GPER in their nuclei. This genetic variation promotes tumor cell migration and invasiveness through the secretion of molecules that stimulate malignant growth.
Combining radionuclide therapy with a PARP inhibitor slows neuroendocrine tumor growth
Researchers found that combining peptide-receptor radionuclide therapy (PRRT) with a PARP inhibitor significantly slows the growth of neuroendocrine tumors. The treatment combination induced more cell death and inhibited cell proliferation in both gastroenteropancreatic and bronchopulmonary NET cell lines.
Engineering a new cancer detection tool
Scientists from Griffith University and partners have engineered a new tool to detect cancer by recognizing an unusual sugar present on tumor cells. The innovation utilizes the E. coli toxin, which binds to Neu5Gc, a substance produced by tumor cells.
'Immunoswitch' particles may be key to more-effective cancer immunotherapy
Scientists at Johns Hopkins created a nanoparticle that carries two different antibodies to simultaneously switch off cancer cells' defensive properties while switching on a robust anticancer immune response in mice. The 'immunoswitch' particles dramatically slowed the growth of mouse melanoma and colon cancer, even eradicating tumors.
Cancer cells send signals boosting survival and drug resistance in other cancer cells
Researchers at University of California San Diego School of Medicine found that cancer cells exploit the unfolded protein response (UPR) to activate Wnt signaling, promoting tumor survival and drug resistance. This mechanism enables cancer cells to cope with nutrient deprivation and therapies, contributing to intra-tumor heterogeneity.
How killer cells take out tumors
F8-TNF stimulates killer cells to target sarcomas by identifying them through dormant viral proteins, offering a new avenue for cancer immunotherapy. The treatment has been shown to completely cure mice of sarcoma and grant immune protection against tumor recurrence.
Blocking cancer-specific mutations in leukemia and brain tumors
Researchers at German Cancer Research Center (DKFZ) found a substance that blocks cancer-promoting metabolic products in leukemia and brain tumors. The investigational compound BAY1436032 is effective against AML and glioblastomas, reducing stem-cell properties and tumor cell growth.
Chemical array draws out malignant cells to guide individualized cancer treatment
Researchers have developed a chemical array technique that can identify and culture malignant stem-like cells within melanoma tumors. This allows for the creation of patient-specific models for individualized cancer treatment.
Moffitt researchers demonstrate mathematical modeling limits aggressive tumor cell growth
Moffitt researchers demonstrate that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to environmental changes. By applying small biological forces, they show that complex systems like cancer can be steered into a less invasive growth pattern.
UTA's AbeXXa Biologics named one of 40 Best University Startups 2017 by NCET2
AbeXXa Biologics identifies targets for cancer treatment from thousands of intracellular proteins, potentially resulting in effective immunotherapies for broad patient groups. The company is developing T cell receptor-like antibody-drug complexes to kill tumor cells with low peptide/HLA targets.
An elegans solution: Worm genetic screen maps cell-to-cell communication in human cancer
Researchers used C. elegans to identify a genetic signature of mesodermal-epithelial communication involved in human cancer cell proliferation. The study uncovered 33 genes conserved between worms and humans that control this network, providing a roadmap for new cancer therapies.
Tumor cells get stiff before becoming invasive
A study published on Nature Communications reveals that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive. This discovery identifies a new signal in tumor cells that can be further explored when designing cancer-targeting therapies.
Metabolic peculiarities betray the identity of relapse-causing breast cancer cells
Researchers discovered that residual tumor cells display alterations in fat metabolism and oxidative stress, which contribute to DNA damage and cancer relapse. Targeting metabolic pathways in these cells could potentially prevent recurrence.
Cell changes drive breast cancer relapse
Researchers at EMBL found that residual breast cancer cells have specific traits that distinguish them from healthy cells and seem to cause relapse. The study suggests lipid metabolism as an exciting therapeutic target to reduce breast cancer recurrence.
Cancer metastasis: The unexpected perils of hypoxia
Research reveals how hypoxia leads to inhibition of miR-34a, a key tumor suppressor, promoting metastasis and EMT. The findings suggest that targeting this process with drugs could be a therapeutic approach for treating metastasizing colon tumors.
Biologists identify key step in lung cancer evolution
Researchers discovered that blocking this Wnt pathway prevents tumor growth and prolongs mouse lifespan. Human lung adenocarcinoma samples also showed high levels of Wnt activation.
Brain cancer discovery reveals clues in quest for new therapies
Scientists have pinpointed two molecules, FOXG1 and SOX2, that drive glioblastoma cells' rapid division and prevent specialization. These findings could lead to the development of new therapies targeting these molecules to slow or stop tumour growth.
Scrib protein identified as a natural suppressor of liver cancer
In liver cancer, Scrib's increased expression suppresses the growth of cancer cells by inhibiting three oncogenes. The study provides the first hard evidence that Scrib functions as a tumor suppressor in human and animal liver cancer.
Deadly nanoparcel for cancer cells
Scientists develop a hybrid nanomaterial that releases a free-radical-generating prodrug inside tumor cells, destroying them even in oxygen-depleted conditions. The material damages cells by a ROS-type radical mechanism without the need for oxygen.
Advanced prostate cancer treatment failure due to cell reprogramming
Researchers discovered that tumor cells in patients with advanced prostate cancer are reprogrammed, reducing response to anti-androgen therapy and creating more aggressive tumors. SOX11 acts as a key regulator in this process, which may be targeted for new treatments.
At last, a clue to where cancer metastases are born
Scientists at Scripps Research Institute discovered that invasive tumors can send out tumor cells earlier than thought, which may seed secondary tumors years later. The escaping cells enter the bloodstream by entering blood vessels deep within the dense tumor core, upending the long-held belief about metastatic cell origin.
Connecting the dots between insulin resistance, unhealthy blood vessels and cancer
Joslin Diabetes Center researchers found impaired insulin effects boost cancer risks in mice with genetically modified intestinal tumors and blood vessels. Insulin resistance may impair blood vessel health and share biological mechanisms with cardiovascular disease.
Pancreatic cancer project scores in research 'lightning round'
Researchers Melissa Skala and Matthew Vander Heiden won a $250,000 award to study the interaction between tumor cells and healthy supporting cells in pancreatic cancer. The project aims to create molecular changes that shut down the tumor's ability to scavenge nutrients, potentially leading to a new type of metabolic cancer therapy.
Defects in epithelial tissue organization -- A question of life or death
Scientists discover that physical arrangement of cells drives cell death and removal, with topological defects causing cells to realign and leading to extrusion. This finding provides new insights into tissue development and control of cell growth.
Wake Forest Baptist researchers find novel way to induce pancreatic cancer cell death
Wake Forest Baptist researchers found that MIR506 inhibits malignant cell growth and metastasis in pancreatic cancer cells. The molecule induces autophagy, a process that promotes cancer cell death.
Method identified to boost detection of highly cancerous stem cells
Researchers at Tokyo Medical and Dental University developed a new process to improve the detection of cancer stem cells in brain tumors. The approach uses iron chelation to increase fluorescence levels, allowing for more accurate identification and removal of these cells. This breakthrough has potential to translate to clinical practice.
Single-cell RNA sequencing reveals detailed composition of two major types of brain tumor
A study at Massachusetts General Hospital found that two major types of brain tumors, astrocytomas and oligodendrogliomas, may originate from the same type of neural progenitor cells. The analysis revealed differences in gene mutation patterns and tumor microenvironments between the two subtypes.
New research explains why even targeted therapies eventually fail in lung cancer
A study led by Raffaella Sordella proposes a novel theory on how cancers circumvent targeted therapy killing power. The research suggests that genetic diversity in tumor cells, caused by non-genetic mechanisms, can help them survive and eventually relapse.
New research shows how metabolism and epigenetics play a role in cancer development
A study published in Briefings in Functional Genomics investigates the role of epigenetics in cancer development, showing that disruptions can activate oncogenes or shut down tumor suppressors. The paper also highlights the link between epigenetic changes and metabolites, which can target and amplify gene expression.
Single-cell analysis reveals subtypes of colorectal tumors
Researchers defined cell-type composition of cancerous cells from 11 colorectal tumors using single-cell genomics and computational techniques. The study identified two distinct subtypes of cancer-associated fibroblasts that contribute to a worse prognosis in colorectal cancer patients.
Tethered nanoparticles make tumor cells more vulnerable
Researchers at MIT developed a strategy to make tumor cells more susceptible to certain types of cancer treatment by coating them with nanoparticles. The particles increase the forces exerted on the cells, making them more likely to die, and were found to be 50% more effective in tests in mice.
Researchers create viruses to selectively attack tumor cells
Scientists at IDIBAPS and IRB Barcelona developed a novel strategy to genetically modify viruses that selectively target tumor cells while sparing healthy tissue. The study's results show promising effectiveness in controlling tumor growth and destroying cancer cells, offering hope for new cancer therapies.