Articles tagged with Vascular Cells
Scientists have developed mini-brains that can grow blood vessels, enabling the study of neurological diseases such as stroke and concussion. The presence of vasculature makes these mini-brains more realistic models of natural brains, allowing researchers to investigate the interaction between the brain and its circulatory system.
Researchers at KIT found that nerve cells dynamically regulate the density of blood vessel networks through fine modulation of sFlt1 and VEGF. This process is crucial for vascular development, particularly during early stages of embryonic growth.
Researchers are developing 3D printed tissues, including skin, bone, cartilage, and bladder models. Organs-on-a-chip systems mimic human tissue structure and function, allowing for the study of physiological differences and drug screening.
A two-year clinical study found that CD34+ cells significantly reduced angina frequency in patients resistant to other therapies. The treatment demonstrated persistent improvement in angina and a trend towards decreasing major cardiac events, offering new treatment options for 'no option' patients.
Researchers found that Zika virus can infect human placental macrophages, known as Hofbauer cells, which have direct access to fetal blood vessels. This infection may allow the virus to cross the placental barrier and enter the fetal circulation, posing a risk to fetal development.
The National Institutes of Health has awarded a two-year grant to explore the use of cells from a patient's own adipose tissue as vascular grafts in arterial bypass surgery. This method could reduce complications and increase accessibility, eliminating the need for vein or artery harvesting.
Researchers have successfully used autologous fat cell transplants to improve symptoms of osteoarthritis in patients. The treatment showed significant improvements in pain management and joint mobility, with most patients experiencing a minimum of 50% score improvement after 12 months.
Researchers at Uppsala University have discovered a novel origin of the lymphatic system, challenging the long-held dogma that it forms via sprouting from veins. The new findings may lead to innovative treatments for conditions such as lymphedema and tissue trauma.
Researchers found the varicella zoster virus in 74% of biopsies with giant cell arteritis but only 8% of normal skin biopsies. The study suggests a new treatment approach for giant cell arteritis, combining steroids with antiviral medication.
Researchers found the varicella zoster virus in 74% of giant cell arteritis biopsies, suggesting a link between the chicken pox virus and the condition. The study suggests treating giant cell arteritis with a combination of steroids and anti-viral treatment may be effective
Researchers at Shanghai University developed a tri-layered artificial blood vessel composed of separate materials for mechanical strength and new cell growth. The composite allowed rapid proliferation and integration of rat fibroblast cells, overcoming limitations of existing vascular grafts.
Researchers identified FoxO1 as a key molecule regulating cell division in vascular wall cells, leading to pulmonary hypertension. Boosting FoxO1 activity has been shown to normalize pathological cell division and potentially cure the disease in rats.
Researchers create implantable tissue scaffold coated with bone growth factors that induce rapid formation of new bone. The scaffold induces the body to rapidly form new bone that looks and behaves like original tissue.
The development of the retinal vascular system follows specific rules and is spatially and temporally consistent with retinal neuron function. Astrocyte-vascular wall cell interactions lead to the maturation of the blood-retinal barrier, a crucial component in maintaining retinal health.
Researchers used multiphoton microscopy to visualize podocyte calcium dynamics in response to glomerular injury, finding a robust calcium wave that spread throughout cells. Additionally, a mutation in the steroidogenic factor 1 (SF-1) gene was identified as causing asplenia and disorder of sexual development in a pediatric patient.
A new blood test measures a protein called cardiac myosin binding protein-C (cMyBP-C) to detect heart attacks more quickly. cMyBP-C is released to the bloodstream within just 15 minutes of cardiac damage, rising to significant levels in three hours.
Gregg Semenza discovered the oxygen-sensing gene HIF-1alpha, a master regulator of cellular response to low oxygen levels. His work has led to translational studies enhancing oxygen and blood flow in conditions like cardiovascular disease and cancer.
Researchers at Johns Hopkins Medicine have developed human induced-pluripotent stem cells that can repair damaged retinal vascular tissue in mice without using viruses. These non-viral, human retinal iPSCs were grown using a safer method and showed comparable ability to human embryonic-derived iPSCs.
Researchers found that thicker leaves have larger cells in all tissues except vascular tissue, and cell walls are proportionally thicker. The team developed new mathematical equations to predict internal anatomy from leaf thickness, providing insights into leaf function and design.
A newly discovered compound has been identified as a potential diagnostic marker for zinc status, which can help detect the harmful effects of zinc deficiency in blood vessel cells. This discovery may lead to faster and easier methods for detecting low zinc levels in the body.
Researchers found that ginkgo biloba extract EGb761 promoted and prolonged the proliferation of neural stem cells in rats with vascular dementia. The treatment significantly improved learning and memory in these animals.
Researchers at Johns Hopkins Medicine have successfully grown new blood vessels from pluripotent stem cells and transplanted them into mice, a crucial step towards developing personalized treatments. The new technique could enable genetically matched blood vessels that are less likely to be rejected by patients' immune systems.
Researchers at Gladstone Institutes have identified the molecular signals that direct blood vessel formation, revealing a precise order and timing of signals that spur artery formation. The study uncovers the role of Vegf and Dll4 in this process, shedding light on a so-called 'black box' of embryonic development.
A new study shows that rapid evaluation for Giant Cell Arteritis (GCA) using Color Doppler Ultrasound (CDUS) followed by immediate treatment significantly reduces permanent vision loss. The 'fast track' approach led to 11.1% transient visual manifestations, with none suffering from permanent visual loss.
Researchers at UNC have identified a key regulatory switch that controls the development of blood vessels. Disrupting this gene, CASZ1, can prevent proper vessel formation and lead to cardiovascular disease. Further study may reveal new therapeutic targets for treating cardiovascular disease.
A new study has characterized cells responsible for driving calcium build-up in vessel walls, providing a potential therapeutic target. The researchers found that certain cells can differentiate into osteoclasts, leading to softening of the blood vessels, and that manipulating these cells could lead to a reduction in heart disease risk.
A CU Cancer Center study reveals that the transcription factor SPDEF regulates E-Cadherin production, inhibiting prostate cancer metastasis. The researchers found that increasing or decreasing SPDEF levels directly affects E-Cadherin expression, making it a crucial factor in preventing cancer spread.
A new 'scarecrow' gene has been found that controls a unique leaf structure, leading to more efficient photosynthesis. This discovery could lead to new varieties of staple crops with significantly higher yields through genetic engineering.
Scientists at Texas Biomedical Research Institute have demonstrated that baboon embryonic stem cells can completely restore a severely damaged artery. The results show promise for developing stem cell therapies to restore human tissues or organs damaged by age or disease.
Scientists at Albert Einstein College of Medicine have discovered that coronary arteries form from cells in the ventricles, which can potentially be used to regenerate healthy vessels. This breakthrough could lead to more effective cardiac care and treatments for heart disease.
A study published in Cell reveals that follicular dendritic cells (FDCs) originate from perivascular precursor cells, which decorate blood vessel walls. This discovery sheds light on the development of lymphoid follicles and has implications for understanding chronic inflammatory conditions and prion infections.
Researchers at Penn University have developed a method to rapidly create vasculature using 3D printed templates of filament networks, improving the function of engineered living tissues. They used a material composed of sugar and other compounds to create stable vascular systems that can be easily dissolved and replaced with cells.
Researchers at Pitt's Swanson School of Engineering and School of Medicine have developed a cell-free, biodegradable artery graft that regenerates an artery in situ within 90 days. The graft's porosity allows for immediate cell infiltration, leading to strong and compliant new arteries.
A study found that ACE2 is protective against diabetic complications in both lab models and human patients. High levels of ACE2 in vascular reparative cells prevent heart function decline and renal failure in diabetics.
A research team has developed a new technique for creating human textiles by weaving donor cells into blood vessels, promising to reduce production costs. The technology uses a combination of cultured cells and medical-textile-making techniques to create strong, biocompatible fibers that can be woven into various structures.
A study published by Johns Hopkins scientists found no substantial evidence that brain cancer blood vessels are composed mainly of cancer cells. The research contradicts previous claims about the composition and potential impact on treatment strategies for these types of tumors.
Scientists at the Diabetes Research Institute developed an oxygen-generating biomaterial to enhance insulin-producing cell survival. The material, PDMS-CaO2, generates critical oxygen for up to six weeks, mimicking the native pancreas environment.
Researchers have found that controlling the balance between two proteins can reduce the growth of dangerous cells in arteries. This finding could lead to a lower risk of further heart attacks and improved cardiovascular health.
Estrogen has been found to help regulate white blood cell activity, preventing them from sticking to blood vessel walls and causing vascular damage. This natural mechanism could have important implications for understanding and treating cardiovascular disease.
Johns Hopkins researchers have discovered a direct link between MCM proteins and the oxygen-sensing HIF-1 protein. The study found that MCM proteins mediate crosstalk between cell division machinery and environmental factors, controlling cell growth based on oxygen availability.
Researchers develop a new paradigm in human tissue regeneration, where engineered tissue constructs induce the body's own reparative mechanisms. The study, published in The FASEB Journal, provides evidence for the first clinical trial of engineered vascular grafts in children.
The Society for Experimental Biology and Medicine has recognized seven outstanding young investigators with the 2011 Young Investigator Award. These researchers demonstrated originality, importance, and presentation of their data in various fields of study, including vascular dysfunction and skeletal muscle microvascular rarefaction.
Professor Alan Stitt has received a Royal Society Wolfson Research Merit Award to support his ground-breaking research on vascular stem cells and eye disease treatment at Queen's University. The award aims to retain top researchers in the UK and reflects the excellence of the School of Medicine, Dentistry and Biomedical Science.
Researchers at the University of East Anglia have made a groundbreaking discovery in cancer treatment. They found that cells can switch from blood vessel to lymphatic cells, potentially changing how anti-cancer drugs are tested.
Research suggests that abnormalities in blood clot formation contribute to AD pathogenesis. A new therapeutic strategy aims to slow cognitive decline by targeting altered blood clotting caused by amyloid peptide.
Researchers have identified the source of cells that form the coronary arteries, a breakthrough that could lead to improved bypass surgeries. By studying mouse embryos, scientists found that these cells originate from the sinus venosus and undergo natural reprogramming as they migrate across the heart.
Researchers studied cell-to-tube transformation in Drosophila, revealing the formation of small-diameter respiratory tubes and their link to capillary development. The study identified key genetic machinery and molecular mechanisms involved, providing insights into the development of fine blood vessels.
A Michigan State University scientist has discovered the process that causes retinal cells to die, leading to diabetic retinopathy. The siah-1 protein serves as a type of chauffeur for another protein, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), shuttling it into the nucleus of Müller cells, causing vascular damage.
A study led by Dr. Frank Winkler followed the steps of tumor cell formation in real-time, revealing four stages required for metastasis development. Blocking angiogenesis with Avastin can suppress emergence of brain metastases.
Researchers at Johns Hopkins have developed therapies using gene therapy and stem cells to increase blood flow, improve movement, and decrease tissue death. The findings hold promise for developing clinical therapies to save limbs from amputation.
Scientists observe aggressive T-cells breaching blood-brain barrier, crawling along vascular walls and forming connections with phagocytes. This breakthrough understanding may aid in developing new treatments for multiple sclerosis.
A group of researchers at the University of Pennsylvania has identified a population of cells resembling pigment-producing skin cells in the atria and pulmonary veins of mice and humans. These melanocyte-like cells may contribute to the development of atrial fibrillation, the most common type of abnormal heart rhythm.
Researchers have found promising results with stem cells obtained from a patient's own adipose tissue in treating multiple sclerosis. The treatment, known as stromal vascular fraction (SVF) cell therapy, has shown dramatic improvement in symptoms for three patients with MS.
Researchers discovered a link between mutated genes and vascular development, which could lead to classification and therapy for congenital blood vessel malformations. The study identified two key genes, Snrk-1 and Dusp-5, as playing crucial roles in angioblast formation and differentiation.
Researchers developed an organic substance that attracts and supports cells necessary for tissue repair and can be directly injected into problem areas. The 'smart scaffolds' work by containing a protein that allows progenitor cells to adhere to damaged tissue and survive long enough to promote healing.
Researchers at Stanford University School of Medicine have shown that distinct groups of proteins each control one of four simple activities involved in the cells' collective migration. The study overturns an assumption common in genomics and provides a powerful tool for developing new therapeutics.
Researchers found lactic acid is an important energy source for tumor cells and discovered a way to destroy hard-to-kill cells by preventing lactate delivery. Blocking lactate transport kills oxygenated cells that starve hypoxic cells, offering a novel approach to treating tumors.
Cells from menstrual blood, known as endometrial regenerative cells (ERCs), have been shown to restore blood flow in a mouse model with advanced peripheral artery disease. This breakthrough discovery holds promise for the treatment of critical limb ischemia, which causes approximately 150,000 amputations per year.
Diabetes can cause gangrene and skin ulcers due to restricted blood supply, leading to impaired healing and tissue dysfunction. New therapies may be developed by suppressing the action of p75NTR, a gene responsible for promoting blood vessel growth in diabetes.
Researchers found that human mesenchymal stem cells (hMSCs) and bone marrow stromal cells (BMSCs) can migrate to damaged brain tissue after a stroke, improving neural function. The transplanted cells may also enhance tissue repair and functional recovery.