Articles tagged with Vascular Cells
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Researchers at UC Riverside have discovered that curcumin promotes vascular endothelial growth factor (VEGF) secretion, helping to grow engineered blood vessels and tissues. The study uses magnetic hydrogels coated with curcumin-coated nanoparticles, which gradually release the compound without injuring cells.
Researchers at UConn Health found that deleting TRPM2 from macrophages in mice reduced atherosclerosis by inhibiting the TRPM2–CD36 inflammatory axis. This approach prevented foamy macrophages and alleviated inflammation in arteries.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.
Researchers found that brains from patients with Alzheimer's disease had higher levels of the protein Fli-1 and fewer pericytes lining their smallest blood vessels, leading to leakage. Blocking Fli-1 improved memory in mice, suggesting a promising new approach to treating the disease.
Patients with severe coronary artery calcium have a significantly increased risk of major adverse cardiovascular events during thoracic radiation therapy for non-small cell lung cancer. The study found that patients with severe coronary artery calcium had a 21.4 times increased risk compared to those with no coronary artery calcium.
Researchers at the CNIC have identified a specific type of neutrophil behavior that predicts cardiovascular disease. The study provides crucial information for developing targeted therapies to minimize the consequences of myocardial infarction.
Researchers have identified a tiny region at the root tip responsible for orchestrating vascular tissue growth. The study provides detailed insights into how plants construct phloem cells, the tissue that transports sugars, revealing key mechanisms involved in plant function and development.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
A USF Health study reveals that fibrinogen can directly interact with neurons, leading to inflammation and neurodegeneration in Alzheimer's disease and traumatic brain injury. The researchers found that blocking the binding of fibrinogen to its receptors may alleviate short-term memory problems associated with these diseases.
Researchers from the CNIC and CIBERCV have created an animal model of HGPS, allowing them to study its effects and test treatments. They found that suppressing progerin expression and restoring lamin A can increase life expectancy by up to 84.5% in mice with mild symptoms, even if treatment is started late.
Microglia play a vital support role in maintaining blood vessels in the brain, regulating blood flow and capillary diameter. This discovery may lead to new therapies for diseases affecting small brain vessels, such as Alzheimer's and stroke.
Researchers find PADI4 and HIF-1 proteins work together to deliver oxygen and nutrients to tumors, allowing them to grow. The discovery provides new avenues for anti-cancer therapies targeting blood vessel development.
A recent study reveals that protein HSP27 plays a crucial role in regulating blood vessel leakage, which is a hallmark of sepsis. By targeting HSP27, researchers hope to develop drugs that can stabilize blood vessel barriers and prevent fluid loss.
A team of scientists at the University of Tsukuba created a computer simulation that models the Delta-Notch signaling pathway in biliary cell differentiation. The study reveals the importance of fine-grained differentiation and proper development, dependent on the rates of production of Delta ligands and Notch receptors.
Researchers identified a novel vascular cell maintenance system where BEH3 competes with other transcription factors to stabilize vascular stem cell multiplication and differentiation. They also found that BEH3 hinders the activity of other BES/BZR transcription factors, indicating its opposing function in regulating vascular stem cells.
A team of researchers has discovered that JMJD3 enzyme promotes inflammation in monocyte/macrophages, leading to the development of abdominal aortic aneurysms. Blocking this enzyme prevents aneurysm formation, providing a potential new target for treatment.
A new study published in Lab on a Chip suggests that electrical stimulation can increase blood vessel permeability, potentially speeding up the wound healing process. This increased permeability allows white blood cells and oxygen to reach injuries more efficiently.
Researchers at UT Southwestern Medical Center identified a mechanism by which exercise strengthens bones and immune function. Movement-induced stimulation creates a specialized environment in the bone marrow that promotes the formation of new bone cells and immune cells.
Researchers have analyzed the leaf vasculature of Arabidopsis thaliana using single cell sequencing, revealing distinct identities of phloem cells and their metabolic pathways. The study also identified specific transporters responsible for sugar and amino acid transport from leaves to roots and seeds.
Researchers developed an algae-based 3D bioprinting method to incorporate vascular patterns within engineered tissues and provide a sustainable source of oxygen for human cells. The approach showed promise for applications in disease modeling, drug development, regenerative and personalized medicine.
Scientists at IST Austria identified a molecular compass that perceives auxin concentration and allows cells to synchronize their behavior for coordinated vein formation and regeneration. This phenomenon also applies to wound healing, enabling the growth of more mechanically resistant plants.
Researchers analyzed almost half a million individual cells to build the most extensive cell atlas of the human heart, revealing diverse cell types and intricate networks. The study promises to enable better understanding of heart disease and guide development of highly individualized treatments.
Researchers at Institute for Basic Science have identified new subsets of gut connective cells crucial for lymphatic growth and fat digestion. The discovery sheds light on the mechanisms that impair lacteal regeneration and reveal a link between intestinal environment and cell interactions.
A recent study published in JNeurosci suggests that age-related hearing loss is primarily caused by the death of hair cells, rather than degradation of the cellular battery powering them. This finding contradicts previous assumptions and has significant implications for preventing or treating age-related hearing loss
Researchers at Universitat Pompeu Fabra discovered that blood vessels communicate with sensory neurons through dynamic protrusions, allowing them to regulate cell growth and maintenance of stem cells. This communication is crucial for the development and regeneration of the peripheral nervous system.
A new study reveals that a key protein in controlling high blood pressure behaves differently in males and females. In female mice, the protein Kv2.1 contracts blood vessels, while in male mice, it dilates them. This difference has significant implications for developing tailored treatment strategies for hypertension in men and women.
Scientists have successfully turned back the biological hands of time by coaxing adult human cells to revert to a primitive state, unlocking their potential to replace and repair damaged blood vessels in the retina. The findings advance regenerative medicine techniques aimed at reversing diabetic retinopathy.
The bioprinting research roadmap identifies key areas of progress and development, including advancements in bioinks, 3D printing processes, and crosslinking techniques. The report also highlights the potential for bioprinting to create complex biological models and therapeutic products.
Old Ginkgo biloba trees display similar gene expression for flavonoids and other resistance genes in young and old trees. Increasing age is not accompanied by a significant decrease in leaf area or growth rate, suggesting that these trees may stay healthy due to robust stress defenses.
Researchers at Johns Hopkins Medicine discovered a new pathway contributing to degeneration of the light-sensitive tissue in the eye. A potential treatment involves blocking a protein called angiopoietin-like 4, which acts synergistically with VEGF activity.
Researchers at McMaster University created a new coating material to prevent clotting and infection in synthetic vascular grafts. The smart coatings selectively attract targeted cells, promoting faster, smoother healing. The coatings have already been approved for use in humans.
Researchers found patients with significant blood vessel calcification were more likely to have a specific variant of HDAC9, implicating the gene in cardiovascular disease. The study suggests HDAC9 causes abnormal changes in vascular cells, resembling bone cells, leading to hardening of arteries.
Researchers from Harvard's Wyss Institute create a new 3D printing method called SWIFT, which allows for the growth of large, vascularized human organ building blocks. The technique enables the creation of viable, organ-specific tissues with high cell density and function.
Researchers identified patterns in cellular behavior that could lead to diagnosis and treatment of chronic diseases. The team developed a biophysical model of energy-driven cellular machinery for understanding allostasis in cells.
A recent study by Anna M. Gruener et al., published in JAMA Ophthalmology, investigated the association between giant cell arteritis and race. The researchers found a significant association between the disorder and certain ethnic groups, with increased risk observed in African Americans, Hispanics, and individuals of mixed ancestry.
A study of over 40,000 patients with polymyalgia rheumatica and/or giant cell arteritis found that oral steroid use significantly increased the risk of infection. The risk increased with higher doses, even at low daily doses.
Researchers used single-cell RNA sequencing to identify genes expressed by each cell in the aorta, grouping them into separate populations based on gene expression profiles. This allowed for accurate distinction between stem cells and other blood vessel cells, providing key insights into their identity.
Researchers at Johns Hopkins Medicine have found that AXT107 stops abnormal blood vessels in the eye from leaking vision-blocking fluids. The compound strengthens connections between cells, creating a watertight barrier and preventing fluid permeation into surrounding tissue.
Scientists discover a new population of immune cells that can aid in regenerative processes, enabling the creation of stable blood vessels.
A team of researchers has developed self-sustaining, bioengineered blood vessels that can safely integrate into the native circulatory systems of patients. The vessels, currently being tested in phase 3 clinical trials, offer a promising alternative to replacing damaged vessels with those from human donors or animals.
Researchers at the University of Bradford have identified a new biomarker that could help diagnose PAH earlier, potentially leading to better treatment options. The study reveals how a faulty gene affects cell death regulation in the blood vessels.
Researchers discovered two types of fat tissue cells that help bone heal: pericytes stimulate blood vessel growth and adventicytes form bone cells. Combination therapy using both cells promotes robust bone repair in mice with skull defects.
Research by De Rybel (VIB-UGent) and Helariutta (SLCU) reveals that DOF-type transcription factors control plant radial growth, enabling targeted breeding for higher biomass production. This understanding can improve atmospheric carbon sequestration and increase crop yields.
Researchers successfully generated human vascular cells with enhanced function through targeted gene editing of the longevity gene FOXO3. These cells demonstrated improved self-renewal, resistance to oxidative injury and therapeutic efficacy in a mouse model of ischemic injury.
Researchers identified adventitial CD90+ and mesenchymal stem cells in human arteries for the first time, providing a clear link to vascular diseases like coronary artery disease. These cells appear to play a key role in mediating vascular diseases.
Researchers successfully restored cartilage tissue and eliminated pain syndrome in a patient using cell technology-based regenerative medicine. This treatment promises to prolong the lives of natural joints by addressing limited regenerative potential of knee cartilage injuries.
A USC study reveals that the brain's cerebrospinal fluid channels a hunger molecule, melanin-concentrating hormone (MCH), which stimulates appetite. The researchers found that MCH release is influenced by circadian clock and daily mealtime routine.
Research identifies a mechanism by which glioma cells develop resistance to anti-angiogenic treatment, using different strategies to spread through the brain. The study reveals a potential target for combination therapies based on Wnt signaling and vessel co-option pathways.
The Mesp1 gene plays a crucial role in cardiovascular lineage segregation and regional specification of the heart. Single-cell molecular profiling identified distinct populations of cardiac progenitors with unique molecular features associated with early lineage restriction and region-specific identity.
Researchers from Kumamoto University have created a comprehensive genetic resource collection of plants with knocked out CLE peptides-encoding genes using CRISPR/Cas9 technology. This collection is expected to contribute significantly to future studies on the function of plant peptide hormones.
A recent analysis of published studies suggests that transradial catheterization can cause persistent damage to the radial artery's cells, persisting for several months after the procedure. Researchers emphasize the need for caution and explore novel techniques to minimize local arterial injury during radial catheterization.
Scientists at University of Pittsburgh create vascularized pancreatic islet organoids using human pluripotent stem cells, offering potential treatment for Type I Diabetes. The innovative approach involves implanting blood vessel fragments into the islets before transplantation.
A year-long trial confirms tocilizumab reduces both symptoms and steroid doses in patients with giant cell arteritis. The therapy offers a potential alternative to traditional steroid treatment, which can have serious side effects.
A study led by Penn and Columbia researchers found a link between the production of an enzyme called ADAMTS7 and smoking-related heart disease. The team discovered that smoking boosts ADAMTS7 production, which can lead to clogged blood vessels and CHD.
A new progeria-on-a-chip model has provided insights into the mechanisms of premature aging and vascular disease. The study found that cells from HGPS donors exhibited an exacerbated response to biomechanical strain, leading to increased inflammation.
York University scientists have developed a 3D beating heart tissue created from three cell types that beat together as one entity. This breakthrough will facilitate better and earlier drug testing, eliminating harmful medications sooner.
Scientists have developed mini-brains that can grow blood vessels, enabling the study of neurological diseases such as stroke and concussion. The presence of vasculature makes these mini-brains more realistic models of natural brains, allowing researchers to investigate the interaction between the brain and its circulatory system.
Researchers at KIT found that nerve cells dynamically regulate the density of blood vessel networks through fine modulation of sFlt1 and VEGF. This process is crucial for vascular development, particularly during early stages of embryonic growth.
Researchers are developing 3D printed tissues, including skin, bone, cartilage, and bladder models. Organs-on-a-chip systems mimic human tissue structure and function, allowing for the study of physiological differences and drug screening.
A two-year clinical study found that CD34+ cells significantly reduced angina frequency in patients resistant to other therapies. The treatment demonstrated persistent improvement in angina and a trend towards decreasing major cardiac events, offering new treatment options for 'no option' patients.