Articles tagged with Vesicles
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Researchers elucidated dynamin's role in forming a screw-like structure to constrict and release vesicles. Specific mutations impairing dynamin function are linked to congenital muscle disorders.
Researchers at EMBL Heidelberg have produced detailed images of the COPI coat surrounding vesicles that transport molecules within cells. The intricate protein structure is composed of repeating building blocks called triads, which organize functional elements in a precise 3D structure.
Researchers at EMBL Heidelberg solved a decades-old cell biology puzzle by clarifying the behavior of clathrin proteins, crucial for endocytosis. The team used new imaging techniques to demonstrate that the surface area of the clathrin coat remains constant during endocytosis, only changing its curvature as it draws the cell membrane i...
Researchers at the University of Notre Dame investigate the clinical potential of microvesicles, shedding light on their role in promoting tumor invasion and metastasis. The study identifies key proteins that guide the formation of these vesicles and suggests a potential link to biomarker development.
Scientists at Cold Spring Harbor Laboratory have revised the theory of how PTEN shuts off growth signals in cells. They found that PTEN proteins travel along microtubule highways to cytoplasmic vesicles containing green signals, which are then pinched off and turned back to red through a process called endocytosis
A new study by University of Cambridge researchers identified a critical threshold in alpha-synuclein protein levels that increases the chances of aggregation and neurodegeneration. The findings provide a mechanistic description of the initial molecular events leading to Parkinson's disease.
Tiny bubbles can adapt to changing conditions by reorganizing their membranes, allowing them to sense and react to their environment. This emergent behavior could help design microbubbles for targeted drug delivery and offer new ways to tap chemical energy in biological systems.
Researchers at Syracuse University have created biomimetic sacs that undergo spontaneous oscillations and tunable frequency, mimicking the behavior of living cells. The discovery has significant implications for the development of artificial cells and clocks.
University of Pennsylvania researchers have developed a novel method to create stable, onion-like vesicles using dendrimers. By controlling the concentration of dendrimers, they can produce vesicles with multiple layers, allowing for sequential release of drugs and potential clinical applications.
Researchers at the Weizmann Institute have discovered a new type of cellular vesicle that actively seeks out and destroys paternal mitochondria upon fertilization. This finding may help explain why only a quarter of IVF pregnancies carry to term, and could lead to a better understanding of mitochondrial turnover and male fertility.
A contest for the best particle tracking technique found that each method has its own strengths, but none were deemed unequivocally superior. The challenge, which aimed to track hundreds of intracellular organelles, was marked by oversimplification in image series, limiting algorithm performance on real data.
Scientists at MIT discovered that marine cyanobacteria continually produce and release extracellular vesicles, which serve as food parcels for other organisms. The vesicles contain DNA, likely facilitating gene transfer among similar bacteria and potentially acting as decoys to deflect viruses.
Randy Schekman and James Rothman, Nobel laureates in cellular vesicle transport, criticize federal research funding cuts and commercialized scientific journals. They emphasize the importance of preserving basic research and promoting alternative measures of individual research value.
Researchers discovered ultrafast recycling of synaptic vesicles in nerve cells, allowing for rapid signal transmission and potentially protecting against neurodegenerative diseases. This process enables the brain and muscles to function continuously without interruption.
Researchers reveal how individual molecules work together during a single act of endocytosis, overcoming an energy barrier through molecular cooperation. This discovery sheds light on a process linked to human diseases and has implications for treating conditions like muscular dystrophy and Alzheimer's disease.
Researchers at Stowers Institute for Medical Research have made crucial discoveries about the development of cell polarity. They found that diffusion traps, created by sticky regions on the membrane, play a crucial role in maintaining cell polarity.
Researchers unexpectedly found that inhibiting protein breakdown delays neurodegeneration and increases longevity in mice. Blocking proteasome activity restored key biochemical characteristics necessary for nerve cell function. The findings pose a challenge to current beliefs about neurodegenerative disorders.
Researchers at EMBL develop method to follow molecules under light and electron microscope, revealing crucial protein interactions in endocytosis process. They discover actin scaffolding protein forms network pulling membrane inwards.
Researchers at University of Pennsylvania develop new approach to making vesicles and fine-tuning their shapes using genetic engineering. They successfully assemble oleosin into vesicles, which offer significant advantages for oral-drug delivery due to their biocompatibility and ability to carry large payloads.
Researchers at the European Molecular Biology Laboratory have discovered a 'transformer' protein that allows cells to create vesicles of different shapes and sizes by changing the shape of individual building blocks. This breakthrough provides new insights into the structure and function of COPI protein-coated vesicles.
Researchers at the University of Illinois discovered that docosahexaenoic acid (DHA) is crucial for constructing the acrosome, a critical structure in fertilization. Without DHA, sperm cells fail to form properly and fertility is compromised.
Researchers developed a microfluidic device to produce stable, biocompatible lipid vesicles that mimic natural cell membranes. This breakthrough overcomes previous hurdles by generating precisely sized droplets in an oil environment, producing an oil-and-water membrane for lipid assembly.
Researchers at NYU Langone Medical Center have discovered a protein called TAT-5 that inhibits the budding of extracellular vesicles from cells, affecting tumor spread, blood clotting, and inflammation. The study reveals new potential strategies to manipulate diseases like cancer.
MDC researchers have determined the molecular structure of dynamin, a key player in cellular nutrient uptake. The study provides fundamental insights into the 'wire-puller' mechanism of dynamin during endocytosis, which is essential for signal transmission and immune system function.
The study reveals exactly how dynamin proteins form large assemblies that pinch off bubbles from cell membranes, allowing cells to 'eat' and compartmentalize external items. Understanding these miniature motors may enable the engineering of cells with new functions.
Researchers found synaptophysin controls vesicle replacement, potentially leading to new treatments for learning deficits. The study may also help explain why people with synaptophysin mutations experience mental retardation.
Research reveals distinct exocytosis regulation mechanisms between living organisms and laboratory tissue cultures. The study used intravital microscopy to examine exocytosis in live mice, finding that secretory vesicles fuse with the plasma membrane one by one under beta-adrenergic receptor stimulation.
Researchers at Max Planck Institute develop new method to measure synaptic vesicle priming, revealing SNAPs play crucial role in recycling SNARE complexes. Disruption of this process can lead to communication breakdown and vital processes like sight or sound detection being impaired.
Researchers at the University of Copenhagen have discovered that brain cell communication relies on three copies of the 'linking bridge' or SNARE complex to enable rapid fusion of vesicles with membranes. This process allows for simultaneous signal transmission, which is crucial for cognitive functions and overall brain activity.
Researchers discovered the structure of dynamin, a protein that pinches off tiny pouches from cells' outer membranes, revealing how vesicles form and advancing knowledge of endocytosis. The findings may lead to better ways for delivering drugs.
Researchers studied scorpion venom's effects on cell release mechanisms, finding a protein production system targeted by the venom that may lead to pancreatitis. The study suggests potential treatments for viruses and advances in chemotherapy through targeted drug delivery.
Scientists have successfully imaged vesicles and filaments involved in neuronal communication, revealing crucial role of filamentous structures in regulating neurotransmitter release. The 3D images were obtained using electron cryotomography, a novel method that rapidly freezes cells while preserving biological structures.
Researchers found that the number of cracks in the membrane determines how many proteins are bound, contradicting earlier ideas about affinity. This knowledge could lead to a better understanding of cellular processes and diseases such as depression and Alzheimer's.
Researchers at University of Wisconsin-Madison discovered that synaptotagmin plays a critical role in initiating fusion by bending a target membrane, providing a point of contact for easier merging. The study also found that the protein overcomes fusion deficiency when mutated and compensates with an endocytic protein.
Scientists have recorded live vesicle fusion on the nano-scale using Fluorescence Resonance Energy Transfer (FRET). This breakthrough allows for real-time measurement of vesicle shape and properties, opening up new avenues for understanding neurological and infectious diseases.
A large protein called Tweek is crucial for recycling and endocytosis in the synaptic process, allowing neurotransmitters to be transported to neurons. The study found that increasing PI(4,5)P2 levels reverses the defect in endocytic processes, highlighting the importance of Tweek in maintaining cellular homeostasis.
Tiny membrane-bound compartments called vesicles rely on axon tension to dump neurotransmitters into the synapse. The researchers found that axons need tension to keep vesicles clustered near the synapse, essential for neuronal signaling. Further research is needed to understand the exact mechanism behind this process.
A study by McConnell et al. reveals that intestinal microvilli extend their function beyond nutrient absorption, releasing vesicles packed with enzymes into the gut lumen for enhanced nutrient breakdown and defense against pathogens like lipopolysaccharide
Researchers at the Max Planck Institute have successfully produced cadmium sulphide particles in microscopically small membrane bubbles, achieving control over nanoparticle size for the first time. The method uses biomimetic compartments similar to cell membranes to synthesize nanoparticles, offering a new approach to optical informati...
New research reveals that cells employ similar molecules for importing and exporting cargo, blurring the line between endocytosis and exocytosis. This challenges traditional biological assumptions about dedicated molecules for specific processes.
Cold Spring Harbor Laboratory researchers discovered that oligophrenin-1 (OPHN1) is crucial for neural signaling by controlling the recycling of synaptic vesicles. Defective OPHN1 signaling leads to misshapen dendritic spines and loss of synaptic strength, contributing to X-linked mental retardation.
Researchers at Scripps Research Institute have identified a single molecule, dynamin, that forms a short collar around emerging membrane fragments and squeezes them tight to separate new vesicles. This process is crucial for cellular endocytosis and may be ubiquitous throughout the cell.
In a developmental program, Dictyostelium cells acquire polarized morphology and aggregate to form a migrating stream. The team discovered that ACA-containing vesicles cluster at the rear of cells, creating a 'breadcrumb trail' that guides fellow cells to join the parade.
Synaptotagmin-1 catalyzes membrane fusion at the synapse, allowing for rapid neurotransmitter release. The protein's C2B domain binds to calcium ions and interacts with both membranes to facilitate fast transmission.
Researchers at Caltech used electron tomography to study the transport of antibodies from mother's milk to newborns' bloodstream. The findings revealed that antibodies are shuttled through large vesicles and form 'tangled messes' before being delivered into the bloodstream.
Ezetimibe works by blocking NPC1L1's entry into cells, reducing cholesterol uptake. Researchers found that cholesterol encourages cells to engulf and internalize NPC1L1 through endocytosis.
The January issues of Biophysical Journal feature studies on the ultra-fast biological motion of Vorticella, which contracts like a spring, and sequence-dependent variations in nucleosome stability. Researchers also explore the biomechanical perspective of vesicle transport regulation in cells.
Researchers at Weill Cornell Medical College have identified the role of Synaptojanin 1 in the synaptic vesicle cycle, a critical aspect of synaptic function. The enzyme's removal slows down endocytosis, highlighting its importance in cell-to-cell information flow.
Researchers at Weill Cornell Medical College have made a breakthrough by observing synaptic vesicle recycling in real time, laying to rest the 'resealable spout' theory of vesicular recycling. The study uses cutting-edge methods to show that neurotransmitter packets must be rebuilt after each cycle.
Scientists at the University of Illinois have created novel biomimetic membranes that can efficiently transport water, making them ideal for desalination and wastewater purification. The membranes' high permeability and selectivity could also be useful for drug delivery applications.
Researchers at Cornell University found that ion channels in membrane-bound vesicles do not carry charged neurotransmitters out of the cell. Instead, positive sodium ions from the outside compensate for the charge, a process known as electrodiffusion.
Researchers discovered that molecular motors play a crucial role in shedding membrane from the tips of microvilli, speeding up nutrient processing. This finding has implications for understanding gastrointestinal physiology and potential new treatments for diseases.
Researchers at Weill Cornell Medical College and Yale University discovered that dynamin 1 is not essential to all synaptic transmission, but rather acts more subtly during moments of high activity. This finding has significant implications for understanding neurological injury and disease.
Researchers at Brown University have discovered that hemifusion, a critical step in membrane fusion, allows vesicles to share membranes without releasing their contents. This stable state enables the rapid delivery of drugs to target cells by controlling the timing of fusion.
Irene Chen's research on protocells and RNA-based systems has led to a deeper understanding of the emergence of cellular behavior. Her work promises exciting insights into the origins of biological complexity, suggesting that evolving higher levels of organization might have been surprisingly easy during the origin of life.
Researchers used a flash-freeze physical-fixation technique to study nematode worms and found that membrane packets of neurotransmitter localize in new places. The technique provides an accurate picture of where synaptic proteins cluster, information previously unknown to scientists.
A Rice University study has identified the complexin protein as a brake that shortens response time for signal transmission in nerve cells, enabling nearly instantaneous passing of information. This breakthrough sheds light on the mechanisms behind rapid neural signaling.
Scientists have visualized individual synaptic vesicles and proteins using Stimulated Emission Depletion (STED) microscopy, resolving the diffraction barrier. They found that synaptotagmin molecules remain together after fusion, enabling efficient neurotransmitter release.
Researchers have developed an assay that visualizes the formation of clathrin-coated vesicles at single clathrin-coated pits with high time resolution. This breakthrough sheds light on fundamental questions about clathrin-mediated endocytosis, including whether single coated pits give rise to multiple vesicles.
Researchers modelled and simulated motor traffic to determine optimal conditions for nanocargo transport in biomimetic systems. The study found that increasing the number of motors while avoiding traffic jams is crucial for efficient cargo transport.