Molecular zip code draws killer T cells straight to brain tumors
Scientists have created a living cell therapy that can navigate to specific organs using a
Mouse Models
Articles tagged with Mouse Models
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Congenital heart defects caused by problems with placenta
Researchers at Nanjing University confirm link between SLC25A1 protein and congenital heart defects caused by placental problems. The study found that loss of SLC25A1 leads to placental growth issues, which in turn cause heart defects.
OU College of Medicine professor earns prestigious pancreatology award
Min Li will receive the 2024 Palade Prize for his contributions to pancreatology, recognizing his pioneering work on pancreatic cancer and metabolic reprogramming. He has been continuously funded by the National Cancer Institute for 15 years and has published over 200 high-impact articles.
Anti-anxiety and hallucination-like effects of psychedelics mediated by distinct neural circuits
Researchers used a mouse model to study the effects of psychedelics on anxiety and hallucinations, finding that distinct neural circuits are responsible. By targeting specific neurons, they were able to reduce anxiety-like behaviors without inducing hallucinations.
Brain immune cells amplify damage caused by Alzheimer’s risk gene, study finds
Researchers at Gladstone Institutes created a new mouse model to study Alzheimer's disease, transplanting human neurons into mouse brains. The study found that immune cells called microglia cause harmful inflammation and clumps of misfolded proteins when interacting with the APOE4 protein.
Cannabis use in adolescence: Visible effects on brain structure
A study led by Graciela Pineyro and Tomas Paus found that cannabis use in adolescence can lead to thinning of the cerebral cortex, affecting communication between neurons. The researchers used a combination of methods to demonstrate THC's impact on brain cells and identified genes associated with cortical thinning.
New drug, WNTinib, delays tumor growth and improves survival in mouse models of children’s liver cancer
Researchers found that WNTinib significantly delayed tumour growth and extended survival in mice with hepatoblastoma cells harboring CTNNB1 mutations. The treatment also showed promise in shrinking tumors in patients' tumor tissue models, with some tumors disappearing completely.
Senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in mice
Researchers used a mouse model to assess the impact of senolytic agents dasatinib and quercetin on pelvic organ prolapse. The study found that D+Q injections did not result in significant differences in prolapse development but reduced cellular senescence markers.
Study shows that Rett syndrome in females is not just less severe, but different
Researchers found that female mouse models of Rett syndrome have a mosaic-like distribution of cells expressing wild-type and mutant MeCP2 protein, leading to dysregulated genes. The study also discovered an unusual disease progression, with females having more dysregulated genes at the pre-symptomatic stage than later on.
Study explores how traumatic brain injury (TBI) may be linked to Alzheimer’s disease
Researchers found TBI increases hyperphosphorylated tau, astro- and microgliosis, synaptic dysfunction and cognitive impairments linked to developing Alzheimer’s. BAG3 overexpression ameliorates tau hyperphosphorylation, synaptic dysfunction and cognitive deficits through the enhancement of the autophagy-lysosome pathway.
Variability in when and how cells divide promotes healthy development in embryos
Researchers have found that variability in when and how cells divide during embryo development leads to more optimal arrangements of cells, promoting robust tissue formation. This study challenges traditional views on the role of cell division variability in embryonic development.
New mouse models offer valuable window into COVID-19 infection
Researchers at La Jolla Institute for Immunology have developed six lines of humanized mice to study human cases of COVID-19, shedding light on SARS-CoV-2's movement through the body and varying symptoms. The models help understand how different genetic backgrounds influence disease progression.
Scientists design new drug to fight malaria
A team of researchers has designed a new antimalarial drug called MED6-189, which is effective against both drug-sensitive and drug-resistant strains of human malaria parasites. The compound works by targeting the apicoplast organelle and vesicular trafficking pathways, making it a promising lead in the fight against malaria.
Mouse study explores 3D structure of DNA in nerve cells
A mouse model study led by Ohio State University researchers reveals the importance of DNA loops and protein complex cohesin in nerve cell regeneration. The study's findings could lead to new treatments for nerve injuries by understanding how chromatin organization affects gene expression.
Intraovarian PRP improves oocyte quality and embryo development in mouse models
Researchers have found that intraovarian PRP injection can improve the number and quality of blastocysts in POI mouse ovaries damaged by high doses of chemotherapy. The study also characterizes the protein content of PRP, suggesting its potential to enhance reproductive function.
The curious immune cells caught between worlds
Researchers at Cold Spring Harbor Laboratory have discovered that innate-like T cells mature differently in humans than in mice, with age playing a critical role in their development. This finding has significant implications for the development of immunotherapeutics, highlighting the need to consider human-specific differences when te...
Proteins in meat, milk, and other foods suppress gut tumors
A new study published in Frontiers in Immunology reveals that certain food proteins like milk and meat can help keep gut tumors from growing by triggering the intestinal immune system. This discovery has potential clinical implications for patients with gastrointestinal conditions.
New study increases understanding of HIV drug’s negative effects on the brain
A new study in ACS Pharmacology & Translational Science investigates the molecular mechanisms behind Efavirenz's negative effects on brain function. The research reveals that the drug alters lipid metabolism and downregulates certain enzymes, which could lead to the development of new drugs to block its negative activity.
Gut microbiome influences location of immune cells
Researchers found that microbial communities in mice influence immune cell populations, with adaptive cells more prominent in lower intestine and innate cells in upper segments. A tool has been created for studying interactions between gut microbes and inflammatory diseases.
The amazing healing abilities of a common immune cell type boosted by Treg
Researchers have discovered that administering regulatory T cells (Tregs) can enhance tissue healing, promoting bone volume, muscle growth, and skin wound closure. The key role of interleukin-10 (IL-10) in supporting tissue repair has also been identified.
New avenues for treating heart failure: uncovering a protective mechanism in the cardiac myocytes
A study published in Nature Communications reveals a cellular signaling pathway that promotes heart cell survival. The Mst1-FoxO1-C/EBP-β interaction stimulates protective mechanisms in cardiac myocytes, potentially paving the way for new therapies.
Fuel level low! Energy deficits harm athletes’ health, new research tool reveals how
Researchers created a mouse model to study relative energy deficiency in sport (REDs), revealing the syndrome impacts the entire body and affects males and females differently. REDs leads to hormonal and reproductive issues, insomnia and fatigue, bone weakness and injury, and anxiety and depression.
Finding new targets for blocking chronic hepatitis
Researchers at Tokyo Medical and Dental University discovered the role of A20 in suppressing chronic hepatitis by inhibiting the DCLK1-JNK pathway-dependent chemokines. In mice lacking A20 expression, hepatic stellate cells displayed spontaneous inflammation and increased chemokine levels.
Consensus paper: Carcinogenicity of gene therapies
Researchers have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease. The treatment approach may represent a potential long-term universal treatment for MSUD.
Mouse study: Proteins do the damage in fetal abdominal inflammation
A Kobe University study establishes a new mouse model to study fetal abdominal inflammation caused by meconium peritonitis. The researchers found that heat-treated proteins in the meconium slurry disrupt digestive enzymes, leading to significant reduction in mortality rates.
Lipid nanoparticle mRNA therapy improves survival in mouse models of maple syrup urine disease
Researchers developed a treatment approach using lipid nanoparticles to deliver mRNA therapy for MSUD, extending survival and reducing serum leucine levels. The study also identified a novel AAV variant with desirable biodistribution properties for targeting peripheral organs.
COPD and BPD: Inhalation of live Lactobacilli lessens lung inflammation and improves lung function
Inhalation of live Lactobacilli bacteria attenuates pulmonary inflammation, improves lung function, and structure for COPD and bronchopulmonary dysplasia. The treatment reduces neutrophilic inflammation, MMP-9, and pro-inflammatory markers.
New anti-CKAP4 antibodies deliver hope for pancreatic cancer treatment
Researchers from Osaka University have developed a humanized antibody that blocks the DKK1–CKAP4 pathway, stimulating cancer cell growth. The new anti-CKAP4 antibody suppressed tumor formation in mice with both human and mouse tumors, as well as modulating anti-tumor immune reactions.
Pink elephants in the brain?
A study published in Neuron reveals that neurons are wired to connect seemingly unrelated concepts, enhancing the brain's ability to predict what we see based on past experiences. Visual experience influences the organisation of feedback projections, which store information about the world.
Molecule restores cognition, memory in Alzheimer’s disease model mice
A UCLA researcher identified a compound that effectively jumpstarts the brain's memory circuitry, restoring cognitive functions in mice with Alzheimer's disease symptoms. The molecule, DDL-920, works by targeting specific neurons to enhance gamma oscillations, which are critical for memory and cognition.
Dopamine treatment alleviates symptoms in Alzheimer’s disease
Researchers found that dopamine treatment increased neprilysin levels and reduced beta-amyloid plaques in mouse brains, improving memory function. Long-term L-DOPA treatment also showed improved cognitive performance in mice.
Preventing Parkinson’s disease may lie in seaweed antioxidants
Researchers at Osaka Metropolitan University found that Ecklonia cava polyphenols can protect against neurodegeneration and improve motor function in Parkinson's disease model mice. The antioxidants activate the AMPK enzyme and inhibit reactive oxygen species production, reducing neuronal cell death.
Improving Alzheimer’s disease imaging — with fluorescent sensors
Scientists create fluorescent sensors that can detect neurotransmitter levels in the brain, allowing for non-invasive live brain imaging. The technology has shown promise for advancing Alzheimer's disease diagnosis and treatment.
An artificial hepatocyte growth factor mimetic ameliorates non-alcoholic steatohepatitis in mouse model
A research group developed a long-acting artificial hepatocyte growth factor (HGF) mimetic molecule using cyclic peptides and protein engineering. The molecule improved liver fibrosis, lipid accumulation, and inflammation in a mouse model with non-alcoholic steatohepatitis (NASH), providing an option for NASH therapeutics.
How does a common skin bacterium cause chronic infections after orthopedic surgeries?
A new study reveals that Cutibacterium acnes can persist in biofilms on implants for weeks, invading deep bone networks and causing chronic infections. The bacteria's ability to invade osteocyte lacuno-canalicular networks provides a novel mechanism for treating difficult-to-treat bone infections.
Researchers are closing in on a mouse model for late-onset Alzheimer’s
Scientists at the Jackson Laboratory created a mouse model for late-onset Alzheimer’s disease by introducing genetic variants associated with the illness into mice. They used transcriptomics to analyze brain tissue and identify key biological signatures, paving the way for testing new therapeutics.
Targeting factors for chemoprevention and cancer interception to tackle mesothelioma
This research perspective reviews the current state of chemoprevention and cancer interception progress in asbestos-induced mesothelioma. The study identifies potential targets for prevention, including inflammatory factors and novel chemoprevention agents.
Switching off inflammatory protein leads to longer, healthier lifespans in mice
Researchers discovered that deactivating IL-11 increases healthy lifespan by 20-25% in mice, with reduced cancer deaths, fibrosis, chronic inflammation, and improved muscle strength. The findings raise the possibility of using anti-IL-11 treatments to study aging in humans.
Novel genome editing approach restores hearing in adult preclinical models with genetic deafness
Researchers developed a CRISPR/Cas9 genome editing approach to target and disrupt a specific mutation causing progressive hearing loss. The study found robust preservation of auditory function, with earlier intervention proving most optimal.
Scientists create first mouse model with complete, functional human immune system
Researchers have developed a humanized mouse model with a fully functional human immune system, enabling the study of immunotherapy development, disease modeling, and vaccine development. The new model, called TruHuX, mounts specific antibody responses and can develop full-fledged systemic lupus autoimmunity.
New insights into osteoporosis
A research team from Osaka University identified a key osteoporosis-related gene, Men1, and developed a new animal model of the disease. The study found that inactivation of Men1 led to cellular senescence in osteoblasts, reducing bone formation activity and increasing bone resorption.
Korea University identifies novel inhibitor HVH-2930 showing promise in overcoming trastuzumab resistance in HER2-positive breast cancer
A novel inhibitor HVH-2930 targeting heat shock protein 90 (HSP90) demonstrates efficacy against drug-resistant breast cancer cells. It selectively downregulates HER2 signaling, crucial for breast cancer progression, without triggering the heat shock response.
Mapping the heart to prevent damage caused by a heart attack
Researchers created an integrated cellular map of a mouse model heart, pinpointing cells and pathways involved in fibrosis. The study identified myofibroblasts as the major drivers of scarring, but also discovered a 'matrifibrocyte' form that may prevent scar resolution.
Research identifies possible new pathway to treatment of colorectal cancer
Researchers at Virginia Tech have discovered a possible new pathway to treat colorectal cancer by targeting the NF-kB-inducing kinase (NIK) protein. The study, led by Irving Coy Allen, identifies changes in a significant signaling pathway in human patients and presents potential targets for therapeutics.
Obesity-cancer connection discovery suggests strategies for improving immunotherapy
A Vanderbilt University Medical Center-led research team discovered a connection between obesity and cancer, revealing that macrophages play an unexpected role in the complicated connection. Obesity increases macrophage frequency in tumors and induces PD-1 expression, which can contribute to both increased cancer risk and enhanced resp...
Proteomics uncover sexual dimorphism and immune changes in aging mice with Werner syndrome
Researchers found that Werner syndrome mice experience age-dependent and sex-specific changes in their livers and immune systems, including fatty liver accumulation and altered lipid metabolism. These findings suggest a potential link between immunoglobulin variants and fatty liver progression in the disorder.
Light-activated drugs targeting adenosine A2A receptors in the brain that induce sleep
Researchers developed a novel light-sensitive drug that enhances extracellular adenosine activity, inducing sleep artificially without genetic modification. The drug overcomes issues with conventional photosensitive drugs, showcasing optochemistry's potential in targeting A2A receptors and regulating brain function.
New biomarkers of response in melanoma immunotherapy
Researchers have identified collagen features as valuable biomarkers for evaluating melanoma immunotherapy response. Single-fiber characteristics were found to be more sensitive to treatment-induced changes than bulk collagen features, offering insights into collagen remodeling over time.
Naturally occurring substance in pomegranates can improve treatment of Alzheimer’s disease
A new study at the University of Copenhagen reveals that urolithin A, a naturally occurring substance in pomegranates, can alleviate memory problems and other consequences of dementia. The substance shows promise in improving brain function by removing damaged mitochondria.
Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
A new animal model has been developed to study periodontitis, allowing researchers to analyze tissue components simultaneously. The study found that the expression of the Il1rl1 gene was higher in peri-root tissue five days after ligation, highlighting its role in inflammation and osteoclast differentiation.
USC study reveals role of iron in allergic asthma and points to potential new therapies
Researchers found that iron is a regulator of energy usage by immune cells in the lungs, which can help treat asthma and other allergic diseases. Blocking or limiting iron uptake may reduce asthma severity.
BTF3L4 overexpression mediates APAP-induced liver injury in mouse and cellular models
Researchers found that BTF3L4 overexpression mediates APAP-induced liver injury by inducing inflammation and damaging mitochondrial function. Increased BTF3L4 expression is positively associated with liver injury and may serve as a biomarker.
Synthetic platelets stanch bleeding, promote healing in animal models
Synthetic platelets made of hydrogel nanoparticles mimic the size and shape of human platelets, promoting clotting and healing. The innovative device has shown promising results in animal models and is being developed for clinical use to treat various medical conditions.
Softer tumors fuel more aggressive spread of triple-negative breast cancer
Researchers have discovered how softer tumor environments prime cancer cells to better survive metastasis. The study found that soft environments alter the cancer cells' preference for 'fuel', equipping them with a more resilient energy pathway.
Successful murine model of dermatomyositis reveals underlying immune system involvement
A new murine model of dermatomyositis reveals the underlying immune system involvement in this highly progressive disease. The study identifies key components of the immune system responsible for disease development and suggests potential treatments targeting interleukin-6.
Geraniol attenuates oxidative stress and cognitive impairment in mouse aging model
Researchers found that geraniol reduces oxidative stress and neuroinflammation-mediated cognitive impairment in a mouse aging model. Geraniol treatment improved spatial learning and memory by enhancing anti-oxidant and anti-inflammatory effects.
Could novel immune cell therapy combat hepatitis B infections?
Researchers identify a promising strategy for combating hepatitis B virus (HBV) by boosting the effects of immune cells called stem cell memory T cells (TSCMs). In a mouse model, introducing TSCMs from patients into mice resulted in the elimination of HBV-infected liver cells.
Morphine tolerance results from Tiam1-mediated maladaptive plasticity in spinal neurons
Researchers at the University of Alabama at Birmingham found that blocking Tiam1 activity in spinal neurons abrogates morphine tolerance and hyperalgesia in a mouse model. Prolonged morphine treatment increased activated Tiam1 levels, leading to dendritic spine morphological changes.
Treatment with anti-inflammatory proteins following heart attack shows promise to reduce the risk of further heart damage
Two anti-inflammatory molecules, TGFβ1 and HpTGM, reduce the inflammatory response within the injured heart and scarring. Treatment with these proteins at the time of reperfusion reduces infarct size and mature scar size.
Small protein plays big role in chronic HIV infection
A study published in Brain, Behavior, and Immunity found that normal levels of interferon-β are required for normal memory function, and its absence changes nerve cell components in a sex-dependent fashion. The research also showed that higher or lower than normal levels of interferon-β affect the brain in a sex-dependent manner.