Articles tagged with Mouse Models
Researchers investigated hepatic hydrogen sulfide production in a mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS) and found reduced H2S levels in RC-fed mice, with partial rescue on high-fat diet. This study suggests that accelerated aging in HGPS may be partially explained by reduced hepatic H2S levels.
A mouse model of multiple sclerosis reveals evidence of inflammatory gene expression spilling over from the brain's barrier to grey matter. The study uses spatial transcriptomics to show a gradient of immune genes and inflammatory markers from meninges to surrounding brain tissue.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
Researchers at UCLA Health have discovered that estriol, a pregnancy hormone, can repair damaged myelin in the brain's cortex of mice with multiple sclerosis. This finding offers hope for developing new treatments to address the disease's progression.
Scientists at RIKEN Center for Brain Science find that somatic mutations in six genes lead to intracranial aneurysms, which can be blocked with a drug. The study establishes the first non-surgical animal model of intracranial aneurysm and provides a potential new treatment option.
Researchers developed a new approach to evaluate HIV infection through the entire male genital tract, showing that productive HIV infection occurs in all organs of the male genital tract. Antiretroviral treatment can suppress HIV production and prevent penile HIV infection by using pre-exposure prophylaxis with an antiviral drug.
A University of Ottawa team has discovered a vital role for the VGLUT3 transporter protein in modulating the development of Huntington's disease. The study shows that blocking glutamate release through this protein can lead to an amelioration of the disease progression, offering new hope for potential treatment approaches.
A new study from the Stowers Institute for Medical Research reveals the placenta's polyploid cells play a vital role in supporting healthy embryonic development. The modified cell cycle controlling polyploidy is governed by the regulatory gene Myc, which supports DNA replication and prevents premature cellular aging.
Researchers found that lymphoid depletion lesions in the spleen of SARS-CoV2-infected mice may trigger novel therapies to restore defective antigen-presenting cell functions in humans. The severity of COVID-19 varies significantly, with dysregulated immune responses linked to poor outcomes.
Cancer cells in brain tumors produce lipids at higher rates than surrounding healthy tissue, offering clues for treatment strategies. The study provides insights into the unique biochemical processes fueling cancer growth in the brain.
Scientists from Brigham and Women's Hospital have developed a new immuno-therapeutic approach using twin stem cells that can target brain metastatic melanomas. The therapy, which uses an engineered 'twin stem cell model,' activates the immune system to suppress tumor growth and prolong survival in representative preclinical models.
A new study in a mouse model of Alzheimer's disease examines the effects of environmental enrichment on AD symptom progression and pathology. The researchers found that living in an enriched environment improved several measures of metabolism and reduced individual behaviors, which became more similar and rigid as the disease progressed.
Researchers successfully demonstrate AAV vector efficacy in aged animal models, showing robust hearing rescue in mice with a mutation equivalent to a defective human gene. The study suggests that virally mediated gene therapy could potentially treat genetic hearing loss, especially for patients diagnosed at advanced age.
A study published in Cell Reports reveals that a family of proteins involved in the regulation of fast twitch muscle fibers plays a significant role in their development. The researchers found that animals exposed to microgravity expressed higher levels of these proteins, leading to faster-to-slow muscle fiber conversion.
Researchers have found that reduced oxygen intake is associated with a 50% increase in lifespan and delayed onset of aging-associated neurological deficits in fast-aging mice. The study's findings suggest that oxygen restriction may hold anti-aging potential for mammals, including humans.
A new study in mice reveals that pancreatic cancer's emergence is fueled by the expansion of cell-to-cell communication. Researchers found that plasticity and inflammation reshape cells' identities and local environments, fostering cancer growth. The study provides insights into the earliest cellular events leading to PDAC and potentia...
CARMN is a long noncoding RNA that regulates contractility in both blood vessels and the gastrointestinal tract. Without CARMN, mice cannot survive due to impaired GI tract contraction, leading to conditions like intestinal pseudo-obstruction.
KNT-127 exhibits anti-stressing and anti-depressant effects in mice, improving social interaction and reducing stress-induced hormone levels. The agent suppresses neuronal inflammation and newborn death without affecting neurogenesis.
Sons of women with PCOS are two times more likely to develop obesity and have high levels of male hormones, leading to insulin resistance and type 2 diabetes. A mouse study confirms these findings, showing fat tissue and metabolism problems in the offspring despite a healthy diet.
A Finnish mitochondrial disease, GRACILE syndrome, exhibits cancer-like changes in cell proliferation, leading to premature ageing. Researchers have identified the c-MYC protein as a key player in this process, and a ketogenic diet has shown promise in reducing excessive cell growth.
Researchers developed a method to predict DCIS progression to invasive breast cancer using mice with human DCIS cells. The study found molecular similarities between humans and mice, including the presence of HER2 protein increasing breast cancer risk.
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
A repurposed HIV drug has been found to restore the brain's autophagy function, helping prevent build-up of misfolded proteins and slowing disease progression in mouse models of Huntington's disease and dementia. This discovery provides clues to how this process could be slowed or prevented in humans.
Researchers discovered ERK signalling is a crucial switch between scarring and regeneration, with prolonged activation promoting regenerative success. Modulating ERK activity could potentially stimulate regeneration in clinical settings.
Researchers found that necroptosis promotes metastasis in breast cancer models, and blocking it leads to inhibition of metastasis. Necroptosis may be a key factor in tumor progression, and targeting its regulators could be critical for mitigating metastasis.
A cell therapy using myeloid cells bound to drug delivery microparticles reduces disease burden in a preclinical multiple sclerosis model. The therapy partially reverses hind limb paralysis and improves motor functions.
Researchers found that an extra copy of a gene controlling synapse formation causes excessive inhibitory signaling in the brain of mice with Down syndrome. This may contribute to conditions such as autism, epilepsy, and bipolar disorder.
Researchers at Moffitt Cancer Center have identified a critical pathway in the development of MYC-driven lymphoma, involving the chemical modification of eIF5A with hypusine. Inhibiting this process prevents lymphoma development and progression in mouse models, offering new therapeutic strategies.
Researchers at UC Davis discovered how oligodendrocyte-lineage cells transfer cell material to neurons in the mouse brain, providing a new mechanism for understanding brain maturation and finding treatments for neurological conditions. This discovery opens new possibilities for treating neurodegenerative diseases like Alzheimer's and P...
Researchers at Duke University have successfully improved the resolution of Magnetic Resonance Imaging (MRI), capturing images of a mouse brain with unprecedented sharpness. The breakthrough allows for the visualization of microscopic details within the brain, enabling new insights into neurodegenerative diseases such as Alzheimer's an...
Researchers at UC Davis School of Veterinary Medicine discovered that tissue resident memory cells are crucial for inducing a powerful immune response against Salmonella. Molecules like interleukin-1 and 2 enhance the formation of these cells in the liver, providing a rapid-response force.
Researchers at MIT have found a way to reverse neurodegeneration and symptoms of Alzheimer's disease by interfering with an overactive brain enzyme called CDK5. The peptide treatment reduced neurodegeneration, DNA damage, and improved behavior in mice with Alzheimer's.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
Research at Texas A&M University reveals that a father's alcohol consumption before conception can lead to FAS-related craniofacial differences in offspring. The study challenges the existing dogma that only maternal alcohol exposure causes fetal growth defects.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
Research using mice models of Alzheimer's disease found that deep brain stimulation activated only a small population of new neurons, restoring cognitive and non-cognitive functions. The study also identified protein pathways involved in improved memory performance and plaque clearance.
Researchers developed a VR imaging system to measure neural activity in mouse brains during behavior, revealing abnormalities in cortical functional network dynamics associated with autism. The system successfully distinguished between autism model mice and wild-type mice based on their brain network patterns.
Researchers have developed a multidisciplinary approach using a new microscope, artificial intelligence algorithm, and voltage indicators to better measure brain activity. The technique enables the imaging of up to 100 neurons at a time, far surpassing previous limits.
Researchers at the University of Wisconsin-Madison have identified a specific cell population, called CD4/CD8 double positive T cells, that causes graft-versus-host disease in bone marrow transplants. The team's findings may lead to targeted treatments and improved patient outcomes.
A study published in Cell Death & Disease reveals that a protein cross-linking enzyme called TG2 exacerbates kidney fibrosis by polarizing M2 macrophages. The researchers hope to develop treatments for diseases caused by inflammation imbalance, such as fibrosis, cancer, and atherosclerosis.
A study by IMBA researchers links muscle degeneration to a deficiency in the enzyme PCYT2, essential for lipid synthesis. PCYT2 depletion affects mitochondrial function and muscle energetics, highlighting the importance of lipid balance in muscle health.
Two novel genetically defined mouse models replicate two subtypes of human multiple myeloma, revealing the interaction of genetic aberrations as a key factor in development. The models will aid in identifying specific therapeutic strategies for individualized treatment.
Researchers created a new mouse model of Down syndrome with milder cognitive traits, showing promise for developing precise treatments. The study's findings may help address the limitations of previous models and improve cognitive function in individuals with Down syndrome.
Researchers at Hokkaido University discovered itaconate's modulatory effect on T helper and T regulatory cells, potentially leading to new treatments for autoimmune diseases. The study found that itaconate inhibits Th17 cell differentiation and promotes Treg cell development, reducing disease symptoms in mice models.
A recent study published in PNAS reveals that the protein TSKS plays a crucial role in eliminating sperm cytoplasm, enabling a streamlined structure necessary for successful fertilization. The findings suggest potential applications for diagnostic tests and male contraceptives.
Researchers from Kumamoto University found that synchronizing ovulation and mating in
Research at Kobe University reveals that endogenous retrovirus activation increases a fetus's susceptibility to autism, leading to differences in brain structure and behavior. The study identifies BTBR/R mice as a more accurate model of autism, exhibiting autistic-like behaviors without reduced learning ability.
Reducing mRNA methylation promotes migration of macrophages into the brain and clearance of toxic protein amyloid-beta. This pathway provides a potential new target for treatment of Alzheimer's disease.
Researchers identified a type of immune cell called age-associated B cells as key drivers of lupus disease. Targeting these cells in a mouse model reduced disease progression, suggesting a potential new therapy for lupus patients.
Researchers discovered a metabolic difference in lung tumor cells between humans and mice, explaining previous study results. The finding suggests targeting the LKB1-controlled metabolic pathway for lung adenocarcinoma treatment.
A recent study published in Immunity found that skipping breakfast can lead to a decline in immune cells and an increased risk of heart disease. The research showed that fasting triggers a stress response in the brain, which negatively affects immune cells.
Researchers at Gladstone Institutes found that ApoE4 from neurons plays a critical role in Alzheimer's disease, contrary to previous focus on glial cells. The study shows that deleting ApoE4 from neurons reduces brain changes resembling Alzheimer's disease, offering new possibilities for treatment.
Scientists at Ben-Gurion University have discovered a groundbreaking treatment approach targeting the mitochondrial gatekeeper VDAC1 for Alzheimer's disease. The new therapy, VBIT-4, demonstrates significant improvement in mouse models, preventing cell death and neuroinflammation while promoting healthy neuron growth.
Researchers found that fasudil reversed reduced pyramidal neuron density and cognitive dysfunction associated with methamphetamine treatment in mice with ARHGAP10 gene mutations. Fasudil also restored the density of pyramidal neurons, improving visual discrimination tests performance.
Scientists have successfully corrected limb length in a mouse model of FZD2-associated autosomal dominant Robinow Syndrome, a genetic disorder that affects skeletal growth and development. The treatment involves using a drug that stimulates the signalling pathway, resulting in significantly longer limbs than untreated mice.
Scientists have developed a mouse model of mpox virus, revealing differences in virulence among genetic groups. The new model shows that the current outbreak strain, clade IIb, has a significantly lower mortality rate than previous strains.
Research found that cocaine use disorder causes significant gene expression changes in brain regions associated with reward and habit formation, contributing to persistent behavioral abnormalities. The study also identified overlapping molecular changes between cocaine and opioid use disorders, offering potential for targeted treatments.
Researchers from Tokyo University of Science discovered β-damascone, a natural aroma compound found in rose fragrance, modulates dendritic cell functions and reduces inflammatory cytokine production. The study showed β-damascone inhibits antigen-dependent activation and Th1 cell development, as well as ear inflammation in mice models.
A mutant SRSF1 gene may cause severe nonalcoholic fatty liver disease (NASH), researchers have found. Mice lacking the gene develop all three hallmarks of NASH: excess fat, inflammation, and scarring in the liver. The study suggests that DNA damage in liver cells triggers this pathology, highlighting the need to protect the genome.
Researchers have developed an inhalable powder called SHIELD that reduces infection in mouse and non-human primate models by reinforcing the body's mucosal layer. The powder is composed of food-grade materials and biodegrades over a 48-hour period, providing protection for up to 8 hours.