Articles tagged with Mouse Models
Researchers from Hokkaido University have identified a link between succinyl-CoA levels and energy metabolism in heart cells affected by chronic heart failure. Supplementation with 5-aminolevulinate acid improved heart function and oxidative phosphorylation capacity in mice with surgically blocked blood supply.
Researchers discovered a molecular link between disrupted circadian rhythms and lung tumor growth, implicating a cancer-signature gene known as HSF1. Disrupted clocks may trigger lung tumors in individuals with irregular sleep patterns or night shifts.
Researchers at Osaka University have developed a mouse model that shows Favine protein can protect against atherosclerosis and thrombosis. The study also found that reduced levels of Favine are associated with calcification and thrombus formation, revealing a new potential therapeutic target for treating atherosclerosis.
Researchers found positive correlations between lipoxin A4 and cognitive brain functions, as well as its potential to potentiate the endocannabinoid system. The study suggests that reducing levels of this substance may weaken the body's defenses against neurodegeneration.
Researchers at Hokkaido University have developed a biosensing technology to detect amyloid β build-up in the brain from biomarkers in blood samples. The Digital ICA TM technology can detect Aβ-binding exosomes in mice, increasing with age and disease progression.
The fasting-mimicking diet reduced Alzheimer's pathology in mice, including amyloid beta and tau protein levels, and showed less brain inflammation. Mice on the diet also performed better on cognitive tests, with some showing improved performance comparable to non-Alzheimer's mice.
A study identifies a molecule called NIK that promotes the growth of bile duct cells in the liver, leading to scarring and liver fibrosis. Removing NIK or blocking its action with inhibitors may prevent disease progression.
Researchers from the University of Copenhagen have identified a new mechanism in ARVC that could lead to a potential treatment strategy. They found that activating sirtuin-3 can slow down disease progression, and honokiol, a natural product extracted from the tulip tree, has been shown to work similarly.
Researchers at Nagoya University have discovered a new treatment for type 1 diabetes that uses leptin to improve insulin-alternative effects in mice. The combination of leptin and a PTP1B inhibitor normalizes blood glucose levels without the need for insulin, reducing hypoglycemia risk.
Researchers have developed a mouse embryo model using only embryonic stem cells, achieving a high level of developmental stages including beating hearts and brain formation. This advancement opens up new avenues for understanding human pregnancy loss and developing organs in culture.
A new study by Kyoto University found that Regnase-1 gene expression is low in patients with pulmonary arterial hypertension (PAH), mirroring the pathology of humans. The protein's mRNA degradation leads to PAH inhibition, offering a potential new treatment for heart failure and premature death.
Researchers identified critical period plasticity in the amygdala that can be treated with therapeutic intervention at key developmental time points. Early pharmacological intervention was shown effective in reducing fear-learning in the mouse model.
A newly identified link between chronic pain and lung cancer in mice suggests that old drugs such as clonidine, capsaicin, and fluphenazine may offer new treatments for chronic pain. The study found that blocking the BH4 pathway reduced pain sensitivity and decreased tumor growth in mouse models of KRAS-driven lung cancer.
A team from the University of Tsukuba has developed a mouse model carrying a disease-associated mitochondrial mutation, which reveals that faulty RNA processing is responsible for metabolic disorders. The study provides new avenues for scientific discovery in understanding mitochondria and multiple diseases.
A team of researchers from Florida Atlantic University and Tel Aviv University are investigating the connection between neuroimmune serotonergic interactions and Alzheimer's-related mood disorders. By studying mice with AD-linked mutations, they aim to determine if immune-serotonin crosstalk plays a role in depressive traits.
Researchers have developed a model mouse embryo that has beating hearts, foundations for a brain, and all the organs in a mouse body. This breakthrough could help understand why some embryos fail and provide insights into repairing synthetic human organs.
Researchers at the University of Cambridge have successfully grown a model embryo with a brain, beating heart, and all other organs using mouse stem cells. This breakthrough could help understand why some pregnancies fail and develop a new approach for repairing synthetic human organs.
Research on mice reveals that older fathers produce pups with reduced vocal complexity and lower body weights, similar to children with neurodevelopmental disorders. The study provides evidence for the risk factor of advanced paternal age on infant development.
A study published in Frontiers in Immunology found that Japanese herbal medicine DKT reduces colitis severity by preventing gut bacteria loss and increasing immune cells. It restores Lactobacillus levels and promotes type 3 innate lymphoid cells, alleviating inflammatory responses.
Researchers found 560 proteins were differentially expressed, with 32 significantly altered, in reductive stress hearts. The proteome signature revealed oxidative stress-related pathways and mitochondrial dysfunction.
A new study by Tokyo University of Science researchers reveals that dendritic cell immunoreceptor (DCIR) plays a crucial role in the development of colorectal tumors. Blocking DCIR may prevent ulcerative colitis and colon cancer, offering a potential therapeutic target for treating these diseases.
A new gene therapy approach using the neuroprotective protein SynCav1 has shown promising results in slowing down ALS disease progression and increasing life span in rodent models. The treatment preserved spinal cord motor neurons and extended longevity in mice, with similar effects observed in a rat model of ALS.
A team from Osaka University developed a silicon-based agent that generates hydrogen when reacting with water, reducing inflammation and symptoms of ulcerative colitis in a mouse model. The study suggests the Si-based agent may be an effective treatment method for this disease.
Researchers at Arizona State University have discovered molecular signatures associated with acute and chronic phases of traumatic brain injury (TBI). The study aims to address current limitations in TBI diagnosis and treatment by identifying biomarkers and understanding the blood-brain barrier's role in drug delivery.
Researchers discovered cancer cells produce a unique collagen that alters the tumor microbiome and promotes cancer progression. Loss of this collagen reduces cancer cell proliferation and boosts anti-tumor immune response, offering a potential therapeutic strategy.
Researchers have created a new mouse model that mimics brain damage caused by severe RVFV infection, enabling the study of disease mechanisms and high-throughput testing of next-generation drugs. This breakthrough has significant implications for developing therapies and vaccines for this devastating virus.
A study published in Cancer Research found that constitutively activated p53 in hepatocytes of chronic liver disease patients creates a microenvironment supportive of tumor formation from hepatic progenitor cells. This novel mechanism challenges the traditional role of p53 as a cancer suppressor.
Researchers at Hokkaido University have discovered a molecular pathway by which stress affects lupus, revealing a potential target for treatment. The study found that sleep deprivation caused the activation of microglial cells in the brain, leading to increased levels of IL12 and IL23, a diagnostic marker for neuropsychiatric SLE.
In a new study, researchers found that microglia cells are responsible for neuronal death in a mitochondrial disease mouse model. Suppressing these cells with the drug Pexidartinib increased life expectancy and reduced motor problems. Further research is needed to understand the specific process by which microglia attack neurons.
Researchers at the University of Illinois Urbana-Champaign have developed a low-cost ultrasound imaging method to study the relationship between Alzheimer's disease and the brain's vascular system. The technique, which provides high-resolution images of animal microvasculature, may aid in early detection of the disease.
A study published in Cell Reports found that a rhythmic small intestinal microbiome prevents obesity and type 2 diabetes in mice. The researchers used mouse models to explore how diet and feeding patterns affect the gut microbiome and its impact on host health, particularly with obesity and type 2 diabetes.
A new combination therapy using a plant virus and an antibody activates natural killer cells to target and destroy cancer cells. The therapy eliminates all tumors and prevents their recurrence, resulting in 100% survival in mouse models of colon cancer.
Researchers found that tendons, not muscles, are the key site where increased mechanosensitivity translates to better running and jumping capabilities. High expression of the calcium-ion channel mechanoreceptor coincided with wider tendons composed of larger collagen fibrils.
A detailed understanding of interleukin 2's role in the immune system has been gained through a new mouse model, enabling scientists to identify potential new uses as an immune-modulating biologic drug. This breakthrough may lead to optimized autoimmune and cancer treatment while avoiding unwanted side effects.
Researchers have discovered an alternative route that pluripotent and endoderm extra-embryonic stem cells can use to form intestinal organs in the lab. This finding could lead to improved cell development and potentially treat diseases, but further function testing is needed.
A drug targeting IDH1 mutations in select cancers also inhibits wild-type form under certain conditions, making it a promising therapeutic option. Laboratory experiments and mouse models demonstrate the efficacy of Ivosidenib against various cancer types, including pancreatic, colorectal, ovarian, and lung cancer.
Researchers at UT Health San Antonio found that rapamycin causes an increase in beta-amyloid protein plaques in mouse models, contradicting its potential benefits. However, a novel method to decrease plaques was discovered by deleting the Tsc1 gene from microglia, leading to increased Trem2 levels and decreased plaques.
Researchers developed nanoparticles that deliver NAD(H), a molecule with anti-inflammatory properties, to treat sepsis in mice. The treatment improved survival rates and prevented multiorgan injury.
Scientists create genetically engineered mouse model that changes color in response to light, allowing them to isolate background noise from blood flow and enhance imaging techniques. This breakthrough enables researchers to observe internal physiology with unprecedented accuracy, paving the way for new treatments and therapies.
This study shows how specific brain regions control the immune response during acute stress, highlighting the detrimental effect on fighting off infection. Researchers found that acute stress prompts a major migration of immune cells, diminishing an immune response to viruses like COVID-19 and influenza.
New experiments in mice contradict fears that COVID-19 vaccination affects fetal growth and fertility. Vaccination is shown to protect the fetus from infection, while infection reduces fetal growth. The study adds further evidence against popular claims of vaccine harms during pregnancy.
A study in a mouse model found that viral infections during pregnancy can affect the mother's brain and disrupt maternal care behavior after birth. The research team identified structural, molecular, and functional changes in the brains of mothers with viral-like immune activation.
Researchers at Hokkaido University discovered that ATP secreted from sensory neuron-interneuron crosstalk triggers inflammation spread across joints, acting as a neurotransmitter and inflammation enhancer. Blocking this pathway prevents the spread of inflammation.
Research found that voluntary wheel running increased dopamine signaling in motor areas of mice. This increase remained even after exercise ended. The study suggests BDNF may catalyze increased dopamine signaling.
A new mouse model study found that stress and depression can increase heart disease risk by preventing the beneficial effects of cholesterol-lowering medications. The research suggests that chronic stress can mediate epigenetic changes that make bone marrow precursors more inflammatory, leading to increased plaque formation.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
Researchers found that hypoxia can activate immune cells called ILC2s, which respond to harmless environmental allergens and drive mucus production and inflammation in the lungs. The study identifies adrenomedullin as a new target for treating inflammatory and allergic lung diseases.
Researchers created patient-derived models of brain metastases that recapitulate human disseminated disease, reflecting clinical manifestations and biological characteristics. These models can be used to test therapeutic value of different treatments and explore new approaches tailored to each patient.
A study led by Kobe University researchers found that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells, leading to immune dysregulation and brain-gut axis disorders. The study used BTBR mice as a model and identified histone deacetylase HDAC1 as a common mechanism underlying these pathologies.
Scientists at Gladstone Institutes have discovered that reducing protein tau levels soon after birth can prevent autism and epilepsy in an experimental model. The study pinpointed the crucial brain cells where tau levels must be reduced to avoid these problems, and showed that lowering tau is still effective when initiated after birth.
Researchers at Tokyo University of Science identify brain regions and signaling pathways involved in fear extinction via delta receptor activation. The study suggests a potential therapeutic agent for post-traumatic stress disorders by suppressing fearful memories.
Researchers found a 1000-fold increase in skin microbiota and larger lesions after smallpox vaccination, but all groups had equal protection from re-infection. The study suggests that manipulating commensal skin microbiota might enhance the efficacy of intradermal vaccines.
A study led by MUSC researchers found that inhibiting the complement system with CR2Crry can prevent long-term brain damage and improve outcomes in premature infants with germinal matrix hemorrhage. The treatment has shown improved survival, weight gain, reduced brain injury, and enhanced motor and cognitive performances.
A team of researchers from Osaka University successfully established a mouse model that can reproduce the severe and persistent cough of pertussis. They found that pertussis toxin, Vag8, and lipooligosaccharide are key bacterial factors involved in inducing coughing, which ultimately leads to bradykinin and TRPV1 signaling.
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
Scientists at University of Illinois and Mie University develop monoclonal antibodies to prevent lung cell death in mouse models of idiopathic pulmonary fibrosis and acute respiratory disease syndrome. Non-invasive diagnostic tools also presented could aid in predicting disease progression and identifying patients at risk.
Researchers at the University of Iowa have identified a fundamental biochemical mechanism underlying memory storage, which is impaired in Alzheimer's disease models. The study reveals that restoring this protein folding mechanism reverses memory impairment in mouse models.
Researchers have identified a novel drug candidate, lonafarnib, that improves neuronal morphological defects, abnormal function, and memory impairments in a mouse model of tuberous sclerosis complex. The study suggests that reducing the levels of active Rheb is crucial for normalizing memory in TSC mice.
BGE-175 effectively prevents death in a mouse model of COVID-19 by reversing immune aging, suggesting its potential to protect elderly patients hospitalized with COVID-19. The drug restores the immune system to a more youthful state by blocking the PGD2-DP1 pathway.