Articles tagged with Mouse Models
Researchers found that tendons, not muscles, are the key site where increased mechanosensitivity translates to better running and jumping capabilities. High expression of the calcium-ion channel mechanoreceptor coincided with wider tendons composed of larger collagen fibrils.
Researchers have discovered an alternative route that pluripotent and endoderm extra-embryonic stem cells can use to form intestinal organs in the lab. This finding could lead to improved cell development and potentially treat diseases, but further function testing is needed.
A detailed understanding of interleukin 2's role in the immune system has been gained through a new mouse model, enabling scientists to identify potential new uses as an immune-modulating biologic drug. This breakthrough may lead to optimized autoimmune and cancer treatment while avoiding unwanted side effects.
A drug targeting IDH1 mutations in select cancers also inhibits wild-type form under certain conditions, making it a promising therapeutic option. Laboratory experiments and mouse models demonstrate the efficacy of Ivosidenib against various cancer types, including pancreatic, colorectal, ovarian, and lung cancer.
Researchers at UT Health San Antonio found that rapamycin causes an increase in beta-amyloid protein plaques in mouse models, contradicting its potential benefits. However, a novel method to decrease plaques was discovered by deleting the Tsc1 gene from microglia, leading to increased Trem2 levels and decreased plaques.
Researchers developed nanoparticles that deliver NAD(H), a molecule with anti-inflammatory properties, to treat sepsis in mice. The treatment improved survival rates and prevented multiorgan injury.
Scientists create genetically engineered mouse model that changes color in response to light, allowing them to isolate background noise from blood flow and enhance imaging techniques. This breakthrough enables researchers to observe internal physiology with unprecedented accuracy, paving the way for new treatments and therapies.
This study shows how specific brain regions control the immune response during acute stress, highlighting the detrimental effect on fighting off infection. Researchers found that acute stress prompts a major migration of immune cells, diminishing an immune response to viruses like COVID-19 and influenza.
New experiments in mice contradict fears that COVID-19 vaccination affects fetal growth and fertility. Vaccination is shown to protect the fetus from infection, while infection reduces fetal growth. The study adds further evidence against popular claims of vaccine harms during pregnancy.
A study in a mouse model found that viral infections during pregnancy can affect the mother's brain and disrupt maternal care behavior after birth. The research team identified structural, molecular, and functional changes in the brains of mothers with viral-like immune activation.
Researchers at Hokkaido University discovered that ATP secreted from sensory neuron-interneuron crosstalk triggers inflammation spread across joints, acting as a neurotransmitter and inflammation enhancer. Blocking this pathway prevents the spread of inflammation.
Research found that voluntary wheel running increased dopamine signaling in motor areas of mice. This increase remained even after exercise ended. The study suggests BDNF may catalyze increased dopamine signaling.
A new mouse model study found that stress and depression can increase heart disease risk by preventing the beneficial effects of cholesterol-lowering medications. The research suggests that chronic stress can mediate epigenetic changes that make bone marrow precursors more inflammatory, leading to increased plaque formation.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
Researchers found that hypoxia can activate immune cells called ILC2s, which respond to harmless environmental allergens and drive mucus production and inflammation in the lungs. The study identifies adrenomedullin as a new target for treating inflammatory and allergic lung diseases.
Researchers created patient-derived models of brain metastases that recapitulate human disseminated disease, reflecting clinical manifestations and biological characteristics. These models can be used to test therapeutic value of different treatments and explore new approaches tailored to each patient.
A study led by Kobe University researchers found that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells, leading to immune dysregulation and brain-gut axis disorders. The study used BTBR mice as a model and identified histone deacetylase HDAC1 as a common mechanism underlying these pathologies.
Scientists at Gladstone Institutes have discovered that reducing protein tau levels soon after birth can prevent autism and epilepsy in an experimental model. The study pinpointed the crucial brain cells where tau levels must be reduced to avoid these problems, and showed that lowering tau is still effective when initiated after birth.
Researchers at Tokyo University of Science identify brain regions and signaling pathways involved in fear extinction via delta receptor activation. The study suggests a potential therapeutic agent for post-traumatic stress disorders by suppressing fearful memories.
Researchers found a 1000-fold increase in skin microbiota and larger lesions after smallpox vaccination, but all groups had equal protection from re-infection. The study suggests that manipulating commensal skin microbiota might enhance the efficacy of intradermal vaccines.
A study led by MUSC researchers found that inhibiting the complement system with CR2Crry can prevent long-term brain damage and improve outcomes in premature infants with germinal matrix hemorrhage. The treatment has shown improved survival, weight gain, reduced brain injury, and enhanced motor and cognitive performances.
A team of researchers from Osaka University successfully established a mouse model that can reproduce the severe and persistent cough of pertussis. They found that pertussis toxin, Vag8, and lipooligosaccharide are key bacterial factors involved in inducing coughing, which ultimately leads to bradykinin and TRPV1 signaling.
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
Researchers at the University of Iowa have identified a fundamental biochemical mechanism underlying memory storage, which is impaired in Alzheimer's disease models. The study reveals that restoring this protein folding mechanism reverses memory impairment in mouse models.
Scientists at University of Illinois and Mie University develop monoclonal antibodies to prevent lung cell death in mouse models of idiopathic pulmonary fibrosis and acute respiratory disease syndrome. Non-invasive diagnostic tools also presented could aid in predicting disease progression and identifying patients at risk.
Researchers have identified a novel drug candidate, lonafarnib, that improves neuronal morphological defects, abnormal function, and memory impairments in a mouse model of tuberous sclerosis complex. The study suggests that reducing the levels of active Rheb is crucial for normalizing memory in TSC mice.
BGE-175 effectively prevents death in a mouse model of COVID-19 by reversing immune aging, suggesting its potential to protect elderly patients hospitalized with COVID-19. The drug restores the immune system to a more youthful state by blocking the PGD2-DP1 pathway.
Researchers from Osaka University discovered a group of brain cells in the claustrum that control stress-induced anxiety behaviors. Activating these cells led to anxious behavior, while deactivating them increased resilience against chronic stress.
A biodegradable nanoparticle has shown promise in reducing skin and lung scarring in mice with scleroderma. The treatment targets specific immune cells responsible for the disease's chronic inflammation and scarring.
Scientists create a hybrid technology called heteroduplex oligonucleotide (HDO) that can safely and effectively silence disease-causing genes in certain immune cells. The HDO delivery method has shown promise in improving symptoms of autoimmune disorders and cancers by regulating the function of T and B lymphocytes.
Researchers found that blocking an overactive signaling pathway during the first five weeks of life prevents autism symptoms from developing in mice. The study suggests that targeting this critical period could lead to a potential cure for autism.
Researchers at the University of Tsukuba investigated the effect of sevoflurane on sleep disturbance caused by systemic inflammation. Sevoflurane preconditioning promoted significant increases in REM sleep after LPS injection, while postconditioning had no effect.
A study using an Alzheimer's disease mouse model found that female brains experience a faster decay in information processing ability compared to male mice. This results in weaker memory formation and increased memory loss, contributing to the increased vulnerability of females to Alzheimer's disease.
A Caltech-led team of researchers discovered that a bacterial metabolite can travel to the brain and alter its function, leading to increased anxiety in mice. The study provides a molecular explanation for recent observations linking gut microbiome changes to complex emotional behaviors.
A new study published in Nature Communications found that amylin peptide plays a crucial role in regulating social contact-seeking behavior in female mice. The researchers discovered that isolation leads to a decrease in amylin levels, while social reunion increases them.
Research found that mothers with metabolic syndrome can switch on an imprinted gene in their mice offspring, leading to liver disease. The study suggests a key role for imprinted genes in the development of non-alcoholic fatty liver disease (NAFLD).
Researchers have developed a new mouse model of Huntington's disease that recapitulates more disease-like characteristics than earlier models. The study provides new clues to the mystery surrounding genetic mutations and gives researchers a powerful tool to test new therapies.
Researchers at MedUni Vienna have developed a new Covid-19 mouse model that can be used to study the disease mechanisms and develop effective treatments. The model uses viral mutations that enable efficient virus infection and replication in mice, allowing for the study of symptoms and potential therapies.
Researchers have discovered a molecular signaling pathway associated with osteoarthritis (OA) pain, which plays a crucial role in producing and transmitting pain signals. By blocking this pathway, the study shows promise for developing new, effective pain treatments for human OA sufferers.
Researchers at University of Illinois Chicago identified changes in the gut microbiome that can lead to gestational diabetes. They found a specific metabolite, kynurenine, that is increased during pregnancy and contributes to insulin resistance.
Researchers developed an experimental drug that silences a faulty FUS gene, potentially treating rare and aggressive forms of ALS. The treatment delayed motor neuron degeneration in mice and showed promise in a patient with FUS-ALS.
Researchers are exploring how an engineered adeno-associated virus (AAV) can compensate for missing protein or swap out genetic mutations that cause vision problems. AAV has been found to be beneficial and is being used as a tool to deliver genes that work as they should.
Researchers developed nanoparticles that activate key cancer fighters by driving up immunity at the tumor site, improving interactions with antibody therapies. The technique left six of 10 mice with lymphoma tumor-free and was effective in melanoma when combined with existing immune response amplifiers.
Scientists at Kumamoto University have developed a novel peptide vaccine that improves obesity-related dyslipidemia and may be cost-effective. The vaccine targets angiopoietin-like protein 3 (ANGPTL3) and has been shown to reduce dyslipidemia in mice, producing antibodies that last for six months.
Researchers have developed a CRISPR/Cas9 gene editing system to enhance the effectiveness of sonodynamic therapy, allowing tumors to be effectively shrunk in a mouse model of liver cancer. The technology reduces antioxidant defense systems, increasing cancer cell death from the treatment.
Researchers found damage to a brain part that regulates hyperactivity contributes to both memory issues and seizures in the most common form of epilepsy. This discovery may lead to earlier diagnosis and new treatments for epilepsy and related disorders.
Researchers found that increasing food amount elevates intestinal absorptive surface and function due to enhanced PPARα expression. Food restriction reverses this process, suggesting potential avenues for limiting obesity.
A UC Riverside-led study found that dicyclohexyl phthalate, a common plasticizer, increases plasma cholesterol levels by binding to the pregnane X receptor, or PXR. The study suggests that PXR activation contributes to the harmful effects of plastic-associated chemicals on cardiovascular health.
A new study published in the Journal of Experimental Medicine showed that a fast-tracked stroke drug, 3K3A-APC, protected mice from injury to the brain's white matter, a leading cause of dementia. The drug may also be effective in slowing down progression of cognitive impairment.
Researchers at the University of Gothenburg have successfully treated high-risk neuroblastoma in mice using a combination of precision medicines, showing potential for a curative treatment. The study's results suggest that patients with this form of childhood cancer may benefit from drug treatment with ATR inhibitors.
Researchers discovered that eliminating α-endosulfine (ENSA) or blocking its function reduces brain changes and improves memory in mice. ENSA blocks a potassium channel, which, when blocked, combats excess ENSA levels associated with Alzheimer's disease.
Researchers at the University of Ottawa have made a breakthrough in reversing memory deficits and slowing disease progression in female mouse models of Alzheimer's disease. The study found that activating a specific receptor was effective in treating females, who make up two-thirds of diagnosed cases.
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
Researchers have made significant breakthroughs in understanding Parkinson's disease, revealing that affected neurons don't die but lose properties. This knowledge opens the door to new therapeutic treatments targeting the cell body, rather than just axons.
Research reveals that cancer cells have softer membranes than normal cells, but stiffening them can prevent abnormal changes in structure and motility. Stiffened breast cancer cells lost the ability to spread to the lungs in mouse experiments, suggesting a potential strategy for cancer treatments.
Researchers found that glatiramer acetate improved cognitive behavior and reduced amyloid plaques in a mouse model of Alzheimer's disease. This study suggests therapies targeting the immune system could be effective in treating the disease.
Researchers at Duke University and UC Irvine identify Kenpaullone, a cancer drug, as an effective analgesic for chronic and challenging-to-treat pain. The compound enhances Kcc2 gene expression, which resets maladaptive genetic switches in neurons, leading to pain signal silencing.
A preclinical study found that blocking the Bach1 protein slowed brain cell deterioration in Parkinson's disease. The researchers identified a potent inhibitor of Bach1 called HPPE, which protected cells from inflammation and oxidative stress, and showed promise as a potential therapeutic target.
Researchers found that slow release of TT-10 from nanoparticles improved heart function after a heart attack, accompanied by increased cardiomyocyte proliferation and smaller infarct size. The study suggests that PLGA nanoparticles could be used to improve treatment administration efficiency for cardiovascular drugs.