Articles tagged with Mouse Models
A biodegradable nanoparticle has shown promise in reducing skin and lung scarring in mice with scleroderma. The treatment targets specific immune cells responsible for the disease's chronic inflammation and scarring.
Scientists create a hybrid technology called heteroduplex oligonucleotide (HDO) that can safely and effectively silence disease-causing genes in certain immune cells. The HDO delivery method has shown promise in improving symptoms of autoimmune disorders and cancers by regulating the function of T and B lymphocytes.
Researchers at the University of Tsukuba investigated the effect of sevoflurane on sleep disturbance caused by systemic inflammation. Sevoflurane preconditioning promoted significant increases in REM sleep after LPS injection, while postconditioning had no effect.
Researchers found that blocking an overactive signaling pathway during the first five weeks of life prevents autism symptoms from developing in mice. The study suggests that targeting this critical period could lead to a potential cure for autism.
A study using an Alzheimer's disease mouse model found that female brains experience a faster decay in information processing ability compared to male mice. This results in weaker memory formation and increased memory loss, contributing to the increased vulnerability of females to Alzheimer's disease.
A Caltech-led team of researchers discovered that a bacterial metabolite can travel to the brain and alter its function, leading to increased anxiety in mice. The study provides a molecular explanation for recent observations linking gut microbiome changes to complex emotional behaviors.
A new study published in Nature Communications found that amylin peptide plays a crucial role in regulating social contact-seeking behavior in female mice. The researchers discovered that isolation leads to a decrease in amylin levels, while social reunion increases them.
Research found that mothers with metabolic syndrome can switch on an imprinted gene in their mice offspring, leading to liver disease. The study suggests a key role for imprinted genes in the development of non-alcoholic fatty liver disease (NAFLD).
Researchers have developed a new mouse model of Huntington's disease that recapitulates more disease-like characteristics than earlier models. The study provides new clues to the mystery surrounding genetic mutations and gives researchers a powerful tool to test new therapies.
Researchers at MedUni Vienna have developed a new Covid-19 mouse model that can be used to study the disease mechanisms and develop effective treatments. The model uses viral mutations that enable efficient virus infection and replication in mice, allowing for the study of symptoms and potential therapies.
Researchers have discovered a molecular signaling pathway associated with osteoarthritis (OA) pain, which plays a crucial role in producing and transmitting pain signals. By blocking this pathway, the study shows promise for developing new, effective pain treatments for human OA sufferers.
Researchers at University of Illinois Chicago identified changes in the gut microbiome that can lead to gestational diabetes. They found a specific metabolite, kynurenine, that is increased during pregnancy and contributes to insulin resistance.
Researchers developed an experimental drug that silences a faulty FUS gene, potentially treating rare and aggressive forms of ALS. The treatment delayed motor neuron degeneration in mice and showed promise in a patient with FUS-ALS.
Researchers are exploring how an engineered adeno-associated virus (AAV) can compensate for missing protein or swap out genetic mutations that cause vision problems. AAV has been found to be beneficial and is being used as a tool to deliver genes that work as they should.
Researchers developed nanoparticles that activate key cancer fighters by driving up immunity at the tumor site, improving interactions with antibody therapies. The technique left six of 10 mice with lymphoma tumor-free and was effective in melanoma when combined with existing immune response amplifiers.
Scientists at Kumamoto University have developed a novel peptide vaccine that improves obesity-related dyslipidemia and may be cost-effective. The vaccine targets angiopoietin-like protein 3 (ANGPTL3) and has been shown to reduce dyslipidemia in mice, producing antibodies that last for six months.
Researchers have developed a CRISPR/Cas9 gene editing system to enhance the effectiveness of sonodynamic therapy, allowing tumors to be effectively shrunk in a mouse model of liver cancer. The technology reduces antioxidant defense systems, increasing cancer cell death from the treatment.
Researchers found damage to a brain part that regulates hyperactivity contributes to both memory issues and seizures in the most common form of epilepsy. This discovery may lead to earlier diagnosis and new treatments for epilepsy and related disorders.
Researchers found that increasing food amount elevates intestinal absorptive surface and function due to enhanced PPARα expression. Food restriction reverses this process, suggesting potential avenues for limiting obesity.
A UC Riverside-led study found that dicyclohexyl phthalate, a common plasticizer, increases plasma cholesterol levels by binding to the pregnane X receptor, or PXR. The study suggests that PXR activation contributes to the harmful effects of plastic-associated chemicals on cardiovascular health.
A new study published in the Journal of Experimental Medicine showed that a fast-tracked stroke drug, 3K3A-APC, protected mice from injury to the brain's white matter, a leading cause of dementia. The drug may also be effective in slowing down progression of cognitive impairment.
Researchers at the University of Gothenburg have successfully treated high-risk neuroblastoma in mice using a combination of precision medicines, showing potential for a curative treatment. The study's results suggest that patients with this form of childhood cancer may benefit from drug treatment with ATR inhibitors.
Researchers discovered that eliminating α-endosulfine (ENSA) or blocking its function reduces brain changes and improves memory in mice. ENSA blocks a potassium channel, which, when blocked, combats excess ENSA levels associated with Alzheimer's disease.
Researchers at the University of Ottawa have made a breakthrough in reversing memory deficits and slowing disease progression in female mouse models of Alzheimer's disease. The study found that activating a specific receptor was effective in treating females, who make up two-thirds of diagnosed cases.
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
Researchers have made significant breakthroughs in understanding Parkinson's disease, revealing that affected neurons don't die but lose properties. This knowledge opens the door to new therapeutic treatments targeting the cell body, rather than just axons.
Research reveals that cancer cells have softer membranes than normal cells, but stiffening them can prevent abnormal changes in structure and motility. Stiffened breast cancer cells lost the ability to spread to the lungs in mouse experiments, suggesting a potential strategy for cancer treatments.
Researchers found that glatiramer acetate improved cognitive behavior and reduced amyloid plaques in a mouse model of Alzheimer's disease. This study suggests therapies targeting the immune system could be effective in treating the disease.
Researchers at Duke University and UC Irvine identify Kenpaullone, a cancer drug, as an effective analgesic for chronic and challenging-to-treat pain. The compound enhances Kcc2 gene expression, which resets maladaptive genetic switches in neurons, leading to pain signal silencing.
A preclinical study found that blocking the Bach1 protein slowed brain cell deterioration in Parkinson's disease. The researchers identified a potent inhibitor of Bach1 called HPPE, which protected cells from inflammation and oxidative stress, and showed promise as a potential therapeutic target.
Researchers found that slow release of TT-10 from nanoparticles improved heart function after a heart attack, accompanied by increased cardiomyocyte proliferation and smaller infarct size. The study suggests that PLGA nanoparticles could be used to improve treatment administration efficiency for cardiovascular drugs.
Researchers at Osaka University studied mice with mutations in ADAR1 and found that impaired Z-RNA recognition contributed to abnormal growth, organ development, and chronic inflammation. This study highlights the importance of proper RNA editing and its relation to Aicardi-Goutières syndrome.
A research team from the University of Zurich has identified a common genetic variant in the AQP1 gene that affects treatment efficacy and patient survival on peritoneal dialysis. Patients carrying this variant have a higher risk of death, but researchers found a way to circumvent the problem using colloid osmotic agents.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
Researchers created the largest metabolome analysis of the mouse brain, revealing distinct chemical conversions between brain regions. Aging mice showed significant metabolic differences in brain sections, with lipids playing a crucial role in changes to brain function.
A recent study suggests that targeting alpha-synuclein protein in Parkinson's disease may not be sufficient to cure most patients. Instead, resolving brain inflammation caused by dysfunctional interferon-beta receptor signaling may hold the key to developing more effective treatments.
Researchers have developed a novel mouse model that accurately replicates the pathological propagation of tau protein isoforms in Alzheimer's disease, corticobasal degeneration, and Pick's disease. The model shows endogenous expression of both 3R and 4R tau, which accumulates in brain regions characteristic of each disease.
A study by Purdue University researchers has discovered a way to use gene therapy to turn glial brain cells into neurons, restoring visual function. This process is more efficient and less damaging than stem cell therapy, offering new hope for patients who have lost vision or motor skills after a stroke.
Researchers at Tokyo University of Science discover that vicarious social defeat can cause psychological stress in mice, leading to depression and decreased neurogenesis. The study sheds light on the pathophysiology of depression and may lead to the development of novel antidepressants.
Researchers at RIKEN Cluster for Pioneering Research have found that Kleefstra syndrome, a genetic disorder leading to intellectual disability, can be reversed after birth. Postnatal treatment with artificially induced GLP production resulted in improved brain and behavioral symptoms.
Researchers at St. Jude Children's Research Hospital found that the tumor suppressor gene PTEN controls rhabdomyosarcoma cell identity and that enhancing PAX7 expression can maintain tumor cell existence, providing a potential treatment target for rhabdomyosarcoma.
A study by Cincinnati Children's Hospital Medical Center reveals that minor cells with mutations in the DDX41 gene can trigger a subset of inherited MDS cases. The research suggests that targeting these cells could lead to new treatment options for patients.
A new approach called an immunobiological algorithm provides a comprehensive assessment of how a patient's immune system will react to tissue from each potential living donor. This method outperforms current HLA testing in identifying the best potential living donor, which could lead to improved organ transplant outcomes.
A new study from Salk Institute researchers found that a critical threshold of miR-218 levels determines the development of ALS in animal models. The study sheds light on the complex control of gene expression and its implications for treating neurological disorders.
A study published in Scientific Reports describes the putative molecular regulators of reductive stress — a microRNA network. The researchers identified a subset of miRNAs that appeared to be direct and dose-dependent targets of Nrf2, and thus putative regulators of reductive stress.
Researchers at St. Jude Children's Research Hospital have developed a more accurate laboratory model for studying retinoblastoma, a rare pediatric eye cancer. The models closely mimic the biology of patient tumors and provide an important resource for studying the earliest stages of the disease as well as screening new therapies.
Researchers identified two proteins, HMW1 and HMW2, that stimulate protective immunity against diverse NTHi strains. Immunization with these proteins provides protection against bacterial colonization by other strains, highlighting the vaccine potential for a nontypeable Haemophilus influenzae vaccine.
Scientists discovered impaired leptin transport to the brain via LepR receptors leads to pre-diabetic state and exhausted insulin secretion. Reintroducing leptin restores pancreatic function-promoting action, suggesting a crucial brain role in type 2 diabetes management.
Researchers found that mice can make fine visual discriminations between slightly different lines, suggesting a more complex decision-making process than previously thought. The study's findings highlight the importance of considering non-perceptual biases in understanding animal behavior and decision-making strategies.
Researchers used genetically engineered mice to study the AgRP hunger neurons, finding that fasting activates these cells, while food cues inhibit their activity. The team discovered that the aversive feeling caused by hunger enhances learning, making dieting difficult due to this persistent sensation.
A diet rich in isoflavone may provide protection against multiple sclerosis-like symptoms when combined with specific gut bacteria that can break down the compound. The study found that mice fed an isoflavone diet had a microbiome similar to healthy individuals, while those without it lacked beneficial bacteria.
Researchers at Kobe University have identified a causal gene, Necdin (NDN), associated with autism spectrum disorder and other developmental disorders. The study reveals that the NDN gene regulates synapse development during critical developmental stages.
Scientists from the Netherlands Institute for Neuroscience found that mice have a region called 'focea' with improved visual sensitivity, similar to the fovea in human retinas. This discovery suggests that mice may be better models for studying human vision than previously thought.
Researchers found that playing broadband sounds during the onset of congenital hearing loss preserved auditory processing of time-related sound features. The intervention also prevented hair cells from dying and maintained sound processing function in brainstems, cochleas, and midbrains.
A team of researchers from Japan and Germany created a mouse model that mimics the human pathology of restrictive cardiomyopathy, allowing for easier study. The model shows changes in protein quality control and autophagy, leading to fibrosis and heart muscle stiffening.
Researchers discovered that a Western diet high in fat and cholesterol can lead to obesity, diabetes, and Non-alcoholic steatohepatitis (NASH), which progresses to liver cancer, kidney disease, and cardiovascular disease. Switching to a normal chow diet improves NASH and liver fibrosis, prevents cancer progression and mortality.
Researchers have discovered a novel consortium of bacteria that can prevent and treat chronic immune-mediated colitis in humanized mouse models. The treatment targets the source of inflammatory bowel disease, restoring normal gut function and reducing symptoms.
The La Jolla Institute for Immunology has partnered with Synbal, Inc. to develop multi-gene, humanized mouse models for COVID-19 research. These new models are expected to provide a better understanding of SARS-CoV-2 infection and disease severity, enabling the development of more effective vaccines and therapies.
Scientists have discovered a novel deafness gene, TMEM43, linked to auditory neuropathy spectrum disorder (ANSD), a rare form of hearing loss that affects speech comprehension. The treatment involves cochlear implants, which have successfully restored speech discrimination in patients, offering new hope for those affected.
Researchers developed a unique pre-clinical model of long-term HIV infection using subset of human CD4 cells, excluding those prone to attacking mouse tissue. The model showed that memory CD4 cells can be infected and killed by HIV or protected by anti-HIV drugs, paving the way for T-cell based therapies