Articles tagged with Bone Formation
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Karin Vargervik is being recognized for her extensive work on experimental and clinical issues related to bone formation and remodeling. Her research has focused on craniofacial growth, development, and malocclusions, with a particular emphasis on etiological factors.
Researchers at NIAID have discovered a protein that appears to regulate bone mass loss, which is a key factor in osteoporosis. The study, conducted on patients with X-linked Hyper IgM Syndrome, found that the loss of this protein accelerates bone loss.
Children with cancer are vulnerable to bone fragility, exacerbated by sedentary behaviors and treatment side effects. Early management through exercise and bisphosphonates can mitigate this risk.
Researchers at NIH have found a second genetic defect causing previously unexplained forms of osteogenesis imperfecta (OI), a disorder weakening bones and resulting in frequent fractures. The affected gene contains information for P3H1 protein, crucial for refining collagen to its final form.
Researchers at University of Pennsylvania School of Medicine discovered targeting a single gene can inhibit bone decay while stimulating bone formation. This concept may lead to drug treatments for osteoporosis and other bone diseases.
A new study found that a low-protein diet can normalize bone formation and bone mass in mice with genetic disorders, while a high-protein diet may reverse skeletal syndromes. The researchers identified ATF4 as a key mediator of neurofibromin signaling, which plays a crucial role in bone development.
Researchers discovered a novel 'Trojan Horse' agent, VEGF121/rGel, that completely prevented bone tumor development in 50% of mice. The agent stops specialized cells within the bone from chewing up bone material to make room for implanted tumors to grow.
A team of researchers has identified a new genetic mutation responsible for osteogenesis imperfecta (OI), a condition that makes bones more likely to break. The study found that mutations in the CRTAP gene reduce the ability of a protein involved in collagen formation, leading to weaker bone and increased risk of fracture.
Researchers found that fluoxetine stimulates new bone formation under normal conditions and reverses total bone loss triggered by inflammation. The study suggests a link between serotonin reuptake inhibitors and improved bone health.
A study found that higher levels of specialized blood cells from bone marrow are associated with liver cancer prognosis. Elevated endothelial progenitor cells were linked to poorer outcomes in patients with inoperable hepatocellular carcinoma.
A new study resolves a long-standing debate on dinosaur metabolism by using mathematical modeling and fossil data to estimate body temperatures. The results suggest that the largest dinosaurs had relatively constant body temperatures maintained through thermal inertia.
Researchers present Phase 2 clinical results showing AC-100 stimulates the formation of new dentin, especially in deepest cavities. The study demonstrates a novel biological approach to promoting dentin formation as a supplement to routine dental care.
The Mayo Clinic has pioneered a novel method of jaw reconstruction for oral cancer patients, utilizing distraction osteogenesis after tumor removal surgery. This approach enables patients to receive both radiation therapy and reconstruction concurrently, minimizing scar tissue and improving patient tolerance.
Researchers found that slightly increasing NFATc1 activity leads to massive bone accumulation in mice, suggesting potential new targets for treating osteoporosis. The study's findings may enable the development of drugs that promote bone formation without causing undesirable side effects.
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a mutation in the ACVR1 gene, leading to an armament of bone that locks movement impossible. The discovery provides a highly specific target for future drug development and holds promise for altering symptoms and the disease itself.
A growing body of research suggests that lead exposure in childhood accelerates bone growth, but ultimately prevents optimal peak bone mass, increasing the risk of osteoporosis and fractures. Clinical study aims to better understand the role of lead in bone development and loss.
UT Southwestern researchers found that activating hedgehog signaling pathway blocks fat formation in mammals, while inhibiting it stimulates fat cell creation. The study opens avenues for potential therapy in humans for obesity, diabetes and osteoporosis.
Researchers at Virginia Tech have developed a new bone tissue engineering material using amorphous calcium phosphates, which they believe could lead to faster and higher quality bone formation. The team's work, in collaboration with the American Dental Association, is currently in press for several scientific journals.
Chronic alcohol abuse can disrupt the balance of bone remodeling, leading to measurable bone loss over a few years. Alcohol-induced bone disease weakens bones and predisposes individuals to increased fracture risk and delayed fracture healing due to decreased osteoblast activity.
Researchers have developed a new cell line to study prostate cancer and its effects on the body. Anti-nerve growth factor therapy shows promise in reducing skeletal pain associated with prostate cancer, outperforming morphine.
Agnès Vignery, an expert in bone development, will conduct collaborative research at Pfizer's Global Research and Development. Her lab has developed a new technology to induce bone formation for fracture prevention, which is being refined in rodents for human translation.
Scientists have developed a laser imaging technique that can assess bone strength more accurately, predicting the likelihood of young women developing osteoporosis in later life. By measuring collagen content, the new Raman spectroscopic technique eliminates the impact of overlying tissues.
The study found that walking is most energy-efficient at low speeds, while running is best for higher speeds. A third walk-run gait is also optimal for intermediate speeds, but humans do not currently use this gait.
Researchers have identified the Dido gene as a potential tumor suppressor involved in myeloproliferative diseases. The study found that 100% of patients with these diseases had Dido expression abnormalities, suggesting a link between the gene and the development of MDS/MPD.
Researchers at Yale University have found that varying oxygen concentrations in alligator eggs alter growth patterns and affect bone development, suggesting a link to fossil records of prehistoric atmospheric oxygen levels. The study provides new insights into the complex interaction between vertebrate development and oxygen levels.
Researchers induce indefinite organ allograft survival in rhesus monkeys by stimulating recipient T cells with donor cells, generating immunosuppressive anergic T cells. These cells suppress renal allograft rejection without additional immunosuppressive agents.
A recent study found that patients taking calcium supplements had a 36 percent reduction in polyp formation, with even greater protection against non-neoplastic hyperplastic polyps. However, the protective effect diminished over time, falling to a non-significant 19 percent after 10 years.
The University of Manchester is conducting a groundbreaking study to investigate the impact of early pregnancy on bone health in teenage mothers. The researchers aim to determine whether calcium and mineral supplements can be beneficial for younger expectant mothers, with findings expected by the end of 2006.
A new study reveals that a secreted signaling protein called Wnt10b stimulates the growth of bone cells and inhibits fat cell development, leading to increased bone mass and density in mice. The research also shows that Wnt10b protects against bone loss from aging or estrogen deficiency.
The oldest known fossils of Homo sapiens have been found in Ethiopia and date back to 195,000 years ago. This pushes the emergence of anatomically modern humans back by approximately 30,000 years, with implications for our understanding of human cultural development.
Researchers found that leg growth occurs primarily when lambs are at rest, potentially explaining growing pains in children. The study provides valuable new data on bone growth spurts and suggests that pressure on growth plates may be eased during rest, allowing bones to elongate.
A new study by Ohio State University researchers found that calcium supplementation significantly increased bone mass development during a critical childhood growth spurt in pre-adolescent girls. The findings suggest that elevated calcium use during this period may help prevent fractures and osteoporosis later in life.
Researchers at the Mayo Clinic have developed a new method to repair cleft palates using distraction osteogenesis, which gradually lengthens bone and soft tissue. The technique has shown promising results in animal studies, with some degree of bony closure observed in most treated animals.
A new high-resolution ultrasound imaging device, SCAD, can monitor and diagnose bone quantity, density and strength in space. The technology has the potential to aid diagnosis for a number of skeletal disorders and improve treatment outcomes for people suffering from osteoporosis.
A four-year project aims to understand how androgen influences the skeleton, with potential implications for stress fracture prevention and treating osteoporosis. The study examines the effects of androgen therapy on bone health in both men and women.
Scientists have identified a crucial role of HDAC4 in regulating bone formation, and its disruption can lead to developmental defects. The discovery opens new possibilities for designing drugs to control bone growth and may help prevent osteoporosis.
Researchers found a reduction in bone mass and size in mice administered an SSRI, highlighting the need for further research into its effects on children and adolescents. The study suggests that anything affecting normal bone development may have far-reaching consequences later in life.
Running and jumping exercises are most effective for strengthening bones in children, as they stimulate new bone growth where it is needed. Unlike swimming or biking, these activities do not affect longitudinal growth, making them a recommended choice.
USC researchers detail process of beak formation in journal Science, identifying BMP4 as a major mediator of beak shape. The study sheds light on how different bird species develop uniquely shaped beaks reflecting their ecological niches.
A recent study suggests that exercise is the predominant lifestyle determinant of bone strength in young women, with daily calcium intake showing little impact on adult bone mass. The research found that physical activity accounted for between 16% and 22% of variation in hip bone mineral density and bending strength.
Researchers at Stanford Medicine have found that fat-derived cells can effectively heal skull defects in mice, outperforming bone marrow cells. The discovery holds promise for developing new treatments for bone fractures, joint replacements, and other skeletal conditions.
Researchers at Northwestern University successfully induced embryonic stem cells to develop into precursor bone marrow and blood cells in genetically mismatched mice. The technique could lead to a renewable alternative to donor bone marrow transplantation, reducing the risk of graft-versus-host disease.
Researchers found that PPAR-gamma deficiency in mice enhances bone development by increasing osteoblast production, while adipocyte differentiation is impaired. This discovery may provide new avenues for osteoporosis therapies.
Researchers identify Twist proteins as transient inhibitors of osteoblast differentiation, negatively regulating Runx2. This finding provides insight into the complexity of osteoblast differentiation and its initiation by the relief of inhibition.
Researchers at Northwestern University have successfully grown nerve cells using an artificial three-dimensional network of nanofibers, a technique important in regenerative medicine. The innovative scaffold directs cell differentiation, driving neural progenitor cells to become neurons and not astrocytes.
Researchers found that the hormone estradiol plays a crucial role in proplatelet formation, enabling the creation of new blood platelets. This discovery may lead to alternative treatments for conditions such as anemia and thrombocytopenia.
UMHS researchers found poor bone quality in rats with high-dose radiation, suggesting new therapies to improve human treatment. The study uses a rat model to analyze the success and failure of distraction osteogenesis in irradiated cancer patients.
The overproduction of noggin during aging may result in impaired bone building and function, leading to net bone loss. Researchers suggest that recombinant BMP2 may prove useful in reversing age-related bone loss.
Researchers developed a costimulatory blockade-based protocol to induce peripheral tolerance in stem cell transplantation. This approach combines donor-specific transfusion and anti-CD154 monoclonal antibody administration to achieve functional HSC populations without myeloablation or GVHD induction.
A boy was diagnosed with acquired osteopetrosis after being given high doses of bisphosphonates to treat weak, painful bones. The condition results from excessive bone formation and can lead to fractures., Researchers emphasize the importance of carefully monitoring medications like bisphosphonates, especially in children.
Researchers develop scaffold that enables bone marrow cells to grow naturally without growth factors, promoting dense new bone growth. The technology has shown promising results in animal studies, with strong new bone replacing the scaffold in just eight weeks.
A team of University of Toronto researchers has created a biodegradable scaffold that accelerates bone healing rates by providing a building structure for bone growth. The scaffold, similar in structure to a dish sponge, eventually dissolves, eliminating the need for expensive chemicals called bone growth factors.
Vitamin A supplements have saved millions of lives by preventing childhood blindness and reducing mortality rates. Dr. Alfred Sommer's research also shows that supplementing women with vitamin A can reduce maternal mortality by an average of 45 percent.
A retrospective cohort study found that pregnant teens, particularly those from under-resourced backgrounds, require adequate calcium intake to support fetal bone growth. The study's findings suggest a correlation between high maternal dairy consumption and improved fetal bone length and overall nutrition.
Researchers found that Noggin prevents premature skull fusion by keeping bone-promoting proteins apart. The discovery could lead to early diagnosis and treatment of infants at risk, offering a promising alternative to complex craniofacial surgery.
A study of wild black bears found that they recover from bone loss caused by inactivity through a mechanism involving increased bone formation during remobilization. This suggests that hibernating bears may minimize bone loss and completely recover lost bone, providing potential insights for treating osteoporosis.
Researchers at Indiana University School of Medicine have localized the original mineral deposit site for most common stone formers and determined the composition of calcium phosphate crystals. This discovery refutes current theories on kidney stone formation, shedding new light on the disease's complex physiology.
Researchers used titanium mesh and bone marrow cells to promote new bone growth in rats, achieving better results with fibronectin-coated mesh and a flow perfusion system. The study presents an alternative method for treating bone defects and highlights the potential for improving cell growth and bone mineralization.
Researchers have discovered that bone formation in a regenerated forelimb combines elements of embryonic development and adult wound healing. MicroCT imaging reveals that bone formation does not occur in the same order as previously thought, but rather follows a pattern similar to normal fracture recovery.
A study by Purdue University scientists found that dogs on fatty diets exhibited reduced growth, bone formation, and immune function. The research suggests that oxidized fats in the diet can contribute to aging and disease development in humans, particularly children during critical stages of growth.